Ursus maritimus (polar bear): 103676308 Help Entry 103676308         CDS       T03271                                  Symbol INSR Name (RefSeq) insulin receptor   KO K04527   insulin receptor [EC:2.7.10.1] Organism umr  Ursus maritimus (polar bear) Pathway umr04010   MAPK signaling pathway umr04014   Ras signaling pathway umr04015   Rap1 signaling pathway umr04022   cGMP-PKG signaling pathway umr04066   HIF-1 signaling pathway umr04068   FoxO signaling pathway umr04072   Phospholipase D signaling pathway umr04150   mTOR signaling pathway umr04151   PI3K-Akt signaling pathway umr04152   AMPK signaling pathway umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04520   Adherens junction umr04910   Insulin signaling pathway umr04913   Ovarian steroidogenesis umr04923   Regulation of lipolysis in adipocytes umr04930   Type II diabetes mellitus umr04931   Insulin resistance umr04932   Non-alcoholic fatty liver disease umr04960   Aldosterone-regulated sodium reabsorption umr05010   Alzheimer disease umr05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103676308 (INSR)    04014 Ras signaling pathway     103676308 (INSR)    04015 Rap1 signaling pathway     103676308 (INSR)    04066 HIF-1 signaling pathway     103676308 (INSR)    04068 FoxO signaling pathway     103676308 (INSR)    04072 Phospholipase D signaling pathway     103676308 (INSR)    04022 cGMP-PKG signaling pathway     103676308 (INSR)    04151 PI3K-Akt signaling pathway     103676308 (INSR)    04152 AMPK signaling pathway     103676308 (INSR)    04150 mTOR signaling pathway     103676308 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     103676308 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     103676308 (INSR)    04923 Regulation of lipolysis in adipocytes     103676308 (INSR)    04913 Ovarian steroidogenesis     103676308 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     103676308 (INSR)   09149 Aging    04211 Longevity regulating pathway     103676308 (INSR)    04213 Longevity regulating pathway - multiple species     103676308 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     103676308 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     103676308 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     103676308 (INSR)    04932 Non-alcoholic fatty liver disease     103676308 (INSR)    04931 Insulin resistance     103676308 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:umr01001]     103676308 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:umr04090]     103676308 (INSR) Enzymes [BR:umr01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      103676308 (INSR) Protein kinases [BR:umr01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    103676308 (INSR) CD molecules [BR:umr04090]  Proteins   103676308 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like DUF4476 B2 Motif Other DBs NCBI-GeneID:  103676308 NCBI-ProteinID:  XP_040485315 UniProt:  A0A8M1FSB7 LinkDB All DBs Position Unknown AA seq 1343 aa AA seqDB search MDIRNNLTRLHELANCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLE SLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLAT IDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQK VCPTICKSHGCTAEGLCCHSECLGNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQD WRCVNFSFCQDLHNKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPK VCHILEGEKTIDSVTSAQELRGCTVVNGSLIINIRGGNNLAAELEANLGLIEEISGYLKI RRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHY NPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWE PYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPG WLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQ IILKWKPPSDPNGNITHYLVFWERQAEDSELYELDYCLKGLKLPSRTWSPPFEAEGSQKH NQSEYEESAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKSSSSPGAEDTRP SRKRRALGDVANVTAAPPTVPGFPNTSTSAPTSPEEHKPFEKVVNKESLVISGLRHFTGY RIELQACNQDSPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPN GLIVLYEVSYRRYGDEELHLCVSRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTE ATYFYVTDYYVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEY LSASDVFPCSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNARDVVKGEAETRVAVKTV NESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLR PEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFG MTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQG LSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFP EVSFFHSEENKAPESEELEMEFEDMESVPLDRASHSQREEAGGRDGGSSLGLKRNYEEHI PYTHMNGGKKNGRILTLPRSNPS NT seq 4032 nt NT seq  +upstreamnt  +downstreamnt atggatatccggaacaacctcacgaggttgcatgagctggccaactgctcagtcatcgaa ggacatttgcagatactgttgatgttcaaaacgaggcccgaggatttccgagacctcagt ttccccaaactcatcatgatcaccgattacttgctgctcttccgggtctacgggctggag agcctgaaggacctgttccccaacctcacggtcatccggggctcgcgcctcttcttcaac tacgcgctggtcatcttcgagatggttcacctgaaggagcttggcctctatagcttgatg aacattaccaggggctccgtccgcatcgagaagaataatgagctctgctacctggccacc atcgactggtcacgcatcctggattccgtggaggataattacattgtgctgaacaaagac gacaatgaggagtgtggggacatctgtccaggcactgcaaagggcaagaccaactgcccg gccactgtcatcaacgggcagtttgtcgagaggtgttggacacacagccactgccagaaa gtttgtcccaccatctgcaagtcgcacggctgcaccgccgagggcctctgctgccacagc gagtgtttaggcaattgctccgagcccgatgaccccaccaagtgcgtggcctgtcgcaac ttctacctggatggcaggtgcgtggagacctgcccgcccccgtactaccacttccaagac tggcgctgcgtgaacttcagcttctgccaggatttgcacaacaaatgcaagaactcccgg agacagggctgccaccagtacgtcattcacaataacaagtgcatccccgagtgcccctct ggctacacgatgaattccagcaacctgatgtgcaccccatgcctgggcccctgtcccaag gtctgccacatcctggagggcgagaagaccatcgactcggtgacctctgcccaggagctt cgaggctgcactgttgtcaacggaagcctcatcatcaacattcgagggggcaacaacctg gcagctgagctggaggccaacctcggactcattgaagaaatttccgggtatctgaaaatc cggagatcctacgctcttgtgtccctttcctttttccggaagttacggctgattcgagga gagaccttggaaatcgggaactactctttctacgccttggacaaccagaacctaaggcag ctgtgggactggagcaaacacaacctcaccatcactcaggggaagctcttcttccactat aatcccaaactctgcttgtcggaaattcacaagatggaggaagtttcaggaaccaagggg cgccaggagaggaacgacattgccctgaagaccaatggggaccaggcgtcttgtgaaaac gaactccttaaattttcttacattcggacatcatatgacaagatcttgctgaaatgggag ccatactggccccctgacttccgagacctcctgggcttcatgcttttctacaaagaggcc ccttatcagaatgtgaccgagttcgacgggcaggacgcgtgtggctccaacagctggacg gtggtggacattgacccgcctttgcggtccaatgaccccaagtcacagaaccacccaggg tggctgatgcggggtctcaagccctggacccagtatgccatctttgtcaagaccttggtc accttttctgatgaacgccgcacgtacggggccaagagtgacatcatctatgtgcagaca gatgccactaacccttccgtccccctggatccaatctccgtctcgaattcctcatcccag attattctgaagtggaagcctccctctgaccccaatggcaacatcacacactacctggtt ttctgggagaggcaggcagaagacagtgagctgtatgaattggattattgcctcaaaggg ttgaagctgccctcccgcacctggtctccgccgttcgaggccgagggctcgcagaagcac aaccagagtgagtacgaggagtctgccggcgagtgctgttcctgccccaagacggactct cagatcctcaaggagctggaggagtcctcgttcaggaagaccttcgaggattacctgcac aatgtggtgttcgtccccagaaaatcctcttcaagccctggtgctgaggacactaggcca tcgcggaaacgcagggccctcggtgacgttgccaatgtgacggcggccccgcccacggtt ccgggtttccccaacacctccaccagcgcacccacgagcccggaggagcacaagcccttc gagaaagtggtgaacaaggaatccctggtcatctctgggctgcgtcacttcactggctac cgcatcgagctgcaggcttgcaaccaagactccccagaggagaggtgcagcgtggcggct tatgtcagcgccaggaccatgcccgaagctaaggcagacgacattgttggccccgtgacc cacgaaatcttcgagaacaacgttgttcacttgatgtggcaggagccaaaggagcccaac ggtctgatcgtgttgtatgaagtgagttaccgacgctacggtgatgaggagttgcacctc tgtgtctcccgcagacactttgctctggagcggggctgcaggctgcgcgggctgccgccg gggaattacagcgtgcgagtccgggccacctccctggccggcaacggctcctggacagaa gccacttacttctacgtgacagactattatgtcccatcgaatattgcaaaaatcatcatc ggccccctcatctttgtctttctcttcagtgttgtgattggaagtatttacctgttcctg agaaagaggcagccggatgggccactgggaccgctgtatgcttcttcaaaccctgagtac ctcagtgcgagtgatgtgtttccatgttctgtgtatgtgccggacgagtgggaggtcccc cgggagaagatcactctgctgcgtgagctggggcagggctccttcggcatggtgtacgaa ggcaacgccagagacgtcgtcaagggcgaggcggagacccgcgtggcggtgaagacggtc aatgagtcggccagtctgcgggagaggatcgagtttctcaacgaggcctcggtcatgaag ggcttcacctgtcatcacgtggtccgcctcctgggggtggtgtccaagggccagccgacg ctggtggtgatggagctgatggcccatggagacctgaagagctacctccgctccctgcgg ccggaggctgagaataaccccggccgccctccccctaccctgcaagagatgattcagatg gcggcggagatcgccgacgggatggcctacctgaacgccaagaagttcgtgcaccgggat ctcgcggcccgaaactgcatggtcgcccacgacttcaccgtcaaaattggagactttggg atgaccagagacatctatgaaacggattactaccggaaaggaggcaagggtctgctcccc gtgcggtggatggccccggaatcgctgaaggacggggtctttaccacttcttctgacatg tggtcctttggcgtggtcctttgggaaatcaccagcttggcagaacagccataccagggt ctgtctaatgaacaggtgttgaaattcgtcatggatggagggtatctggatcaacccgac aattgtccagagagagtcaccgacctgatgcgcatgtgctggcagttcaatcccaagatg cggcccaccttcctggagatcgtcgacctgctcaaggacgacctgcaccccagctttccg gaagtttccttcttccatagcgaggagaacaaggcgcctgagagcgaggagctggagatg gagttcgaggacatggagagtgtccccctggatcgggcctcacactctcagagggaggag gccgggggccgggatggagggtcctccctgggcctcaagcgaaactacgaggagcacatc ccctacacccacatgaacgggggcaagaaaaacggacggattctgactctgccgaggtcg aatccttcctaa

DBGET integrated database retrieval system