+E	Polyketide biosynthesis proteins	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Polyketide Biosynthesis Proteins - Aspergillus niger (black aspergilli)</h2>
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A<b>Polyketide synthase (PKS)</b>
B  Modular type I PKS
C    cis-AT PKS
D      Erythronolide PKS
D      Oleandomycin synthase
D      Pikromycin PKS
D      Avermectin PKS
D      Tylactone synthase
D      Protomycinolide IV synthase
D      Niddamycin PKS
D      Rapamycin PKS
D      Immunomycin PKS
D      Ansamitocin PKS
D      Rifamycin PKS
D      Polyene macrolide PKS
D      Pimaricinolide synthase
D      Candicidin PKS
D      Soraphen PKS
D      Stigmatellin PKS
D      Mycolactone PKS
D      Coelimycin PKS
D      Aureothin PKS
D      Spectinabilin PKS
D      Phthiocerol / Phenolphthiocerol PKS
C    trans-AT PKS
D      Bacillanene hybrid PKS-NRPS
D      Chivosazol hybrid PKS-NRPS
E        ------  chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D      Macrolactin PKS
D      Difficidin PKS
D      Rhizoxin hybrid PKS-NRPS
D      Myxovirescin hybrid PKS-NRPS
E        ------  taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D      Albicidin synthase, hybrid PKS-NRPS
E        ------  albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E        ------  albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D      Etnangien PKS
E        ------  etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B  Iterative type I PKS
C    Fungal nonreducing PKS (NR-PKS)
D      An09g05730 uncharacterized protein	K15321 WA; naphtho-gamma-pyrone polyketide synthase 
D      An11g07310 uncharacterized protein	K15317 APTA; asperthecin polyketide synthase 
C    Fungal partially reducing PKS (PR-PKS)
D      An10g00140 uncharacterized protein	K15320 ATX; 6-methylsalicylic acid synthase [EC:2.3.1.165] 
C    Fungal highly reducing PKS (HR-PKS)
C    Fungal hybrid type
D      Zearalenone synthase
D      Asperfuranone NR/HR-PKS
E        ------  AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034]
E        ------  AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036]
C    Bacterial type
B  Type II PKS
C    C9-C14 cyclized polyketide type
D      Spore pigment PKS
C    C7-C14 cyclized polyketide type
D      Octaketide PKS
D      Nonaketide PKS
D      Decaketide PKS
B  Type III PKS
C    Plant type
C    Fungal type
D      An06g00430 uncharacterized protein	K16231 csyA; fungal type III polyketide synthase 
C    Bacterial type
D      ------  arsB; alkylresorcinol synthase [AVN:Avin_29550]
D      ------  arsC; alkylpyrone synthase [AVN:Avin_29530]
B  PKS-NRPS hybrid
C    Bacterial type (modular)
D      Myxalamid hybrid PKS-NRPS
D      Myxothiazol hybrid PKS-NRPS
E        ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D      Coronatine hybrid PKS-NRPS
D      Microcystin synthetase
D      Epothilone synthetase
D      Bleomycin synthetase
D      Colibactin synthetase
C    Fungal type (trans-ER, iterative)
D      Aspyridone synthetase
C    Fungal type (iterative)
D      An08g03790 uncharacterized protein	K15394 ACE1; hybrid polyketide synthase / nonribosomal peptide synthetase ACE1 
D      An14g01910 uncharacterized protein	K15394 ACE1; hybrid polyketide synthase / nonribosomal peptide synthetase ACE1 
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A<b>Nonribosomal peptide synthetase (NRPS)</b>
B  Linear NRPS
C    ------  EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545]
C    ------  lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C    ------  mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C    ACV synthetase
C    Bacitracin synthetase
C    Viomycin synthetase
C    Pristinamycin I synthetase
C    Tyrocidine synthetase
C    Surfactin family lipopeptide synthetase
C    Iturin family lipopeptide synthetase
C    Fengycin family lipopeptide synthetase
C    Arthrofactin type cyclic lipopeptide synthetase
C    Vancomycin synthetase
C    Nocardicin synthetase
C    Bialaphos synthetase
C    L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B  Iterative NRPS
C    Enterobactin synthetase
C    Bacillibactin synthetase
C    Gramicidin synthetase
B  Nonlinear NRPS
C    Yersiniabactin synthetase
C    Pyochelin synthetase
C    Mycobactin synthetase
C    Vibriobactin synthetase
C    Myxochelin synthetase
C    Petrobacin synthetase
C    Syringomycin synthetase
C    Vanchrobactin synthetase
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A<b>Polyketide tailoring proteins</b>
B  Hydrolase
C    An11g07320 uncharacterized protein	K15318 APTB; hydrolase 
B  Ketoreductase
B  Oxygenase
C    An11g07330 uncharacterized protein	K15319 APTC; monooxygenase 
B  Methylase
B  Glycosyltransferase
B  Halogenase
B  beta-Branched incorporating proteins
B  Others
C    An13g03940 uncharacterized protein	K15389 APDG; acyl-CoA dehydrogenase 
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A<b>Nonribosomal peptide tailoring proteins</b>
B  Reductase
B  Thioesterase
B  Oxygenase
B  Glycosyltransferase
B  Aminotransferase
B  Others
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#Last updated: June 19, 2024