+D Protein KO
#
Membrane Trafficking - Cordyceps militaris
%
!
AExocytosis
B Calcium ion-dependent exocytosis
C Synaptotagmins
C Septins
D CCM_03005 cell division control protein 3 K16944 SEPT7; septin 7
C DOC-2 proteins
C Acrosomal exocytosis proteins
D CCM_07467 serine/threonine protein kinase, putative K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
C Phospholipases
D CCM_06860 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D CCM_03328 phospholipase C K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D CCM_07897 PLC-like phosphodiesterase K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D CCM_00524 phospholipase D1 K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D CCM_04322 phospholipase D K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D CCM_02988 phospholipase PldA, putative K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
C Kinases and associated proteins
D CCM_01361 phosphatidylinositol-4-phosphate 5-kinase its3 K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D CCM_05107 sexual development serine/threonine kinase PakA K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
D CCM_03756 Mst3-like protein kinase, putative K08838 STK24_25_MST4; serine/threonine-protein kinase 24/25/MST4 [EC:2.7.11.1]
D CCM_00815 serine/threonine-protein kinase 24 K08838 STK24_25_MST4; serine/threonine-protein kinase 24/25/MST4 [EC:2.7.11.1]
D CCM_07126 nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D CCM_00348 serine/threonine protein kinase Kin1, putative K19852 KIN1_2; serine/threonine protein kinase KIN1/2 [EC:2.7.11.1]
C Others
D CCM_04192 calcium sensor NCS-1 K19932 NCS1; neuronal calcium sensor
B Small GTPases and associated proteins
C Rab GTPases
D CCM_07176 GTP-binding protein SAS1 K07901 RAB8A; Ras-related protein Rab-8A
C Rab associated proteins
D CCM_03968 calmodulin K02183 CALM; calmodulin
D CCM_06554 GDP/GTP exchange factor Sec2p, putative K19940 SEC2; Rab guanine nucleotide exchange factor SEC2
D CCM_07569 Sec1 family superfamily K15292 STXBP1; syntaxin-binding protein 1
D CCM_01302 SNARE-dependent exocytosis protein (Sro7), putative K08518 STXBP5; syntaxin-binding protein 5
D CCM_09079 phosphatase family protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D CCM_08370 GTPase activating protein (Gyp3) K19953 GRTP1; TBC1 domain family member 6
D CCM_03353 GTPase-activating protein GYP5 K19951 TBC1D8_9; TBC1 domain family member 8/9
D CCM_07007 peroxisomal targeting signal receptor K13342 PEX5; peroxin-5
D CCM_03733 rab proteins geranylgeranyltransferase component A K23460 CHM; Rab proteins geranylgeranyltransferase component A
D CCM_07472 protein prenyltransferase K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D CCM_05579 geranylgeranyltransferase beta subunit K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D CCM_07462 WD repeat protein K24155 DMXL; rabconnectin-3a
C Rho GTPases
D CCM_00979 Cell division control protein 42 K04393 CDC42; cell division control protein 42
C Other small GTPases and associated proteins
B Tethering complex
C Exocyst complex
D CCM_00358 Exocyst complex, component Exoc1 K19983 EXOC1; exocyst complex component 1
D CCM_04170 exocyst complex component Sec5 K17637 EXOC2; exocyst complex component 2
D CCM_09203 exocyst complex component Sec6 K06110 EXOC3; exocyst complex component 3
D CCM_03235 Exocyst complex component Sec8 K06111 EXOC4; exocyst complex component 4
D CCM_06940 exocyst complex component Sec10 K19984 EXOC5; exocyst complex component 5
D CCM_05816 Exocyst complex component Sec15, putative K19985 EXOC6; exocyst complex component 6
D CCM_02922 exocyst complex protein EXO70 K07195 EXOC7; exocyst complex component 7
D CCM_04271 exocyst complex component EXO84 K19986 EXOC8; exocyst complex component 8
C Exocyst complex assembly proteins
D CCM_08270 DSS1/SEM1 family protein K10881 SHFM1; 26 proteasome complex subunit DSS1
D CCM_03917 tropomyosin, putative K17945 TPM1_2; tropomyosin, fungi type
B Others
C Exomer complex
D CCM_03611 chitin biosynthesis protein (Chs5), putative K19877 CHS5; chitin biosynthesis protein CHS5
D CCM_08359 clathrin-coated vesiclec protein (Bud7), putative K19881 BUD7; Chs5-Arf1p-binding protein BUD7/BCH1
C Others
D CCM_04649 vacuolar segregation protein (Pep7), putative K12481 RBSN; rabenosyn-5
D CCM_06491 CRAL/TRIO domain protein K19996 SFH5; phosphatidylinositol transfer protein SFH5
#
ASNARE
B Syntaxin (Qa)
C Stx-PM
D CCM_00519 t-SNARE K08486 STX1B_2_3; syntaxin 1B/2/3
D CCM_08170 syntaxin K08486 STX1B_2_3; syntaxin 1B/2/3
C Stx-Endo
C Stx-TGN / EE
D CCM_03969 SNARE complex subunit Tlg2 K08489 STX16; syntaxin 16
C Stx-cisGolgi
D CCM_06559 syntaxin 5 K08490 STX5; syntaxin 5
C Stx-sER
C Stx-rER
B SNAP-25[N] (Qb)
C Vti1
D CCM_02492 vesicle transport v-SNARE protein K08493 VTI1; vesicle transport through interaction with t-SNAREs 1
C NPSN
C Gos1 (Gos28)
D CCM_05898 vesicle transport v-SNARE protein Gos1, putative K08495 GOSR1; golgi SNAP receptor complex member 1
C Bos1 / Membrin
D CCM_02876 membrin K08496 GOSR2; golgi SNAP receptor complex member 2
C Sec20
D CCM_06286 Sec20 domain protein K08497 SEC20; protein transport protein SEC20
B SNAP-25[C] (Qc)
C STX6
C STX8
D CCM_07469 SNARE complex subunit (Syn8) K08501 STX8; syntaxin 8
D CCM_02769 SNARE complex subunit (Vam7), putative K08502 VAM7; regulator of vacuolar morphogenesis
C STX10
C Bet1
D CCM_03500 ER-golgi SNARE complex subunit Bet1, putative K08504 BET1; blocked early in transport 1
D CCM_05110 SNARE protein K08504 BET1; blocked early in transport 1
C Sft1
C Syp7
C Use1
B SNAP-25 (Qb,c)
C SNAP-23
C SNAP-25
D CCM_06670 plasma membrane SNARE protein (Sec9) K19950 SEC9; protein transport protein SEC9
C SNAP-29
C SNAP-47
B VAMP, Ykt6, Sec22 (R)
C VAMP
D CCM_09170 SNARE protein Snc2, putative K08513 VAMP4; vesicle-associated membrane protein 4
D CCM_09252 vesicle-associated membrane protein K08515 VAMP7; vesicle-associated membrane protein 7
C Ykt6
D CCM_04254 SNARE protein, putative K08516 YKT6; synaptobrevin homolog YKT6
C Sec22
D CCM_07819 protein transport protein sec22 K08517 SEC22; vesicle transport protein SEC22
C Tomosyn
D CCM_01302 SNARE-dependent exocytosis protein (Sro7), putative K08518 STXBP5; syntaxin-binding protein 5
C Putative SNAREs
B SNARE associated proteins
C Syntaxin-binding proteins
D CCM_07569 Sec1 family superfamily K15292 STXBP1; syntaxin-binding protein 1
D CCM_08504 SNARE docking complex subunit K19998 SCFD1; sec1 family domain-containing protein 1
D CCM_07903 alpha-taxilin, putative K26808 TXLN; taxilin
C Palmitoyltransferases
D CCM_07896 palmitoyltransferase PFA3 K20028 ZDHHC2_15_20; palmitoyltransferase ZDHHC2/15/20 [EC:2.3.1.225]
D CCM_04060 DHHC zinc finger domain protein K20003 ZDHHC4; palmitoyltransferase ZDHHC4 [EC:2.3.1.225]
D CCM_08100 palmitoyltransferase AKR1 K20032 ZDHHC13_17; palmitoyltransferase ZDHHC13/17 [EC:2.3.1.225]
C Others
D CCM_08519 vesicular-fusion protein SEC18 K06027 NSF; vesicle-fusing ATPase [EC:3.6.4.6]
D CCM_04534 vesicular-fusion protein sec17 K15296 NAPA; alpha-soluble NSF attachment protein
D CCM_04989 vacuolar targeting protein Atg24 K17919 SNX4; sorting nexin-4
D CCM_02637 sorting nexin-41 K21996 SNX41_42; sorting nexin-41/42
D CCM_01271 vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
D CCM_00971 cell division control protein Cdc48 K13525 VCP; transitional endoplasmic reticulum ATPase
D CCM_09514 Cdc48-dependent protein degradation adaptor protein (Shp1), putative K14012 NSFL1C; UBX domain-containing protein 1
D CCM_05812 protein VTS1 K27407 VTS1; RNA-binding protein VTS1
#
AEndocytosis
B Clathrin-mediated endocytosis
C Clathrin
D CCM_07275 clathrin heavy chain K04646 CLTC; clathrin heavy chain
C Dynamin
D CCM_06631 dynamin-2 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
C AP-2 complex
D CCM_04791 AP-2 adaptor complex subunit alpha, putative K11824 AP2A; AP-2 complex subunit alpha
D CCM_04095 AP-2 complex subunit beta K11825 AP2B1; AP-2 complex subunit beta-1
D CCM_08987 AP-2 complex subunit mu-1 K11826 AP2M1; AP-2 complex subunit mu-1
C Other core components
D CCM_08764 Fes/CIP4 domain-containing protein K20042 FCHO; F-BAR domain only protein
D CCM_04479 Epsin-like protein ent1/2 K12471 EPN; epsin
D CCM_00125 epsin-3 K12471 EPN; epsin
D CCM_09202 EF hand domain protein K12472 EPS15; epidermal growth factor receptor substrate 15
D CCM_01095 ENTH domain containing protein K20044 PICALM; phosphatidylinositol-binding clathrin assembly protein
D CCM_08124 Amphiphysin-like protein K12562 AMPH; amphiphysin
D CCM_09681 Actin cytoskeleton-regulatory complex protein K20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1
D CCM_02645 polyA nuclease K20047 PAN1; actin cytoskeleton-regulatory complex protein PAN1
D CCM_04075 Eps15-like protein pan1p K20048 END3; actin cytoskeleton-regulatory complex protein END3
D CCM_05489 heat shock protein 70 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D CCM_04804 heat shock 70 kDa protein K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C Low-density lipoprotein receptor (LDLR) family proteins
C LDLR adaptor proteins
D CCM_01361 phosphatidylinositol-4-phosphate 5-kinase its3 K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
C GPCR adaptor proteins
D CCM_02593 arrestin (or S-antigen) domain protein K20059 LDB19; arrestin-related trafficking adapter 1
D CCM_04517 carbon catabolite repression protein CreD, putative K20062 ART4_5_7; arrestin-related trafficking adapter 4/5/7
D CCM_05909 pH response protein PalF K20063 RIM8; arrestin-related trafficking adapter 9
C Receptor tyrosine kinase (RTK) adaptor proteins
C Inositol 5-phosphatases
D CCM_09079 phosphatase family protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D CCM_06956 endonuclease/Exonuclease/phosphatase K20279 SYNJ; synaptojanin [EC:3.1.3.36]
C Kinases
D CCM_07252 serine/threonine protein kinase, putative K08853 AAK; AP2-associated kinase [EC:2.7.11.1]
D CCM_04690 protein kinase domain-containing protein ppk32 K17541 SCYL2; SCY1-like protein 2
C Ubiquitin E3 ligases
D CCM_01092 ubiquitin ligase (Nedd4/Rsp5p) K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
D CCM_08969 TRAF-like signal transducer, putative K03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
C Others
D CCM_06521 cytoskeleton assembly control protein Sla2 K20040 HIP1R; huntingtin-interacting protein 1-related protein
D CCM_06292 calnexin precursor K08054 CANX; calnexin
D CCM_09295 adaptin ear-binding coat-associated protein 2 K20069 NECAP1_2; adaptin ear-binding coat-associated protein 1/2
B Lipid raft mediated endocytosis
C Caveolin-mediated endocytosis
D CCM_06631 dynamin-2 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
D CCM_00005 Protein kinase C K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
C Flotillin-dependent endocytosis
D CCM_02112 flotillin domain-containing protein K07192 FLOT; flotillin
C GRAF1-dependent endocytosis
D CCM_00979 Cell division control protein 42 K04393 CDC42; cell division control protein 42
D CCM_05891 ADP-ribosylation factor K07937 ARF1_2; ADP-ribosylation factor 1/2
C Arf6-dependent endocytosis
D CCM_09667 ADP-ribosylation factor 6 K07941 ARF6; ADP-ribosylation factor 6
C RhoA-dependent endocytosis
D CCM_04768 Rho GTPase Rho4, putative K04513 RHOA; Ras homolog gene family, member A
D CCM_01759 GTP-binding protein rho1, putative K04513 RHOA; Ras homolog gene family, member A
D CCM_06631 dynamin-2 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
B Phagocytosis
C Fc receptors
C Integrins (complement receptors)
C Opsonins
C Toll-like receptors
C C-lectin receptors
C Scavenger receptors
C Coronins
C Others
D CCM_05994 myosin-5 K10356 MYO1; myosin I
B Macropinocytosis
C Ras GTPases
D CCM_06996 Ras-like protein K07827 KRAS; GTPase KRas
D CCM_01978 ras-2 protein K07827 KRAS; GTPase KRas
D CCM_00979 Cell division control protein 42 K04393 CDC42; cell division control protein 42
C Kinases
D CCM_03362 phosphoinositide 3-kinase, putative K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D CCM_07600 1-phosphatidylinositol-3-phosphate 5-kinase (Fab1) K00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
D CCM_05107 sexual development serine/threonine kinase PakA K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
C Phospholipase C
D CCM_06860 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D CCM_03328 phospholipase C K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D CCM_07897 PLC-like phosphodiesterase K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
C Sorting nexins
D CCM_07835 Vps5-like protein K17917 SNX1_2; sorting nexin-1/2
C Others
B Bin/Amphiphysin/Rvs (BAR) family proteins
C N-BAR proteins
D CCM_08124 Amphiphysin-like protein K12562 AMPH; amphiphysin
D CCM_09077 protein hob3 K20120 BIN3; bridging integrator 3
C F-BAR proteins
D CCM_08463 actin polymerization protein Bzz1, putative K20121 FNBP1; formin-binding protein 1
D CCM_08764 Fes/CIP4 domain-containing protein K20042 FCHO; F-BAR domain only protein
D CCM_03603 Rho GTPase activator (Rgd1), putative K20643 RGD1; Rho GTPase-activating protein RGD1
C I-BAR proteins
B Rab GTPases and associated proteins
C Rab GTPases
D CCM_04114 Rab5-like protein ypt5 K07889 RAB5C; Ras-related protein Rab-5C
D CCM_07528 Rab5-like protein ypt51 K07889 RAB5C; Ras-related protein Rab-5C
C Rab associated proteins
D CCM_09533 guanine nucleotide exchange factor Vps9 K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D CCM_04649 vacuolar segregation protein (Pep7), putative K12481 RBSN; rabenosyn-5
D CCM_09079 phosphatase family protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D CCM_03362 phosphoinositide 3-kinase, putative K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D CCM_03014 Armadillo-type fold domain containing protein K08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
B Arf GTPases and associated proteins
C Arf GTPases
D CCM_05891 ADP-ribosylation factor K07937 ARF1_2; ADP-ribosylation factor 1/2
D CCM_09667 ADP-ribosylation factor 6 K07941 ARF6; ADP-ribosylation factor 6
C Arf associated proteins
D CCM_05109 stromal membrane-associated protein K12486 SMAP; stromal membrane-associated protein
B Others
C Fucosyltransferase
C EFR3-PI4KIII alpha complex and associated proteins
D CCM_06818 phosphatidylinositol 3-kinase 3 K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D CCM_00787 protein EFR3 K21842 EFR3; protein EFR3
D CCM_02812 filamentation protein (Rhf1), putative K21845 YPP1; cargo-transport protein YPP1
C Insulin-like growth factor-binding proteins
C Others
#
AEndosome - Lysosome transport
B Rab GTPases and associated proteins
C Rab GTPases
D CCM_04114 Rab5-like protein ypt5 K07889 RAB5C; Ras-related protein Rab-5C
D CCM_07528 Rab5-like protein ypt51 K07889 RAB5C; Ras-related protein Rab-5C
D CCM_07750 Ras-related protein Rab7 K07897 RAB7A; Ras-related protein Rab-7A
C Retromer subcomplex
D CCM_00630 vacuolar sorting protein 35 K18468 VPS35; vacuolar protein sorting-associated protein 35
D CCM_08927 retrograde transporter K18467 VPS29; vacuolar protein sorting-associated protein 29
D CCM_06824 vacuolar protein sorting 26 K18466 VPS26A_B; vacuolar protein sorting-associated protein 26A/B
C FTS/Hook/FHIP (FHF) complex
D CCM_07478 microtubule binding protein HOOK3, putative K16536 HOOK3; protein HOOK3
C Rab associated proteins
D CCM_02978 RING finger domain protein, putative K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
D CCM_03362 phosphoinositide 3-kinase, putative K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D CCM_01484 proteasome component PRE6 K02731 PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
D CCM_02421 TBC domain-containing protein K18469 TBC1D5; TBC1 domain family member 5
D CCM_07154 GTPase-activating protein GYP7 K20168 TBC1D15; TBC1 domain family member 15
D CCM_03733 rab proteins geranylgeranyltransferase component A K23460 CHM; Rab proteins geranylgeranyltransferase component A
D CCM_07472 protein prenyltransferase K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D CCM_05579 geranylgeranyltransferase beta subunit K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D CCM_09104 TBC domain protein, putative K20176 SGSM3; small G protein signaling modulator 3
D CCM_01271 vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
B Arf GTPases and associated proteins
C Arf GTPases
D CCM_08748 ADP-ribosylation factor family protein K07955 ARL8; ADP-ribosylation factor-like protein 8
C BLOC-one-related complex (BORC)
C N-acetyl transferase complex C (NatC)
D CCM_01241 Acyl-CoA N-acyltransferase K00670 NAA30; N-alpha-acetyltransferase 30 [EC:2.3.1.256]
D CCM_04752 amino-acid N-acetyltransferase subunit Mak10, putative K20823 NAA35; N-alpha-acetyltransferase 35, NatC auxiliary subunit
D CCM_05470 LSM domain protein K20824 NAA38; N-alpha-acetyltransferase 38, NatC auxiliary subunit
C Other Arf associated proteins
B Endosomal sorting complexes required for transport (ESCRT)
C ESCRT-0 complex
D CCM_05070 vacuolar sorting-associated protein (Vps27), putative K12182 HGS; hepatocyte growth factor-regulated tyrosine kinase substrate
D CCM_04484 SH3 domain protein K04705 STAM; signal transducing adaptor molecule
C ESCRT-I complex
D CCM_06753 tumor susceptibility protein K12183 TSG101; ESCRT-I complex subunit TSG101
D CCM_07598 vacuolar protein sorting-associated protein Vps28 K12184 VPS28; ESCRT-I complex subunit VPS28
C ESCRT-II complex
D CCM_09464 ELL complex subunit Eap30, putative K12188 SNF8; ESCRT-II complex subunit VPS22
D CCM_07214 vacuolar protein-sorting-associated protein 36 K12190 VPS36; ESCRT-II complex subunit VPS36
C ESCRT-III complex
D CCM_08659 vacuolar protein-sorting-associated protein 46 K12197 CHMP1; charged multivesicular body protein 1
D CCM_09451 SNF7 family protein K12191 CHMP2A; charged multivesicular body protein 2A
D CCM_08544 charged multivesicular body protein 3 K12193 VPS24; charged multivesicular body protein 3
D CCM_03705 vacuolar sorting protein 32 K12194 CHMP4A_B; charged multivesicular body protein 4A/B
D CCM_08617 Snf7 protein K12198 CHMP5; charged multivesicular body protein 5
D CCM_02450 SNF7 family protein K12195 CHMP6; charged multivesicular body protein 6
D CCM_00424 Snf7 K15053 CHMP7; charged multivesicular body protein 7
D CCM_00460 vacuolar protein sorting-associated protein VPS4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
C ESCRT associated proteins
D CCM_02849 hypothetical protein K12199 VTA1; vacuolar protein sorting-associated protein VTA1
D CCM_02111 pH-response regulator protein palA/RIM20 K12200 PDCD6IP; programmed cell death 6-interacting protein
B Tethering complex
C CORVET complex
D CCM_03987 TGF beta receptor associated protein 1, putative K20177 VPS3; vacuolar protein sorting-associated protein 3
D CCM_05438 golgi complex component K20178 VPS8; vacuolar protein sorting-associated protein 8
D CCM_02178 vacuolar protein sorting protein K20179 VPS11; vacuolar protein sorting-associated protein 11
D CCM_06783 vacuolar protein sorting vps16 K20180 VPS16; vacuolar protein sorting-associated protein 16
D CCM_07494 vacuolar protein sorting protein DigA K20181 VPS18; vacuolar protein sorting-associated protein 18
C Hops complex
D CCM_02178 vacuolar protein sorting protein K20179 VPS11; vacuolar protein sorting-associated protein 11
D CCM_06783 vacuolar protein sorting vps16 K20180 VPS16; vacuolar protein sorting-associated protein 16
D CCM_07494 vacuolar protein sorting protein DigA K20181 VPS18; vacuolar protein sorting-associated protein 18
D CCM_06786 AvaB protein K20183 VPS39; Vam6/Vps39-like protein vacuolar protein sorting-associated protein 39
D CCM_01002 vacuolar assembly protein, putative K20184 VPS41; vacuolar protein sorting-associated protein 41
B Acidification regulators
C Rabconnectin-3 complex
D CCM_07462 WD repeat protein K24155 DMXL; rabconnectin-3a
C RAVE complex
D CCM_07462 WD repeat protein K24155 DMXL; rabconnectin-3a
D CCM_02669 SCF complex subunit Skp1 K03094 SKP1; S-phase kinase-associated protein 1
B Others
C AP-3 complex
D CCM_03909 AP-3 complex subunit delta K12396 AP3D; AP-3 complex subunit delta
D CCM_00024 AP-3 adaptor complex subunit beta K12397 AP3B; AP-3 complex subunit beta
D CCM_09163 adaptor protein complex 3 K12398 AP3M; AP-3 complex subunit mu
D CCM_00225 AP-3 complex subunit sigma K12399 AP3S; AP-3 complex subunit sigma
C BLOC-1 complex
C BLOC-1 complex (yeast)
D CCM_00189 hypothetical protein K22243 KXD1; biogenesis of lysosome-related organelles complex 1 subunit KXD1
C BLOC-2 complex
C BLOC-3 complex
C Ferlins
C Others
D CCM_01566 vacuolar fusion protein mon1 K20195 MON1; vacuolar fusion protein MON1
D CCM_05071 ubiquitin carboxyl-terminal hydrolase 2 K11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
D CCM_00458 endosome-associated ubiquitin isopeptidase (AmsH), putative K11866 STAMBP; STAM-binding protein [EC:3.4.19.12]
D CCM_01387 vacuolar sorting protein 1 K23481 VPS1; vacuolar protein sorting-associated protein 1
D CCM_01136 beige/BEACH domain-containing protein K24781 BPH1; beige protein homolog 1
#
AProtein recycling
B Rab GTPases and associated proteins
C Rab GTPases
D CCM_06707 Ras GTPase Rab11, putative K07904 RAB11A; Ras-related protein Rab-11A
C Rab4 associated proteins
D CCM_04649 vacuolar segregation protein (Pep7), putative K12481 RBSN; rabenosyn-5
D CCM_04989 vacuolar targeting protein Atg24 K17919 SNX4; sorting nexin-4
D CCM_05207 dynein light intermediate chain K10416 DYNC1LI; dynein cytoplasmic 1 light intermediate chain
C Rab11 associated proteins
D CCM_02075 WD repeat containing protein 44 K20241 WDR44; WD repeat-containing protein 44
D CCM_00315 protein transport protein SEC13 K14004 SEC13; protein transport protein SEC13
D CCM_05816 Exocyst complex component Sec15, putative K19985 EXOC6; exocyst complex component 6
D CCM_01271 vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
C Other Rab GTPase associated proteins
D CCM_09079 phosphatase family protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D CCM_09533 guanine nucleotide exchange factor Vps9 K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D CCM_06822 DNA repair protein RAD51 K04482 RAD51; DNA repair protein RAD51
B Others
C Glutamate receptor-interacting proteins (GRIPs)
C GRIP associated proteins
C EARP complex
D CCM_01286 Vps51/Vps67 K20296 ANG2; vacuolar protein sorting-associated protein 51
D CCM_02958 Vps52 / Sac2 family protein K20298 VPS52; vacuolar protein sorting-associated protein 52
D CCM_05421 GARP complex subunit Vps53, putative K20299 VPS53; vacuolar protein sorting-associated protein 53
C WASH complex
D CCM_06919 F-actin capping protein beta subunit K10365 CAPZB; F-actin-capping protein subunit beta
C Retriever complex
D CCM_08927 retrograde transporter K18467 VPS29; vacuolar protein sorting-associated protein 29
C Others
D CCM_06334 ankyrin, putative K21440 ANKRD50; ankyrin repeat domain-containing protein 50
#
AEndosome - Golgi transport
B Rab GTPases and associated proteins
C Rab GTPases
D CCM_00444 RAS small monomeric GTPase Rab6 K07893 RAB6A; Ras-related protein Rab-6A
C Rab associated proteins
D CCM_01271 vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
D CCM_03353 GTPase-activating protein GYP5 K19951 TBC1D8_9; TBC1 domain family member 8/9
D CCM_06652 hypothetical protein K20286 TMF1; TATA element modulatory factor
D CCM_03303 hypothetical protein K10419 DYNLRB; dynein light chain roadblock-type
D CCM_04587 dynactin K04648 DCTN1; dynactin 1
D CCM_09079 phosphatase family protein K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D CCM_00177 vacuolar protein sorting-associated protein vps13 K19525 VPS13A_C; vacuolar protein sorting-associated protein 13A/C
B Arf GTPases and associated proteins
C Arf GTPases
D CCM_05891 ADP-ribosylation factor K07937 ARF1_2; ADP-ribosylation factor 1/2
D CCM_02667 ADP-ribosylation factor-like protein 1 K07942 ARL1; ADP-ribosylation factor-like protein 1
D CCM_07545 ADP-ribosylation factor family protein K07952 ARFRP1; ADP-ribosylation factor related protein 1
C Arf GTPase associated proteins
D CCM_04130 zinc finger protein gcs1 K12492 ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1
D CCM_04030 GTPase-activating protein K12493 ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2/3
D CCM_05109 stromal membrane-associated protein K12486 SMAP; stromal membrane-associated protein
D CCM_01420 ARF GTPase activator K12488 ASAP; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein
D CCM_05681 guanyl-nucleotide exchange factor (Sec7), putative K18442 ARFGEF; brefeldin A-inhibited guanine nucleotide-exchange protein
D CCM_00388 cytohesin-2 K18443 GBF1; golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
B Tethering complex
C Conserved oligomeric Golgi (COG) complex
D CCM_07291 Vps51/Vps67 K20288 COG1; conserved oligomeric Golgi complex subunit 1
D CCM_07975 Conserved oligomeric golgi complex subunit 2 K20289 COG2; conserved oligomeric Golgi complex subunit 2
D CCM_01328 Golgi complex component Cog3, putative K20290 COG3; conserved oligomeric Golgi complex subunit 3
D CCM_06221 golgi transport complex subunit Cog4 K20291 COG4; conserved oligomeric Golgi complex subunit 4
C GARP complex
D CCM_01286 Vps51/Vps67 K20296 ANG2; vacuolar protein sorting-associated protein 51
D CCM_02958 Vps52 / Sac2 family protein K20298 VPS52; vacuolar protein sorting-associated protein 52
D CCM_05421 GARP complex subunit Vps53, putative K20299 VPS53; vacuolar protein sorting-associated protein 53
D CCM_08911 GARP complex component (Vps54), putative K17600 VPS54; vacuolar protein sorting-associated protein 54
D CCM_03200 Vps54-like protein K17600 VPS54; vacuolar protein sorting-associated protein 54
C TRAPP complex II
D CCM_02706 TRAPP complex subunit (Bet5), putative K20300 TRAPPC1; trafficking protein particle complex subunit 1
D CCM_07520 trafficking protein particle complex subunit 2, putative K20301 TRAPPC2; trafficking protein particle complex subunit 2
D CCM_09165 Longin-like protein K20301 TRAPPC2; trafficking protein particle complex subunit 2
D CCM_06749 TRAPP complex component Bet3, putative K20302 TRAPPC3; trafficking protein particle complex subunit 3
D CCM_06881 Sybindin-like family protein K20303 TRAPPC4; trafficking protein particle complex subunit 4
D CCM_07857 BET3 family protein K20280 TRAPPC5; trafficking protein particle complex subunit 5
D CCM_05783 trafficking protein particle complex subunit 6B K20304 TRAPPC6; trafficking protein particle complex subunit 6
D CCM_00429 hypothetical protein K20305 TRAPPC8; trafficking protein particle complex subunit 8
D CCM_07159 hypercellular protein HypA K20306 TRAPPC9; trafficking protein particle complex subunit 9
D CCM_00839 TMEM1 family protein K20307 TRAPPC10; trafficking protein particle complex subunit 10
D CCM_05045 hypothetical protein K20308 TRAPPC11; trafficking protein particle complex subunit 11
D CCM_00701 hypothetical protein K20309 TRAPPC12; trafficking protein particle complex subunit 12
D CCM_08850 DUF974 domain-containing protein K20310 TRAPPC13; trafficking protein particle complex subunit 13
B Others
C AP-1 complex
D CCM_03967 AP-1 complex subunit gamma-1 K12391 AP1G1; AP-1 complex subunit gamma-1
D CCM_01289 AP-1 complex subunit beta-1 K12392 AP1B1; AP-1 complex subunit beta-1
D CCM_02509 AP-1 complex subunit mu K12393 AP1M; AP-1 complex subunit mu
D CCM_08132 AP-2 complex subunit sigma K12394 AP1S1_2; AP-1 complex subunit sigma 1/2
C AP-3 complex
D CCM_03909 AP-3 complex subunit delta K12396 AP3D; AP-3 complex subunit delta
D CCM_00024 AP-3 adaptor complex subunit beta K12397 AP3B; AP-3 complex subunit beta
D CCM_09163 adaptor protein complex 3 K12398 AP3M; AP-3 complex subunit mu
D CCM_00225 AP-3 complex subunit sigma K12399 AP3S; AP-3 complex subunit sigma
C AP-4 complex
C GGA
D CCM_01267 ADP-ribosylation factor-binding protein GGA1 K12404 GGA; ADP-ribosylation factor-binding protein GGA
C Aftiphilin/p200/gamma-synergin complex
D CCM_02655 HEAT repeat protein K24814 HEATR5; HEAT repeat-containing protein 5
C Others
D CCM_00524 phospholipase D1 K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D CCM_04322 phospholipase D K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D CCM_02988 phospholipase PldA, putative K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D CCM_06818 phosphatidylinositol 3-kinase 3 K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D CCM_01361 phosphatidylinositol-4-phosphate 5-kinase its3 K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D CCM_07600 1-phosphatidylinositol-3-phosphate 5-kinase (Fab1) K00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
D CCM_06861 bZIP transcription factor, putative K20316 SCOC; short coiled-coil protein
D CCM_01363 SYS1-related integral membrane protein K20318 SYS1; protein SYS1
D CCM_06426 UPF0016 domain protein, putative K23541 TMEM165; Ca2+/H+ antiporter, TMEM165/GDT1 family
D CCM_00495 hypothetical protein K23542 TMEM199; TMEM199 family protein
D CCM_00982 hypothetical protein K23543 CCDC115; coiled-coil domain-containing protein 115
D CCM_02933 membrane protein TMS1, putative K23544 SERINC1; serine incorporator 1
D CCM_06551 sorting nexin-3 K17918 SNX3_12; sorting nexin-3/12
D CCM_09119 sorting nexin Mvp1 K17922 SNX8; sorting nexin-8
D CCM_04668 endosomal peripheral membrane protein K26678 MON2; protein MON2
D CCM_01564 cellular morphogenesis regulator DopA K26680 DOP1; protein dopey
D CCM_05376 COPI-coated vesicle protein, putative K26750 TVP15; golgi apparatus membrane protein TVP15
D CCM_04681 clathrin-coated vesicle protein, putative K26751 TVP18; golgi apparatus membrane protein TVP18
D CCM_06351 golgi apparatus membrane protein tvp23 K26752 TVP23; golgi apparatus membrane protein TVP23
D CCM_01549 TLG2-vesicle protein of 38 kDa K26753 TVP38; golgi apparatus membrane protein TVP38
D CCM_01387 vacuolar sorting protein 1 K23481 VPS1; vacuolar protein sorting-associated protein 1
#
AEndoplasmic reticulum (ER) - Golgi transport
B Forward pathways
C Coat protein complex II (COP-II)
D CCM_00315 protein transport protein SEC13 K14004 SEC13; protein transport protein SEC13
D CCM_04544 protein transport protein (SEC31), putative K14005 SEC31; protein transport protein SEC31
D CCM_03949 protein transport protein SEC23 K14006 SEC23; protein transport protein SEC23
D CCM_01236 Sec23/Sec24 trunk region K14007 SEC24; protein transport protein SEC24
D CCM_01370 Sec23/Sec24 family protein K14007 SEC24; protein transport protein SEC24
D CCM_07801 COPII coat assembly protein sec16 K20353 SEC16; COPII coat assembly protein SEC16
C TRAPP complex I
D CCM_02706 TRAPP complex subunit (Bet5), putative K20300 TRAPPC1; trafficking protein particle complex subunit 1
D CCM_07520 trafficking protein particle complex subunit 2, putative K20301 TRAPPC2; trafficking protein particle complex subunit 2
D CCM_09165 Longin-like protein K20301 TRAPPC2; trafficking protein particle complex subunit 2
D CCM_06749 TRAPP complex component Bet3, putative K20302 TRAPPC3; trafficking protein particle complex subunit 3
D CCM_06881 Sybindin-like family protein K20303 TRAPPC4; trafficking protein particle complex subunit 4
D CCM_07857 BET3 family protein K20280 TRAPPC5; trafficking protein particle complex subunit 5
D CCM_05783 trafficking protein particle complex subunit 6B K20304 TRAPPC6; trafficking protein particle complex subunit 6
C p24 family proteins
D CCM_00922 ERP1 protein precursor K20346 TMED4_9_11; p24 family protein alpha
D CCM_05890 endosomal P24B protein K20347 TMED2; p24 family protein beta-1
D CCM_02029 ERV25 protein K20352 TMED10; p24 family protein delta-1
C PDI family proteins
D CCM_06952 protein disulfide-isomerase K09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]
D CCM_01377 protein disulfide-isomerase tigA precursor K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
D CCM_07865 disulfide isomerase, putative K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C Rab GTPases
D CCM_02460 GTP-binding protein ypt1 K07874 RAB1A; Ras-related protein Rab-1A
D CCM_08904 secretion related GTPase SrgD K07877 RAB2A; Ras-related protein Rab-2A
C Rab associated proteins
D CCM_06377 prenylated Rab acceptor 1 K20359 RABAC1; PRA1 family protein 1
D CCM_02957 RabGAP/TBC K20372 TBC1D20; TBC1 domain family member 20
D CCM_01089 GTPase activating protein (Gyp1), putative K20360 TBC1D22; TBC1 domain family member 2
D CCM_03335 ER to Golgi transport protein Yif1 K20362 YIF1; protein transport protein YIF1
D CCM_00862 protein transport protein yos1, putative K22939 IER3IP1; immediate early response 3-interacting protein 1
D CCM_07459 intracellular protein transport protein (UsoA), putative K20361 USO1; intracellular protein transport protein USO1
C ER-Golgi intermediate compartment (ERGIC) proteins
D CCM_01589 lectin family integral membrane protein, putative K10080 LMAN1; lectin, mannose-binding 1
D CCM_01779 vesicular integral-membrane protein VIP36 precursor K10082 LMAN2; lectin, mannose-binding 2
D CCM_04718 glycosyl hydrolase family 47 protein K01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D CCM_02902 glycosyl hydrolase family 47 protein K01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D CCM_08733 mannosidase MsdS K01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D CCM_02744 class I alpha-mannosidase K01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D CCM_01277 class I alpha-mannosidase K01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D CCM_08185 mannosyl-oligosaccharide 1,2-alpha-mannosidase K23741 MAN1B; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]
D CCM_03682 COPII-coated vesicle protein (Erv41), putative K20366 ERGIC2; endoplasmic reticulum-Golgi intermediate compartment protein 2
D CCM_02255 endoplasmic reticulum-Golgi intermediate compartment protein 3 K20367 ERGIC3; endoplasmic reticulum-Golgi intermediate compartment protein 3
D CCM_06262 COPII-coated vesicle protein SurF4/Erv29 K20369 ERV29; ER-derived vesicles protein
D CCM_05087 glucose-regulated protein K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
B Retrieval pathways
C Coat protein complex I (COP-I)
D CCM_01178 Coatomer, WD associated region K05236 COPA; coatomer subunit alpha
D CCM_00748 coatomer beta subunit K17301 COPB1; coatomer subunit beta
D CCM_09294 coatomer beta' subunit K17302 COPB2; coatomer subunit beta'
D CCM_00786 Coatomer subunit gamma, putative K17267 COPG; coatomer subunit gamma
D CCM_07396 Coatomer subunit delta, putative K20471 COPD; coatomer subunit delta
D CCM_06219 coatomer zeta subunit K20472 COPZ; coatomer subunit zeta
C NRZ (DSL1) complex
D CCM_01326 RINT-1 family protein K20474 RINT1; RAD50-interacting protein 1
D CCM_07899 hypothetical protein K11578 ZW10; protein transport protein DSL1/ZW10
D CCM_03954 protein transport protein Sec39, putative K20475 SEC39; protein transport protein SEC39
C Golgi to ER traffic proteins (GET)
D CCM_01763 CHD5 domain containing protein K22384 GET1; tail-anchored protein insertion receptor
D CCM_08142 arsenite translocating ATPase ArsA, putative K01551 arsA; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
D CCM_07795 protein family UPF0363 K23387 GET4; golgi to ER traffic protein 4
D CCM_04564 Ubiquitin supergroup K23388 UBL4; ubiquitin-like protein 4
C Rab GTPases
D CCM_00444 RAS small monomeric GTPase Rab6 K07893 RAB6A; Ras-related protein Rab-6A
C Rab associated proteins
D CCM_01140 DUF1339 domain protein K20476 RIC1; RAB6A-GEF complex partner protein 1
D CCM_05127 Rgp1 K20477 RGP1; RAB6A-GEF complex partner protein 2
D CCM_02133 HDEL sequence binding protein, putative K10949 KDELR; ER lumen protein retaining receptor
D CCM_04649 vacuolar segregation protein (Pep7), putative K12481 RBSN; rabenosyn-5
D CCM_01089 GTPase activating protein (Gyp1), putative K20360 TBC1D22; TBC1 domain family member 2
B Others
C Oxysterol-binding proteins
D CCM_03162 oxysterol binding protein K20456 OSBP; oxysterol-binding protein 1
D CCM_02319 oxysterol binding protein Osh7, putative K22285 OSBPL8; oxysterol-binding protein-related protein 8
D CCM_06135 oxysterol binding protein (Orp8), putative K20465 OSBPL9_10_11; oxysterol-binding protein-related protein 9/10/11
D CCM_00742 oxysterol binding protein (Osh5), putative K20465 OSBPL9_10_11; oxysterol-binding protein-related protein 9/10/11
C FXYD proteins
C YIPF proteins
D CCM_02961 Yip1 domain family K22940 YIPF1_2; protein YIPF1/2
D CCM_05282 Golgi membrane protein, putative K20363 YIPF5_7; protein YIPF5/7
D CCM_02948 Yip1 domain protein K22943 YIPF6; protein YIPF6
C ER membrane protein complex
D CCM_05158 hypothetical protein K23562 EMC1; ER membrane protein complex subunit 1
D CCM_03906 tetratricopeptide repeat domain-containing protein K23563 EMC2; ER membrane protein complex subunit 2
D CCM_07268 DUF850 domain protein K23564 EMC3; ER membrane protein complex subunit 3
D CCM_04096 ER membrane DUF1077 domain protein, putative K23565 EMC4; ER membrane protein complex subunit 4
D CCM_06681 Magnesium transporter K23566 MMGT1; membrane magnesium transporter 1
D CCM_06672 DUF786 family protein K23567 EMC6; ER membrane protein complex subunit 6
C SEC61 complex
D CCM_09589 protein transport protein SEC61 alpha subunit K10956 SEC61A; protein transport protein SEC61 subunit alpha
D CCM_00994 Preprotein translocase Sec, Sec61-beta subunit, eukarya K09481 SEC61B; protein transport protein SEC61 subunit beta
D CCM_07028 protein translocase, putative K07342 SEC61G; protein transport protein SEC61 subunit gamma and related proteins
C TRAP complex
C Multi-pass translocon (MPT) complex
D CCM_01880 DUF1682 domain protein K24962 CCDC47; PAT complex subunit CCDC47
C Post-GPI attachment to proteins factors (PGAP)
D CCM_02932 GPI inositol-deacylase K05294 PGAP1; GPI inositol-deacylase [EC:3.-.-.-]
D CCM_06898 Mn2+ homeostasis protein Per1 K23553 PGAP3; post-GPI attachment to proteins factor 3
D CCM_07607 manganese ion homeostasis (Fr), putative K23362 MPPE1; ethanolamine phosphate phosphodiesterase [EC:3.1.-.-]
C Others
D CCM_08504 SNARE docking complex subunit K19998 SCFD1; sec1 family domain-containing protein 1
D CCM_08757 hypothetical protein K20724 TMEM33; transmembrane protein 33
D CCM_01271 vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
D CCM_07354 INSIG domain protein K26681 INSIG; insulin-induced protein
D CCM_04257 Got1 family protein K26683 GOLT1; vesicle transport protein GOT1
D CCM_04810 protein SEY1 K22698 SEY1; protein SEY1 [EC:3.6.5.-]
#
AAutophagy
B Autophagosome formation proteins
C ULK complex
D CCM_04483 autophagy protein Atg13, putative K08331 ATG13; autophagy-related protein 13
D CCM_02647 DUF1649 domain protein K19730 ATG101; autophagy-related protein 101
C Atg1 complex
D CCM_07279 serine/threonine protein kinase (Pdd7p), putative K08269 ULK2; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
D CCM_04483 autophagy protein Atg13, putative K08331 ATG13; autophagy-related protein 13
D CCM_05872 kinase activator (Atg17), putative K08329 ATG17; autophagy-related protein 17
C PI3K complex
D CCM_03362 phosphoinositide 3-kinase, putative K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D CCM_03014 Armadillo-type fold domain containing protein K08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
D CCM_04101 autophagy protein Apg6, putative K08334 BECN; beclin
C ATG9 transmembrane protein
D CCM_01215 Autophagy-related protein 9 K17907 ATG9; autophagy-related protein 9
C Atg18-Atg2 complex
D CCM_07441 protein-vacuolar targeting protein Atg18 K17908 WIPI1_2; autophagy-related protein 18
C Atg12 conjugation proteins
D CCM_04064 autophagy protein Apg12, putative K08336 ATG12; ubiquitin-like protein ATG12
D CCM_00278 E1-like protein-activating enzyme Gsa7p/Apg7p K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D CCM_08186 hypothetical protein K17888 ATG10L; ubiquitin-like-conjugating enzyme ATG10
D CCM_00910 autophagy protein 5 K08339 ATG5; autophagy-related protein 5
C Atg8 conjugation proteins
D CCM_07484 Light chain 3 (LC3) K08341 GABARAP; GABA(A) receptor-associated protein
D CCM_00278 E1-like protein-activating enzyme Gsa7p/Apg7p K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D CCM_06512 autophagocytosis protein Aut1, putative K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
B Cytoplasm to vacuolar targeting (CVT) pathway
C Selective cargos
D CCM_03061 vacuolar aspartyl aminopeptidase Lap4, putative K01268 LAP4; aminopeptidase I [EC:3.4.11.22]
D CCM_06392 alpha-mannosidase K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24]
D CCM_02807 aspartyl aminopeptidase K01267 DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]
C Cargo receptors
C Scaffold protein
D CCM_02272 Autophagy-related protein 11 K08330 ATG11; autophagy-related protein 11
C Other Cvt associated proteins
D CCM_02637 sorting nexin-41 K21996 SNX41_42; sorting nexin-41/42
D CCM_04989 vacuolar targeting protein Atg24 K17919 SNX4; sorting nexin-4
D CCM_06112 autophagy related lipase K17900 ATG15; lipase ATG15 [EC:3.1.1.3]
D CCM_08954 Autophagy-related protein 27 K21141 ATG27; autophagy-related protein 27
D CCM_09420 vacuolar protein 8 K08332 VAC8; vacuolar protein 8
B Mitophagy
C Cargo receptors
C Scaffold proteins
D CCM_02272 Autophagy-related protein 11 K08330 ATG11; autophagy-related protein 11
C PINK1-Parkin associated proteins
D CCM_09450 transmembrane GTPase Fzo1, putative K06030 MFN2; mitofusin 2 [EC:3.6.5.-]
D CCM_00534 ZZ type zinc finger domain protein K17987 NBR1; next to BRCA1 gene 1 protein
C Other mitophagy associated proteins
D CCM_04625 hexokinase-1 K00844 HK; hexokinase [EC:2.7.1.1]
D CCM_08316 glucokinase K00844 HK; hexokinase [EC:2.7.1.1]
D CCM_03320 glucokinase K00844 HK; hexokinase [EC:2.7.1.1]
D CCM_06280 hexokinase K00844 HK; hexokinase [EC:2.7.1.1]
D CCM_06382 hypothetical protein K22255 ATPIF1; ATPase inhibitor, mitochondrial
D CCM_03759 Mitochondrial outer membrane translocase complex, subunitt Tom7 K17771 TOM7; mitochondrial import receptor subunit TOM7
D CCM_06269 hypothetical protein K19717 ATG33; autophagy-related protein 33
B Pexophagy
C Selective cargos
D CCM_02648 peroxisomal membrane protein Pex3, putative K13336 PEX3; peroxin-3
D CCM_00303 peroxisomal membrane anchor protein Pex14, putative K13343 PEX14; peroxin-14
C Cargo receptors
C Other pexophagy associated proteins
D CCM_00534 ZZ type zinc finger domain protein K17987 NBR1; next to BRCA1 gene 1 protein
D CCM_05572 peroxisome biosynthesis protein (PAS1/Peroxin-1), putative K13338 PEX1; peroxin-1
D CCM_07262 peroxisomal biogenesis factor 6 K13339 PEX6; peroxin-6
B Aggrephagy
C Cargo receptors
D CCM_00534 ZZ type zinc finger domain protein K17987 NBR1; next to BRCA1 gene 1 protein
C Scaffold proteins
C Other aggrephagy associated proteins
D CCM_00971 cell division control protein Cdc48 K13525 VCP; transitional endoplasmic reticulum ATPase
D CCM_06710 histone deacetylase K11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]
D CCM_07379 U-box domain containing protein K09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]
B Xenophagy
C Cargo receptors
D CCM_00534 ZZ type zinc finger domain protein K17987 NBR1; next to BRCA1 gene 1 protein
C Other xenophagy associated proteins
B Chaperone mediated autophagy (CMA)
C Selective cargos
D CCM_05388 aspartate aminotransferase K14454 GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
D CCM_04549 glyceraldehyde 3-phosphate dehydrogenase (GAPDH) K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D CCM_06062 pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D CCM_00102 ubiquitin-like protein DskB, putative K04523 UBQLN; ubiquilin
C Cargo receptors
C Chaperones
D CCM_05489 heat shock protein 70 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D CCM_04804 heat shock 70 kDa protein K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D CCM_07839 heat shock protein 90 K04079 HSP90A; molecular chaperone HtpG
C Co-chaperones
C Other CMA associated proteins
D CCM_00809 elongation factor 1-alpha K03231 EEF1A; elongation factor 1-alpha
D CCM_05858 carboxypeptidase Y precursor K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
D CCM_02146 carboxypeptidase Y K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
D CCM_06411 carboxypeptidase Y K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
B Other autophagy associated proteins
C RNautophagy/DNautophagy
C Micronucleophagy
D CCM_09420 vacuolar protein 8 K08332 VAC8; vacuolar protein 8
C Midbophagy
D CCM_00534 ZZ type zinc finger domain protein K17987 NBR1; next to BRCA1 gene 1 protein
C Glycophagy
C TRIM-directed selective autophagy
C ER-mitochondria tethering complex
D CCM_09450 transmembrane GTPase Fzo1, putative K06030 MFN2; mitofusin 2 [EC:3.6.5.-]
C mTORC1 complex
D CCM_04900 phosphatidylinositol 3-kinase tor2 K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D CCM_00551 WD-repeat protein pop3 K08266 MLST8; target of rapamycin complex subunit LST8
D CCM_03247 TORC1 growth control complex subunit Kog1 K07204 RAPTOR; regulatory associated protein of mTOR
C mTORC2 complex
D CCM_04900 phosphatidylinositol 3-kinase tor2 K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D CCM_00551 WD-repeat protein pop3 K08266 MLST8; target of rapamycin complex subunit LST8
D CCM_01074 stress activated MAP kinase interacting protein Sin1 K20410 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1/AVO1
D CCM_09433 cytosolic regulator Pianissimo, putative K08267 RICTOR; rapamycin-insensitive companion of mTOR
C SEACIT/GATOR1 complex
D CCM_03036 Dishevelled, Egl-10, and Pleckstrin domain protein K20404 DEPDC5; SEA/GATOR complex protein SEA1/DEPDC5
D CCM_00101 Nitrogen permease regulator 2 K20405 NPRL2; nitrogen permease regulator 2
D CCM_01117 protein family UPF0171 K20406 NPRL3; nitrogen permease regulator 3
C SEACAT/GATOR2 complex
D CCM_07687 WD repeat protein K20408 WDR24; SEA/GATOR complex protein SEA2/WDR24
D CCM_03389 WD repeat protein K20409 WDR59; SEA/GATOR complex protein SEA3/WDR59
D CCM_02620 WD repeat protein, putative K20407 MIOS; SEA/GATOR complex protein SEA4/MIOS
D CCM_02538 nucleoporin seh1 K14299 SEH1; nucleoporin SEH1
D CCM_00315 protein transport protein SEC13 K14004 SEC13; protein transport protein SEC13
C KICSTOR complex
C Rab GTPases
D CCM_02460 GTP-binding protein ypt1 K07874 RAB1A; Ras-related protein Rab-1A
D CCM_07176 GTP-binding protein SAS1 K07901 RAB8A; Ras-related protein Rab-8A
C Rab associated proteins
C Others
D CCM_04272 serine/threonine-protein phosphatase PP2A catalytic subunit K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
D CCM_04289 TOR signaling pathway regulator (TapA), putative K17606 IGBP1; immunoglobulin-binding protein 1
D CCM_07686 UV radiation resistance protein, putative K21249 UVRAG; UV radiation resistance-associated gene protein
D CCM_06917 Major facilitator superfamily transporter K06902 UMF1; MFS transporter, UMF1 family
D CCM_07762 amino acid transporter, putative K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D CCM_06029 amino acid transporter K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D CCM_05210 phosphatidylinositol 3,5-bisphosphate-binding protein, putative K22991 WDR45; WD repeat-containing protein 45
D CCM_06979 vacuolar ATPase assembly integral membrane protein K23952 VMA21; vacuolar ATPase assembly integral membrane protein VMA21
D CCM_00057 UPF0183 domain-containing protein K27411 PHAF1; phagosome assembly factor 1
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AOthers
B NADPH oxidases (Nox) and associated proteins
C NADPH oxidases
D CCM_08161 NADPH oxidase (NoxA), putative K08008 NOX1; NADPH oxidase 1
D CCM_01357 NADPH oxidase isoform 2 K21421 NOX2; NADPH oxidase 2 [EC:1.-.-.-]
C Nox associated proteins
B Actin-binding proteins
C Myosins
D CCM_05994 myosin-5 K10356 MYO1; myosin I
D CCM_03939 class V myosin (Myo4), putative K10357 MYO5; myosin V
C Arp2/3 complex
D CCM_09185 actin related protein 2/3 complex subunit K05757 ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
D CCM_02229 ARP2/3 complex 34 kDa subunit K05758 ARPC2; actin related protein 2/3 complex, subunit 2
D CCM_09049 ARP2/3 complex 21 kDa subunit K05756 ARPC3; actin related protein 2/3 complex, subunit 3
D CCM_06488 ARP2/3 complex 20 kDa subunit K05755 ARPC4; actin related protein 2/3 complex, subunit 4
D CCM_04789 Arp2/3 complex subunit Arc16, putative K05754 ARPC5; actin related protein 2/3 complex, subunit 5
D CCM_09669 actin-related protein 2 K17260 ACTR2; actin-related protein 2
D CCM_02483 actin-like protein 3 K18584 ACTR3; actin-related protein 3
C Nucleation-promoting factors (NPFs)
D CCM_06541 WASP-like pretein las17p K23612 WASL; neural Wiskott-Aldrich syndrome protein
D CCM_06628 actin binding protein, putative K20520 DBNL; drebrin-like protein
D CCM_02645 polyA nuclease K20047 PAN1; actin cytoskeleton-regulatory complex protein PAN1
D CCM_08124 Amphiphysin-like protein K12562 AMPH; amphiphysin
D CCM_09681 Actin cytoskeleton-regulatory complex protein K20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1
D CCM_07344 SH3 domain protein K20521 BBC1; myosin tail region-interacting protein MTI1
D CCM_00772 SH3 domain protein K20522 LSB1_2; LAS seventeen-binding protein 1/2
D CCM_05111 DUF500 and domain-containing protein K20523 SH3YL1; SH3 domain-containing YSC84-like protein 1
D CCM_04626 VHS domain protein K20524 LSB5; LAS seventeen-binding protein 5
D CCM_02448 Phosphatidylinositol 3-/4-kinase, catalytic K13711 PI4K2; phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]
C Others
D CCM_04256 profilin K05759 PFN; profilin
D CCM_04563 cofilin, putative K05765 CFL; cofilin
D CCM_02925 adenylyl cyclase-associated protein K17261 CAP1_2; adenylyl cyclase-associated protein
D CCM_05365 kinesin heavy chain K10396 KIF5; kinesin family member 5
D CCM_08548 calponin-like protein K20526 TAGLN; transgelin
B Mucins
C Membrane bound mucins
C Secretory mucins
B Rab GTPases of specific organelles
C Melanosome
C Auto phagosome
C Lipid droplets
C Mitochondrion
B Rho GTPase associated proteins
C Rho GTPase-activating proteins
D CCM_03603 Rho GTPase activator (Rgd1), putative K20643 RGD1; Rho GTPase-activating protein RGD1
D CCM_06161 RhoGAP domain-containing protein K08773 RALBP1; RalA-binding protein 1
C Rho guanine nucleotide exchange factors (GEFs)
D CCM_05925 Rho guanyl nucleotide exchange factor K20705 DNMBP; dynamin-binding protein
D CCM_00236 SH3 and Ded-cyto domain protein, putative K05727 DOCK3; dedicator of cytokinesis protein 3
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: May 15, 2024