Ursus arctos horribilis (North American brown bear): 113242935
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Entry
113242935 CDS
T05909
Symbol
INSR
Name
(RefSeq) insulin receptor isoform X1
KO
K04527
insulin receptor [EC:
2.7.10.1
]
Organism
uah
Ursus arctos horribilis (North American brown bear)
Pathway
uah04010
MAPK signaling pathway
uah04014
Ras signaling pathway
uah04015
Rap1 signaling pathway
uah04022
cGMP-PKG signaling pathway
uah04066
HIF-1 signaling pathway
uah04068
FoxO signaling pathway
uah04072
Phospholipase D signaling pathway
uah04150
mTOR signaling pathway
uah04151
PI3K-Akt signaling pathway
uah04152
AMPK signaling pathway
uah04211
Longevity regulating pathway
uah04213
Longevity regulating pathway - multiple species
uah04520
Adherens junction
uah04910
Insulin signaling pathway
uah04913
Ovarian steroidogenesis
uah04923
Regulation of lipolysis in adipocytes
uah04930
Type II diabetes mellitus
uah04931
Insulin resistance
uah04932
Non-alcoholic fatty liver disease
uah04960
Aldosterone-regulated sodium reabsorption
uah05010
Alzheimer disease
uah05415
Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:
uah00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
113242935 (INSR)
04014 Ras signaling pathway
113242935 (INSR)
04015 Rap1 signaling pathway
113242935 (INSR)
04066 HIF-1 signaling pathway
113242935 (INSR)
04068 FoxO signaling pathway
113242935 (INSR)
04072 Phospholipase D signaling pathway
113242935 (INSR)
04022 cGMP-PKG signaling pathway
113242935 (INSR)
04151 PI3K-Akt signaling pathway
113242935 (INSR)
04152 AMPK signaling pathway
113242935 (INSR)
04150 mTOR signaling pathway
113242935 (INSR)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04520 Adherens junction
113242935 (INSR)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
113242935 (INSR)
04923 Regulation of lipolysis in adipocytes
113242935 (INSR)
04913 Ovarian steroidogenesis
113242935 (INSR)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
113242935 (INSR)
09149 Aging
04211 Longevity regulating pathway
113242935 (INSR)
04213 Longevity regulating pathway - multiple species
113242935 (INSR)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
113242935 (INSR)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
113242935 (INSR)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
113242935 (INSR)
04932 Non-alcoholic fatty liver disease
113242935 (INSR)
04931 Insulin resistance
113242935 (INSR)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
uah01001
]
113242935 (INSR)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
uah04090
]
113242935 (INSR)
Enzymes [BR:
uah01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
113242935 (INSR)
Protein kinases [BR:
uah01001
]
Receptor tyrosine kinases (RTK)
INSR family [OT]
113242935 (INSR)
CD molecules [BR:
uah04090
]
Proteins
113242935 (INSR)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
Pkinase
Furin-like
Insulin_TMD
fn3
Kinase-like
DUF4476
B2
Motif
Other DBs
NCBI-GeneID:
113242935
NCBI-ProteinID:
XP_026337093
LinkDB
All DBs
Position
Unknown
AA seq
1381 aa
AA seq
DB search
MGAGAGRGAATAPLLLAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL
QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL
VIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE
ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL
GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNKCKNSRRQG
CHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHILEGEKTIDSVTSAQELRGC
TVVNGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL
EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ
NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS
DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE
RQAEDSELYELDYCLKGLKLPSRTWSPPFEAEGSQKHNQSEYEESAGECCSCPKTDSQIL
KELEESSFRKTFEDYLHNVVFVPRKSSSSPGAEDTRPSRKRRALGDVANVTAAPPTVPGF
PNTSTSAPTSPEEHKPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYVS
ARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVS
RRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIGP
LIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPRE
KITLLRELGQGSFGMVYEGNARDVVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGF
TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAA
EIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR
WMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNC
PERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEMEF
EDMESVPLDRASHSQREEAGGRDGGSSLGLKRNYEEHIPYTHMNGGKKNGRILTLPRSNP
S
NT seq
4146 nt
NT seq
+upstream
nt +downstream
nt
atgggcgccggggctgggcggggggcggcgaccgcgccgctgctgctggcggtggccgcg
ctgctgctgggtgccgcgggccacctgtaccccggagaggtgtgtcctggcatggatatc
cggaacaacctcacgaggttgcatgagctggccaactgctcagtcattgaaggacatttg
cagatactgttgatgttcaaaacgaggcccgaggatttccgagacctcagtttccccaaa
ctcatcatgatcaccgattacttgctgctcttccgggtctacgggctggagagcctgaag
gacctgttccccaacctcacggtcatccggggctcgcgcctcttcttcaactacgcgctg
gtcatcttcgagatggttcacctgaaggagcttggcctctatagcttgatgaacattacc
aggggctccgtccgcatcgagaagaataatgagctctgctacctggccaccatcgactgg
tcacgcatcctggattccgtggaggataattacattgtgctgaacaaagacgacaatgag
gagtgtggggacatctgtccaggcactgcaaagggcaagaccaactgcccggccactgtc
atcaacgggcagtttgtcgagaggtgttggacacacagccactgccagaaagtttgtccc
accatctgcaagtcgcacggctgcaccgccgagggcctctgctgccacagcgagtgttta
ggcaattgctccgagcccgatgaccccaccaagtgcgtggcctgtcgcaacttctacctg
gatggcaggtgcgtggagacctgcccgcccccgtactaccacttccaagactggcgctgc
gtgaacttcagcttctgccaggatttgcacaacaaatgcaagaactcccggagacagggc
tgccaccagtacgtcattcacaataacaagtgcatccccgagtgcccctctggctacacg
atgaattccagcaacctgatgtgcaccccatgcctgggcccctgtcccaaggtctgccac
atcctggagggcgagaagaccatcgactcggtgacctctgcccaggagcttcgaggctgc
actgttgtcaacggaagcctcatcatcaacattcgagggggcaacaacctggcagctgag
ctggaggccaacctcggactcattgaagaaatttccgggtatctgaaaatccggagatcc
tacgctcttgtgtccctttcctttttccggaagttacggctgattcgaggagagaccttg
gaaatcgggaactactctttctacgccttggacaaccagaacctaaggcagctgtgggac
tggagcaaacacaacctcaccatcactcaggggaagctcttcttccactataatcccaaa
ctctgcttgtcggaaattcacaagatggaggaagtttcaggaaccaaggggcgccaggag
aggaatgacattgccctgaagaccaatggggaccaggcgtcttgtgaaaacgaactcctt
aaattttcttacattcggacatcatatgacaagatcttgctgaaatgggagccatactgg
ccccctgacttccgagacctcctgggcttcatgcttttctacaaagaggccccttatcag
aatgtgaccgagttcgacgggcaggacgcgtgtggctccaacagctggacggtggtggac
attgacccgcctttgcggtccaatgaccccaagtcacagaaccacccagggtggctgatg
cggggtctcaagccctggacccagtatgccatctttgtcaagaccttggtcaccttttct
gatgaacgccgcacgtacggggccaagagtgacatcatctatgtgcagacagatgccact
aacccttccgtccccctggatccaatctccgtctcgaattcctcatcccagattattctg
aagtggaagcctccctctgaccccaacggcaacatcacacactacctggttttctgggag
aggcaggcagaagacagtgagctgtatgaattggattattgcctcaaagggttgaagctg
ccctcccgcacctggtctccgccgttcgaggccgagggctcgcagaagcacaaccagagt
gagtacgaggagtctgccggcgagtgctgttcctgccccaagacggactctcagatcctc
aaggagctggaggagtcctcgttcaggaagaccttcgaggattacctgcacaatgtggtg
ttcgtccccagaaaatcctcttcaagccctggtgctgaggacactaggccatcgcggaaa
cgcagggccctcggtgacgttgccaatgtgacggcggccccgcccacggttccgggtttc
cccaacacctccaccagcgcacccacgagcccggaggagcacaagcccttcgagaaagtg
gtgaacaaggaatccctggtcatctctgggctgcgtcacttcactggctaccgcatcgag
ctgcaggcttgcaaccaagactccccagaggagaggtgcagcgtggcggcttatgtcagc
gccaggaccatgcccgaagctaaggcagacgacattgttggccccgtgacccacgaaatc
ttcgagaacaacgttgttcacttgatgtggcaggagccaaaggagcccaacggtctgatc
gtgttgtatgaagtgagttaccgacgctacggtgatgaggagctgcacctctgtgtctcc
cgcagacactttgctctggagcggggctgcaggctgcgcgggctgccgccggggaattac
agcgtgcgagtccgggccacctccctggccggcaacggctcctggacagaagccacttac
ttctacgtgacagactatttagatgtcccatcgaatattgcaaaaatcatcatcggcccc
ctcatctttgtctttctcttcagtgttgtgattggaagtatttacctgttcctgagaaag
aggcagccggatgggccactgggaccgctgtatgcttcttcaaaccctgagtacctcagt
gcgagtgatgtgtttccatgttctgtgtatgtgccggacgagtgggaggtcccccgggag
aagatcactctgctgcgtgagctggggcagggctccttcggcatggtgtacgaaggcaac
gccagagacgtcgtcaagggcgaggcggagacccgcgtggcggtgaagacggtcaatgag
tcggccagtctgcgggagaggatcgagtttctcaacgaggcctcggtcatgaagggcttc
acctgtcatcacgtggtccgcctcctgggggtggtgtccaagggccagccgacgctggtg
gtgatggagctgatggcccatggagacctgaagagctacctccgctccctgcggccggag
gctgagaataaccccggccgccctccccctaccctgcaagagatgattcagatggcggcg
gagatcgccgacgggatggcctacctgaacgccaagaagttcgtgcaccgggatctcgcg
gcccgaaactgcatggtcgcccacgacttcaccgtcaaaattggagactttgggatgacc
agagacatctatgaaacggattactaccggaaaggaggcaagggtctgctccccgtgcgg
tggatggccccggaatccctgaaggacggggtctttaccacttcttctgacatgtggtcc
tttggcgtggtcctttgggaaatcaccagcttggcagaacagccataccagggtctgtct
aatgaacaggtgttgaaattcgtcatggatggagggtatctggatcaacccgacaattgt
ccagagagagtcaccgacctgatgcgcatgtgctggcagttcaatcccaagatgcggccc
accttcctggagatcgtcgacctgctcaaggacgacctgcaccccagctttccggaagtt
tccttcttccatagcgaggagaacaaggcgcctgagagcgaggagctggagatggagttc
gaggacatggagagtgtccccctggatcgggcctcacactctcagagggaggaggccggg
ggccgggatggagggtcctccctgggcctcaagcgaaactacgaggagcacatcccctac
acccacatgaacgggggcaagaaaaacggacggattctgactctgccgaggtcgaatcct
tcctaa
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integrated database retrieval system
