Talpa occidentalis (Iberian mole): 119240531
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Entry
119240531 CDS
T07495
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
tod
Talpa occidentalis (Iberian mole)
Pathway
tod00310
Lysine degradation
tod01100
Metabolic pathways
tod05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
tod00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
119240531 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
119240531 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
tod03036
]
119240531 (DOT1L)
Enzymes [BR:
tod01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
119240531 (DOT1L)
Chromosome and associated proteins [BR:
tod03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
119240531 (DOT1L)
HMT complexes
Dot1-containing complex
119240531 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
119240531
NCBI-ProteinID:
XP_037360894
LinkDB
All DBs
Position
Unknown
AA seq
1730 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNTTTPTKVP
ESKAAIPADTPLDSGGEEEKAGTTSVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTA
NPERKPKKNQTALDLLHAQTVSQTASPSPQDAYKSPHSPFYQLPPSVQRHPPDQLLLAPT
PPALQKLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKDNRALRGQSLQLL
KARCEELKLDWATLSLENLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDDSLSVHLRGKGNLGRELETEPGRLHLELDCTKFSLPPFNSMSPELSMNGHAASY
DLCSSLSRPSSKQNTPQYLASPLDQEVVPCTPSHSVRPRLEKLSGLALPDYTRVSPAKLV
LRRHLSQDHMASGKVTTGELHPRAEHAKENGLPYQSPGMANGIKLSPQDPRPSSPVSLQM
AGEKGSEKGLKERAYGSSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRVEKVRST
PSPVPQTREASSTLDKQMTANAHGAGSKSLASAPSGFSYAGSVAISGALAGSPAPLASGP
DPATFDESSSSGSLFATMGSRSSTPQHPPLLVQSRNSGSASPAHQLCSSPRLSGTAQGLL
PEASKGDLPSDAGYSDPESEAKRRIIFTISAVSSSAKQSPSNKHSPLPSGARADSAQSHG
QDSRKRGRRKRASTGTPSLSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVNNINQPLEI
TAISSPESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPSSARI
ERKIATISLESKSPPKTLENGGSVVGRKLMPASEPVNSSKWKSTFSPISDIGLAKSADSP
LQASSTLSQGSLFAFRPTMEEPSPTDTKLASHPRKSFSGPLSAGGLSPSNNPPNGFAFSG
GLAADLSLHSFNDGASLSHKGPEAASLSAPLSFPTPRSKEGSTSEPGPFLNKRQMDGLGV
PKGEGGKGKEVTEPGLPPCGPLEKASLAHSVKAGRGRDREPDFKSGHNLFISAAAVPPGG
LLSGPGLTTVASSVGSTAPSAQTHRPFLGTFAPGPQFTLGPMSLQANLGSSVLQSLFSSV
PAAAGLVHVSSAATRLTNSHAMGSFSSGVAGGAVGGVFNHAVPSASSHLFGASFGSGAAC
RSATLSLTPLQAVAGTPASSFQGPSSAETRPPPPPPAQHLGRPPPGQPTLHAPPPPNAAL
PPPPALLASNSEPVLLQSLASIPANKTFLPASSAASLQPANASLSIKLASLPHKVSHPSF
TVHHQPLPGLTLAQAAPVIPQASSTGPSAVWVSLGMPPPYATRLAGVKPR
NT seq
5193 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtctatgacaaacaccatgatgctgctcacgaaatcatcgagacc
atccgttgggtctgtgaagaaatcccagatctcaagcttgcaatggaaaattatgtttta
atcgactacgataccaaaagctttgaaagcatgcagaggctttgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggaactacccagcccatgaagctaaacact
cgaccatccaacgggctcctgcggcacatcctgcagcaggtctacaaccactcagtgaca
gaccccgagaagctcaacaactatgagcccttctcccccgaggtgtatggggagacctcc
tttgaccttgtggcacagatgatcgatgagatcaagatgaccgaggatgacctgtttgtg
gacctgggcagtggtgttggccaggttgtgctacaggttgccgcggccaccaactgcaaa
catcactatggcgtcgagaaagctgacatcccagccaagtacgcggagaccatggaccga
gaattcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggaaaga
ggcgattttctctcagaagagtggagagagcggatcgcaaacacaagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcgattcgcaaacatg
aaggaaggtggcagaattgtgtcctcaaaaccctttgccccactaaacttcagaatcaac
agtagaaacttgagtgacattggcaccatcatgcgtgtggtggagctgtcgccgctgaaa
ggttccgtgtcctggacggggaagccggtctcctactacctgcacactattgaccgcacc
atacttgaaaactatttttctagtctgaaaaatccaaaactcagggaggaacaagaggca
gctcggcgacggcagcagcgagaaagcaagagtaacacgaccacccccaccaaggtgccc
gaaagcaaggcagccatacccgcagacacccctctggactctggtggcgaggaggagaaa
gcggggacgacttctgtcaaaaagccctctccctccaaagctcggaagaagaagctaaac
aagaaaggacggaagatggccgggcggaagcgtgggcgtcccaagaagatgagcactgca
aaccctgagcgtaagcccaagaagaaccaaactgcactggacctcctgcacgcgcagact
gtgtctcagacagcgtctccctcgccgcaggatgcgtacaagtcacctcacagcccattt
tatcagctacctcccagtgtgcagcggcatcctcctgaccagctgctgctggcccccacc
ccacccgcactgcagaagctgctagaatccttcaagattcagtacttacagttcttggca
tacacaaagacccctcagtacaaagccaacctgcagcagctgctggaccaggagaaggaa
aagaatgcccggctgctgggtgccgcgcagcagctctttggccactgccaagcccagaag
gaggagatcaagaggctcttccagcagaagctggatgagttgggagtgaaggccctgacc
tacaatgacctgattcaagcacagaaggagatctcggcccacaaccagcagctgagggag
cagacagagcagctggagaaggacaacagggcacttcggggccagagcctgcagctgctc
aaggctcggtgtgaggagttgaagctcgactgggccacgttgtccctggagaacttgctg
aaggagaagcaagcgctgaagagccagatctccgagaagcagagacattgcctggagctg
cagatcagcattgtggagctggagaagagccagcggcagcaggaactcctgcagctcaag
tcctgcgtgccacccgatgacagcctgtctgtgcaccttcgagggaagggtaacctgggc
cgggagctggagacggagcctggccgattgcatctagagctcgactgcaccaagttctcc
ctgcctcctttcaacagcatgagccccgagctctccatgaacggccatgcagccagctat
gacctctgcagctcactgagccggccctcatccaagcaaaacaccccccagtatctggcc
tcacccttggaccaggaagtcgtgccctgtacccccagccacagtgttcggccgaggctc
gaaaagctgtccggtctggccttgcctgactacacccgggtgtccccggccaagctggtg
ctgcggcgacacctgagccaggaccacatggccagtggcaaggtgactacgggcgaactg
catcctcgagctgagcatgccaaggagaacggtctcccataccagagccccggcatggca
aatggcatcaagctgagcccgcaggacccgcggccctcatcccccgtgtccttacagatg
gcaggagagaagggcagtgagaagggtttgaaggagcgcgcctatggcagcagtggggag
gccatcaccagccttcccgtcagcatcccgctcagcactgtgcagcccagcaagctgcct
gtcagcattcccctggccagcgtggtgctgcccagcagagtcgaaaaagtgagaagcact
cccagcccggtgccacagacccgggaggcctcttccacactagacaagcagatgactgct
aatgcccacggggctgggagtaaaagccttgcctctgctccttcaggcttctcctatgct
ggctcggtggctatcagcggggccctagcaggcagcccagcaccactggcctcgggacct
gaccctgccacctttgacgagtcctccagctcgggaagcctttttgccaccatggggtcc
cgcagctcgaccccacagcaccctccgctgctggtgcaatcccgcaactccggctcagcc
tcgcctgcccaccagctatgctctagtcctcggctcagtggcaccgctcagggcctgctt
cccgaggctagtaagggagaccttccctcagacgccggctactcagacccggagagtgaa
gccaagaggaggattatcttcaccatctcggccgtttccagtagcgccaagcagtctccc
tccaacaagcacagccccctaccttcgggtgcccgtgcagacagcgcacagagccacggg
caggacagccgcaagcgaggcaggaggaagcgggcctcaactggaactcccagcctgagc
tcgggtgtgtccccaaagcgccgggctctaccatctgtcgctggcctcttcacgcagtca
tcagggtcgccccttaacctcaactccatggtcaacaacatcaaccagcccttggagatc
acggccatctcgtcccctgagagctccctgaagagctccccagtcccttaccaggacaat
gaccagccacccgtgctcaagaaggagaagccactgagccagaccaatggggcacactac
tctccgctgacctcggatgaggagcagggctccgaggacgaaccgagcagcgccagaatt
gagagaaaaattgcaacaatctccttagaaagcaaatctcctccaaaaaccttagaaaat
ggtggcagcgtggtgggcaggaagctgatgcctgccagtgagcccgtcaacagcagcaag
tggaagtccaccttctcgccaatctccgacattggactggccaagtctgcggacagccca
ctgcaggccagctccacactgagccagggctccctgttcgctttccggcccaccatggag
gaacccagcccgacggacaccaagctcgccagtcaccccaggaaaagcttttctggcccc
ttgtcggctggtgggctcagcccaagcaacaaccctcccaacggctttgccttcagtggg
ggcctggccgctgacctcagtttacacagcttcaacgatggtgcttctctctcccacaag
ggccctgaggcagccagcctgagtgcccccctgagcttccctacccctcgcagcaaggag
ggcagcacctcggagcctggcccctttctgaacaagaggcagatggatggactgggcgtc
ccaaaaggcgaggggggcaagggcaaggaggtgactgagccgggtctgcccccatgtggg
cccctggagaaagcctccctggcgcacagtgtcaaggctggccggggcagggaccgagaa
cctgacttcaagagcggtcacaaccttttcatctctgcagctgctgtgccccctgggggc
ctgctcagtggccctggcctcaccacggtggcatcttctgtgggtagtacggcgccctcc
gcccagacgcaccgccccttcctgggcacctttgcccccggcccacagttcacgctgggc
cccatgtccctgcaggccaacctgggctcatcagtgctacagtccttgttcagctccgtg
ccggctgctgctggcctggtgcatgtctcatccgctgcaaccagactgaccaactcgcac
gccatgggcagcttctcttccggggtggccggtggcgcagttggaggtgtctttaaccac
gcggtgccttccgcctcctctcatctgtttggagccagtttcggcagcggggctgcatgt
cgcagcgccacgctgagcttaaccccgctgcaggcggtggccggcacccccgcctcttcc
tttcagggcccgtcctctgcagagacgaggccacccccacccccgcctgctcagcacctg
ggccgaccccctccggggcagcccaccctccacgcaccccccccacctaacgctgccttg
cctcctccccccgcgctgctcgcgtctaactctgagcccgtgcttctgcagagcctagcg
tccatcccggctaacaaaactttcttacccgcctcttctgctgcctctctccagcctgct
aacgcctctttgtccatcaagctcgcctccctcccgcacaaggtgtcccacccctccttc
acggtgcaccaccaaccactgcctgggctcaccctggcgcaggccgcgcccgtgatcccg
caggccagctccacagggccgtccgctgtgtgggtttcccttggcatgccgcctccgtat
gccacgcgccttgcgggggttaagccacgataa
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integrated database retrieval system
