Streptomyces sp. CNQ-509: AA958_20205
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Entry
AA958_20205 CDS
T03968
Name
(GenBank) uroporphyrin-III methyltransferase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
strc
Streptomyces sp. CNQ-509
Pathway
strc00860
Porphyrin metabolism
strc01100
Metabolic pathways
strc01110
Biosynthesis of secondary metabolites
strc01120
Microbial metabolism in diverse environments
strc01240
Biosynthesis of cofactors
Module
strc_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
strc_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
strc00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
AA958_20205
Enzymes [BR:
strc01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
AA958_20205
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
AA958_20205
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
AKH86922
UniProt:
A0A0F7NJG1
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Position
4710680..4712308
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AA seq
542 aa
AA seq
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MGAGPGDPGLLTLRAVEALSAADVLIADPKVLAVVRAHARVGAVMPHTSSAAAPAAHTSA
AAGDDEPPTAADAGHLVMEAARAGRRVVHAVAGDPGLDGGAAQAMRACAAEGISFEVVPG
VATAVGVPAYAGVPLHDPQGTDVRVVDAATASEQIWGEAGASDCTLVVQTSLEATAATAR
ELVAAGRKPDTPMTVTLAGTTTRQRTFSATLGSVAQVLKAAKVLPSPDAGQAVIAVVGEQ
SAPARREQLAWFESKPLFGWHVLVPRTKEQAASLSEQLRSYGAVPHEVPTIAVEPPRTPQ
QMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIKVAAVGEQTAAALVE
FGVRPDLQPSGEQSSHGLLEDWPPYDPVFDPIDRVFLPRADIATETLVAGLKDLGWEVDD
ITAYRTVRASPPPAETREAIKGGGFDAVLFTSSSTVRNLVGIAGKPHNVTVIACIGPATA
KTAEEHGLRVDVMAPEPSVHRLAEALAEFGARRRAAAVEAGEHVTRPSERRPRRRARTTT
TS
NT seq
1629 nt
NT seq
+upstream
nt +downstream
nt
ctgggcgcaggacccggggaccccggactgctgacgctgcgcgccgtggaagcgctgtct
gcggcagacgtcctgatcgccgaccccaaggtcctcgccgtcgtacgcgcccacgcgcgc
gtcggcgcggtcatgccgcacacgtcgtcggcggccgcgcccgcggcgcatacgtcggcg
gccgcgggggacgacgaaccgccaacggccgctgacgcaggccatcttgtcatggaggcc
gcgcgcgccggcaggcgggtcgtgcatgccgtggcgggcgatccgggcctcgacggcggt
gccgcgcaggcgatgcgcgcgtgcgccgccgagggcatctccttcgaggtggtgcccggg
gtcgcgaccgccgtcggcgtgcccgcgtacgccggcgtgccgctgcacgacccgcagggt
acggacgtacgcgtcgtggacgcggcgaccgcctcggagcagatctggggcgaggcgggc
gccagcgactgcacgctcgtggtgcagacgtccctggaggccaccgcggcgacggcgcgc
gagctggtcgccgcgggccgcaagccggacaccccgatgacggtcacgctcgcgggcacg
acgacgcggcagcggacgttcagcgccacgctcggcagcgtcgcgcaggtgctgaaggcc
gcgaaggtgctgccgtcgccggacgccggacaggcggtcatagcggtcgtcggcgagcag
agcgcaccggcccgccgcgagcagttggcctggttcgagtccaagccgctcttcggctgg
cacgtgctcgtgccgcggacgaaggagcaggcggcgtcgctctccgagcaactgcgctcg
tacggtgccgtgccgcacgaggtgccgaccatcgccgtcgagccgccgcgcaccccgcag
cagatggagcgggcggtcaagggcctggtcaccgggcggtacgagtggatcgccttcacg
tccgtcaacgccgtcaaggcggtgcgggagaagttcgaggagtacgggctggacgcccgc
gcgttcgccgggatcaaggtcgccgcggtcggcgagcagacggcggcggcgctggtggag
ttcggcgtacggcccgacctgcagcccagcggcgagcagtcgtcgcacgggctgctggag
gactggccgccgtacgacccggtcttcgacccgatcgaccgggtgttcctgccgcgggcc
gacatcgccaccgagacgctcgtggcggggctgaaggacctcggctgggaggtcgacgac
atcaccgcgtaccgcacggtgcgcgcgtcgccgccgccggccgagacccgcgaggcgatc
aagggcggcgggttcgacgccgtgctcttcacctcgtcctcgacggtgcggaacctcgtc
ggcatcgcgggcaagccgcacaacgtgacggtcatcgcctgtatcggcccggccacggcg
aagacggcggaggagcacgggctgcgcgtcgacgtcatggcgccggagccgtccgtgcac
cggctggccgaggcgctggcggagttcggcgcgcggcgccgggcggcggcggtcgaggcc
ggggagcacgtcacccggcccagcgagcgcaggccgcggcggcgggcgcggacgacgacc
acgagctga
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