Ursus maritimus (polar bear): 103668166
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Entry
103668166 CDS
T03271
Symbol
PDHA1
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
umr
Ursus maritimus (polar bear)
Pathway
umr00010
Glycolysis / Gluconeogenesis
umr00020
Citrate cycle (TCA cycle)
umr00620
Pyruvate metabolism
umr00785
Lipoic acid metabolism
umr01100
Metabolic pathways
umr01200
Carbon metabolism
umr01210
2-Oxocarboxylic acid metabolism
umr04066
HIF-1 signaling pathway
umr04922
Glucagon signaling pathway
umr05230
Central carbon metabolism in cancer
umr05415
Diabetic cardiomyopathy
Module
umr_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
umr00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
103668166 (PDHA1)
00020 Citrate cycle (TCA cycle)
103668166 (PDHA1)
00620 Pyruvate metabolism
103668166 (PDHA1)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
103668166 (PDHA1)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
103668166 (PDHA1)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
103668166 (PDHA1)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
103668166 (PDHA1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
103668166 (PDHA1)
Enzymes [BR:
umr01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
103668166 (PDHA1)
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Paralog
GFIT
Motif
Pfam:
E1_dh
DXP_synthase_N
TPP_enzyme_C
Motif
Other DBs
NCBI-GeneID:
103668166
NCBI-ProteinID:
XP_040489653
UniProt:
A0A8M1G207
LinkDB
All DBs
Position
X
AA seq
390 aa
AA seq
DB search
MRKMLAAVSRVLSGAAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLRYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEASINPTDHLITAYRA
HGFTFTRGLSVREILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATRFAAAHCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSIS
NT seq
1173 nt
NT seq
+upstream
nt +downstream
nt
atgaggaaaatgctcgccgctgtctctcgcgtgttgtcgggcgccgcccagaagccggca
agcagagttctcgtggcttcccgtaattttgcaaatgatgctacatttgaaattaagaaa
tgcgatcttcaccggctagaagagggcccccctgtcaccacagtgctcaccagggaggac
gggctcaggtactataggatgatgcagactgttcgccggatggagttaaaggcagatcag
ctgtataaacagaaaattattcgtggtttctgtcacttgtgtgatggtcaggaagcttgt
tgtgtgggcctggaggccagcataaatcccacagaccatcttatcacagcctatcgggct
catggctttacctttactcgtgggctttctgtccgagaaattctcgcagagcttacagga
cgaagaggaggctgtgctaaagggaaaggtggatcgatgcatatgtatgccaagaacttc
tatgggggcaatggcatcgttggagctcaggtgcccctgggagcggggattgctctggcc
tgtaagtataatggaaaggatgaggtctgtttgactttatatggcgatggtgctgctaat
cagggtcagatatttgaagcttataacatggcagctttgtggaaattgccatgtattttc
atctgtgagaataaccgctatggaatgggaacgtccgttgagagagcagcggccagcact
gattactacaagagaggcgacttcattcctggactgagggtcgatggaatggatatcttg
tgtgtccgggaggcaacaaggtttgcagctgcccactgtagatctggaaaggggcccata
ctgatggagctacagacttaccgttaccatggacacagcatgagcgaccctggagtcagt
taccgtacgcgagaagagattcaggaagtaagaagtaagagtgaccctattatgcttctc
aaggatagaatggtgaacagcaatctggccagtgttgaagaattaaaggaaattgatgtt
gaagtgaggaaggaaattgaggatgctgcccagtttgccactgctgatcctgaaccgcct
ttggaagaactaggctatcacatttacagcagcgacccgccttttgaagttcggggtgca
aatcagtggatcaagtttaagtccatcagttaa
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