Streptomyces nigra: DC008_19770
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Entry
DC008_19770 CDS
T05839
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
snz
Streptomyces nigra
Pathway
snz00860
Porphyrin metabolism
snz01100
Metabolic pathways
snz01110
Biosynthesis of secondary metabolites
snz01120
Microbial metabolism in diverse environments
snz01240
Biosynthesis of cofactors
Module
snz_M00121
Heme biosynthesis, plants and bacteria, glutamate => heme
snz_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
snz_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
snz00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
DC008_19770
Enzymes [BR:
snz01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
DC008_19770
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
DC008_19770
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Motif
Pfam:
HEM4
TP_methylase
RodZ_C
Motif
Other DBs
NCBI-ProteinID:
AWE51704
UniProt:
A0A2S1IGH9
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Position
4261564..4263270
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AA seq
568 aa
AA seq
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MSPTTLTAGLDHGHVTFLGAGPGDPGLLTLRAVEALAHADVLVAEHDVLDVVRQHARQGV
AEVHTDTGPDGDTVPGTGTPQLAVVDGASTTAALPAVRDAAHLVMEAARGGRRVVRAVSG
DPGLDTYAADEMLACAAAGVPFEVVPGVAAAVGVPAYAGVPLRDAQGTDVRFVDARTASD
RCWTEVGASDGTVVVSTTLDSVGAAAGELVSAGRKPDTPMTVTVAGTTTRQRTWTATLGT
IAQTLKQAKVLPSPEGGRPVIAVVGERSAAAQRDQLSWFESKPLFGWRVLVPRTKEQAAS
LSDQLRSYGAVPHEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFE
EYGLDARAFAGIKVAAVGEQTAKALIAFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPID
RVFLPRADIATETLVAGLIELGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVLFTSS
STVRNLVGIAGKPHNVTVIACIGPATAKTAEEHGLRVDVMAPEPSVHKLAEALADFGARR
RAAALDAGDPVTRPSERRPGARRRRSTT
NT seq
1707 nt
NT seq
+upstream
nt +downstream
nt
gtgagccccaccacccttaccgccggcctcgatcacgggcacgtcaccttcctgggtgcc
ggacccggggatccgggactgctgactctgcgcgccgtcgaggcgctggcgcacgcggac
gtcctggtcgccgagcacgatgtgctcgacgtcgtacgtcagcacgccaggcagggcgtc
gccgaagtgcacacggacacgggccccgacggggacaccgtcccgggcacaggcacgccc
cagctggccgtagttgacggcgcgtcaacgaccgctgcgctacccgcggtgcgggatgcc
gcacatcttgtcatggaggccgcgcggggcggcaggcgggtcgtgcgtgcggtgtccggg
gaccccgggctcgacacgtacgccgccgacgagatgctggcctgcgccgcggccggtgtg
ccgttcgaggtcgtgcccggtgtcgccgcggccgtcggcgtgcccgcgtacgccggtgtg
ccgctgcgcgacgcccagggcacggacgtgcggttcgtcgacgcgcgcaccgcgtccgac
cggtgctggaccgaggtgggcgcgtcggacgggaccgtcgtcgtgtcgacgaccctcgac
agcgtgggcgccgcggcgggcgagctggtgtcggccgggcgcaagcccgacaccccgatg
acggtgaccgtcgccggcaccaccacccggcagcggacgtggacggcgaccctcgggacg
atcgcccagacgctgaagcaggccaaggtgctgccctcgcccgagggcggccggccggtg
atagccgtggtcggtgagcgttccgccgccgcccagcgcgaccagttgtcctggttcgag
tccaagccgctgttcggctggagggtgctcgtaccgcggacgaaggagcaggcggcctcg
ctctccgaccagctgcgctcctacggggccgtgccgcacgaggtgccgacgatcgccgtc
gagccgccgcgcacgccccagcagatggaacgggccgtcaagggcctcgtcaccggccgc
tacgagtggatcgcgttcacctcggtcaacgcggtcaaggcggtacgggagaagttcgag
gagtacggcctcgacgcccgggcgttcgccgggatcaaggtcgccgcggtcggtgagcag
accgccaaggcgctcatcgccttcggcgtgaagccggacctcgtgccgagcggcgagcag
tcggccgccgggctgctggaggactggccgccctacgacccggtcttcgacccgatcgac
cgcgtcttcctgccccgcgccgacatcgcaacggagaccctcgtcgccgggctgatcgag
ctgggctgggaggtcgacgacgtcacggcctaccggaccgtacgggcctcgccgccgccg
gcggagacccgcgaggcgatcaagggcggcggcttcgacgccgtgctcttcacgtcctcg
tcgacggtgcggaacctggtcggcatcgcgggcaagccgcacaacgtgacggtgatcgcc
tgtatcggtcccgccacggccaagaccgccgaggagcacggtctgcgggtggacgtgatg
gcccccgagccgtccgtgcacaagttggcggaggccctggcggacttcggcgcccggcgc
cgggcggccgcgctcgacgcgggcgacccggtcacccgcccgagcgagcggcgcccgggg
gcgcggagacgccggtcgacgacctga
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