Streptomyces lincolnensis: SLINC_4836
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Entry
SLINC_4836 CDS
T04801
Name
(GenBank) uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
sls
Streptomyces lincolnensis
Pathway
sls00860
Porphyrin metabolism
sls01100
Metabolic pathways
sls01110
Biosynthesis of secondary metabolites
sls01120
Microbial metabolism in diverse environments
sls01240
Biosynthesis of cofactors
Module
sls_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
sls_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
sls00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
SLINC_4836
Enzymes [BR:
sls01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
SLINC_4836
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
SLINC_4836
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
ANS67060
UniProt:
A0A1B1MEK5
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Position
5784861..5786591
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AA seq
576 aa
AA seq
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MSPTTLPVAGPEHGHVTFLGAGPGDPGLLTLRAVEALATADVLVAGHEVLDVVRTHARSG
VAVVNTDADPAGRPADLSSGPTPGTGAPQLTVVDGASTTAGVPAVRDAAHLVMEAARGGR
RVVRAVSGDPGLDAYAAEEMLACARAGVPFEVVPGVAAAVGVPAYAGVPLRDAQGADVRF
VDARTASDRCWTEVGASDGTVVVSTTLDSMAAAAGELVAAGRKPDTPLTVTVAGTTTRQR
TWTATLGTIAQTLKQAKVLPSPDGARPVIAVVGERSATAQREQLSWFESKPLFGWKVLVP
RTKEQAASLSDQLRSYGAVPHEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAV
KAVREKFEEYGLDARAFAGIKVAAVGEQTAKALVAFGVKPDLVPSGEQSAAGLLEDWPPY
DPVFDPIDRVFLPRADIATETLVAGLIELGWEVDDVTAYRTVRASPPPAETREAIKGGGF
DAVLFTSSSTVRNLVGIAGKPHNVTVIACIGPATAKTAEEHGLRVDVMAPEPSVHKLAEA
LADFGSRRRAAAVEAGDPVTRPSERRPGARRRRTTT
NT seq
1731 nt
NT seq
+upstream
nt +downstream
nt
gtgagccccaccacccttcccgtcgccggtcctgaacacgggcacgtcaccttcctcggt
gccggacccggggatccgggactacttactctgcgcgccgtcgaggcactggcaaccgcg
gacgttctcgtcgccgggcacgaagtgctcgacgtcgtacgtacgcatgccaggtccggt
gtcgccgtggtgaacacggatgcggatcccgcgggtcgccccgcggatctttcctccggt
cccacgccgggcacaggcgcgcctcaactaacggttgttgacggcgcgtcaacaaccgct
ggcgtccccgccgtgcgggatgccgcacatcttgtcatggaggccgcgcggggcggcagg
cgggtcgtacgtgcggtgtccggggaccccggactcgacgcgtacgccgccgaggagatg
ctggcctgcgcccgcgcgggggtgcctttcgaggtcgttcccggtgtcgcagccgccgtc
ggcgtgcccgcctacgccggtgtgccgctgcgggacgcgcagggggccgacgtccggttc
gtggacgcgcggaccgcgtccgaccggtgctggacggaggtgggggcctcggacgggacg
gtcgttgtgtcgacgaccctcgactccatggccgccgccgccggcgaactcgtcgccgcc
ggccgtaagcccgacacgccgttgaccgtgaccgtcgccgggaccaccacgcggcagcgg
acctggaccgccacgctcggcaccatcgcgcagacgctgaagcaggcgaaggtgctgccg
tccccggacggggcccggccggtgatagccgtggtcggcgagcggtccgccacggctcag
cgtgagcagctctcgtggttcgagtccaagccgctgttcggctggaaggtgctcgtgccg
cgcaccaaggagcaggcggcctcgctctccgaccagctgcggtcctacggggccgtgccg
cacgaggtgccgaccatcgccgtcgagccgccgcggacgccccagcagatggagcgggcg
gtcaaggggctggtgaccgggcggtacgagtggatcgccttcacctcggtgaacgcggtg
aaggccgttcgcgagaagttcgaggagtacgggctcgacgctcgggccttcgccgggatc
aaggtcgcggcggtcggggagcagaccgccaaggcgctcgtcgcgttcggtgtgaagccg
gatctggtgccgagcggggagcagtcggctgcggggttgctggaggactggcctccgtat
gatcccgtattcgatcccatcgaccgggttttcctgcctcgggccgatatcgccacggag
accctggtcgccgggctgatcgagctcgggtgggaggtcgacgacgtcaccgcctatcgg
accgtgcgggcttcgccgccgccggccgagacccgggaggcgatcaaggggggtggcttc
gacgccgttctcttcacctcgtcgagcacggtgcggaacctggtgggtatcgccgggaag
ccgcacaacgtgaccgtgatcgcctgtatcgggcccgccacggcgaagactgctgaggag
catggactgcgggtggatgtgatggctcctgagccgtccgtgcacaagttggccgaggcg
ttggccgacttcgggtctcggcggcgggcggctgctgttgaggccggggatcccgttact
cggccgagtgagcggcggccgggggctcggcggcggcggaccaccacctga
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