+C	Two-component system	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Two-Component System - Aeromonas bestiarum</h2>
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A<b>OmpR family</b>
B  PhoR-PhoB (phosphate starvation response)
C    IU367_15690 phoR; phosphate regulon sensor histidine kinase PhoR	K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] 
C    IU367_15695 phoB; phosphate regulon transcriptional regulator PhoB	K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB 
B  SenX3-RegX3 (phosphate starvation response)
B  PhoQ-PhoP (magnesium transport)
C    IU367_15215 GHKL domain-containing protein	K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3] 
C    IU367_15210 response regulator	K07660 phoP; two-component system, OmpR family, response regulator PhoP 
B  EnvZ-OmpR (osmotic stress response)
C    IU367_01160 envZ; two-component system sensor histidine kinase EnvZ	K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] 
C    IU367_01155 ompR; two-component system response regulator OmpR	K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR 
B  RstB-RstA
C    IU367_20995 rstB; two-component system sensor histidine kinase RstB	K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3] 
C    IU367_20990 rstA; two-component system response regulator RstA	K07661 rstA; two-component system, OmpR family, response regulator RstA 
B  CpxA-CpxR (envelope stress response)
C    IU367_00585 HAMP domain-containing protein	K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3] 
C    IU367_00590 response regulator	K07662 cpxR; two-component system, OmpR family, response regulator CpxR 
B  CssS-CssR (secretion stress response)
B  CreC-CreB (phosphate regulation)
C    IU367_21680 blrB; beta-lactam sensor histidine kinase BlrB	K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3] 
C    IU367_21675 blrA; beta-lactam response regulator transcription factor BlrA	K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB 
B  BaeS-BaeR (envelope stress response)
B  BasS-BasR (antimicrobial peptide resistance)
B  CusS-CusR (copper tolerance)
B  QseC-QseB (quorum sensing)
C    IU367_05355 sensor histidine kinase N-terminal domain-containing protein	K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3] 
C    IU367_05360 response regulator	K07666 qseB; two-component system, OmpR family, response regulator QseB 
B  KdpD-KdpE (potassium transport)
C    IU367_00085 sensor histidine kinase KdpD	K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] 
C    IU367_00080 response regulator	K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE 
B  TorS-TorR (TMAO respiration)
B  ArcB-ArcA (anoxic redox control)
C    IU367_17145 arcB; aerobic respiration two-component sensor histidine kinase ArcB	K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3] 
C    IU367_06345 arcA; two-component system response regulator ArcA	K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA 
B  TctE-TctD (tricarboxylic acid transport)
B  ResE-ResD (aerobic and anaerobic respiration)
B  VicK-VicR (cell wall metabolism)
B  MprB-MprA (maintenance of persistent infection)
B  MtrB-MtrA (osmotic stress response)
B  PrrB-PrrA (intracellular multiplication)
B  TrcS-TrcR
B  NrsS-NrsR (nickel tolerance)
B  ManS-ManR (manganese homeostasis)
B  NblS-NblR (photosynthesis)
B  SasA-RpaAB (circadian timing mediating)
B  SaeS-SaeR (staphylococcal virulence regulation)
B  BceS-BceR (bacitracin transport)
B  BraS-BraR (bacitracin transport)
B  GraS-GraR (cationic antimicrobial peptide transport)
B  YxdK-YxdJ (antimicrobial peptide response)
B  ChvG-ChvI (acidity sensing)
B  CiaH-CiaR
B  ParS-ParR (polymyxin-adaptive resistance)
B  AdeS-AdeR
B  VanS-VanR (VanB type vancomycin resistance)
B  VanS-VanR (VanE type vancomycin resistance)
B  VanS-VanR (actinomycete type vancomycin resistance)
B  ArlS-ArlR (virulence regulation)
B  Ihk-Irr (virulence regulation)
B  PfeS-PfeR (enterobactin-dependent iron acquisition)
B  NisK-NisR (lantibiotic biosynthesis)
B  Unclassified
C    IU367_17910 HAMP domain-containing protein	K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] 
C    IU367_17905 response regulator transcription factor	K02483 K02483; two-component system, OmpR family, response regulator 
C    IU367_20020 response regulator	K02483 K02483; two-component system, OmpR family, response regulator 
C    IU367_20455 response regulator transcription factor	K02483 K02483; two-component system, OmpR family, response regulator 
C    IU367_21310 response regulator transcription factor	K02483 K02483; two-component system, OmpR family, response regulator 
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A<b>NarL family</b>
B  NarX-NarL (nitrate respiration)
B  NarQ-NarP (nitrate respiration)
C    IU367_14060 narQ; nitrate/nitrite two-component system sensor histidine kinase NarQ	K07674 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3] 
C    IU367_14065 narL; two-component system response regulator NarL	K07685 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP 
B  UhpB-UhpA (hexose phosphates uptake)
C    IU367_07550 uhpB; signal transduction histidine-protein kinase/phosphatase UhpB	K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3] 
C    IU367_07555 uhpA; transcriptional regulator UhpA	K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA 
B  FusK-FusR (virulence regulation)
B  RcsC-RcsD-RcsB (capsule synthesis)
B  BarA-UvrY (central carbon metabolism)
C    IU367_17660 barA; two-component sensor histidine kinase BarA	K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3] 
C    IU367_07740 uvrY; UvrY/SirA/GacA family response regulator transcription factor	K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY 
B  ComP-ComA (competence)
B  EvgS-EvgA (acid and drug tolerance)
C    IU367_10665 transporter substrate-binding domain-containing protein	K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3] 
C    IU367_17130 transporter substrate-binding domain-containing protein	K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3] 
C    IU367_00335 transporter substrate-binding domain-containing protein	K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3] 
C    IU367_00330 response regulator transcription factor	K07690 evgA; two-component system, NarL family, response regulator EvgA 
B  DegS-DegU (multicellular behavior control)
B  DesK-DesR (membrane lipid fluidity regulation)
B  VraS-VraR (cell-wall peptidoglycan synthesis)
B  LiaS-LiaR (cell wall stress response)
B  DevS-DevR (redox response)
B  NreB-NreC (dissimilatory nitrate/nitrite reduction)
B  YdfH-YdfI
B  SalK-SalR
B  PprA–PprB (biofilm formation)
B  Unclassified
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A<b>Spo family</b>
B  KinABCDE-Spo0FA (sporulation control)
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A<b>CitB family</b>
B  CitA-CitB (citrate fermentation)
B  CitS-CitT (magnesium-citrate transport)
B  DcuS-DcuR (C4-dicarboxylate metabolism)
B  DctS-DctR (C4-dicarboxylate transport)
B  MalK-MalR (malate transport)
B  Unclassified
C    IU367_09725 sensor histidine kinase	K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3] 
C    IU367_09730 response regulator	K02475 K02475; two-component system, CitB family, response regulator 
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A<b>LytTR family</b>
B  LysS-LysR
B  AlgZ-AlgR (alginate production)
B  NatK-NatR (sodium extrusion)
B  AgrC-AgrA (exoprotein synthesis)
B  AgrC2-AgrA2 (virulence regulation)
B  ComD-ComE (competence)
B  Unclassified
C    IU367_04935 sensor histidine kinase	K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] 
C    IU367_08610 sensor histidine kinase	K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] 
C    IU367_00345 sensor histidine kinase	K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] 
C    IU367_04930 yehT; two-component system response regulator BtsR	K02477 K02477; two-component system, LytTR family, response regulator 
C    IU367_08605 yehT; two-component system response regulator BtsR	K02477 K02477; two-component system, LytTR family, response regulator 
C    IU367_00350 response regulator transcription factor	K02477 K02477; two-component system, LytTR family, response regulator 
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A<b>NtrC family</b>
B  GlnL-GlnG (nitrogen regulation)
C    IU367_01005 glnL; nitrogen regulation protein NR(II)	K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3] 
C    IU367_01000 glnG; nitrogen regulation protein NR(I)	K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG 
B  NtrY-NtrX (nitrogen regulation)
B  HydH-HydG (metal tolerance)
B  AtoS-AtoC (cPHB biosynthesis)
B  PilS-PilR (type 4 fimbriae synthesis)
B  GlrK-GlrR (amino sugar metabolism)
C    IU367_20495 HAMP domain-containing histidine kinase	K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3] 
C    IU367_20485 sigma 54-interacting transcriptional regulator	K07715 glrR; two-component system, NtrC family, response regulator GlrR 
B  PgtB-PgtA (phosphoglycerate transport)
C    IU367_00170 HAMP domain-containing protein	K08475 pgtB; two-component system, NtrC family, phosphoglycerate transport system sensor histidine kinase PgtB [EC:2.7.13.3] 
C    IU367_00175 sigma-54-dependent Fis family transcriptional regulator	K08476 pgtA; two-component system, NtrC family, phosphoglycerate transport system response regulator PgtA 
B  DctB-DctD (C4-dicarboxylate transport)
B  KinB-AlgB (alginate production)
B  HupT-HupR (hydrogenase synthesis regulation)
B  Unclassified
C    IU367_06095 cache domain-containing protein	K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3] 
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A<b>CheA family</b>
B  CheA-CheYBV (chemotaxis)
C    IU367_12735 chemotaxis protein CheA	K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] 
C    IU367_15010 chemotaxis protein CheA	K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] 
C    IU367_16535 chemotaxis protein CheA	K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] 
C    IU367_12725 response regulator	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    IU367_15020 cheY; chemotaxis response regulator CheY	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    IU367_16525 response regulator	K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY 
C    IU367_12755 chemotaxis response regulator protein-glutamate methylesterase	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    IU367_15005 chemotaxis response regulator protein-glutamate methylesterase	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    IU367_16565 chemotaxis response regulator protein-glutamate methylesterase	K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] 
C    IU367_07300 chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
C    IU367_16695 chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
C    IU367_17260 chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
C    IU367_19365 chemotaxis protein CheV	K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV 
B  ChpA-ChpB/PilGH (chemosensory)
B  PixL-PixGH (positive phototaxis)
B  WspE-WspRF (chemosensory)
B  Cph1-Rcp1 (light response)
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A<b>Cell cycle family</b>
B  PleC-PleD (cell fate control)
B  CckA-CtrA/CpdR (cell cycle control)
B  Hk1-Rrp1 (glycerol uptake and utilization)
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A<b>Lux family</b>
B  LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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A<b>LuxR family</b>
B  DctS-DctR (C4-dicarboxylate transport)
B  TtrS-TtrR (tetrathionate respiration)
B  FixL-FixJ (nitrogen fixation)
B  SsrA-SsrB
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A<b>Other families</b>
B  FlrB-FlrC (polar flagellar synthesis)
C    IU367_07395 sensor histidine kinase	K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3] 
C    IU367_07400 sigma-54-dependent Fis family transcriptional regulator	K10943 flrC; two-component system, response regulator FlrC 
B  AauS-AauR (acidic amino acids utilization)
B  SLN1-YPD1-SSK1/SKN7 (osmosensing)
B  RpfC-RpfG (cell-to-cell signaling)
B  GlnK-GlnL (glutamine utilization)
B  HspS-HspR (hexose phosphates uptake)
B  YesM-YesN
B  CikA
B  RegB-RegA (redox response)
B  FitF-FitH (insecticidal toxin regulation)
B  PhcS-PhcRQ
B  SagS-HptB-HsbR (swarming activity and biofilm formation)
C    IU367_14075 response regulator	K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3] 
B  PdtaS-PdtaR
B  NasS-NasT
C    IU367_04315 ANTAR domain-containing protein	K07183 nasT; two-component system, response regulator / RNA-binding antiterminator 
B  Unclassified
C    IU367_06015 response regulator	K19694 chiS; two-component system, sensor histidine kinase ChiS 
C    IU367_01735 response regulator	K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] 
C    IU367_06165 hybrid sensor histidine kinase/response regulator	K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] 
C    IU367_09865 response regulator	K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] 
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#Last updated: December 14, 2023