+F Repair protein KO
#
DNA Repair and Recombination Proteins - Cimex lectularius (bed bug)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 106663582 DNA oxidative demethylase ALKBH2-like K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 106673118 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 106670359 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 106670554 uncharacterized protein LOC106670554 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 106669980 uncharacterized protein LOC106669980 isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 106667760 G/T mismatch-specific thymine DNA glycosylase-like K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 106666078 DNA-3-methyladenine glycosylase-like K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 106666661 uncharacterized protein LOC106666661 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 106661734 single-strand selective monofunctional uracil DNA glycosylase-like isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 106661517 methyl-CpG-binding domain protein 4-like K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 106666305 N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 106665853 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 106666412 DNA-(apurinic or apyrimidinic site) lyase K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 106670528 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 106673387 DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
F 106665136 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 106663202 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 106666331 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 106665219 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 106669725 DNA polymerase epsilon subunit 4-like K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 106667644 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 106662149 flap endonuclease 1 isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 106661569 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 106668061 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 106669006 DNA repair protein XRCC1-like isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 106662577 DNA ligase 3 isoform X3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 106665819 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 106663263 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 106672142 uncharacterized protein F21D5.5 isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 106666905 high mobility group protein B3-like K10802 HMGB1; high mobility group protein B1
E 106668272 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 106665379 DNA repair protein complementing XP-C cells K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 106664442 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 106670935 caltractin-like isoform X2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 106666282 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 106672664 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 106671251 DNA damage-binding protein 1 isoform X2 K10610 DDB1; DNA damage-binding protein 1
F 106666549 DNA damage-binding protein 2-like K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 106674451 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 106669097 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 106665697 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 106663200 DNA-directed RNA polymerase II 16 kDa polypeptide K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 106668338 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 106662759 DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 106669166 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 106662971 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 106665481 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 106663243 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 106669707 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F 106666282 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 106672664 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 106671251 DNA damage-binding protein 1 isoform X2 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 106668263 DNA excision repair protein ERCC-6-like isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 106669581 UV-stimulated scaffold protein A-like isoform X2 K23720 UVSSA; UV-stimulated scaffold protein A
F 106666566 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 106670342 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 106666130 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 106666225 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 106668282 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 106668736 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 106662293 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 106660876 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 106666543 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 106664669 cyclin-H K06634 CCNH; cyclin H
E 106663211 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 106662336 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 106667901 replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 106666821 uncharacterized protein LOC106666821 isoform X2 K10740 RPA3; replication factor A3
D Other NER factors
E 106667214 DNA repair protein complementing XP-A cells homolog isoform X1 K10847 XPA; DNA-repair protein complementing XP-A cells
E 106674147 DNA excision repair protein ERCC-1 isoform X1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 106673733 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 106665668 DNA repair protein complementing XP-G cells homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 106661569 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 106670035 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 106666741 cullin-3 isoform X1 K03869 CUL3; cullin 3
E 106665250 cullin-5 isoform X1 K10612 CUL5; cullin 5
E 106662325 elongin-C isoform X1 K03872 ELOC; elongin-C
E 106660880 elongin-B isoform X1 K03873 ELOB; elongin-B
E 106668614 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 106663308 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 106665222 DNA mismatch repair protein Msh2-like K08735 MSH2; DNA mismatch repair protein MSH2
E 106668181 DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 106669283 PMS1 protein homolog 1-like isoform X2 K10864 PMS1; DNA mismatch repair protein PMS1
E 106667043 DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 106666031 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 106670528 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 106673387 DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
E 106665136 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 106662336 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 106667901 replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 106666821 uncharacterized protein LOC106666821 isoform X2 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 106665092 replication factor C subunit 1-like K10754 RFC1; replication factor C subunit 1
E 106674275 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 106666101 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 106672181 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 106662908 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 106667644 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 106662886 exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 106666905 high mobility group protein B3-like K10802 HMGB1; high mobility group protein B1
E 106661569 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 106666789 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 106661520 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 106666363 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
E 106665263 uncharacterized protein LOC106665263 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 106667844 BRCA1-associated RING domain protein 1-like K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 106665263 uncharacterized protein LOC106665263 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
D BRCA1-B complex
E 106665263 uncharacterized protein LOC106665263 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 106664056 DNA topoisomerase 2-binding protein 1-like isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
E 106664396 DNA topoisomerase 2-binding protein 1-like isoform X2 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 106665263 uncharacterized protein LOC106665263 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 106661520 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 106666363 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E 106665263 uncharacterized protein LOC106665263 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 106663279 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 106663279 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 106673040 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 106664868 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 106662669 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 106672211 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 106665223 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 106667310 uncharacterized protein LOC106667310 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 106664033 DNA repair and recombination protein RAD54B-like K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 106663997 Werner syndrome ATP-dependent helicase-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 106669964 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106662667 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 106669964 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106672680 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106666087 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106661806 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 106662336 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 106667901 replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 106666821 uncharacterized protein LOC106666821 isoform X2 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 106663768 serine/threonine-protein phosphatase 4 catalytic subunit-like K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 106665238 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 106673830 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 106661184 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 106669822 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 106667089 serine/threonine-protein phosphatase 4 regulatory subunit 4-like isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
D SMC5-SMC6 complex
E 106665754 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 106664522 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 106668355 E3 SUMO-protein ligase NSE2-like K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 106660965 uncharacterized protein LOC106660965 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 106663024 uncharacterized protein LOC106663024 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 106673439 crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 106667556 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 106666153 structure-specific endonuclease subunit SLX1 homolog K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 106663407 flap endonuclease GEN K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 106672948 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 106662623 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 106670430 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 106661957 uncharacterized protein LOC106661957 K23112 BRAT1; BRCA1-associated ATM activator 1
E 106667077 protein C21orf2 homolog isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 106662764 heat shock factor 2-binding protein-like K25791 HSF2BP; heat shock factor 2-binding protein
E 106670522 uncharacterized protein LOC106670522 K25791 HSF2BP; heat shock factor 2-binding protein
E 106669062 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 106665857 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 106662531 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 106669382 Werner Syndrome-like exonuclease isoform X1 K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 106664503 X-ray repair cross-complementing protein 5-like K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 106665635 X-ray repair cross-complementing protein 5-like K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 106666628 DNA-dependent protein kinase catalytic subunit-like isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 106661520 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 106666363 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 106664724 DNA ligase 4 isoform X1 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 106664596 uncharacterized protein LOC106664596 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 106668061 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 106663263 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 106672318 protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 106663577 Fanconi anemia group A protein-like K10888 FANCA; fanconi anemia group A protein
E 106672088 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
D FA core complex binding factors
E 106671959 transcription factor HES-1-like K06054 HES1; hairy and enhancer of split 1
E 106668499 centromere protein S-like K11511 APITD1; centromere protein S
D Bloom's syndrome complex (BTR)
E 106669964 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106672680 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106666087 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106661806 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 106666184 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 106665263 uncharacterized protein LOC106665263 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
D Other FA pathway factors
E 106669381 fanconi-associated nuclease 1-like isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 106663279 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 106673040 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 106669715 ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 106674400 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 106667813 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
D Ubiquitin ligases
E 106670080 E3 ubiquitin-protein ligase rnf8-B-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 112127323 E3 ubiquitin-protein ligase rnf168-like K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 106669642 E3 ubiquitin-protein ligase rnf168-like K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 106667810 E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 106663771 telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 106662306 zinc finger CW-type PWWP domain protein 1-like K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 106667802 gastrulation defective protein 1 homolog isoform X1 K24752 WDR70; WD repeat-containing protein 70
E 106666789 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 106668524 DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 106667058 DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 106662820 DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 106673666 ubiquitin-conjugating enzyme E2-17 kDa isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 106665107 E3 ubiquitin-protein ligase RAD18-like K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 106667430 ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 106663537 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 106661375 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 106667644 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 106672151 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 106673106 acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 106669189 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 106663420 checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 106674247 cell cycle checkpoint protein RAD1-like K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 106673887 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 106674275 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 106666101 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 106672181 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 106662908 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 106674247 cell cycle checkpoint protein RAD1-like K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 106664907 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 106664405 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 106668026 claspin-like isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 106672697 TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
D 106667656 TELO2-interacting protein 2-like K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 106674324 large proline-rich protein bag6-A isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 106670842 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 106666173 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 106666619 serine/threonine-protein kinase atr-like isoform X4 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 106664980 serine-protein kinase ATM-like isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 106667684 serine/threonine-protein kinase grp isoform X1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 106664898 ovarian-specific serine/threonine-protein kinase Lok K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 106673069 M-phase inducer phosphatase-like isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 106665013 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 106661078 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 106672638 wee1-like protein kinase isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 106667354 period circadian protein isoform X5 K02633 PER2; period circadian protein 2
D 106670701 plastin-2 K17336 PLS3; plastin-3
D 106666425 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 106670480 KN motif and ankyrin repeat domain-containing protein 3 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 106664470 vacuolar protein sorting-associated protein 4-like isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 106661748 vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 106674304 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 106665449 DNA polymerase theta-like K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 106670452 uncharacterized protein LOC106670452 K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D 106661990 three-prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 106671966 ankyrin repeat and LEM domain-containing protein 1-like K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
C PSO4 complex
D 106661603 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 106669493 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 106666233 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 106662835 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 106670004 7,8-dihydro-8-oxoguanine triphosphatase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 106672324 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 106664443 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 106672623 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 106663235 ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 106670359 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 106670554 uncharacterized protein LOC106670554 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 106661734 single-strand selective monofunctional uracil DNA glycosylase-like isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 106666078 DNA-3-methyladenine glycosylase-like K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 106666661 uncharacterized protein LOC106666661 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 106665853 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 106661332 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 106661332 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 106664443 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024