+F	Repair protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Repair and Recombination Proteins - Chelonia mydas (green sea turtle)</h2>
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A<b>Eukaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      102941237 MGMT; methylated-DNA--protein-cysteine methyltransferase isoform X1	K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 
D      102942598 ALKBH2; DNA oxidative demethylase ALKBH2	K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33] 
D      102946097 ALKBH3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X1	K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54] 
D      102943142 ASCC3; activating signal cointegrator 1 complex subunit 3 isoform X1	K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4] 
D      102937787 deoxyribodipyrimidine photo-lyase	K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] 
C    BER (base exicision repair)
D      DNA glycosylases
E        102935891 UNG; uracil-DNA glycosylase	K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] 
E        102937316 CCNO; cyclin-O	K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-] 
E        102941802 TDG; G/T mismatch-specific thymine DNA glycosylase isoform X1	K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29] 
E        102946047 MPG; DNA-3-methyladenine glycosylase	K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] 
E        102945286 SMUG1; single-strand selective monofunctional uracil DNA glycosylase isoform X1	K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-] 
E        102935984 MUTYH; adenine DNA glycosylase isoform X1	K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] 
E        102937178 MBD4; methyl-CpG-binding domain protein 4 isoform X2	K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-] 
E        102939880 OGG1; N-glycosylase/DNA lyase	K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18] 
E        102946492 NEIL1; endonuclease 8-like 1 isoform X2	K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18] 
E        102931564 NEIL2; endonuclease 8-like 2	K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18] 
E        102943219 NEIL3; endonuclease 8-like 3 isoform X6	K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18] 
E        102946228 NTHL1; endonuclease III-like protein 1	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
E        102941002 APEX1; DNA-(apurinic or apyrimidinic site) endonuclease	K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2] 
E        102936240 APEX2; DNA-(apurinic or apyrimidinic site) endonuclease 2	K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2] 
D      Long Patch-BER factors
E        DNA polymerase delta complex
F          102939109 POLD1; DNA polymerase delta catalytic subunit	K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7] 
F          102948291 POLD2; DNA polymerase delta subunit 2 isoform X1	K02328 POLD2; DNA polymerase delta subunit 2 
F          102934210 POLD3; DNA polymerase delta subunit 3 isoform X1	K03504 POLD3; DNA polymerase delta subunit 3 
F          102947619 POLD4; DNA polymerase delta subunit 4 isoform X1	K03505 POLD4; DNA polymerase delta subunit 4 
E        DNA polymerase epsilon complex
F          102936542 POLE; DNA polymerase epsilon catalytic subunit A isoform X1	K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7] 
F          102939528 POLE2; DNA polymerase epsilon subunit 2 isoform X1	K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7] 
F          102933347 POLE3; DNA polymerase epsilon subunit 3 isoform X3	K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7] 
F          114019409 POLE4; DNA polymerase epsilon subunit 4	K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7] 
E        102945568 PCNA; proliferating cell nuclear antigen	K04802 PCNA; proliferating cell nuclear antigen 
E        102932155 FEN1; flap endonuclease 1	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
E        114021972 flap endonuclease 1	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
E        102943387 LIG1; DNA ligase 1 isoform X1	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
D      Short Patch-BER factors
E        102931250 POLB; DNA polymerase beta isoform X2	K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-] 
E        119567187 XNDC1N; putative short transient receptor potential channel 2-like protein isoform X2	K10803 XRCC1; DNA-repair protein XRCC1 
E        102932854 XRCC1; DNA repair protein XRCC1 isoform X1	K10803 XRCC1; DNA-repair protein XRCC1 
E        102932236 LIG3; DNA ligase 3 isoform X1	K10776 LIG3; DNA ligase 3 [EC:6.5.1.1] 
D      Other BER factors
E        102934986 TDP1; tyrosyl-DNA phosphodiesterase 1 isoform X1	K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-] 
E        102939347 APTX; aprataxin isoform X1	K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72] 
E        102941193 APLF; aprataxin and PNK-like factor isoform X1	K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-] 
E        119565045 bifunctional polynucleotide phosphatase/kinase	K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78] 
E        102935166 HMGB1; high mobility group protein B1 isoform X1	K10802 HMGB1; high mobility group protein B1 
E        102947270 POLL; DNA polymerase lambda isoform X1	K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-] 
E        102946142 PARP1; poly [ADP-ribose] polymerase 1	K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] 
E        102942568 PARP2; poly [ADP-ribose] polymerase 2 isoform X4	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
E        102939938 PARP4; protein mono-ADP-ribosyltransferase PARP4 isoform X1	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
E        102945727 PARP3; protein mono-ADP-ribosyltransferase PARP3 isoform X3	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
E        XPC-HR23B-CETN2 complex
F          102932059 XPC; DNA repair protein complementing XP-C cells isoform X2	K10838 XPC; xeroderma pigmentosum group C-complementing protein 
F          102938897 RAD23B; UV excision repair protein RAD23 homolog B isoform X1	K10839 RAD23; UV excision repair protein RAD23 
F          102938244 RAD23A; UV excision repair protein RAD23 homolog A isoform X1	K10839 RAD23; UV excision repair protein RAD23 
F          102945808 centrin-2 isoform X1	K10840 CETN2; centrin-2 
F          102932385 centrin-2 isoform X2	K10840 CETN2; centrin-2 
E        Cul4-DDB2 complex
F          102943754 RBX1; E3 ubiquitin-protein ligase RBX1	K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32] 
F          102938840 CUL4B; cullin-4B	K10609 CUL4; cullin 4 
F          102932602 CUL4A; cullin-4A	K10609 CUL4; cullin 4 
F          102933282 DDB1; DNA damage-binding protein 1	K10610 DDB1; DNA damage-binding protein 1 
F          102941615 DDB2; DNA damage-binding protein 2 isoform X4	K10140 DDB2; DNA damage-binding protein 2 
E        NER4 complex
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase II complex
F          102931328 POLR2B; DNA-directed RNA polymerase II subunit RPB2	K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6] 
F          102929331 POLR2C; DNA-directed RNA polymerase II subunit RPB3	K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3 
F          102933530 POLR2D; DNA-directed RNA polymerase II subunit RPB4	K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4 
F          102942937 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1	K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1 
F          102939889 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1	K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2 
F          102943762 POLR2G; DNA-directed RNA polymerase II subunit RPB7	K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7 
F          102935557 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1	K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3 
F          102943375 POLR2I; DNA-directed RNA polymerase II subunit RPB9 isoform X1	K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9 
F          114019477 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 isoform X1	K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5 
F          119564895 DNA-directed RNA polymerases I, II, and III subunit RPABC5 isoform X1	K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5 
F          102947998 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a	K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11 
F          102944774 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform X2	K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4 
E        Cul4-CSA complex
F          102943754 RBX1; E3 ubiquitin-protein ligase RBX1	K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32] 
F          102938840 CUL4B; cullin-4B	K10609 CUL4; cullin 4 
F          102932602 CUL4A; cullin-4A	K10609 CUL4; cullin 4 
F          102933282 DDB1; DNA damage-binding protein 1	K10610 DDB1; DNA damage-binding protein 1 
F          102944052 ERCC8; DNA excision repair protein ERCC-8 isoform X2	K10570 ERCC8; DNA excision repair protein ERCC-8 
E        Other TCR factor
F          102932545 ERCC6; DNA excision repair protein ERCC-6 isoform X2	K10841 ERCC6; DNA excision repair protein ERCC-6 
F          102932070 UVSSA; UV-stimulated scaffold protein A isoform X1	K23720 UVSSA; UV-stimulated scaffold protein A 
F          102931676 ELOF1; transcription elongation factor 1 homolog	K25829 ELOF1; transcription elongation factor 1 
D      TFIIH complex
E        102940262 ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB isoform X2	K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4] 
E        102938938 ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD isoform X1	K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3] 
E        102935866 GTF2H1; general transcription factor IIH subunit 1	K03141 TFIIH1; transcription initiation factor TFIIH subunit 1 
E        102941100 GTF2H2; general transcription factor IIH subunit 2 isoform X1	K03142 TFIIH2; transcription initiation factor TFIIH subunit 2 
E        102930267 GTF2H3; general transcription factor IIH subunit 3	K03143 TFIIH3; transcription initiation factor TFIIH subunit 3 
E        102939007 GTF2H4; general transcription factor IIH subunit 4 isoform X2	K03144 TFIIH4; transcription initiation factor TFIIH subunit 4 
E        102937965 GTF2H5; general transcription factor IIH subunit 5	K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit 
E        102929831 CDK7; cyclin-dependent kinase 7 isoform X1	K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23] 
E        102932272 CCNH; cyclin-H isoform X1	K06634 CCNH; cyclin H 
E        102942251 MNAT1; CDK-activating kinase assembly factor MAT1 isoform X9	K10842 MNAT1; CDK-activating kinase assembly factor MAT1 
D      RPA (replication factor A)
E        102942378 RPA1; replication protein A 70 kDa DNA-binding subunit	K07466 RFA1; replication factor A1 
E        102932984 RPA2; replication protein A 32 kDa subunit isoform X1	K10739 RFA2; replication factor A2 
E        102947531 RPA3; replication protein A 14 kDa subunit	K10740 RPA3; replication factor A3 
D      Other NER factors
E        102943111 XPA; DNA repair protein complementing XP-A cells	K10847 XPA; DNA-repair protein complementing XP-A cells 
E        102938503 ERCC1; DNA excision repair protein ERCC-1	K10849 ERCC1; DNA excision repair protein ERCC-1 
E        102934996 ERCC4; DNA repair endonuclease XPF isoform X1	K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-] 
E        102932898 ERCC5; DNA excision repair protein ERCC-5	K10846 ERCC5; DNA excision repair protein ERCC-5 
E        102943387 LIG1; DNA ligase 1 isoform X1	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
E        102945216 MMS19; MMS19 nucleotide excision repair protein homolog isoform X4	K15075 MET18; DNA repair/transcription protein MET18/MMS19 
E        102944665 CUL3; cullin-3	K03869 CUL3; cullin 3 
E        102935529 CUL5; cullin-5 isoform X1	K10612 CUL5; cullin 5 
E        102941339 ELOC; elongin-C isoform X2	K03872 ELOC; elongin-C 
E        102929860 ELOB; elongin-B	K03873 ELOB; elongin-B 
E        102936684 elongin-B	K03873 ELOB; elongin-B 
E        102933674 ELOA; elongin-A isoform X1	K15076 ELOA; elongin-A 
E        102937320 elongin-A	K15076 ELOA; elongin-A 
E        102940694 UBAP2L; ubiquitin-associated protein 2-like isoform X1	K26545 UBAP2; ubiquitin-associated protein 2 
E        102936963 UBAP2; ubiquitin-associated protein 2 isoform X1	K26545 UBAP2; ubiquitin-associated protein 2 
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
E        102929651 MSH2; DNA mismatch repair protein Msh2 isoform X1	K08735 MSH2; DNA mismatch repair protein MSH2 
E        102941347 MSH3; DNA mismatch repair protein Msh3 isoform X2	K08736 MSH3; DNA mismatch repair protein MSH3 
E        102943356 MSH6; DNA mismatch repair protein Msh6	K08737 MSH6; DNA mismatch repair protein MSH6 
D      MutL homologs
E        102936534 PMS1; PMS1 protein homolog 1 isoform X2	K10864 PMS1; DNA mismatch repair protein PMS1 
E        102932050 MLH1; DNA mismatch repair protein Mlh1 isoform X1	K08734 MLH1; DNA mismatch repair protein MLH1 
E        102946696 PMS2; mismatch repair endonuclease PMS2 isoform X1	K10858 PMS2; DNA mismatch repair protein PMS2 
E        102935022 MLH3; DNA mismatch repair protein Mlh3 isoform X1	K08739 MLH3; DNA mismatch repair protein MLH3 
D      DNA polymerase delta complex
E        102939109 POLD1; DNA polymerase delta catalytic subunit	K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7] 
E        102948291 POLD2; DNA polymerase delta subunit 2 isoform X1	K02328 POLD2; DNA polymerase delta subunit 2 
E        102934210 POLD3; DNA polymerase delta subunit 3 isoform X1	K03504 POLD3; DNA polymerase delta subunit 3 
E        102947619 POLD4; DNA polymerase delta subunit 4 isoform X1	K03505 POLD4; DNA polymerase delta subunit 4 
D      RPA (replication factor A)
E        102942378 RPA1; replication protein A 70 kDa DNA-binding subunit	K07466 RFA1; replication factor A1 
E        102932984 RPA2; replication protein A 32 kDa subunit isoform X1	K10739 RFA2; replication factor A2 
E        102947531 RPA3; replication protein A 14 kDa subunit	K10740 RPA3; replication factor A3 
D      RFC (replication factor C)
E        102940466 RFC1; replication factor C subunit 1 isoform X4	K10754 RFC1; replication factor C subunit 1 
E        102931649 RFC4; replication factor C subunit 4 isoform X1	K10755 RFC2_4; replication factor C subunit 2/4 
E        102947568 RFC2; replication factor C subunit 2	K10755 RFC2_4; replication factor C subunit 2/4 
E        102943745 RFC3; replication factor C subunit 3	K10756 RFC3_5; replication factor C subunit 3/5 
E        102942277 RFC5; replication factor C subunit 5 isoform X1	K10756 RFC3_5; replication factor C subunit 3/5 
D      Other MMR factors
E        102945568 PCNA; proliferating cell nuclear antigen	K04802 PCNA; proliferating cell nuclear antigen 
E        102931378 EXO1; exonuclease 1	K10746 EXO1; exonuclease 1 [EC:3.1.-.-] 
E        102935166 HMGB1; high mobility group protein B1 isoform X1	K10802 HMGB1; high mobility group protein B1 
E        102943387 LIG1; DNA ligase 1 isoform X1	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
E        102932134 WDR76; WD repeat-containing protein 76 isoform X1	K24755 WDR76; WD repeat-containing protein 76 
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      MRN(MRX) complex
E        102946855 MRE11; double-strand break repair protein MRE11 isoform X1	K10865 MRE11; double-strand break repair protein MRE11 
E        102935242 RAD50; DNA repair protein RAD50	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
E        102939912 NBN; nibrin isoform X1	K10867 NBN; nibrin 
D      BRCA1-core complex
E        102936790 BRCA1; breast cancer type 1 susceptibility protein isoform X1	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        102939754 BARD1; BRCA1-associated RING domain protein 1 isoform X1	K10683 BARD1; BRCA1-associated RING domain protein 1 
D      BRCA1-A complex
E        102936790 BRCA1; breast cancer type 1 susceptibility protein isoform X1	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        102946252 ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X1	K20774 FAM175A; BRCA1-A complex subunit Abraxas 
E        102944902 UIMC1; BRCA1-A complex subunit RAP80 isoform X1	K20775 UIMC1; BRCA1-A complex subunit RAP80 
E        102938071 BABAM1; BRISC and BRCA1-A complex member 1	K20776 BABAM; BRISC and BRCA1-A complex member 1 
E        102948018 BABAM2; BRISC and BRCA1-A complex member 2 isoform X4	K12173 BRE; BRCA1-A complex subunit BRE 
E        102945937 BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X2	K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-] 
D      BRCA1-B complex
E        102936790 BRCA1; breast cancer type 1 susceptibility protein isoform X1	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        102930925 BRIP1; Fanconi anemia group J protein isoform X4	K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3] 
E        102942321 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X2	K10728 TOPBP1; topoisomerase (DNA) II binding protein 1 
D      BRCA1-C complex
E        102936790 BRCA1; breast cancer type 1 susceptibility protein isoform X1	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        102934829 RBBP8; DNA endonuclease RBBP8 isoform X1	K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-] 
E        102946855 MRE11; double-strand break repair protein MRE11 isoform X1	K10865 MRE11; double-strand break repair protein MRE11 
E        102935242 RAD50; DNA repair protein RAD50	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
E        102939912 NBN; nibrin isoform X1	K10867 NBN; nibrin 
D      BRCA complex
E        102936790 BRCA1; breast cancer type 1 susceptibility protein isoform X1	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        102945068 BRCA2; breast cancer type 2 susceptibility protein isoform X1	K08775 BRCA2; breast cancer 2 susceptibility protein 
E        102930706 PALB2; partner and localizer of BRCA2 isoform X1	K10897 PALB2; partner and localizer of BRCA2 
E        102945447 RAD51; DNA repair protein RAD51 homolog 1	K04482 RAD51; DNA repair protein RAD51 
D      RecA family proteins
E        102945447 RAD51; DNA repair protein RAD51 homolog 1	K04482 RAD51; DNA repair protein RAD51 
E        102933697 RAD51B; DNA repair protein RAD51 homolog 2 isoform X1	K10869 RAD51L1; RAD51-like protein 1 
E        102931827 RAD51C; DNA repair protein RAD51 homolog 3 isoform X1	K10870 RAD51L2; RAD51-like protein 2 
E        102932008 RAD51D; DNA repair protein RAD51 homolog 4 isoform X1	K10871 RAD51L3; RAD51-like protein 3 
E        102948120 XRCC2; DNA repair protein XRCC2	K10879 XRCC2; DNA-repair protein XRCC2 
E        102944528 XRCC3; DNA repair protein XRCC3 isoform X1	K10880 XRCC3; DNA-repair protein XRCC3 
D      Rad52 family proteins
E        102938801 RAD52; DNA repair protein RAD52 homolog isoform X5	K10873 RAD52; DNA repair and recombination protein RAD52 
E        114021590 RDM1; RAD52 motif-containing protein 1 isoform X1	K10874 RDM1; RAD52 motif-containing protein 1 
D      Rad54 family proteins
E        102931351 RAD54L; DNA repair and recombination protein RAD54-like isoform X1	K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-] 
E        102939579 RAD54L2; helicase ARIP4 isoform X1	K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-] 
E        102937083 RAD54B; DNA repair and recombination protein RAD54B	K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-] 
D      RecQ family DNA helicases
E        102943312 RECQL; ATP-dependent DNA helicase Q1	K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4] 
E        102948137 WRN; Werner syndrome ATP-dependent helicase isoform X2	K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4] 
E        102932365 BLM; Bloom syndrome protein isoform X1	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        102944897 RECQL4; ATP-dependent DNA helicase Q4 isoform X2	K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4] 
E        102943970 RECQL5; ATP-dependent DNA helicase Q5 isoform X1	K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4] 
D      Bloom's syndrome complex (BTR)
E        102932365 BLM; Bloom syndrome protein isoform X1	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        102941994 TOP3B; DNA topoisomerase 3-beta-1 isoform X1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        102942962 TOP3A; DNA topoisomerase 3-alpha isoform X1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        102937365 RMI1; recQ-mediated genome instability protein 1 isoform X1	K10990 RMI1; RecQ-mediated genome instability protein 1 
E        119567168 RMI2; recQ-mediated genome instability protein 2	K15365 RMI2; RecQ-mediated genome instability protein 2 
D      RPA (replication factor A)
E        102942378 RPA1; replication protein A 70 kDa DNA-binding subunit	K07466 RFA1; replication factor A1 
E        102932984 RPA2; replication protein A 32 kDa subunit isoform X1	K10739 RFA2; replication factor A2 
E        102947531 RPA3; replication protein A 14 kDa subunit	K10740 RPA3; replication factor A3 
D      Protein phosphatase 4
E        114022379 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit	K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16] 
E        102942976 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1	K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 
E        102934476 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X2	K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 
E        102942102 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X2	K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 
E        102946272 PPP4R3B; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X2	K17491 SMEK; protein phosphatase 4 regulatory subunit 3 
E        102930478 PPP4R3A; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1	K17491 SMEK; protein phosphatase 4 regulatory subunit 3 
E        102932222 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1	K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 
D      AP-5 complex
E        102946390 AP5B1; AP-5 complex subunit beta-1	K19022 AP5B1; AP-5 complex subunit beta-1 
E        102935701 AP5M1; AP-5 complex subunit mu-1 isoform X1	K19023 AP5M1; AP-5 complex subunit mu-1 
E        102929863 AP5S1; AP-5 complex subunit sigma-1 isoform X1	K19024 AP5S1; AP-5 complex subunit sigma-1 
E        102943943 AP5Z1; AP-5 complex subunit zeta-1 isoform X1	K19025 AP5Z1; AP-5 complex subunit zeta-1 
D      SMC5-SMC6 complex
E        102945122 SMC5; structural maintenance of chromosomes protein 5 isoform X1	K22803 SMC5; structural maintenance of chromosomes protein 5 
E        102946512 SMC6; structural maintenance of chromosomes protein 6 isoform X2	K22804 SMC6; structural maintenance of chromosomes protein 6 
E        102948022 LRATD1; protein LRATD1	K22805 FAM84A; protein FAM84A 
E        102946788 NSMCE1; non-structural maintenance of chromosomes element 1 homolog isoform X1	K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27] 
E        102942367 NSMCE2; E3 SUMO-protein ligase NSE2	K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-] 
E        102932998 non-structural maintenance of chromosomes element 3 homolog	K22823 NSMCE3; non-structural maintenance of chromosomes element 3 
E        102942038 non-structural maintenance of chromosomes element 3 homolog	K22823 NSMCE3; non-structural maintenance of chromosomes element 3 
E        102938114 NSMCE4A; non-structural maintenance of chromosomes element 4 homolog A	K22825 NSMCE4; non-structural maintenance of chromosomes element 4 
E        102947205 SLF1; SMC5-SMC6 complex localization factor protein 1 isoform X2	K26126 SLF1; SMC5-SMC6 complex localization factor protein 1 
E        102938565 SLF2; SMC5-SMC6 complex localization factor protein 2 isoform X1	K26127 SLF2; SMC5-SMC6 complex localization factor protein 2 
D      Other HR factors
E        102936250 EME1; crossover junction endonuclease EME1 isoform X2	K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-] 
E        102931960 EXD2; exonuclease 3'-5' domain-containing protein 2 isoform X1	K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1] 
E        102948254 MUS81; crossover junction endonuclease MUS81 isoform X1	K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-] 
E        114019971 SEM1; 26S proteasome complex subunit SEM1	K10881 SHFM1; 26 proteasome complex subunit DSS1 
E        102934912 SWI5; DNA repair protein SWI5 homolog	K10991 SWI5; DNA repair protein Swi5/Sae3 
E        102944287 SFR1; swi5-dependent recombination DNA repair protein 1 homolog	K10992 SFR1; Swi5-dependent recombination DNA repair protein 1 
E        119566292 SLX1A; structure-specific endonuclease subunit SLX1 isoform X2	K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-] 
E        102941971 SLX4; structure-specific endonuclease subunit SLX4 isoform X1	K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) 
E        102946286 GEN1; flap endonuclease GEN homolog 1 isoform X1	K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-] 
E        102931301 SPG11; spatacsin isoform X1	K19026 SPG11; spatacsin 
E        102948028 ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X9	K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26 
E        102936868 RAD51AP1; RAD51-associated protein 1 isoform X1	K20778 RAD51AP1; RAD51-associated protein 1 
E        102930857 MORF4L1; mortality factor 4-like protein 1 isoform X1	K11339 MORF4L1; mortality factor 4-like protein 1 
E        102929297 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1	K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-] 
E        102932815 FIGNL1; fidgetin-like protein 1	K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-] 
E        102932646 SPIDR; DNA repair-scaffolding protein isoform X2	K22806 SPIDR; DNA repair-scaffolding protein 
E        102941925 LRATD2; protein LRATD2 isoform X1	K22810 FAM84B; protein FAM84B 
E        102931627 BRAT1; BRCA1-associated ATM activator 1 isoform X1	K23112 BRAT1; BRCA1-associated ATM activator 1 
E        102947060 CFAP410; cilia- and flagella-associated protein 410	K23456 CFAP410; cilla- and flagella-associated protein 
E        102939619 HDGFL2; hepatoma-derived growth factor-related protein 2	K25065 HDGFL2; hepatoma-derived growth factor-related protein 2 
E        102936570 ZSWIM7; zinc finger SWIM domain-containing protein 7 isoform X10	K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7 
E        102940655 SWSAP1; ATPase SWSAP1	K25771 SWSAP1; ATPase SWSAP1 
E        102929905 EMSY; BRCA2-interacting transcriptional repressor EMSY isoform X2	K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY 
E        102933736 heat shock factor 2-binding protein isoform X1	K25791 HSF2BP; heat shock factor 2-binding protein 
E        102945148 MMS22L; protein MMS22-like isoform X2	K26125 MMS22L; protein MMS22-like 
E        102939471 TONSL; tonsoku-like protein isoform X1	K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2 
E        102932276 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 isoform X1	K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 
E        102932484 PCNA-interacting partner isoform X1	K27412 PARPBP; PCNA-interacting partner 
C    NHEJ (non-homologous end-joining)
D      DNA-PK complex
E        102946603 XRCC6; X-ray repair cross-complementing protein 6 isoform X1	K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1 
E        102939818 XRCC5; X-ray repair cross-complementing protein 5 isoform X1	K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2 
E        102937565 PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1	K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1] 
D      MRX complex
E        102946855 MRE11; double-strand break repair protein MRE11 isoform X1	K10865 MRE11; double-strand break repair protein MRE11 
E        102935242 RAD50; DNA repair protein RAD50	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
D      DNA Ligase 4 complex
E        102931065 LIG4; DNA ligase 4	K10777 LIG4; DNA ligase 4 [EC:6.5.1.1] 
E        102942856 XRCC4; DNA repair protein XRCC4 isoform X3	K10886 XRCC4; DNA-repair protein XRCC4 
E        102938626 NHEJ1; non-homologous end-joining factor 1	K10980 NHEJ1; non-homologous end-joining factor 1 
D      X-family DNA polymerases
E        102947270 POLL; DNA polymerase lambda isoform X1	K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-] 
E        102930239 POLM; DNA-directed DNA/RNA polymerase mu isoform X3	K03513 POLM; DNA polymerase mu [EC:2.7.7.7] 
E        102947062 DNTT; DNA nucleotidylexotransferase	K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31] 
E        102931250 POLB; DNA polymerase beta isoform X2	K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-] 
D      Other NHEJ factors
E        102939347 APTX; aprataxin isoform X1	K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72] 
E        102941193 APLF; aprataxin and PNK-like factor isoform X1	K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-] 
E        102937269 DCLRE1C; protein artemis isoform X1	K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-] 
E        102931611 TDP2; tyrosyl-DNA phosphodiesterase 2 isoform X1	K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-] 
E        102940396 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X2	K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 
E        102942052 PWWP3A; PWWP domain-containing DNA repair factor 3A isoform X1	K23386 PWWP3; PWWP domain-containing DNA repair factor 3 
E        102945515 PAXX; protein PAXX isoform X2	K25772 PAXX; protein PAXX 
E        102930803 CYREN; cell cycle regulator of non-homologous end joining isoform X2	K26155 CYREN; cell cycle regulator of non-homologous end joining 
E        102942808 JMJD8; jmjC domain-containing protein 8 isoform X2	K25792 JMJD8; jumonji domain-containing protein 8 
E        114021525 SHLD1; shieldin complex subunit 1 isoform X1	K26128 SHLD1; shieldin complex subunit 1 
E        102939757 SHLD2; shieldin complex subunit 2 isoform X2	K26129 SHLD2; shieldin complex subunit 2 
E        114019325 SHLD3; shieldin complex subunit 3	K26130 SHLD3; shieldin complex subunit 3 
C    FA (Fanconi anemia) pathway
D      FA core complex
E        102930981 FANCA; Fanconi anemia group A protein isoform X3	K10888 FANCA; fanconi anemia group A protein 
E        102945822 FANCB; Fanconi anemia group B protein isoform X1	K10889 FANCB; fanconi anemia group B protein 
E        102933703 FANCC; Fanconi anemia group C protein isoform X2	K10890 FANCC; fanconi anemia group C protein 
E        102943209 FANCE; Fanconi anemia group E protein isoform X2	K10892 FANCE; fanconi anemia group E protein 
E        119566412 FANCF; Fanconi anemia group F protein	K10893 FANCF; fanconi anemia group F protein 
E        102945249 FANCG; LOW QUALITY PROTEIN: Fanconi anemia group G protein	K10894 FANCG; fanconi anemia group G protein 
E        102934818 FANCL; E3 ubiquitin-protein ligase FANCL isoform X1	K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27] 
E        102940185 FANCM; Fanconi anemia group M protein isoform X2	K10896 FANCM; fanconi anemia group M protein 
E        102939283 FAAP24; Fanconi anemia core complex-associated protein 24 isoform X2	K10898 FAAP24; fanconi anemia-associated protein 
E        102930170 FAAP100; Fanconi anemia core complex-associated protein 100 isoform X1	K10993 FAAP100; fanconi anemia core complex 100 kDa subunit 
D      FA core complex binding factors
E        102942708 HES4; transcription factor HES-4 isoform X2	K06054 HES1; hairy and enhancer of split 1 
E        102940045 HES1; transcription factor HES-1	K06054 HES1; hairy and enhancer of split 1 
E        102936475 CENPS; centromere protein S isoform X1	K11511 APITD1; centromere protein S 
E        102938413 CENPX; centromere protein X isoform X2	K15360 STRA13; centromere protein X 
E        102945156 UBE2T; ubiquitin-conjugating enzyme E2 T	K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23] 
D      Bloom's syndrome complex (BTR)
E        102932365 BLM; Bloom syndrome protein isoform X1	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        102941994 TOP3B; DNA topoisomerase 3-beta-1 isoform X1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        102942962 TOP3A; DNA topoisomerase 3-alpha isoform X1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        102937365 RMI1; recQ-mediated genome instability protein 1 isoform X1	K10990 RMI1; RecQ-mediated genome instability protein 1 
E        119567168 RMI2; recQ-mediated genome instability protein 2	K15365 RMI2; RecQ-mediated genome instability protein 2 
D      FANCD2-I complex
E        102941496 FANCD2; Fanconi anemia group D2 protein isoform X1	K10891 FANCD2; fanconi anemia group D2 protein 
E        102937800 FANCI; Fanconi anemia group I protein isoform X1	K10895 FANCI; fanconi anemia group I protein 
D      Downstream FA components
E        102936790 BRCA1; breast cancer type 1 susceptibility protein isoform X1	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        102945068 BRCA2; breast cancer type 2 susceptibility protein isoform X1	K08775 BRCA2; breast cancer 2 susceptibility protein 
E        102930925 BRIP1; Fanconi anemia group J protein isoform X4	K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3] 
E        102930706 PALB2; partner and localizer of BRCA2 isoform X1	K10897 PALB2; partner and localizer of BRCA2 
D      Other FA pathway factors
E        102944718 FAN1; fanconi-associated nuclease 1 isoform X1	K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1] 
E        102945447 RAD51; DNA repair protein RAD51 homolog 1	K04482 RAD51; DNA repair protein RAD51 
E        102931827 RAD51C; DNA repair protein RAD51 homolog 3 isoform X1	K10870 RAD51L2; RAD51-like protein 2 
E        102941469 TELO2; telomere length regulation protein TEL2 homolog isoform X2	K11137 TELO2; telomere length regulation protein 
E        102935301 USP1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1	K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12] 
E        102931978 WDR48; WD repeat-containing protein 48	K15361 WDR48; WD repeat-containing protein 48 
C    Other DSBR factors
D      Protein phosphatase 6
E        102941330 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit	K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16] 
E        102940139 PPP6R1; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 6 regulatory subunit 1	K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1 
E        102947775 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1	K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 
E        102944592 PPP6R3; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 6 regulatory subunit 3	K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 
E        102946151 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1	K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A 
E        102935647 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1	K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B 
E        102946117 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C isoform X1	K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C 
D      Ubiquitin ligases
E        119565823 RNF8; E3 ubiquitin-protein ligase RNF8 isoform X2	K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27] 
E        102931334 RNF168; E3 ubiquitin-protein ligase RNF168 isoform X4	K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31] 
E        102934874 RNF169; E3 ubiquitin-protein ligase RNF169	K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31] 
E        102934857 HERC2; E3 ubiquitin-protein ligase HERC2 isoform X4	K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26] 
D      Others
E        102942119 WRAP53; telomerase Cajal body protein 1 isoform X1	K23314 WRAP53; telomerase Cajal body protein 1 
E        102947622 TPRN; taperin isoform X1	K24164 TPRN; taperin 
E        102937315 ZCWPW1; zinc finger CW-type PWWP domain protein 1 isoform X1	K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1 
E        102946648 WDR70; WD repeat-containing protein 70 isoform X1	K24752 WDR70; WD repeat-containing protein 70 
E        102932134 WDR76; WD repeat-containing protein 76 isoform X1	K24755 WDR76; WD repeat-containing protein 76 
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
D      102938806 POLH; DNA polymerase eta isoform X1	K03509 POLH; DNA polymerase eta [EC:2.7.7.7] 
D      102939840 POLI; DNA polymerase iota isoform X3	K03510 POLI; DNA polymerase iota [EC:2.7.7.7] 
D      102929336 POLK; DNA polymerase kappa isoform X1	K03511 POLK; DNA polymerase kappa [EC:2.7.7.7] 
D      102940474 REV1; DNA repair protein REV1 isoform X9	K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-] 
C    B-family DNA polymerases
D      102946083 REV3L; LOW QUALITY PROTEIN: DNA polymerase zeta catalytic subunit	K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7] 
C    A-family DNA polymerase
D      102942952 POLN; DNA polymerase nu	K16618 POLN; DNA polymerase nu [EC:2.7.7.7] 
C    Rad6 epistasis group
D      102936356 UBE2A; ubiquitin-conjugating enzyme E2 A	K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23] 
D      102935725 UBE2B; ubiquitin-conjugating enzyme E2 B isoform X1	K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23] 
D      102941266 RAD18; E3 ubiquitin-protein ligase RAD18 isoform X1	K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27] 
D      102929384 HLTF; helicase-like transcription factor isoform X3	K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27] 
D      102930343 UBE2V1; ubiquitin-conjugating enzyme E2 variant 1 isoform X1	K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant 
D      102932425 UBE2V2; ubiquitin-conjugating enzyme E2 variant 2 isoform X2	K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant 
D      102945983 UBE2N; ubiquitin-conjugating enzyme E2 N	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
C    Other TLS factors
D      102945568 PCNA; proliferating cell nuclear antigen	K04802 PCNA; proliferating cell nuclear antigen 
D      102932484 PCNA-interacting partner isoform X1	K27412 PARPBP; PCNA-interacting partner 
D      102944837 SPRTN; DNA-dependent metalloprotease SPRTN	K24051 SPRTN; SprT-like domain-contaning protein Spartan 
D      114021153 GCNA; acidic repeat-containing protein isoform X5	K26957 GCNA; germ cell nuclear acidic protein 
B  Check point factors
C    Rad9-Hus1-Rad1 complex
D      102931278 RAD9A; cell cycle checkpoint control protein RAD9A isoform X3	K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2] 
D      102932958 RAD9B; cell cycle checkpoint control protein RAD9B	K10995 RAD9B; cell cycle checkpoint control protein RAD9B 
D      102935757 HUS1; checkpoint protein HUS1 isoform X1	K10903 HUS1; HUS1 checkpoint protein 
D      102932976 RAD1; cell cycle checkpoint protein RAD1	K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] 
C    HRAD17(Rad24)-RFC complex
D      102940659 RAD17; cell cycle checkpoint protein RAD17 isoform X1	K06662 HRAD17; cell cycle checkpoint protein 
D      102931649 RFC4; replication factor C subunit 4 isoform X1	K10755 RFC2_4; replication factor C subunit 2/4 
D      102947568 RFC2; replication factor C subunit 2	K10755 RFC2_4; replication factor C subunit 2/4 
D      102943745 RFC3; replication factor C subunit 3	K10756 RFC3_5; replication factor C subunit 3/5 
D      102942277 RFC5; replication factor C subunit 5 isoform X1	K10756 RFC3_5; replication factor C subunit 3/5 
C    Rad17-Mec3-Ddc1 complex
D      102932976 RAD1; cell cycle checkpoint protein RAD1	K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] 
C    FPC (fork protection complex)
D      102932604 TIMELESS; protein timeless homolog isoform X1	K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1 
D      102945324 TIPIN; TIMELESS-interacting protein isoform X2	K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3 
D      102933261 CLSPN; claspin isoform X3	K25773 CLSPN; claspin 
C    Triple T complex
D      102941469 TELO2; telomere length regulation protein TEL2 homolog isoform X2	K11137 TELO2; telomere length regulation protein 
D      102930972 TTI1; TELO2-interacting protein 1 homolog isoform X1	K20403 TTI1; TELO2-interacting protein 1 
D      102933974 TTI2; TELO2-interacting protein 2	K23115 TTI2; TELO2-interacting protein 2 
C    BAG6-UBL4A-GET4 complex
D      102936549 UBL4A; ubiquitin-like protein 4A	K23388 UBL4; ubiquitin-like protein 4 
D      102942288 ubiquitin-like protein 4A	K23388 UBL4; ubiquitin-like protein 4 
D      102936062 GET4; Golgi to ER traffic protein 4 homolog	K23387 GET4; golgi to ER traffic protein 4 
C    Other check point factors
D      102936864 ATR; serine/threonine-protein kinase ATR isoform X1	K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1] 
D      102944948 ATR-interacting protein isoform X3	K10905 ATRIP; ATR interacting protein 
D      102933488 ATM; serine-protein kinase ATM isoform X1	K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1] 
D      102934531 TP53; cellular tumor antigen p53	K04451 TP53; tumor protein p53 
D      102945662 CHEK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk1	K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1] 
D      102947582 CHEK2; serine/threonine-protein kinase Chk2 isoform X1	K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1] 
D      102931776 CDC25A; M-phase inducer phosphatase 1 isoform X1	K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48] 
D      102929649 CDC25B; M-phase inducer phosphatase 2	K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48] 
D      102945797 CDC25C; M-phase inducer phosphatase 3 isoform X1	K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48] 
D      102930030 YWHAQ; 14-3-3 protein theta	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      102932246 YWHAZ; 14-3-3 protein zeta/delta isoform X2	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      102929790 YWHAB; 14-3-3 protein beta/alpha	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      102944773 YWHAG; 14-3-3 protein gamma isoform X1	K16198 YWHAG_H; 14-3-3 protein gamma/eta 
D      102930640 YWHAH; 14-3-3 protein eta	K16198 YWHAG_H; 14-3-3 protein gamma/eta 
D      102944738 YWHAE; 14-3-3 protein epsilon isoform X1	K06630 YWHAE; 14-3-3 protein epsilon 
D      102946261 NAV2; neuron navigator 2 isoform X2	K19483 NAV2; neuron navigator 2 [EC:5.6.2.4] 
D      102943465 WEE2; wee1-like protein kinase 2 isoform X1	K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1] 
D      102942149 WEE1; wee1-like protein kinase isoform X1	K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1] 
D      119564639 PER1; LOW QUALITY PROTEIN: period circadian protein homolog 1	K21944 PER1; period circadian protein 1 
D      102936723 PER2; period circadian protein homolog 2 isoform X1	K02633 PER2; period circadian protein 2 
D      102929509 MDC1; mediator of DNA damage checkpoint protein 1 isoform X1	K20780 MDC1; mediator of DNA damage checkpoint protein 1 
D      102942144 PLS3; plastin-3 isoform X2	K17336 PLS3; plastin-3 
D      102938691 AEN; apoptosis-enhancing nuclease isoform X1	K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-] 
D      102930864 PLK3; serine/threonine-protein kinase PLK3	K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21] 
D      102946145 PLK5; inactive serine/threonine-protein kinase PLK5 isoform X1	K19596 PLK5; inactive serine/threonine-protein kinase PLK5 
D      102947290 NEK4; serine/threonine-protein kinase Nek4 isoform X3	K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] 
D      102942101 NEK1; serine/threonine-protein kinase Nek1 isoform X2	K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] 
D      102937442 NEK5; serine/threonine-protein kinase Nek5	K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] 
D      102948387 NEK10; serine/threonine-protein kinase Nek10 isoform X1	K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1] 
D      102947164 NEK11; serine/threonine-protein kinase Nek11 isoform X1	K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1] 
D      102930360 DONSON; protein downstream neighbor of Son isoform X1	K22422 DONSON; protein downstream neighbor of Son 
D      102935524 KANK4; KN motif and ankyrin repeat domain-containing protein 4	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      102937567 KANK3; KN motif and ankyrin repeat domain-containing protein 3 isoform X2	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      102947692 KANK1; KN motif and ankyrin repeat domain-containing protein 1 isoform X1	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      114020988 KANK2; LOW QUALITY PROTEIN: KN motif and ankyrin repeat domain-containing protein 2	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      102931585 CHMP4C; charged multivesicular body protein 4c	K24782 CHMP4C; charged multivesicular body protein 4C 
D      102947817 VPS4B; vacuolar protein sorting-associated protein 4B	K12196 VPS4; vacuolar protein-sorting-associated protein 4 
D      102934928 VPS4A; vacuolar protein sorting-associated protein 4A isoform X4	K12196 VPS4; vacuolar protein-sorting-associated protein 4 
D      102932351 ZFYVE19; abscission/NoCut checkpoint regulator isoform X1	K24778 ZFYVE19; abscission/NoCut checkpoint regulator 
D      102933758 SDE2; replication stress response regulator SDE2	K25059 SDE2; replication stress response regulator SDE2 
B  Other factors with a suspected DNA repair function
C    DNA polymerases
D      102942973 POLQ; DNA polymerase theta isoform X1	K02349 POLQ; DNA polymerase theta [EC:2.7.7.7] 
D      102937476 MYBBP1A; myb-binding protein 1A	K02331 POL5; DNA polymerase phi [EC:2.7.7.7] 
D      102941842 PRIMPOL; DNA-directed primase/polymerase protein isoform X1	K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7] 
C    Nucleases
D      102942578 TREX2; three prime repair exonuclease 2 isoform X1	K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2] 
D      102931290 DCLRE1A; DNA cross-link repair 1A protein	K15340 DCLRE1A; DNA cross-link repair 1A protein 
D      102931680 DCLRE1B; 5' exonuclease Apollo isoform X1	K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-] 
D      102941917 EXO5; exonuclease V	K17815 EXO5; exonuclease V [EC:3.1.-.-] 
D      102944730 ENDOV; endonuclease V isoform X1	K21813 ENDOV; endonuclease V [EC:3.1.26.-] 
D      102945182 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X3	K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-] 
D      102943242 ANKLE1; ankyrin repeat and LEM domain-containing protein 1 isoform X1	K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1 
C    Helicases
D      102943576 HELQ; helicase POLQ-like isoform X1	K19178 HELQ; POLQ-like helicase [EC:5.6.2.4] 
D      102933477 ERCC6L2; DNA excision repair protein ERCC-6-like 2 isoform X4	K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-] 
C    PSO4 complex
D      102937236 PRPF19; pre-mRNA-processing factor 19 isoform X1	K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27] 
D      102945187 CDC5L; cell division cycle 5-like protein	K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1 
D      102938251 BCAS2; pre-mRNA-splicing factor SPF27	K12861 BCAS2; pre-mRNA-splicing factor SPF27 
D      102936921 PLRG1; pleiotropic regulator 1 isoform X1	K12862 PLRG1; pleiotropic regulator 1 
C    Modulation of nucleotide pools
D      102937375 NUDT15; nucleotide triphosphate diphosphatase NUDT15	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      102932983 NUDT1; 7,8-dihydro-8-oxoguanine triphosphatase	K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56] 
D      102935770 NUDT18; 8-oxo-dGDP phosphatase NUDT18 isoform X1	K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58] 
D      102947328 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
D      102936455 RRM1; ribonucleoside-diphosphate reductase large subunit	K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] 
D      102929591 RRM2; ribonucleoside-diphosphate reductase subunit M2	K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] 
D      102938774 RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1	K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] 
#
A<b>Prokaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      102941237 MGMT; methylated-DNA--protein-cysteine methyltransferase isoform X1	K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 
D      102937787 deoxyribodipyrimidine photo-lyase	K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] 
C    BER (base exicision repair)
D      DNA glycosylases
E        102935891 UNG; uracil-DNA glycosylase	K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] 
E        102945286 SMUG1; single-strand selective monofunctional uracil DNA glycosylase isoform X1	K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-] 
E        102946047 MPG; DNA-3-methyladenine glycosylase	K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] 
E        102935984 MUTYH; adenine DNA glycosylase isoform X1	K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] 
E        102946228 NTHL1; endonuclease III-like protein 1	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
D      RecJ
D      DNA ligase
D      DNA polymerase I
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase complex (RNAP)
E        TRCF (transcription-repair coupling factor)
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
D      Molecular matchmaker
D      Strand discrimination factor
D      DNA exonucleases
D      DNA polymerase III holoenzyme
D      DNA ligase
D      Other MMR factors
E        102939695 SSBP1; single-stranded DNA-binding protein, mitochondrial	K03111 ssb; single-strand DNA-binding protein 
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      RecBC pathway proteins
D      RecFOR pathway proteins
D      AddAB pathway proteins
D      Other HR factor
D      Archaeal homologous recombinant proteins
C    NHEJ (non-homologous end-joining)
D      Two-component NHEJ DNA repair complex
D      SHIIR (short-homology-independent illegitimate recombination)
E        Facilitator
E        Supressor
D      SHDIR (short-homology-dependent illegitimate recombination)
E        RecET pathway
E        Facilitator
E        Supressor
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
C    Other SOS response factors
D      102939695 SSBP1; single-stranded DNA-binding protein, mitochondrial	K03111 ssb; single-strand DNA-binding protein 
B  Other factors with a suspected DNA repair function
C    DNA polymerase
C    DNA helicases
C    Modulation of nucleotide pools
D      102937375 NUDT15; nucleotide triphosphate diphosphatase NUDT15	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      102947328 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
C    Others
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#Last updated: March 29, 2024