Streptococcus pyogenes MGAS10270 (serotype M2): MGAS10270_Spy0869
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Entry
MGAS10270_Spy0869 CDS
T00355
Symbol
acoA
Name
(GenBank) Pyruvate dehydrogenase E1 component alpha subunit
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
sph
Streptococcus pyogenes MGAS10270 (serotype M2)
Pathway
sph00010
Glycolysis / Gluconeogenesis
sph00020
Citrate cycle (TCA cycle)
sph00620
Pyruvate metabolism
sph00785
Lipoic acid metabolism
sph01100
Metabolic pathways
sph01110
Biosynthesis of secondary metabolites
sph01120
Microbial metabolism in diverse environments
sph01200
Carbon metabolism
sph01210
2-Oxocarboxylic acid metabolism
Module
sph_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
sph00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
MGAS10270_Spy0869 (acoA)
00020 Citrate cycle (TCA cycle)
MGAS10270_Spy0869 (acoA)
00620 Pyruvate metabolism
MGAS10270_Spy0869 (acoA)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
MGAS10270_Spy0869 (acoA)
Enzymes [BR:
sph01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
MGAS10270_Spy0869 (acoA)
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GFIT
Motif
Pfam:
E1_dh
TPP_enzyme_C
Transketolase_N
DXP_synthase_N
Motif
Other DBs
NCBI-ProteinID:
ABF33934
UniProt:
Q1JH60
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All DBs
Position
824252..825232
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AA seq
326 aa
AA seq
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MEAEMVTVSKEQHLDMFLKMERIREFDSRINKLVRRGFVQGMTHFSVGEEAANVGAVAHL
SYDDIIFSNHRGHGQSIAKDMDLNKMMAELAGKATGVSKGRGGSMHLADFEKGNYGTNGI
VGGGYALAVGAALTQQYKGTNNIAVAFSGDGATNEGSFHESVNMAATWKLPVIFFIINNR
YGISMSINNATNTPHLYTRAEAYGIPGFYCEDGNDVMAVYETMGKAVEHVRGGNGPAIVE
VESYRWFGHSTADAGKYRTKEEVDEWKEKDPMIKYRTYLTSEGIATDDELDAIQAQVKKE
VDDAYEFAQNSPDPELSVAFEDVWVD
NT seq
981 nt
NT seq
+upstream
nt +downstream
nt
atggaggccgaaatggtaacagtttctaaagaacaacatttagatatgttccttaaaatg
gaacgtattcgtgaatttgattcacgtattaataaactcgtccgtcgtggatttgtacaa
gggatgactcacttctcagttggtgaagaagcagccaatgttggagcggtggctcacttg
tcttacgatgacattattttttcaaaccaccgtggacatggacaatcaatcgctaaagac
atggaccttaataaaatgatggctgagcttgctggtaaagcaactggtgtttctaaaggg
cgtggtggctcaatgcacttggctgattttgaaaaaggaaactatggtaccaatggtatc
gttggtggtggttacgctcttgcagttggtgctgccctcactcaacaatacaaaggaact
aacaatatagctgttgctttctcaggtgatggcgctactaacgaaggatcattccacgag
tctgttaatatggctgcaacatggaaacttcctgttattttcttcatcatcaacaaccgt
tatggaatttcaatgagcatcaataatgcaacaaatacaccacatttatacacacgtgca
gaagcttacggaattcctggtttctactgtgaagatggcaatgacgtgatggctgtctat
gaaacaatgggcaaagccgttgaacatgttcgtggtggaaatggcccagctattgttgag
gtagaatcataccgttggtttggtcactcgactgcagatgctggtaaataccgtactaaa
gaagaagtggatgagtggaaagaaaaagatccaatgatcaaatatcgtacttatctgaca
agcgaaggcattgccactgatgacgaattggatgctattcaagcacaagtcaaaaaagaa
gttgacgatgcttatgaatttgcacaaaatagtccagatccagaactttcagtagccttc
gaagacgtttgggttgactaa
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