+E Ubiquitin system KO
#
Ubiquitin System - Aspergillus puulaauensis
%
!
AUbiquitins and ubiquitin-like proteins
B Ubiquitins
B Ubiquitin-like proteins (UBLs)
C APUU_10443S RPS30A; ribosomal protein S30A K02983 RP-S30e; small subunit ribosomal protein S30e
C APUU_41229A ATG8; ubiquitin-like protein atg8 K08341 GABARAP; GABA(A) receptor-associated protein
C APUU_21355S ATG12; ubiquitin-like protein K08336 ATG12; ubiquitin-like protein ATG12
C APUU_10776S URM1; ubiquitin-like modifier 1 K12161 URM1; ubiquitin related modifier 1
#
AUbiquitin-activating enzymes (E1)
B Ubiquitin activating enzyme
C APUU_20475A UBA1; E1 ubiquitin-activating protein K03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]
B UBL-activating enzymes
C APUU_20634S uncharacterized protein K10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]
C APUU_20859A UBA2; E1 ubiquitin-activating protein uba2 K10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]
C APUU_20814A uncharacterized protein K10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]
C APUU_20847S uncharacterized protein K04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit
C APUU_20668S UBA4; urmylation protein K11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C APUU_80622S ATG7; autophagy protein 7 K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
#
AUbiquitin-conjugating enzymes (E2)
B Ubiquitin-conjugating enzymes
C APUU_10153A UBC2; ubiquitin-conjugating enzyme E2 2 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
C APUU_40832S UBC11; ubiquitin-conjugating enzyme E2 11 K06688 UBE2C; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]
C APUU_31180S UBC4; ubiquitin-conjugating enzyme E2 4 K06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
C APUU_10160A UBC15; ubiquitin-conjugating enzyme E2 15 K10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]
C APUU_60587A UBC7; ubiquitin-conjugating enzyme E2 7 K04555 UBE2G2; ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]
C APUU_21354A UBC8; ubiquitin-conjugating enzyme E2 8 K10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]
C APUU_20386S uncharacterized protein K10578 UBE2J1; ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23]
C APUU_80653S UBC6; ubiquitin-conjugating enzyme E2 6 K04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]
C APUU_20521A uncharacterized protein K04649 UBE2K; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]
C APUU_10440S UBC13; ubiquitin-conjugating enzyme 13 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C APUU_30376A uncharacterized protein K10581 UBE2O; ubiquitin-conjugating enzyme E2 O [EC:2.3.2.24]
C APUU_11913A uncharacterized protein K02207 UBE2R; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23]
C APUU_50591S uncharacterized protein K10583 UBE2S; ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]
C APUU_20811S uncharacterized protein K10688 UBE2W; ubiquitin-conjugating enzyme E2 W [EC:2.3.2.23 2.3.2.25]
C APUU_80378S uncharacterized protein K10585 UBE2Z; ubiquitin-conjugating enzyme E2 Z [EC:2.3.2.23]
C APUU_80251A uncharacterized protein K10689 PEX4; peroxin-4 [EC:2.3.2.23]
B UBL-conjugating enzymes
C APUU_70583S UBC9; E2 SUMO-conjugating protein ubc9 K10577 UBE2I; ubiquitin-conjugating enzyme E2 I
C APUU_30215A UBC12; NEDD8-conjugating protein ubc12 K10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]
C APUU_80159S ATG3; E2-like enzyme K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
#
AUbiquitin ligases (E3)
B HECT type E3
C APUU_40351A uncharacterized protein K10589 UBE3C; ubiquitin-protein ligase E3 C [EC:2.3.2.26]
C APUU_30584S uncharacterized protein K20803 UBE3D; ubiquitin-protein ligase E3 D [EC:2.3.2.26]
C APUU_21366A UFD4; ubiquitin fusion degradation protein 4 K10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]
C APUU_50370S uncharacterized protein K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
C APUU_21091S uncharacterized protein K10592 HUWE1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]
C APUU_11611S HUL4_2; putative E3 ubiquitin-protein ligase K12232 HECTD2; E3 ubiquitin-protein ligase HECTD2 [EC:2.3.2.26]
C HECT type E3 associated proteins
B U-box type E3
C APUU_70630S uncharacterized protein K10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]
C APUU_10925A uncharacterized protein K09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]
C APUU_12209S CYP8; peptidyl-prolyl cis-trans isomerase Cyp8 K10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]
C APUU_12223A uncharacterized protein K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
B Single Ring-finger type E3
C BRE1 proteins
D APUU_10709S BRE1; E3 ubiquitin-protein ligase bre1 K10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]
C CBL proteins
C SINA (Seven in absentia) proteins
C Ligand of Numb proteins
C March proteins
D APUU_51063A uncharacterized protein K10661 MARCH6; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]
C MDM2/MDM4 proteins
C NFX1 proteins
D APUU_40686A FAP1; FKBP12-associated protein K12236 NFX1; transcriptional repressor NF-X1
C Pellino proteins
C Peripheral membrane proteins
D APUU_41059A PEX10; peroxisome biogenesis factor 10 K13346 PEX10; peroxin-10
D APUU_20255S PEX12; ubiquitin-protein ligase peroxin 12 K13345 PEX12; peroxin-12
D APUU_40291A PEX2; peroxisome assembly protein (peroxin-2) K06664 PEX2; peroxin-2
C RBR proteins
D APUU_40752S uncharacterized protein K11968 ARIH1; ariadne-1 [EC:2.3.2.31]
D APUU_10665S ITT1; translation termination inhibitor protein itt1 K11971 RNF14; E3 ubiquitin-protein ligase RNF14 [EC:2.3.2.31]
D APUU_20462S uncharacterized protein K11976 RNF216; E3 ubiquitin-protein ligase RNF216 [EC:2.3.2.31]
C TRAF proteins
C TRIM/RBCC proteins
C UBR box proteins
D APUU_40436A uncharacterized protein K10625 UBR1; E3 ubiquitin-protein ligase UBR1 [EC:2.3.2.27]
D APUU_30306S uncharacterized protein K11979 UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]
C ATL proteins
C Other single Ring-finger type E3
D APUU_21052S uncharacterized protein K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]
D APUU_20840S uncharacterized protein K10639 CCNB1IP1; E3 ubiquitin-protein ligase CCNP1IP1 [EC:2.3.2.27]
D APUU_21386S NOT4; transcriptional repressor general negative regulator of transcription subunit 4 K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
D APUU_11279A uncharacterized protein K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
D APUU_20258S RAD18; E3 ubiquitin-protein ligase rad18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D APUU_41301A uncharacterized protein K26979 RNF10; E3 ubiquitin-protein ligase RNF10 [EC:2.3.2.27]
D APUU_51266A uncharacterized protein K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
D APUU_21060A uncharacterized protein K11984 SART1; U4/U6.U5 tri-snRNP-associated protein 1
D APUU_41159S uncharacterized protein K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]
D APUU_20575A uncharacterized protein K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D APUU_21729S HRD1; E3 ubiquitin-protein ligase hrd1 K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
D APUU_11737A uncharacterized protein K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
D APUU_50695S uncharacterized protein K23788 TUL1; transmembrane E3 ubiquitin-protein ligase [EC:2.3.2.27]
D APUU_12228S uncharacterized protein K23787 DMA1_2; E3 ubiquitin-protein ligase DMA1/2 [EC:2.3.2.27]
B Atypical E3
C APUU_50229S uncharacterized protein K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
B UBL E3 ligases
C APUU_70423A RBX1; RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
C APUU_20220A DCN1; scaffold-type E3 ligase K17822 DCUN1D1_2; DCN1-like protein 1/2
B Multi subunit Ring-finger type E3
C SCF complex
D Ring finger protein
E APUU_70423A RBX1; RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E APUU_50766S uncharacterized protein K03347 CUL1; cullin 1
D Adaptor protein
E APUU_20639A uncharacterized protein K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit (F-box)
E APUU_40952S uncharacterized protein K03362 FBXW1_11; F-box and WD-40 domain protein 1/11
E APUU_30708A uncharacterized protein K03362 FBXW1_11; F-box and WD-40 domain protein 1/11
E APUU_51329A uncharacterized protein K10259 MET30; F-box and WD-40 domain protein MET30
E APUU_40859S CDC4_1; SCF ubiquitin ligase complex subunit cdc4 K03361 CDC4; F-box and WD-40 domain protein CDC4
E APUU_51158S uncharacterized protein K03361 CDC4; F-box and WD-40 domain protein CDC4
E APUU_70738A uncharacterized protein K10268 FBXL2_20; F-box and leucine-rich repeat protein 2/20
E APUU_70709A uncharacterized protein K10273 FBXL7; F-box and leucine-rich repeat protein 7
E APUU_80592S JHD1; JmjC domain-containing histone demethylation protein 1 K10276 FBXL10_11; F-box and leucine-rich repeat protein 10/11 [EC:1.14.11.27]
E APUU_31575A uncharacterized protein K15069 POF3; F-box/TPR repeat protein Pof3
E APUU_11178A uncharacterized protein K10295 FBXO9; F-box protein 9
E APUU_31514A uncharacterized protein K10301 FBXO21; F-box protein 21
E APUU_11741A RCY1; F-box protein: endocytic membrane traffic, recycling ReCYcling 1 K15071 RCY1; recyclin-1
C Cul2 complex
D Ring finger protein
E APUU_70423A RBX1; RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adoptor protein
E APUU_20857A uncharacterized protein K03872 ELOC; elongin-C
D Target recognizing subunit
C Cul3 complex
D Ring finger protein
E APUU_70423A RBX1; RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E APUU_40418A CUL3; cullin-3 K03869 CUL3; cullin 3
D Adoptor and target recognizing subunit (BTB)
E APUU_10541S uncharacterized protein K10520 ABTB1; ankyrin repeat and BTB/POZ domain-containing protein 1
C Cul4 complex
D Ring finger protein
E APUU_70423A RBX1; RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adoptor protein
E APUU_11476A uncharacterized protein K10610 DDB1; DNA damage-binding protein 1
D Target recognizing subunit (DCAF)
E APUU_41406S uncharacterized protein K10570 ERCC8; DNA excision repair protein ERCC-8
E APUU_11834A uncharacterized protein K11795 DCAF6; DDB1- and CUL4-associated factor 6
E APUU_21423A uncharacterized protein K11805 DCAF7; DDB1- and CUL4-associated factor 7
E APUU_31091S uncharacterized protein K11801 DCAF11; DDB1- and CUL4-associated factor 11
E APUU_60471S SOF1; rRNA-processing protein sof1 K11806 DCAF13; DDB1- and CUL4-associated factor 13
E APUU_41557S uncharacterized protein K22382 WDR26; WD repeat-containing protein 26
E APUU_20524S uncharacterized protein K24752 WDR70; WD repeat-containing protein 70
E APUU_40730A uncharacterized protein K24755 WDR76; WD repeat-containing protein 76
C Cul5 complex
D Ring finger protein
D Cullin
D Adoptor protein
E APUU_20857A uncharacterized protein K03872 ELOC; elongin-C
D Target recognizing subunit
C Cul7 complex
D Ring finger protein
E APUU_70423A RBX1; RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
E APUU_20639A uncharacterized protein K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit
C Cul8 complex
D Ring finger protein
E APUU_70423A RBX1; RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
D Target recognizing subunit
C Cul9 complex
D Ring finger protein
E APUU_70423A RBX1; RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
C APC/C
D Ring finger protein
E APUU_31431S APC11; ubiquitin-protein ligase anaphase promoting complex K03358 APC11; anaphase-promoting complex subunit 11
D Cullin
E APUU_20949A uncharacterized protein K03349 APC2; anaphase-promoting complex subunit 2
D Target recognizing subunit
E APUU_51003A CDC20; ubiquitin-protein transferase activating protein K03363 CDC20; cell division cycle 20, cofactor of APC complex
E APUU_30574S CDH1; substrate-specific activator of APC-dependent proteolysis K03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex
D Other subunits
E APUU_31191A APC1; anaphase-promoting complex subunit 1 K03348 APC1; anaphase-promoting complex subunit 1
E APUU_51069S CDC27; anaphase-promoting complex subunit cdc27 K03350 APC3; anaphase-promoting complex subunit 3
E APUU_50896A uncharacterized protein K03351 APC4; anaphase-promoting complex subunit 4
E APUU_31166A APC5; anaphase promoting complex subunit 5 K03352 APC5; anaphase-promoting complex subunit 5
E APUU_41571A CDC16; anaphase promoting complex subunit cdc16 K03353 APC6; anaphase-promoting complex subunit 6
E APUU_41561A CDC23; anaphase-promoting complex subunit 23 K03355 APC8; anaphase-promoting complex subunit 8
E APUU_50890A DOC1; anaphase promoting complex subunit doc1 K03357 APC10; anaphase-promoting complex subunit 10
C BRCC complex
D APUU_50497A RAD51; recombinase rad51 K04482 RAD51; DNA repair protein RAD51
C KPC complex
C LUBAC complex
C CTLH complex
D APUU_11629A uncharacterized protein K23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]
D APUU_31562A uncharacterized protein K23334 RANBP9_10; Ran-binding protein 9/10
D APUU_41263S uncharacterized protein K23336 ARMC8; armadillo repeat-containing protein 8
D APUU_70429A FYV10; GID complex subunit containing RING finger motif K18624 MAEA; macrophage erythroblast attacher
D APUU_50564A uncharacterized protein K23335 GID4; glucose-induced degradation protein 4
D APUU_80539S uncharacterized protein K23338 GID8; glucose-induced degradation protein 8
D APUU_41557S uncharacterized protein K22382 WDR26; WD repeat-containing protein 26
C ERAD complex
C LMBR1L-GP78-UBAC2 complex
D APUU_40928S uncharacterized protein K25216 UBAC2; ubiquitin-associated domain-containing protein 2
C SLX5-SLX8 complex
C Multi subunit type E3 associated proteins
D APUU_20867S uncharacterized protein K17263 CAND1; cullin-associated NEDD8-dissociated protein 1
D APUU_41053A uncharacterized protein K24350 UBXN7; UBX domain-containing protein 7
#
ADeubiquitinating enzyme (DUB)
B Ubiquitin-specific proteases (UBPs)
C UCH
D APUU_50900S uncharacterized protein K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
D APUU_61347A uncharacterized protein K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
D APUU_70179S uncharacterized protein K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
D APUU_80554S uncharacterized protein K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
D APUU_50870S uncharacterized protein K05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]
D APUU_31495A uncharacterized protein K05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]
C UBP/USP
D APUU_51324A UBP12; CSN-associated deubiquitinating enzyme Ubp12 K11835 USP4_11; ubiquitin carboxyl-terminal hydrolase 4/11 [EC:3.4.19.12]
D APUU_80629S uncharacterized protein K11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.4.19.12]
D APUU_60673A uncharacterized protein K11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
D APUU_20991A DOA4; ubiquitin-specific protease doa4 K11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
D APUU_41302S uncharacterized protein K11841 USP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]
D APUU_10435S UBP6; deubiquitinating enzyme K11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]
D APUU_40772S uncharacterized protein K11366 USP22_27_51; ubiquitin carboxyl-terminal hydrolase 22/27/51 [EC:3.4.19.12]
D APUU_41047A UBP2; ubiquitin-specific protease ubp2 K11849 USP25; ubiquitin carboxyl-terminal hydrolase 25 [EC:3.4.19.12]
D APUU_51095S uncharacterized protein K11853 USP34; ubiquitin carboxyl-terminal hydrolase 34 [EC:3.4.19.12]
D APUU_12233S uncharacterized protein K11870 UBP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
D APUU_60286A uncharacterized protein K11872 UBP9_13; ubiquitin carboxyl-terminal hydrolase 9/13 [EC:3.4.19.12]
D APUU_30692A UBP16; ubiquitin-specific protease K11874 UBP16; ubiquitin carboxyl-terminal hydrolase 16 [EC:3.4.19.12]
C OTU
D APUU_31108A uncharacterized protein K09602 OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]
D APUU_41007S uncharacterized protein K18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]
C MJD
C MINDY
D APUU_41493A uncharacterized protein K01309 MINDY1_2; ubiquitin carboxyl-terminal hydrolase MINDY-1/2 [EC:3.4.19.12]
C JAMM
D APUU_70690A RPN11; multicatalytic endopeptidase K03030 PSMD14; 26S proteasome regulatory subunit N11
D APUU_30556S uncharacterized protein K11866 STAMBP; STAM-binding protein [EC:3.4.19.12]
C PPPDE
C ZUFSP
C BRISC complex
B UBL-specific proteases (ULPs)
C APUU_40696A uncharacterized protein K08597 SENP8; sentrin-specific protease 8 [EC:3.4.22.68]
C APUU_50900S uncharacterized protein K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
C APUU_61347A uncharacterized protein K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
C APUU_70179S uncharacterized protein K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
C APUU_80554S uncharacterized protein K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
C APUU_12235S uncharacterized protein K22762 DESI1; desumoylating isopeptidase 1 [EC:3.4.-.-]
C COP9 signalosome (CSN) complex
D APUU_21726S uncharacterized protein K12175 GPS1; COP9 signalosome complex subunit 1
D APUU_31110A uncharacterized protein K12176 COPS2; COP9 signalosome complex subunit 2
D APUU_10803S uncharacterized protein K12177 COPS3; COP9 signalosome complex subunit 3
D APUU_21668A uncharacterized protein K12178 COPS4; COP9 signalosome complex subunit 4
D APUU_20423S RRI1; COP9 signalosome catalytic subunit rri1 K09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]
D APUU_20546A uncharacterized protein K12179 COPS6; COP9 signalosome complex subunit 6
D APUU_60255S uncharacterized protein K12180 COPS7; COP9 signalosome complex subunit 7
D APUU_21771S uncharacterized protein K12181 COPS8; COP9 signalosome complex subunit 8
D APUU_11627S CSN12; COP9 signalosome (CSN) subunit K24364 CSN12; COP9 signalosome complex subunit 12
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: June 27, 2024