+F Repair protein KO
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DNA Repair and Recombination Proteins - Gottschalkia acidurici
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D Curi_c03350 ogt; methylated-DNA--protein-cysteinemethyltransferase Ogt K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E Curi_c26770 ung; uracil-DNA glycosylase Ung K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E Curi_c12270 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E Curi_c02840 8-oxoguanine DNA glycosylase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E Curi_c10770 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D Curi_c12820 NUDIX hydrolase domain-containing protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D Curi_c03350 ogt; methylated-DNA--protein-cysteinemethyltransferase Ogt K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E Curi_c26770 ung; uracil-DNA glycosylase Ung K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E Curi_c27910 uracil-DNA glycosylase-like protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E Curi_c12270 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E Curi_c10770 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E Curi_c11140 exoA; exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E Curi_c10740 nfo; endonuclease IV K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
E Curi_c17390 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E Curi_c03120 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E Curi_c09890 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E Curi_c20520 uvrA; exinuclease ABC system, subunit A K03701 uvrA; excinuclease ABC subunit A
E Curi_c20530 uvrB; exinuclease ABC system, subunit B K03702 uvrB; excinuclease ABC subunit B
E Curi_c28050 uvrC2; exinuclease ABC system, subunit C K03703 uvrC; excinuclease ABC subunit C
E Curi_c20350 uvrC1; exinuclease ABC system, subunit C K03703 uvrC; excinuclease ABC subunit C
E Curi_c03110 pcrA; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Curi_c28020 uvrD; DNA helicase UvrD K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Curi_c06300 ATP-dependent DNA helicase, UvrD/REP family K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Curi_c09890 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E Curi_c03120 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F Curi_c22710 rpoB; DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F Curi_c22700 rpoC; DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F Curi_c22350 rpoA; DNA-directed RNA polymerase, subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F Curi_c16880 rpoZ; DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F Curi_c23830 mfd; transcription-repair-coupling factor Mfd K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E Curi_c15170 mutS3; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
E Curi_c08640 mutS1; DNA mismatch repair protein MutS K07456 mutS2; DNA mismatch repair protein MutS2
E Curi_c21380 mutS5; DNA mismatch repair protein K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E Curi_c15180 mutL; DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E Curi_c13840 xseA; exodeoxyribonuclease 7 large subunit XseA K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E Curi_c13850 xseB; exodeoxyribonuclease 7 small subunit XseB K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E Curi_c20220 dnaE; DNA polymerase III, subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E Curi_c00020 dnaN; DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E Curi_c18390 holA; DNA polymerase III, subunit delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E Curi_c01140 holB; DNA polymerase III, subunit delta' K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E Curi_c00990 dnaX; DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E Curi_c03120 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E Curi_c03110 pcrA; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Curi_c28020 uvrD; DNA helicase UvrD K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Curi_c06300 ATP-dependent DNA helicase, UvrD/REP family K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Curi_c28580 ssb2; single-stranded DNA-binding protein Ssb K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E Curi_c02360 recD; RecD/TraA family helicase RecD K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E Curi_c15410 recA; recombinase A K03553 recA; recombination protein RecA
E Curi_c10560 ruvA; holliday junction ATP-dependent DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E Curi_c10570 ruvB; holliday junction ATP-dependent DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E Curi_c10550 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E Curi_c16860 priA; primosome assembly protein PriA K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E Curi_c19050 sbcC; exonuclease, subunit C K03546 sbcC; DNA repair protein SbcC/Rad50
E Curi_c19080 sbcD; exonuclease SbcCD, subunit D K03547 sbcD; DNA repair protein SbcD/Mre11
E Curi_c06590 metallophosphoesterase K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E Curi_c15410 recA; recombinase A K03553 recA; recombination protein RecA
E Curi_c23170 radA; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E Curi_c00040 recF; DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E Curi_c16690 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E Curi_c17390 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E Curi_c18090 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E Curi_c01010 recR; recombination protein RecR K06187 recR; recombination protein RecR
E Curi_c13900 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E Curi_c22060 holliday junction resolvase RecU-like protein K03700 recU; recombination protein U
E Curi_c10560 ruvA; holliday junction ATP-dependent DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E Curi_c10570 ruvB; holliday junction ATP-dependent DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E Curi_c10550 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
E Curi_c19090 addA; ATP-dependent helicase/deoxyribonuclease, subunit A K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E Curi_c19100 addB; ATP-dependent helicase/deoxyribonuclease, subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
E Curi_c06250 cas1; CRISPR-associated endonuclease Cas1 K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
E Curi_c19050 sbcC; exonuclease, subunit C K03546 sbcC; DNA repair protein SbcC/Rad50
E Curi_c19080 sbcD; exonuclease SbcCD, subunit D K03547 sbcD; DNA repair protein SbcD/Mre11
E Curi_c06590 metallophosphoesterase K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F Curi_c00070 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F Curi_c00060 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F Curi_c16100 topA; DNA topoisomerase 1 K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F Curi_c23780 hup; DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F Curi_c17390 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F Curi_c18090 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F Curi_c01010 recR; recombination protein RecR K06187 recR; recombination protein RecR
F Curi_c03120 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F Curi_c26320 recQ; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F Curi_c20520 uvrA; exinuclease ABC system, subunit A K03701 uvrA; excinuclease ABC subunit A
F Curi_c20530 uvrB; exinuclease ABC system, subunit B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D Curi_c10140 dinB; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D Curi_c15410 recA; recombinase A K03553 recA; recombination protein RecA
D Curi_c15250 lexA; transcriptional repressor LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
D Curi_c13900 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D Curi_c28580 ssb2; single-stranded DNA-binding protein Ssb K03111 ssb; single-strand DNA-binding protein
D Curi_c17610 recX; regulatory protein RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D Curi_c12820 NUDIX hydrolase domain-containing protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D Curi_c23480 nrdZ; ribonucleoside-diphosphate reductase NrdZ K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
C Others
D Curi_c15540 RecJ-like phosphoesterase domain-containing protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024