Talpa occidentalis (Iberian mole): 119238768
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Entry
119238768 CDS
T07495
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
tod
Talpa occidentalis (Iberian mole)
Pathway
tod01521
EGFR tyrosine kinase inhibitor resistance
tod01522
Endocrine resistance
tod04010
MAPK signaling pathway
tod04012
ErbB signaling pathway
tod04014
Ras signaling pathway
tod04015
Rap1 signaling pathway
tod04022
cGMP-PKG signaling pathway
tod04024
cAMP signaling pathway
tod04062
Chemokine signaling pathway
tod04066
HIF-1 signaling pathway
tod04068
FoxO signaling pathway
tod04071
Sphingolipid signaling pathway
tod04072
Phospholipase D signaling pathway
tod04114
Oocyte meiosis
tod04140
Autophagy - animal
tod04148
Efferocytosis
tod04150
mTOR signaling pathway
tod04151
PI3K-Akt signaling pathway
tod04210
Apoptosis
tod04218
Cellular senescence
tod04270
Vascular smooth muscle contraction
tod04370
VEGF signaling pathway
tod04371
Apelin signaling pathway
tod04380
Osteoclast differentiation
tod04510
Focal adhesion
tod04540
Gap junction
tod04550
Signaling pathways regulating pluripotency of stem cells
tod04613
Neutrophil extracellular trap formation
tod04620
Toll-like receptor signaling pathway
tod04650
Natural killer cell mediated cytotoxicity
tod04660
T cell receptor signaling pathway
tod04662
B cell receptor signaling pathway
tod04664
Fc epsilon RI signaling pathway
tod04666
Fc gamma R-mediated phagocytosis
tod04668
TNF signaling pathway
tod04720
Long-term potentiation
tod04722
Neurotrophin signaling pathway
tod04725
Cholinergic synapse
tod04726
Serotonergic synapse
tod04730
Long-term depression
tod04810
Regulation of actin cytoskeleton
tod04910
Insulin signaling pathway
tod04912
GnRH signaling pathway
tod04914
Progesterone-mediated oocyte maturation
tod04915
Estrogen signaling pathway
tod04916
Melanogenesis
tod04917
Prolactin signaling pathway
tod04919
Thyroid hormone signaling pathway
tod04921
Oxytocin signaling pathway
tod04926
Relaxin signaling pathway
tod04928
Parathyroid hormone synthesis, secretion and action
tod04929
GnRH secretion
tod04934
Cushing syndrome
tod04935
Growth hormone synthesis, secretion and action
tod05010
Alzheimer disease
tod05022
Pathways of neurodegeneration - multiple diseases
tod05034
Alcoholism
tod05132
Salmonella infection
tod05135
Yersinia infection
tod05160
Hepatitis C
tod05161
Hepatitis B
tod05163
Human cytomegalovirus infection
tod05164
Influenza A
tod05165
Human papillomavirus infection
tod05166
Human T-cell leukemia virus 1 infection
tod05167
Kaposi sarcoma-associated herpesvirus infection
tod05170
Human immunodeficiency virus 1 infection
tod05200
Pathways in cancer
tod05205
Proteoglycans in cancer
tod05206
MicroRNAs in cancer
tod05207
Chemical carcinogenesis - receptor activation
tod05208
Chemical carcinogenesis - reactive oxygen species
tod05210
Colorectal cancer
tod05211
Renal cell carcinoma
tod05212
Pancreatic cancer
tod05213
Endometrial cancer
tod05214
Glioma
tod05215
Prostate cancer
tod05216
Thyroid cancer
tod05218
Melanoma
tod05219
Bladder cancer
tod05220
Chronic myeloid leukemia
tod05221
Acute myeloid leukemia
tod05223
Non-small cell lung cancer
tod05224
Breast cancer
tod05225
Hepatocellular carcinoma
tod05226
Gastric cancer
tod05230
Central carbon metabolism in cancer
tod05231
Choline metabolism in cancer
tod05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
tod00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
119238768 (MAP2K1)
04012 ErbB signaling pathway
119238768 (MAP2K1)
04014 Ras signaling pathway
119238768 (MAP2K1)
04015 Rap1 signaling pathway
119238768 (MAP2K1)
04370 VEGF signaling pathway
119238768 (MAP2K1)
04371 Apelin signaling pathway
119238768 (MAP2K1)
04668 TNF signaling pathway
119238768 (MAP2K1)
04066 HIF-1 signaling pathway
119238768 (MAP2K1)
04068 FoxO signaling pathway
119238768 (MAP2K1)
04072 Phospholipase D signaling pathway
119238768 (MAP2K1)
04071 Sphingolipid signaling pathway
119238768 (MAP2K1)
04024 cAMP signaling pathway
119238768 (MAP2K1)
04022 cGMP-PKG signaling pathway
119238768 (MAP2K1)
04151 PI3K-Akt signaling pathway
119238768 (MAP2K1)
04150 mTOR signaling pathway
119238768 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
119238768 (MAP2K1)
04148 Efferocytosis
119238768 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
119238768 (MAP2K1)
04210 Apoptosis
119238768 (MAP2K1)
04218 Cellular senescence
119238768 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
119238768 (MAP2K1)
04540 Gap junction
119238768 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
119238768 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
119238768 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
119238768 (MAP2K1)
04620 Toll-like receptor signaling pathway
119238768 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
119238768 (MAP2K1)
04660 T cell receptor signaling pathway
119238768 (MAP2K1)
04662 B cell receptor signaling pathway
119238768 (MAP2K1)
04664 Fc epsilon RI signaling pathway
119238768 (MAP2K1)
04666 Fc gamma R-mediated phagocytosis
119238768 (MAP2K1)
04062 Chemokine signaling pathway
119238768 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
119238768 (MAP2K1)
04929 GnRH secretion
119238768 (MAP2K1)
04912 GnRH signaling pathway
119238768 (MAP2K1)
04915 Estrogen signaling pathway
119238768 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
119238768 (MAP2K1)
04917 Prolactin signaling pathway
119238768 (MAP2K1)
04921 Oxytocin signaling pathway
119238768 (MAP2K1)
04926 Relaxin signaling pathway
119238768 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
119238768 (MAP2K1)
04919 Thyroid hormone signaling pathway
119238768 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
119238768 (MAP2K1)
04916 Melanogenesis
119238768 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
119238768 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
119238768 (MAP2K1)
04726 Serotonergic synapse
119238768 (MAP2K1)
04720 Long-term potentiation
119238768 (MAP2K1)
04730 Long-term depression
119238768 (MAP2K1)
04722 Neurotrophin signaling pathway
119238768 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
119238768 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
119238768 (MAP2K1)
05206 MicroRNAs in cancer
119238768 (MAP2K1)
05205 Proteoglycans in cancer
119238768 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
119238768 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
119238768 (MAP2K1)
05230 Central carbon metabolism in cancer
119238768 (MAP2K1)
05231 Choline metabolism in cancer
119238768 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
119238768 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
119238768 (MAP2K1)
05212 Pancreatic cancer
119238768 (MAP2K1)
05225 Hepatocellular carcinoma
119238768 (MAP2K1)
05226 Gastric cancer
119238768 (MAP2K1)
05214 Glioma
119238768 (MAP2K1)
05216 Thyroid cancer
119238768 (MAP2K1)
05221 Acute myeloid leukemia
119238768 (MAP2K1)
05220 Chronic myeloid leukemia
119238768 (MAP2K1)
05218 Melanoma
119238768 (MAP2K1)
05211 Renal cell carcinoma
119238768 (MAP2K1)
05219 Bladder cancer
119238768 (MAP2K1)
05215 Prostate cancer
119238768 (MAP2K1)
05213 Endometrial cancer
119238768 (MAP2K1)
05224 Breast cancer
119238768 (MAP2K1)
05223 Non-small cell lung cancer
119238768 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
119238768 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
119238768 (MAP2K1)
05161 Hepatitis B
119238768 (MAP2K1)
05160 Hepatitis C
119238768 (MAP2K1)
05164 Influenza A
119238768 (MAP2K1)
05163 Human cytomegalovirus infection
119238768 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
119238768 (MAP2K1)
05165 Human papillomavirus infection
119238768 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
119238768 (MAP2K1)
05135 Yersinia infection
119238768 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
119238768 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
119238768 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
119238768 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
119238768 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
119238768 (MAP2K1)
01522 Endocrine resistance
119238768 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
tod01001
]
119238768 (MAP2K1)
Enzymes [BR:
tod01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
119238768 (MAP2K1)
Protein kinases [BR:
tod01001
]
Serine/threonine kinases: STE group
STE7 family
119238768 (MAP2K1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Seadorna_VP7
Kinase-like
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
119238768
NCBI-ProteinID:
XP_037358658
LinkDB
All DBs
Position
Unknown
AA seq
396 aa
AA seq
DB search
MRVFFSMTVCRNMPWEGNLYDFRSLFDSKGTNLEALQKKLEELELDEQQRKRLEAFLTQK
QKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV
LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL
TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG
THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL
SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV
HAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq
1191 nt
NT seq
+upstream
nt +downstream
nt
atgcgtgtgtttttcagcatgactgtctgcagaaacatgccgtgggaaggtaatttatat
gatttcagaagcctgtttgattccaaggggactaacctggaggccttgcagaagaagttg
gaggagctggagctcgatgagcagcaacggaagcgccttgaggcctttcttacccagaag
cagaaggtgggggagctaaaggacgatgactttgagaaaatcagtgagctgggtgctggc
aatggtggcgtggtgttcaaggtttcccacaagccgtccggcctggtcatggccagaaag
ctaattcacctggagattaaacctgcaatccggaatcagatcataagggagctacaggtt
cttcatgaatgcaactccccatacattgtgggcttctatggtgcattctacagtgatggc
gagatcagcatctgcatggagcacatggatgggggctcgttggatcaagtcctgaagaaa
gctggaagaattcctgaacaaattctaggaaaagttagcattgctgtaataaaaggcttg
acatacctgagggagaagcacaagattatgcatagagatgtcaagccctccaacatccta
gtgaactctcgtggggagatcaagctctgtgactttggggtcagtgggcagctgattgac
tccatggccaactccttcgtgggcacaaggtcctacatgtcgccagaacgactccagggg
acacattactcggtgcagtctgacatctggagcatggggctctcgctggttgagatggcg
gttgggaggtatcccatccctcctccggatgccaaggagctggagctgatgtttgggtgc
caggttgaaggagatgcagctgagacaccgccaaggccgaggacccctgggaggcccctc
agctcttatggaatggacagtcgacctcccatggcaatttttgagttgttggattacata
gtcaatgagcctcctccaaaactgcccagtggagtattcagtctggaatttcaagatttt
gtgaataaatgcttaataaaaaaccctgcagagagagcagatttgaagcaactcatggtt
catgcttttatcaagagatctgatgctgaggaagtggattttgcaggttggctctgctcc
accatcggccttaaccagcccagcacaccaactcatgcggctggtgtctaa
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integrated database retrieval system