Streptomyces koyangensis: D0C37_19265
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Entry
D0C37_19265 CDS
T06436
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
sky
Streptomyces koyangensis
Pathway
sky00860
Porphyrin metabolism
sky01100
Metabolic pathways
sky01110
Biosynthesis of secondary metabolites
sky01120
Microbial metabolism in diverse environments
sky01240
Biosynthesis of cofactors
Module
sky_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
sky_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
sky00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
D0C37_19265
Enzymes [BR:
sky01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
D0C37_19265
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
D0C37_19265
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
AXQ56518
UniProt:
A0A385DDP0
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Position
4348297..4349934
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AA seq
545 aa
AA seq
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MFSDHGHVTFLGAGPGDPGLLTLRAVEALAAADVLVAEEQVLDVVRAHARAGADMPQLSA
DEASTSAEARRFGDAANLVMGAARAGKRVVRAVQGDPGLDSEAVREMLACAAEGVTFEVV
PGIAEAVGVPAYAGIPLRDETGADVRFVDARTATERCWTEVGASDGTVVVSTSLDQAAAT
AGELVAAGRKPDTPMTLTVAGTTTRQRTWEATLGTVAQVLKQAKVLPSPDGGRPVIAVVG
EHCAPARRDQLSWFESKPLFGWKVLVPRTKEQAASLSDQLRSYGAVPHEVPTIAVEPPRT
PQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIKVAAVGEQTAAAL
IAFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATETLVAGLIELGWEV
DDVTAYRTVRASPPPADTREAIKGGGFDAVLFTSSSTVRNLVGIAGKPHNVTVIACIGPA
TAKTAEEHGLRVDVMAPEPSVHKLAEALASFGAERRAAALEAGESVARPSERRPGARRRR
AASSS
NT seq
1638 nt
NT seq
+upstream
nt +downstream
nt
atgttctccgaccatgggcacgtcaccttcctcggtgccggtcctggcgacccggggctt
ctcactctgcgcgccgtcgaggcgctggccgcggccgacgtcctggtcgcggaggagcag
gtgctcgacgtcgtcagggcgcatgccagggcgggcgcggacatgccgcaactttccgct
gacgaggcgtcaacctccgcggaggcccgccgattcggcgatgccgccaatcttgtcatg
ggggccgcgcgcgccggaaagcgggtcgtccgggccgtccagggcgacccggggctcgac
tccgaggccgtccgcgagatgctcgcctgcgccgccgagggcgtcaccttcgaggtggtc
cccggcatcgcggaggcggtcggcgtccccgcgtacgccggtatcccgctgcgtgacgag
accggcgccgacgtgcgcttcgtcgacgcgcgcaccgccaccgagcgctgctggaccgag
gtgggcgccagcgacggcaccgtcgtcgtctccaccagcctcgaccaggccgcggccacc
gcgggcgaactggtggcggccgggcgtaagcccgacaccccgatgacgctcaccgtcgcc
gggaccaccacccgccagcggacctgggaggcgacgctcggcaccgtcgcgcaggttctc
aagcaggccaaggtgctgccctcgcccgacggcggccgcccggtgatagccgtggtcggt
gagcactgcgccccggcccgccgcgaccagctctcctggttcgagtcgaagccgctcttc
ggctggaaggtcctggtgccgcgcaccaaggagcaggcggcctcgctctccgaccagctg
cgctcctacggtgcggtaccgcacgaggtgccgaccatcgccgtcgagccgccgcgcacc
ccgcagcagatggaacgggccgtcaagggcctcgtcaccggacgctacgagtggatcgcg
ttcaccagcgtcaacgcggtcaaggcggtccgggagaagttcgaggagtacgggctcgac
gcgcgggccttcgccggcatcaaggtcgccgccgtcggcgagcagaccgccgccgcgctg
atcgccttcggcgtcaagcccgacctcgtcccctcgggcgagcagtccgcggccgggctc
ctggaggactggccgccgtacgacccggtcttcgacccgatcgaccgggtgttcctgccg
cgcgccgacatcgccaccgagaccctggtggccgggctgatcgagctgggctgggaggtg
gacgacgtcaccgcctaccggacggtgcgcgcctcgccgccgccggccgacacccgcgag
gcgatcaagggcggcggcttcgacgcggtcctgttcacctcgtcctcgaccgtccgcaac
ctggtcggcatcgcgggcaagccgcacaacgtcacggtcatcgcctgtatcgggcccgcc
accgccaagacggcggaggagcacgggctgagagtcgacgtgatggcgcccgagccctcg
gtgcacaagctggccgaggcgctcgcctccttcggcgcggagcgccgggcggccgcgctg
gaggccggggagagcgtcgcccggcccagcgagcggcgccccggcgcccggcgccgcagg
gccgcctcctcctcgtga
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