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Functional Hierarchies

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KEGG BRITE is a collection of manually created hierarchical text (htext) files capturing functional hierarchies of various biological objects, especially those represented as KEGG objects. Some BRITE hierarchy files contain tab-delimited attributes that are added manually or computationally. BRITE table files are now used to focus more on such multi-column attributes rather than hierarchy relationships. In contrast to KEGG PATHWAY, which is limited to molecular interactions and reactions, KEGG BRITE incorporates many different types of relationships including: KEGG BRITE is a reference database for Brite Mapping.

Brite Identifiers

Each brite hierarchy/table is identified by the combination of 2-4 letter prefix code and 5 digit number (see KEGG Identifier). The prefix has the following meaning:
br
non-gene/protein reference hierarchy or table
jp
non-gene/protein reference hierarchy or table in Japanese
ko
gene/protein reference hiearchy for KO expansion
<org>
organism-specific hierarchy generated by converting KOs to gene identifiers

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Pathway and Brite

1. Genes and Proteins

1.1 Orthologs and modules (K/M nubmers)
1.2 Protein families: metabolism (K numbers)
1.3 Protein families: genetic information processing (K numbers)
1.4 Protein families: signaling and cellular processes (K numbers)
1.5 RNA family (K numbers)
1.6 Sequence data collection: antimicrobial resistance
1.7 Sequence data collection: nomenclature
1.8 Annotation guide

2. Compounds and Reactions

2.1 Compounds (C numbers)
2.2 Reactions (R/RC numbers)

3. Drugs

3.1 Drug classifications (D numbers)
08340
(table) Antineoplastics
08350
(table) Antibacterials
08351
(table) Antivirals
08352
(table) Antifungals
08353
(table) Antiparasitics
08361
(table) Antidiabetics
08365
(table) Hypolipidemic agents
08368
(table) Osteoporosis drugs
08364
(table) Cardiovascular agents
08363
(table) Psychiatric agents
08367
(table) Neurological agents
08362
(table) Anti-allergic agents
08366
(table) Antirheumatic and antigout drugs
08369
(table) Anesthetics, analgesics and anti-inflammatory drugs
08372
(table) Respiratory agents
08371
(table) Gastrointestinal agents
08373
(table) Endocrine and hormonal agents
08370
(table) Dermatological agents
3.2 Other drug information (D/E/C numbers)

4. Diseases

4.1 Human diseases (H numbers)
4.2 Disease genes and markers

5. Organisms and Cells

5.1 Organisms
5.2 Cells, tissues, and organs

Brite Mapping

KEGG BRITE mapping is the process to map molecular datasets, especially large-scale datasets in genomics, transcriptomics, proteomics, and metabolomics, to the BRITE functional hierarchies for biological interpretation of higher-level systemic functions.

Binary Relationships

The following binary relation files may be used in the KEGG Mapper tool Join Brite to computationally extend the Brite hierarchy file.
K number to:    COG    GO    TC    CAZy
D number to:    Target    Enzyme    Transporter   
H number to:    Human gene    Pathogen genome   
KEGG organism code to:    Keywords   

Codes and Abbreviations


Last updated: December 1, 2017
KEGG GenomeNet Kanehisa Laboratories