Streptomyces fodineus: BFF78_18740
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Entry
BFF78_18740 CDS
T05140
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
spun
Streptomyces fodineus
Pathway
spun00860
Porphyrin metabolism
spun01100
Metabolic pathways
spun01110
Biosynthesis of secondary metabolites
spun01120
Microbial metabolism in diverse environments
spun01240
Biosynthesis of cofactors
Module
spun_M00121
Heme biosynthesis, plants and bacteria, glutamate => heme
spun_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
spun_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
spun00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
BFF78_18740
Enzymes [BR:
spun01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
BFF78_18740
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
BFF78_18740
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Gene cluster
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Motif
Pfam:
HEM4
TP_methylase
RodZ_C
Motif
Other DBs
NCBI-ProteinID:
AOR32832
UniProt:
A0A1D7YB93
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Position
complement(4465430..4467142)
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AA seq
570 aa
AA seq
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MSPTALPAAGPEHGHVTFLGAGPGDPGLLTLRAVEALSNADVLVAEHEVLDVIRTHARQG
VSVVQMDADPSSVSPPGTGTPQLTVVDGTSTTAAVPAAARDAAHLVMEAARGGRRVVRAV
SGDPGLDTYAAEEMLACAAAGVPFEVVPGVAAAVGVPAYAGVPLRDAEGADVRFVDARTA
SDRCWTEVGASDGTVVVSTTLDAVAAAAGELVSAGRKPDTPLSVTIAGTTTRQRTWTATL
GTIAQTLKQAKVLPSPDGGRPVIAVVGERSAAARRDQLSWFESKPLFGWKVLVPRTKEQA
ASLSDQLRSYGAVPHEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREK
FEEYGLDARAFAGIKVAAVGEQTAKALVAFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDP
IDRVFLPRADIATETLVAGLIELGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVLFT
SSSTVRNLVGIAGKPHNVTVIACIGPATAKTAEEHGLRVDVMAPEPSVHKLAEALADFGL
KRRAAAVENGDPVTRPSERRPGARRRRSTT
NT seq
1713 nt
NT seq
+upstream
nt +downstream
nt
ttgagccccaccgcccttcctgccgccggtcctgaacacgggcacgtcaccttcctcggt
gccggacccggagatccgggactgctgactctgcgcgccgtggaggcgctgtcgaacgcg
gacgtcctggtcgccgagcacgaggtgctcgacgtgatccggacgcacgcccgacagggc
gtctccgtcgtgcagatggacgccgatccctcttcggtctcgccgccgggcacgggcacg
ccccagctgacggtcgttgacggcacgtcaacaaccgccgctgtcccggccgctgcccgg
gatgccgctcatcttgtcatggaggctgcgcggggcggcaggcgggtcgtccgtgcggtg
tccggggacccgggacttgatacgtacgcggccgaggaaatgctcgcctgcgccgccgcc
ggggttccgttcgaggtggtgcccggtgtcgcggcggcggtcggcgtgcccgcgtacgcc
ggtgtgccgctgcgggacgccgagggcgcggacgtccgtttcgtggacgcccggaccgcc
tccgaccggtgctggacggaggtgggcgcctccgacggcacggtggtcgtctccacgacc
ctggacgcggtggcggcagcggcgggcgaactggtctcggcgggccgcaagcccgacacc
cccctgtcggtcaccatcgcgggtacgacgacccgccagcgcacctggacggcgacgctc
ggcacgatcgcgcagacgctgaagcaggcgaaggtgctgccgtccccggacggcggccgg
ccggtcatagccgtggtcggcgagcgttccgccgccgcccggcgcgaccagctgtcgtgg
ttcgagtccaagccgctgttcggctggaaggtgctcgtgccgcggacgaaggagcaggcg
gcgtcgctctccgaccagctgcggtcctacggcgcggtgccgcacgaggtcccgacgatc
gcggtggagccgccgcgcacgccccagcagatggaacgtgccgtcaagggcctggtgacg
ggccggtacgagtggatcgccttcacgtcggtgaacgcggtgaaggcggtccgggagaag
ttcgaggagtacggccttgatgctcgggcttttgcgggtatcaaggtggctgcggtgggc
gagcagaccgcgaaggcgctggtcgcgttcggtgtgaagccggacctggtgccgagcggc
gagcagtcggcggcgggtctgctggaggactggccgccgtacgacccggtgttcgacccg
atcgaccgggtgttcctgccgcgtgccgacatcgccaccgagaccctggtcgccgggctg
atcgagctgggctgggaggtcgacgacgtcaccgcctaccggacggtccgcgcctcgcct
ccgccggccgagacccgcgaggcgatcaagggcggcggcttcgacgcggtcctcttcacg
tcgtcgtccacggtccgcaacctggtgggcatcgcgggcaagccgcacaacgtgacggtg
atcgcgtgcatcggcccggccacggcgaagacggccgaggagcacgggctgcgggtggac
gtcatggccccggagccgtccgtccacaagctggccgaggcgctggccgacttcgggctg
aagcggcgggctgccgccgtggagaacggggatccggtgacgcggcctagcgagcgtcgg
ccgggggcgcggaggcggcgctcgacgacctga
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