Streptomyces subrutilus: CP968_14830
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Entry
CP968_14830 CDS
T07087
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
ssub
Streptomyces subrutilus
Pathway
ssub00860
Porphyrin metabolism
ssub01100
Metabolic pathways
ssub01110
Biosynthesis of secondary metabolites
ssub01120
Microbial metabolism in diverse environments
ssub01240
Biosynthesis of cofactors
Module
ssub_M00121
Heme biosynthesis, plants and bacteria, glutamate => heme
ssub_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
ssub_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
ssub00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
CP968_14830
Enzymes [BR:
ssub01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
CP968_14830
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
CP968_14830
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Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
QEU79425
UniProt:
A0A5P2UM70
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Position
complement(3389662..3391335)
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AA seq
557 aa
AA seq
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MNPTRPTTSAFPAVAAHGHVTFLGAGPGDPGLLTLRAVEALAAADVLIAEPDVLDVVRTH
ARVNVDTPQLTVADEKSAAAGVPVIRDAANLVMEAARSGRRVVRAVTGDPGLDGNTAEEM
LVCASEGIPFEVVPGIPTAVGVPAYAGVPLRDRLGDDHGVRFVDARSASARCWSDAGASD
GTVVVSATLETVSAAAAELVSAGRKPDTPLSVTVAGTTTRQRTWSATLGTIAQVFKQGKV
LPSPEGARPVIAVVGEHSAAARRDELAWFESKPLFGWRVLVPRTKEQAASLSDQLRSYGA
VPHEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFA
GIKVAAVGEQTAASLVEFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIA
TETLVAGLIELGWEVDDVTAYRTVRASPPPADTREAIKGGGFDAVMFTSSSTVRNLVGIA
GKPHNVTVIACIGPATAKTAEEHGLRVDVLSPEPSVSKLAEALAEYGAARREAAKEAGET
VFRPSERRPGARRRRTT
NT seq
1674 nt
NT seq
+upstream
nt +downstream
nt
gtgaaccccacacgtcccaccacctccgcttttccggcggtcgccgcccacggacacgtc
accttcctcggtgccggccccggcgacccgggtctgctcacgctgcgcgccgtcgaggcg
ctggcggccgcggacgtgctgatcgcggagcccgatgtgctcgacgtcgtgcgcacccat
gcgcgcgtcaacgtcgacacgccgcagctgacggtagctgacgagaagtcagcagccgcc
ggtgtcccggtgatccgggacgcggccaatcttgtcatggaggccgcgcgctccggcagg
cgggtcgtgcgtgccgtcaccggggaccccgggctcgacgggaacacggccgaggagatg
ctcgtctgcgcctccgagggcatccccttcgaggtcgtgccgggcatccccaccgcggtg
ggcgtcccggcgtacgccggggtgccgctgcgggacaggctgggcgacgaccacggcgtg
cggttcgtggacgcgcgcagcgcgtcggcgcgctgctggagcgacgcgggcgcgagcgac
gggaccgtcgtggtgtccgcgacgctggagacggtctcggcggccgccgcggagctggtg
agcgccgggcgcaagcccgacaccccgctgtcggtgaccgtcgcgggtacgaccacgcgc
cagcggacctggtccgcgacgctgggcacgatcgcccaggtgttcaagcagggcaaggtg
ctgccgtcgcccgagggcgcccggccggtcatagccgtggtcggggagcacagtgccgcc
gcgcggcgcgacgagctggcctggttcgagtcgaagccgctgttcggctggcgggtgctc
gtgccgcgcaccaaggagcaggccgcgtcgctctccgaccagctgcgttcgtacggcgcg
gtgccgcacgaggtgccgaccatcgcggtggagccgccgcggaccccgcagcagatggag
cgggccgtgaagggcctggtgacgggccgctacgagtggatcgccttcacctccgtcaac
gccgtgaaggcggtgcgggagaagttcgaggagtacgggctcgacgcgcgcgcgttcgcc
gggatcaaggtcgccgcggtgggcgagcagaccgcggcctcgctggtcgagttcggggtg
aagccggacctggtgccgagcggtgagcagtccgcggccgggctgctggaggactggccg
ccgtacgacccggtcttcgacccgatcgaccgcgtgttcctgccgcgggccgacatcgcg
acggagacgctggtcgccgggctgatcgagctcgggtgggaggtcgacgacgtcaccgcc
taccggaccgtccgcgcctcgccgccgcccgcggacacgcgcgaggcgatcaaggggggc
gggttcgacgcggtcatgttcacctcgtcctccaccgtccgcaacctggtggggatcgcg
ggcaagccgcacaacgtgaccgtcatcgcgtgcatcggcccggccacggcgaagacggcc
gaggagcacgggctgcgcgtggacgtgctgtcgccggagccgtcggtgtcgaagctggcg
gaggcgctggccgagtacggggccgcgcgccgcgaggccgccaaggaggccggcgagacg
gtgttccggccgagcgagcgccggccgggcgcgcgcaggcgccggacgacctga
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