Ursus maritimus (polar bear): 103660272
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Entry
103660272 CDS
T03271
Symbol
PDE8A
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
umr
Ursus maritimus (polar bear)
Pathway
umr00230
Purine metabolism
umr01100
Metabolic pathways
umr04927
Cortisol synthesis and secretion
umr04934
Cushing syndrome
umr05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
umr00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
103660272 (PDE8A)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
103660272 (PDE8A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
103660272 (PDE8A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
103660272 (PDE8A)
Enzymes [BR:
umr01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
103660272 (PDE8A)
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Ortholog
Paralog
GFIT
Motif
Pfam:
PDEase_I
PAS
PAS_9
PDE8
PAS_4
PAS_3
PAS_8
DUF5894
Sina_ZnF
Response_reg
Motif
Other DBs
NCBI-GeneID:
103660272
NCBI-ProteinID:
XP_040498776
UniProt:
A0A8M1GST5
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All DBs
Position
Unknown
AA seq
836 aa
AA seq
DB search
MGCAPSIHISEGRAVYHGGKEAEDAPGAAAPPPPPPAGPRLPPGQKTTASPGARGAGLAE
SEPRDGSGRKVAVADVQFGPMRFHPDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKE
AQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTIIIGVVRRTDREESSV
MPLIAAGFTRRYVENPSLMACYNELLQLEFGEVRSQLKLRACNSIFTALEKSQEAIEITS
EDRIIQYANPAFETTMGYQSGELIGKELAEVPINEKKADLLDTINSCIRIGKEWQGIYHT
KKKNGDNVQQNVKIIPVIGQGGKIRHYVSIIRVCNGSNKAEKIECVQSDTHTDNQSGKHK
DRRKSSLDVRTLASRSSEVGSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTE
ALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKTLQQVPS
SVITPISLHDVPPRIARAMENEEYWDFNIFELEAATHKRPLIYLGLKMFARFGICEFLNC
SETTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLCKERIKQTLDPVDEVAALIAA
TIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTRDDKCNIFKNMERND
YRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLAALEENGEVNRDEEAINTMLRTPEN
RTLIKRMLIKCADVSNPCRPLEQCIEWAARISEEYFSQTDEEKRQDLPVVMPVFDRNTCS
IPKSQISFIDYFITDMFDAWDAFVDLPELMQHLDNNFKYWKGLDEMKLRSLRPPPE
NT seq
2511 nt
NT seq
+upstream
nt +downstream
nt
atgggctgcgccccgagcatccacatttccgagggccgggcggtgtaccacggcggcaag
gaggccgaggacgcgccgggcgccgccgcgccgccgccgccaccgcccgccgggccgcgc
ctcccacccggccagaagaccaccgcctcgcccggggcccgcggcgccggcctcgcggag
tccgagcctcgcgacggcagcggcaggaaggtagcagtagctgatgtgcagtttggcccc
atgagatttcatccagatcaactccaggtacttttagtgtttaccaaagaagataaccag
tgtaatggattctgcagggcgtgtgaaaaagcagggtttaagtgcacagttaccaaggag
gctcaggctgttcttgcctgtttcctggacaaacatcatgacatcatcatcattgaccac
agaaacccccggcagctggacgcggaggcgctgtgcaggtctattagatcatccaagctc
tctgaaaacacaattattattggtgtagtacgcaggacggatagagaagagtcatccgtg
atgcccctcattgctgctggctttacaaggaggtatgtggaaaaccccagcctcatggcc
tgttacaatgaactgctccagctggagttcggagaggtgcggtcccagctaaaactcagg
gcttgtaactcaatattcactgcattagagaaaagtcaagaagcaattgaaattacaagt
gaagaccgcattatacagtatgcaaatcctgcatttgaaacaaccatgggctatcagtca
ggtgaattaataggaaaggagttagcagaagtgcctataaatgaaaaaaaggctgatttg
ctcgatactataaattcatgcatcaggataggcaaggagtggcaaggaatctaccacacc
aaaaagaaaaacggagataatgtgcaacaaaatgtgaagataatacctgtcattggacag
ggaggaaaaattagacactatgtgtccattatcagagtgtgcaatggcagcaataaggct
gagaaaattgaatgtgttcagtctgacacgcatacagataatcagtcaggcaaacataaa
gacagaaggaaaagctcgctagatgtcagaactcttgcttctcgatcaagtgaagttggc
agccagagacgacactcctccatggcccggatacattccatgacgatcgaggcgcccatc
accaaggtgatcaacattatcaatgctgcccaggaaagcagccccatgcctgtgacagaa
gccttagaccgtgtgctggaaattctaagaaccactgaattatattcaccacagtttggt
gctaaggatgacgatcctcacgccaatgacctcgttgggggcttaatgtctgatggtttg
cgaagactatctgggaatgagtatgttctttcaacaaaaactcttcagcaggtgcccagc
agtgtaatcacccccatctcccttcacgacgtccccccgcggatagctcgggccatggaa
aacgaggagtactgggactttaatatttttgaactggaggctgccactcataaaaggcct
ttgatttatcttggtctcaaaatgtttgctcgcttcggaatctgtgaattcttgaactgc
tccgagacaacgctaagatcgtggttacagattattgaagccaattaccactcttctaac
ccctaccacaactcgacacactctgccgacgtgcttcatgccactgcctactttctctgc
aaagagaggataaagcaaactttagatccggttgacgaggtcgctgccctcatcgcagcc
accatccacgacgtggaccaccccggcaggaccaactcattcctgtgcaacgctggcagc
gagctggccattttgtataacgacactgcggtgctggagagccatcacgcagccttggcc
ttccagctgacaacccgagatgacaaatgcaatatcttcaagaacatggagaggaatgac
tatcggacgctgcgccagggtattatcgacatggtcttagccacagaaatgacaaagcac
ttcgagcacgtcaacaaatttgtcaacagcatcaacaagcccctggcagccctcgaagaa
aatggggaagtgaatagagacgaagaagccataaacactatgctcaggactccagagaac
cggactctaattaaacgaatgctgattaaatgcgcagatgtgtccaatccctgccgaccc
ctggagcagtgcattgagtgggccgcacgcatctcagaagaatatttttctcagacggat
gaggagaagcggcaggacctgcctgtggtgatgccggtctttgacaggaacacctgcagc
atccccaagtcccagatctccttcatcgactacttcatcaccgacatgtttgacgcgtgg
gacgcctttgtagacctgcccgagctaatgcagcatcttgacaacaactttaaatactgg
aaaggcctggacgaaatgaagctgcggagcctccgaccgccccctgaatag
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