Spirochaeta thermophila DSM 6578: Spith_0111
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Entry
Spith_0111 CDS
T02016
Name
(GenBank) 3-isopropylmalate dehydratase large subunit
KO
K01703
3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:
4.2.1.33
4.2.1.35
]
Organism
stq
Spirochaeta thermophila DSM 6578
Pathway
stq00290
Valine, leucine and isoleucine biosynthesis
stq00660
C5-Branched dibasic acid metabolism
stq01100
Metabolic pathways
stq01110
Biosynthesis of secondary metabolites
stq01210
2-Oxocarboxylic acid metabolism
stq01230
Biosynthesis of amino acids
Module
stq_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
stq00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00660 C5-Branched dibasic acid metabolism
Spith_0111
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
Spith_0111
Enzymes [BR:
stq01000
]
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.33 3-isopropylmalate dehydratase
Spith_0111
4.2.1.35 (R)-2-methylmalate dehydratase
Spith_0111
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Gene cluster
GFIT
Motif
Pfam:
Aconitase
Motif
Other DBs
NCBI-ProteinID:
AEJ60398
UniProt:
G0GC34
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All DBs
Position
138383..139786
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AA seq
467 aa
AA seq
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MAGKTLFQKVWEAHVVDRLPTGQYQLFIGLHLIHEVTSPQAFAALREKGLKVAFPERTFA
TVDHIVPTHDQGRPFVDPQAERMMQELEKNVREFGIRFFNLESGRQGIVHVIGPELGLTQ
PGMTIACGDSHTSTHGAFGSLGFGIGTSQIRDVLATGTLAMEPLKVRKIEVNGRLGPGVT
PKDVILFIINRLGVKGGIGYAYEYAGDVFENMEMDGRMTVCNMSIEGGARIGYVNPDEKT
FAYLKGREFAPRGEAWDRAVSYWRSVASDPDAVYDDVVVFDAAEIAPMVTWGITPGQSVP
VDGVLPDPAALPESEREIAELAYRHMGFRPGMRILGTRIDVAFVGSCTNGRISDLRAAAE
VVRGKKVAPHVRAFVVPGSMQVKRQAEEEGLHEIFMDAGFEWRGAGCSICLGMNLDRLEG
DQISASSSNRNFIGRQGSPKGRTLLMSPQMVAAAAIAGEVVDIREVG
NT seq
1404 nt
NT seq
+upstream
nt +downstream
nt
atggccgggaagaccctctttcaaaaggtgtgggaggcacacgtggtggatcgactgccc
acggggcagtaccagctcttcatcgggctccacctcatccacgaggtgacgagcccccag
gcgttcgcggccctgagggagaaggggctcaaggtggcgttccctgagcgcaccttcgcc
acggtggatcacatcgtccccacccacgaccagggacggcccttcgtggatccacaggcg
gaacgcatgatgcaggagctcgagaagaacgtgcgtgagttcggcatcaggttcttcaac
ctggagagcggacggcaggggatcgtccatgtgatagggccggagctcggtctcacccag
cccggcatgaccatcgcgtgcggcgattcgcatacctcgacgcatggggccttcgggtcg
ctcggattcggtatcggtacgagtcagatccgtgatgtgctcgccacgggtaccctcgcc
atggagccgctcaaggtgaggaagatagaggtgaacgggcgactcggtccgggggtgacc
ccgaaggacgtgatcctcttcatcatcaaccggctcggtgtgaaggggggtatagggtac
gcctatgagtatgcaggggatgtcttcgagaacatggagatggatggtcggatgacggtg
tgcaacatgtcgatagagggtggggcgaggatcggatacgtgaaccccgatgagaagacc
tttgcctatctcaaaggcagggagttcgcccccaggggagaggcatgggacagggccgtc
tcgtactggaggagtgtggcctctgatccggatgcggtctacgatgacgtggtggtcttc
gatgctgccgagatcgcgcccatggtgacgtgggggatcacgccgggacagagtgtgccc
gtggacggggtgctcccggatcctgcggccctgcccgagagcgagcgggagatcgccgag
ttggcgtaccgccatatggggttcaggccgggcatgcggatcctcggcaccaggatcgac
gtggccttcgtggggagctgtacgaacggccggatctccgacctcagggccgcggcggag
gtggtgaggggcaagaaggtggcgcctcatgtgcgggccttcgtggtgccgggatcgatg
caggtgaagcggcaggccgaggaggaggggcttcacgagatcttcatggatgccggattc
gagtggcgcggggccggatgctcgatctgtctggggatgaacctcgacaggctcgagggc
gaccagatcagcgcgagctcgagcaacaggaacttcatcggtcgtcaggggagtcccaag
gggcgtaccctgctcatgtccccgcagatggtggctgctgcggccatcgcaggggaagta
gtggatatacgagaggtaggatag
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