Streptomyces sp. 769: GZL_04933
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Entry
GZL_04933 CDS
T03587
Name
(GenBank) uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
stre
Streptomyces sp. 769
Pathway
stre00860
Porphyrin metabolism
stre01100
Metabolic pathways
stre01110
Biosynthesis of secondary metabolites
stre01120
Microbial metabolism in diverse environments
stre01240
Biosynthesis of cofactors
Module
stre_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
stre_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
stre00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
GZL_04933
Enzymes [BR:
stre01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
GZL_04933
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
GZL_04933
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
AJC57510
UniProt:
A0A0A8EMT1
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Position
5328889..5330550
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AA seq
553 aa
AA seq
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MNPTAPNHSASGQVTFLGAGPGDPGLLTLRAVEALASADVLVADPQVLDVVRVHARAQVD
TPLQASADAVSNPGSPHGVSALRDTANLVMAAARAGKRVVRAVTGDPGLDGYVAEEMLAC
AAEGIVFEVVPGIAAAVGVPAYAGVPLRDAQGTDVRFIDARSADDRCWSELGTSDATAVV
STSLDSVAAAAGELVAAGRKPDTPMTVTVAGTTTRQRTWTATLGSVAQVLKAAKVLPSPD
GGQPVIAVVGERSAAAQRDQLSWFENKPLFGWRVLVPRTKEQAASLSDQLVSYGAVPHEV
PTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIKVA
AVGEQTAKALVAFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATETLV
AGLIELGWEVDDVTAYRTVRASPPPAETREAIKGGGFDAVLFTSSSTVRNLVGIAGKPHN
VTVIACIGPATAKTAEEHGLRVDVMSPEPSVHKLAEALAEFGAARRDAALEAGDPVTRPS
ERRPGARRRRATP
NT seq
1662 nt
NT seq
+upstream
nt +downstream
nt
ttgaaccccaccgccccaaaccactccgcctccggtcaggtcaccttcctgggtgccggg
ccgggagacccgggtctgctgacgctgcgcgccgtggaagcgctggcgtccgcagacgtc
ctcgtcgccgacccgcaggtcctggacgtcgtgcgtgtgcacgcacgcgcacaggtggac
acgccactgcaggcgtcagctgacgcggtgtcaaaccccggcagtccccatggcgtttcc
gcccttcgggacaccgccaatcttgtcatggcggctgcccgcgcgggcaagcgggtcgtc
cgtgcggtgaccggtgaccccggcctcgacggctacgtcgccgaggagatgctggcctgc
gccgccgagggcatcgtcttcgaggtggtccccggcatcgccgccgcggtcggcgtgccc
gcgtacgccggcgtgccgctgcgcgacgcccagggcaccgacgtgcgcttcatcgacgcc
cgcagcgccgacgaccgctgctggtccgagctgggcaccagcgacgccaccgcggtggtc
tccaccagcttggactcggtggccgcggcggccggcgagctggtggccgcaggccgcaag
ccggacaccccgatgaccgtcacggtcgccggcaccaccacccggcagcgcacctggacc
gccaccctcgggagcgtcgcccaggtgctgaaggccgccaaggtgctgccgtcgccggac
ggcggccagccggtcatagccgtggtcggcgagcgcagcgccgcggcgcagcgggaccag
ctctcgtggttcgagaacaagccgctgttcggctggcgggtgctggtgccgcggaccaag
gagcaggccgcgtcgctctccgaccagctcgtctcgtacggcgcggtgccgcacgaggtc
ccgaccatcgccgtcgaaccgccgcgcaccccgcagcagatggagcgcgcggtcaagggc
ctggtcaccggccgctacgagtggatcgccttcacctcggtcaacgccgtcaaggcggtc
cgggagaagttcgaggagtacgggctggacgcccgggcgttcgccgggatcaaggtcgcg
gcggtcggcgagcagaccgccaaggcgctggtggccttcggcgtgaagcccgacctggtg
ccgtccggcgagcagtccgcggccgggctgctggaggactggccgccctacgacccggtc
ttcgacccgatcgaccgcgtcttcctgccgcgcgccgacatcgccaccgagacgctggtg
gccggcctgatcgagctgggctgggaggtcgacgacgtcaccgcctaccggaccgtgcgc
gcctcgccgccgccggccgagacccgtgaggcgatcaagggcggcggcttcgacgcggtg
ctcttcacctcgtcctcgaccgtgcggaacctcgtcggcatcgccggcaagccgcacaac
gtgaccgtgatcgcctgcatcggcccggccaccgccaagaccgccgaggagcacgggctg
cgggtggacgtgatgtcgcccgagccgtcggtccacaagctggccgaggcgctcgcggag
ttcggcgcggcgcggcgcgatgccgcgctggaggccggcgacccggtgacgcggccgagc
gagcggcgcccgggcgcccgccggaggcgagccaccccgtag
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