Streptomyces tirandamycinicus: DDW44_17180
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Entry
DDW44_17180 CDS
T06843
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
stir
Streptomyces tirandamycinicus
Pathway
stir00860
Porphyrin metabolism
stir01100
Metabolic pathways
stir01110
Biosynthesis of secondary metabolites
stir01120
Microbial metabolism in diverse environments
stir01240
Biosynthesis of cofactors
Module
stir_M00121
Heme biosynthesis, plants and bacteria, glutamate => heme
stir_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
stir_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
stir00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
DDW44_17180
Enzymes [BR:
stir01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
DDW44_17180
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
DDW44_17180
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GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
AWI30311
UniProt:
A0A2S1SV87
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Position
3872155..3873813
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AA seq
552 aa
AA seq
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MSPTTSNVPAGPVHGQVTFLGAGPGDPGLLTLRAVEALAGADVLIAEPEVLDVVRGHARA
GVSTPELTVVDDASTTADVPVLRDAANLVMEAVRGGKRVVRAVSGDPGLDGDAGAEMLAC
AAEGIPFEVVPGVATAVGVPAYAGVPLRDAHGTDVRFIDARTADARCWTEVGASDGTVVV
STTLDAVAPAAGELVSAGRKPDTPLTVTVAGTTTRQRTWTATLGTIAQVFKQGKVLPSPE
GHRPVIVVVGERSAAAQRDQLAWFESKPLFGWKVLVPRTKEQAASLSDQLRSYGAVPHEV
PTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIKVA
AVGEQTARSLIEFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATETLV
AGLIELGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVLFTSSSTVRNLVGIAGKPHN
VTVIACIGPATAKTAEEHGLRVDVLSPEPSVHKLAEALAEFGARRREAALEAGDPVTRPS
ERRPGARRRRTT
NT seq
1659 nt
NT seq
+upstream
nt +downstream
nt
ttgagccccaccacctcgaacgtccctgctggtccggtacacgggcaggtcaccttcctc
ggcgccggtcccggtgatccgggcctgctgacgctgcgcgccgtcgaggcgctggcgggt
gcggacgtgttgatcgccgagccggaagtcctcgacgtcgttcgcggccacgcgcgcgcc
ggagtgagcacacctgagctgaccgttgttgacgatgcctcaacaaccgccgatgtcccg
gtgttgagggacgcggccaatcttgtcatggaggccgtgcggggcggcaagcgggtggtc
cgtgccgtgagcggtgaccccgggctcgacggcgacgccggggccgagatgctcgcctgc
gccgccgagggcatccccttcgaggtcgtgccgggtgtggcgaccgcggtcggggtgccc
gcgtacgcgggtgtgccgctgcgtgacgcgcacggcacggatgtgcggttcatcgacgcc
cggaccgcggacgcccgctgctggaccgaggtcggtgcctcggacggcaccgtcgtggtg
tccacgacgctggacgccgtggcgccggcggccggggagctggtgtcggccgggcgcaag
cccgacaccccgctgacggtgacggtggccggtacgacgacgcggcagcggacgtggacg
gcgacgctcgggaccatcgcccaggtcttcaagcagggcaaggtgctgccgtcgccggag
ggccaccggccggtcatagtcgtggtcggcgagcgcagcgccgccgcgcagcgcgaccag
ctcgcctggttcgagtccaagccgctgttcggctggaaggtgctcgtgccgcgcaccaag
gagcaggccgcttcgctctccgaccagctcaggtcctacggagccgtgccgcacgaggtt
ccgaccatcgccgtcgagccgccgcgtacgccgcagcagatggagcgcgcggtcaagggg
ctggtcaccggccgctacgagtggatcgccttcacctcggtcaacgccgtgaaggcggtg
cgggagaagttcgaggagtacgggctggacgcccgcgccttcgccgggatcaaggtggcg
gcggtgggcgagcagaccgcgcggtcgctgatcgagttcggcgtcaaaccggatctggtg
ccgagcggtgagcagtcggcggcgggtctgctggaggactggccgccgtacgacccggtg
ttcgacccgatcgaccgggtgttcctgccgcgggccgacatcgccaccgagaccctggtg
gcgggcctgatcgagctgggctgggaggtcgacgacgtcaccgcctaccggaccgtgcgg
gcctcgccgccgccggcggagacccgggaggcgatcaagggcggcggtttcgacgccgtg
ctcttcacctcgtcgtccaccgtgcggaacctggtcggcatcgccggcaagccgcacaac
gtgacggtgatcgcctgtatcggtcccgcgaccgcgaagacggcggaggagcacgggctg
cgggtcgacgtgctgtcgcccgagccgtcggtgcacaagctggccgaggcgctcgcggag
ttcggggcgcggcgccgggaggccgcgctggaggcgggcgacccggtgacgcggccgagc
gagcggcgtccgggagcgcgtagacgccggacgacgtga
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