Streptomyces avermitilis: SAVERM_4741
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Entry
SAVERM_4741 CDS
T00126
Symbol
hemD
Name
(GenBank) putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
sma
Streptomyces avermitilis
Pathway
sma00860
Porphyrin metabolism
sma01100
Metabolic pathways
sma01110
Biosynthesis of secondary metabolites
sma01120
Microbial metabolism in diverse environments
sma01240
Biosynthesis of cofactors
Module
sma_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
sma_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
sma00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
SAVERM_4741 (hemD)
Enzymes [BR:
sma01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
SAVERM_4741 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
SAVERM_4741 (hemD)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
BAC72453
NITE:
SAV4741
UniProt:
Q82E75
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Position
5780485..5782200
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AA seq
571 aa
AA seq
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MSPTTLPAGPEHGHVTFLGAGPGDPGLLTLRAVEALARADVLVAEHEVLDVVRTHARQGV
AVLNTSSDAYSDTSSGTYSATSTPQLAVVDSTSTTAGTPASRDAANLVMEAARGGRRVVR
AVSGDPGLDTYAAEEMLACAAAGVPFEVVPGIAAAVGVPAYAGVPLRDAQGADVRFVDAR
SASERCWTEVGASDGTVVVSATLDSVAAAAGELVAAGRKPDTPMSVTIAGTTTRQRTWSA
TLGSIAQTLKQAKVLPSPDGGRPVIAVVGERSAAAQRDQLSWFESKPLFGWKVLVPRTKE
QAASLSDQLRSYGAVPHEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVR
EKFEEYGLDARAFAGIKVAAVGEQTAKALVAFGVKPDLVPSGEQSAAGLLEDWPPYDPVF
DPIDRVFLPRADIATETLVAGLIELGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVL
FTSSSTVRNLVGIAGKPHNVTVIACIGPATAKTAEEHGLRVDVMAPEPSVLKLAEALADF
GLRRRASALDAGDPVTRPSERRPGSRRRRTT
NT seq
1716 nt
NT seq
+upstream
nt +downstream
nt
ttgagccccaccacccttcccgccggtccggaacacgggcacgtcaccttcctgggtgcc
ggtcccggagatccgggactgctcacactgcgcgccgtggaggcgctggcgagagcggac
gttcttgtcgccgagcatgaggtgctcgacgtggtccgtacgcatgccaggcaaggcgtc
gccgtgctgaacacgtcttcggatgcgtattcggatacgtcgtcaggtacgtattcggcc
acaagcacgcctcaactagcggttgttgacagcacgtcgacgaccgctgggacccccgcg
tcgagggatgccgccaatcttgtcatggaggccgcgcggggcggcaggcgggtcgtgcgt
gcggtgtccggtgaccccggcctcgacacgtacgcggccgaggagatgctggcgtgcgcc
gccgcgggcgtgccgttcgaggtggtgcccggcatcgcggccgccgtgggtgtgcccgct
tacgcgggtgtgccgctgcgggacgcgcagggcgccgacgtgcggttcgtggacgcccgt
tcggcgtcggagcggtgctggaccgaggtgggcgcgtccgatgggaccgtcgtcgtctcg
gccacgctggattccgtggccgcggccgcgggcgagctggtcgccgccggccgtaagccc
gacactccgatgtcggtgaccatcgccggtaccaccacacggcagcgcacctggtccgcc
acgctcgggtccatcgcgcagacgctgaagcaggcgaaggtgctgccctcgcccgacggc
ggccgaccggtgatagccgtggtcggtgagcgttccgccgccgcccagcgcgaccagctg
tcgtggttcgagtccaagccgctgttcggctggaaggtgctcgtgccgcggacgaaggag
caggcggcgtcgctctccgaccagctgcggtcgtacggggccgtgccgcacgaggtgccg
acgatcgccgtcgaaccgccgcggacgccccagcagatggagcgcgcggtcaagggcctg
gtgacgggccggtacgagtggatcgccttcacctcggtgaacgcggtcaaggccgtgcgg
gagaagttcgaggagtacgggctcgatgcccgggccttcgccgggatcaaggtcgcggcg
gtgggcgagcagaccgcgaaggcgctggtcgccttcggtgtgaagccggacctggtgccg
agcggtgagcagtcggccgccggtctgctggaggactggccgccgtacgacccggtcttc
gacccgatcgaccgggtgttcctgccgcgggcggacatcgcgaccgagacgctggtcgcc
gggctcatcgagctgggctgggaggtcgacgacgtcacggcgtaccggacggtgcgcgcg
tcgccgccgccggccgagacgcgggaggccatcaagggcggtggcttcgacgccgtgctg
ttcacgtcgtcctcgacggtgcgcaacctggtcggcatcgcgggcaagccgcacaacgtg
acggtgatcgcgtgcatcggtcccgccacggccaagacggccgaggagcacgggctgcgg
gtggacgtcatggctcccgagccctcggtgctcaagctggcggaggcgctggcggacttc
gggctgcggcgccgtgcgtcggcgctggacgccggggatccggtgacgcggccgagcgag
cggcggccggggtcgcggcggcggcgtacgacgtag
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