Streptomyces nitrosporeus: CP967_19345
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Entry
CP967_19345 CDS
T06889
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
snk
Streptomyces nitrosporeus
Pathway
snk00860
Porphyrin metabolism
snk01100
Metabolic pathways
snk01110
Biosynthesis of secondary metabolites
snk01120
Microbial metabolism in diverse environments
snk01240
Biosynthesis of cofactors
Module
snk_M00121
Heme biosynthesis, plants and bacteria, glutamate => heme
snk_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
snk_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
snk00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
CP967_19345
Enzymes [BR:
snk01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
CP967_19345
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
CP967_19345
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Gene cluster
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Motif
Pfam:
HEM4
TP_methylase
B12-binding
DUF348
Motif
Other DBs
NCBI-ProteinID:
QEU73859
UniProt:
A0A5J6FBK1
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Position
4329174..4330844
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AA seq
556 aa
AA seq
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MSPTGPVVSDFPVLSSGHVTFLGAGPGDPGLLTLRAVEALASADVLVAEPEVLDVVRGHA
RAGVSTPEMTVVDSSSAAVGVPVLRDAANLVMEAAKGGRRVVRAVSGDPGMDGDTGAEML
ACAAAGVPFEVVPGVANAVGVPAYAGVPLRDAQGTDVRFVDARTATDRCWSEVGASDATV
VVSTSLDAVAAAAGELVSAGRKPDTPMTVTVAGTTTRQRTWTATLGTVGQVLKQAKVLPS
PEGHRPVIAVVGERSSAAQRDQLSWFESKPLFGWKVLVPRTKEQAASLSDQLRSYGAVPH
EVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIK
VAAVGEQTAAALVDFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATET
LVAGLIELGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVLFTSSSTVRNLVGIAGKP
HNVTVIACIGPATAKTAEEHGLRVDVLSPEPSVHKLAQALSDFGARRRDAAKEAGDPVTR
PSERRPGARRRRSTTT
NT seq
1671 nt
NT seq
+upstream
nt +downstream
nt
ttgagccccaccggccccgtcgtatccgacttccctgtcctgtcctcagggcacgtcacc
ttcctcggcgccggtcccggcgacccgggactgctgactctgcgcgctgtcgaggcgctc
gcgagcgcggacgtccttgtagccgagcccgaggtgctcgacgtcgtccggggccatgcg
cgggcaggggtgagcacgcctgagatgacggttgtcgactcttcgtcagcagccgtcggt
gtacccgttctcagggatgccgccaatcttgtcatggaggccgcgaagggtggcaggcgg
gtcgtccgtgccgtcagcggcgacccgggcatggacggtgacacgggtgcggagatgctc
gcctgcgccgccgcgggtgtgcccttcgaggtggtgcccggggtggccaacgccgtcggt
gtgccggcgtacgccggtgtgccgctgcgtgacgcgcagggcaccgatgtgcgtttcgtg
gacgcccgtacggcgacggaccgttgctggtccgaggtcggggcgagcgacgcgacggtc
gtggtgtcgacgtcgctggacgcggtggccgccgccgcgggtgagctggtctcggccggc
cgcaagcccgacaccccgatgacggtgaccgtggccgggacgacgacgcgccagcggacc
tggacggcgacgctcggcacggtcgggcaggtgctgaagcaggcgaaggtcctcccctcg
ccggaggggcaccggccggtcatagccgtggtcggggagcgcagctcggccgcccagcgt
gaccagctgtcgtggttcgagtccaagccgctgttcggctggaaggtgctcgtgccgcgt
acgaaggagcaggcggcctcgctctccgaccagctgcgttcgtacggcgccgtgccgcac
gaggtgccgaccatcgcggtcgagccgccgcgtacgccccagcagatggagcgcgcggtc
aagggcctggtgacggggcggtacgagtggatcgcgttcacctcggtcaacgcggtgaag
gcggtccgggagaagttcgaggagtacgggctggacgcccgtgccttcgccgggatcaag
gtcgcggccgtcggtgagcagacggcggcggcgctggtcgacttcggggtgaagccggac
ctggtgccgtcgggtgagcagtcggccgcgggcctgctggaggactggccgccgtacgac
ccggtcttcgacccgatcgaccgggtgttcctgccgcgtgcggacatcgccacggagacg
ctggtggccgggctgatcgagctgggctgggaggtcgacgacgtgaccgcgtaccgcacg
gtccgcgcgtcgccgccgccggccgagacccgtgaggcgatcaagggcggcgggttcgac
gcggtgctcttcacctcgtcctcgacggtgcgcaacctggtcggtatcgcgggcaagccg
cacaacgtgacggtgatcgcgtgtatcggtccggcgacggcgaagacggcggaggagcac
ggtctgcgggtcgacgttctctccccggagccgtcggtccacaagctggcgcaggcgctg
tcggacttcggcgcgcggcgccgggacgcggcgaaggaggccggtgacccggtgacccgg
ccgagcgagcggcgtccgggtgcgagacgccggcggtcgacgacgacctga
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