KEGG   Talpa occidentalis (Iberian mole): 119238768
Entry
119238768         CDS       T07495                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
tod  Talpa occidentalis (Iberian mole)
Pathway
tod01521  EGFR tyrosine kinase inhibitor resistance
tod01522  Endocrine resistance
tod04010  MAPK signaling pathway
tod04012  ErbB signaling pathway
tod04014  Ras signaling pathway
tod04015  Rap1 signaling pathway
tod04022  cGMP-PKG signaling pathway
tod04024  cAMP signaling pathway
tod04062  Chemokine signaling pathway
tod04066  HIF-1 signaling pathway
tod04068  FoxO signaling pathway
tod04071  Sphingolipid signaling pathway
tod04072  Phospholipase D signaling pathway
tod04114  Oocyte meiosis
tod04140  Autophagy - animal
tod04148  Efferocytosis
tod04150  mTOR signaling pathway
tod04151  PI3K-Akt signaling pathway
tod04210  Apoptosis
tod04218  Cellular senescence
tod04270  Vascular smooth muscle contraction
tod04370  VEGF signaling pathway
tod04371  Apelin signaling pathway
tod04380  Osteoclast differentiation
tod04510  Focal adhesion
tod04540  Gap junction
tod04550  Signaling pathways regulating pluripotency of stem cells
tod04613  Neutrophil extracellular trap formation
tod04620  Toll-like receptor signaling pathway
tod04650  Natural killer cell mediated cytotoxicity
tod04660  T cell receptor signaling pathway
tod04662  B cell receptor signaling pathway
tod04664  Fc epsilon RI signaling pathway
tod04666  Fc gamma R-mediated phagocytosis
tod04668  TNF signaling pathway
tod04720  Long-term potentiation
tod04722  Neurotrophin signaling pathway
tod04725  Cholinergic synapse
tod04726  Serotonergic synapse
tod04730  Long-term depression
tod04810  Regulation of actin cytoskeleton
tod04910  Insulin signaling pathway
tod04912  GnRH signaling pathway
tod04914  Progesterone-mediated oocyte maturation
tod04915  Estrogen signaling pathway
tod04916  Melanogenesis
tod04917  Prolactin signaling pathway
tod04919  Thyroid hormone signaling pathway
tod04921  Oxytocin signaling pathway
tod04926  Relaxin signaling pathway
tod04928  Parathyroid hormone synthesis, secretion and action
tod04929  GnRH secretion
tod04934  Cushing syndrome
tod04935  Growth hormone synthesis, secretion and action
tod05010  Alzheimer disease
tod05022  Pathways of neurodegeneration - multiple diseases
tod05034  Alcoholism
tod05132  Salmonella infection
tod05135  Yersinia infection
tod05160  Hepatitis C
tod05161  Hepatitis B
tod05163  Human cytomegalovirus infection
tod05164  Influenza A
tod05165  Human papillomavirus infection
tod05166  Human T-cell leukemia virus 1 infection
tod05167  Kaposi sarcoma-associated herpesvirus infection
tod05170  Human immunodeficiency virus 1 infection
tod05200  Pathways in cancer
tod05205  Proteoglycans in cancer
tod05206  MicroRNAs in cancer
tod05207  Chemical carcinogenesis - receptor activation
tod05208  Chemical carcinogenesis - reactive oxygen species
tod05210  Colorectal cancer
tod05211  Renal cell carcinoma
tod05212  Pancreatic cancer
tod05213  Endometrial cancer
tod05214  Glioma
tod05215  Prostate cancer
tod05216  Thyroid cancer
tod05218  Melanoma
tod05219  Bladder cancer
tod05220  Chronic myeloid leukemia
tod05221  Acute myeloid leukemia
tod05223  Non-small cell lung cancer
tod05224  Breast cancer
tod05225  Hepatocellular carcinoma
tod05226  Gastric cancer
tod05230  Central carbon metabolism in cancer
tod05231  Choline metabolism in cancer
tod05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:tod00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    119238768 (MAP2K1)
   04012 ErbB signaling pathway
    119238768 (MAP2K1)
   04014 Ras signaling pathway
    119238768 (MAP2K1)
   04015 Rap1 signaling pathway
    119238768 (MAP2K1)
   04370 VEGF signaling pathway
    119238768 (MAP2K1)
   04371 Apelin signaling pathway
    119238768 (MAP2K1)
   04668 TNF signaling pathway
    119238768 (MAP2K1)
   04066 HIF-1 signaling pathway
    119238768 (MAP2K1)
   04068 FoxO signaling pathway
    119238768 (MAP2K1)
   04072 Phospholipase D signaling pathway
    119238768 (MAP2K1)
   04071 Sphingolipid signaling pathway
    119238768 (MAP2K1)
   04024 cAMP signaling pathway
    119238768 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    119238768 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    119238768 (MAP2K1)
   04150 mTOR signaling pathway
    119238768 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    119238768 (MAP2K1)
   04148 Efferocytosis
    119238768 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    119238768 (MAP2K1)
   04210 Apoptosis
    119238768 (MAP2K1)
   04218 Cellular senescence
    119238768 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    119238768 (MAP2K1)
   04540 Gap junction
    119238768 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    119238768 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    119238768 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    119238768 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    119238768 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    119238768 (MAP2K1)
   04660 T cell receptor signaling pathway
    119238768 (MAP2K1)
   04662 B cell receptor signaling pathway
    119238768 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    119238768 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    119238768 (MAP2K1)
   04062 Chemokine signaling pathway
    119238768 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119238768 (MAP2K1)
   04929 GnRH secretion
    119238768 (MAP2K1)
   04912 GnRH signaling pathway
    119238768 (MAP2K1)
   04915 Estrogen signaling pathway
    119238768 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    119238768 (MAP2K1)
   04917 Prolactin signaling pathway
    119238768 (MAP2K1)
   04921 Oxytocin signaling pathway
    119238768 (MAP2K1)
   04926 Relaxin signaling pathway
    119238768 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    119238768 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    119238768 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    119238768 (MAP2K1)
   04916 Melanogenesis
    119238768 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    119238768 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    119238768 (MAP2K1)
   04726 Serotonergic synapse
    119238768 (MAP2K1)
   04720 Long-term potentiation
    119238768 (MAP2K1)
   04730 Long-term depression
    119238768 (MAP2K1)
   04722 Neurotrophin signaling pathway
    119238768 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    119238768 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119238768 (MAP2K1)
   05206 MicroRNAs in cancer
    119238768 (MAP2K1)
   05205 Proteoglycans in cancer
    119238768 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    119238768 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    119238768 (MAP2K1)
   05230 Central carbon metabolism in cancer
    119238768 (MAP2K1)
   05231 Choline metabolism in cancer
    119238768 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    119238768 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119238768 (MAP2K1)
   05212 Pancreatic cancer
    119238768 (MAP2K1)
   05225 Hepatocellular carcinoma
    119238768 (MAP2K1)
   05226 Gastric cancer
    119238768 (MAP2K1)
   05214 Glioma
    119238768 (MAP2K1)
   05216 Thyroid cancer
    119238768 (MAP2K1)
   05221 Acute myeloid leukemia
    119238768 (MAP2K1)
   05220 Chronic myeloid leukemia
    119238768 (MAP2K1)
   05218 Melanoma
    119238768 (MAP2K1)
   05211 Renal cell carcinoma
    119238768 (MAP2K1)
   05219 Bladder cancer
    119238768 (MAP2K1)
   05215 Prostate cancer
    119238768 (MAP2K1)
   05213 Endometrial cancer
    119238768 (MAP2K1)
   05224 Breast cancer
    119238768 (MAP2K1)
   05223 Non-small cell lung cancer
    119238768 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    119238768 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    119238768 (MAP2K1)
   05161 Hepatitis B
    119238768 (MAP2K1)
   05160 Hepatitis C
    119238768 (MAP2K1)
   05164 Influenza A
    119238768 (MAP2K1)
   05163 Human cytomegalovirus infection
    119238768 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    119238768 (MAP2K1)
   05165 Human papillomavirus infection
    119238768 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    119238768 (MAP2K1)
   05135 Yersinia infection
    119238768 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119238768 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    119238768 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    119238768 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    119238768 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119238768 (MAP2K1)
   01522 Endocrine resistance
    119238768 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tod01001]
    119238768 (MAP2K1)
Enzymes [BR:tod01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     119238768 (MAP2K1)
Protein kinases [BR:tod01001]
 Serine/threonine kinases: STE group
  STE7 family
   119238768 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Seadorna_VP7 Kinase-like Haspin_kinase
Other DBs
NCBI-GeneID: 119238768
NCBI-ProteinID: XP_037358658
LinkDB
Position
Unknown
AA seq 396 aa
MRVFFSMTVCRNMPWEGNLYDFRSLFDSKGTNLEALQKKLEELELDEQQRKRLEAFLTQK
QKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV
LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL
TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG
THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL
SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV
HAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1191 nt   +upstreamnt  +downstreamnt
atgcgtgtgtttttcagcatgactgtctgcagaaacatgccgtgggaaggtaatttatat
gatttcagaagcctgtttgattccaaggggactaacctggaggccttgcagaagaagttg
gaggagctggagctcgatgagcagcaacggaagcgccttgaggcctttcttacccagaag
cagaaggtgggggagctaaaggacgatgactttgagaaaatcagtgagctgggtgctggc
aatggtggcgtggtgttcaaggtttcccacaagccgtccggcctggtcatggccagaaag
ctaattcacctggagattaaacctgcaatccggaatcagatcataagggagctacaggtt
cttcatgaatgcaactccccatacattgtgggcttctatggtgcattctacagtgatggc
gagatcagcatctgcatggagcacatggatgggggctcgttggatcaagtcctgaagaaa
gctggaagaattcctgaacaaattctaggaaaagttagcattgctgtaataaaaggcttg
acatacctgagggagaagcacaagattatgcatagagatgtcaagccctccaacatccta
gtgaactctcgtggggagatcaagctctgtgactttggggtcagtgggcagctgattgac
tccatggccaactccttcgtgggcacaaggtcctacatgtcgccagaacgactccagggg
acacattactcggtgcagtctgacatctggagcatggggctctcgctggttgagatggcg
gttgggaggtatcccatccctcctccggatgccaaggagctggagctgatgtttgggtgc
caggttgaaggagatgcagctgagacaccgccaaggccgaggacccctgggaggcccctc
agctcttatggaatggacagtcgacctcccatggcaatttttgagttgttggattacata
gtcaatgagcctcctccaaaactgcccagtggagtattcagtctggaatttcaagatttt
gtgaataaatgcttaataaaaaaccctgcagagagagcagatttgaagcaactcatggtt
catgcttttatcaagagatctgatgctgaggaagtggattttgcaggttggctctgctcc
accatcggccttaaccagcccagcacaccaactcatgcggctggtgtctaa

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