Streptomyces alfalfae: A7J05_15930
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Entry
A7J05_15930 CDS
T05110
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
ssia
Streptomyces alfalfae
Pathway
ssia00860
Porphyrin metabolism
ssia01100
Metabolic pathways
ssia01110
Biosynthesis of secondary metabolites
ssia01120
Microbial metabolism in diverse environments
ssia01240
Biosynthesis of cofactors
Module
ssia_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
ssia_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
ssia00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
A7J05_15930
Enzymes [BR:
ssia01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
A7J05_15930
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
A7J05_15930
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Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
APY87024
UniProt:
A0A1P8THC8
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Position
complement(3870069..3871727)
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AA seq
552 aa
AA seq
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MSPTSNLPGIPAHGHVTFLGAGPGDPGLLTLRAVEALTRAEVLIAEPDVLDVVRVHARGG
VDTPLPKATDDMSAAPDTATFRAAANLVMEAARGGRRVVRAVSGDPGLDTYAAEEMLACA
AEGIPFEVVPGIAAAVGVPAYAGVPLRDAQGADVRFIDARTASERCWSEVGASDGTVVVS
TSLDSVAAAAGELVAAGRKPDTPLTVTVGGTTTRQRTWNATLGTIAQVFKQAKVLPSPDG
GRPVIAVVGERSSAAQRDQLSWFESKPLFGWRVLVPRTKEQAASLSDQLRSYGAVPHEVP
TIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIKVAA
VGEQTAAALIAFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATETLVA
GLIDLGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVLFTSSSTVRNLVGIAGKPHNV
TVIACIGPATAKTAEEHGLRVDVMAPEPSVHKLAEALAQFGAQRRAAALEAGDPVTRPSE
RRPGSRRRRTAP
NT seq
1659 nt
NT seq
+upstream
nt +downstream
nt
ttgagccccacctcgaaccttcccggcattcccgcacacgggcacgtcaccttcctgggt
gccggacccggagatccgggactgctgaccctgcgcgccgtcgaggcgctgacccgagcg
gaagtgctgatcgccgagccggatgtgctcgacgtcgtccgcgtgcacgccaggggaggt
gtggacacacccctgccgaaggcgactgacgacatgtcagcagcccctgacacggcgact
ttccgagccgccgccaatcttgtcatggaggccgcgaggggcggcaggcgggtcgtgcgt
gcggtcagcggcgaccccggcctcgacacgtacgcggccgaggagatgctcgcctgcgcc
gccgagggcatccccttcgaggtcgtccccggcatcgcggcggccgtcggcgtgcccgcg
tacgccggtgtgccgctgcgggacgcgcagggcgccgacgtgcggttcatcgacgcccgt
acggcgtccgagcgctgctggagcgaggtcggcgcgtccgacgggaccgtcgtggtctcg
acgtcgctcgactccgtcgccgccgccgcgggcgagctggtggccgcgggccgcaagccc
gacaccccgctcaccgtgaccgtcggcggcacgacgacgcgccagcgcacctggaacgcc
accctcggcaccatcgcgcaggtcttcaagcaggcgaaggtgctgccctcgcccgacggc
ggccggccggtcatagccgtggtcggcgagcggagctcggccgcccagcgcgaccagctc
tcgtggttcgagtcgaagccgctcttcggctggcgcgtcctcgtaccgcgtacgaaggag
caggccgcctcgctctccgaccagctccgctcctacggcgccgtgccgcacgaggtgccg
accatcgcggtcgagccgccgcgcacgccccagcagatggagcgcgcggtgaagggcctc
gtcaccggacggtacgagtggatcgctttcacgtccgtgaacgccgtcaaggcggtgcgc
gagaagttcgaggagtacgggctcgacgcccgcgccttcgccgggatcaaggtcgcggcc
gtcggtgagcagaccgccgccgcgctcattgccttcggcgtcaagccggacctggtgccg
agcggcgagcagtcggccgcaggtctccttgaggactggccgccgtacgacccggtcttc
gacccgatcgaccgggtgttcctgccgcgggccgacatcgccacggagacgctggtggcg
ggcctgatcgacctcggctgggaggtggacgacgtgaccgcctaccggacggtgcgcgcc
tcgccgccgccggccgagacccgggaggccatcaagggcggcggcttcgacgccgtgctc
ttcacctcctcctccacggtccgcaacctcgtcggcatcgcgggcaagccgcacaacgtc
accgtgatcgcgtgcatcggccccgccacggcgaagaccgccgaggagcacgggctgcgc
gtggacgtgatggctcccgagccgtcggtccacaagctcgccgaggcgctggcccagttc
ggtgcgcagcggcgcgccgcggccctggaggccggggacccggtgacccgcccgagcgag
cggcgtcccggttcgcgacgacggcgtacagcgccatag
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