+F Repair protein KO
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DNA Repair and Recombination Proteins - Escherichia coli JJ1886
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D P423_07830 O-6-alkylguanine-DNA:cysteine-protein methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D P423_03460 deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E P423_14105 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E P423_16250 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E P423_08735 endonuclease IV K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D P423_00510 nucleoside triphosphate pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D P423_20215 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D P423_07830 O-6-alkylguanine-DNA:cysteine-protein methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D P423_12415 transcriptional regulator K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D P423_03460 deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D P423_12410 alpha-ketoglutarate-dependent dioxygenase K03919 alkB; DNA oxidative demethylase [EC:1.14.11.33]
C BER (base exicision repair)
D DNA glycosylases
E P423_14105 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E P423_17335 DNA glycosylase K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E P423_11720 3-methyl-adenine DNA glycosylase K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E P423_16250 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E P423_19760 DNA-3-methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E P423_20185 5-hydroxymethyluracil DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E P423_03490 endoribonuclease SymE K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E P423_08735 endonuclease IV K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E P423_09315 exonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E P423_12145 endonuclease V K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E P423_22160 endonuclease VIII K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7]
D RecJ
E P423_15875 ssDNA exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E P423_13380 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E P423_20245 ligB; NAD-dependent DNA ligase LigB K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E P423_21455 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E P423_22575 excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E P423_03855 excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
E P423_10420 uvrC; excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E P423_09270 nucleotide excision repair endonuclease K05984 cho; excinuclease Cho [EC:3.1.25.-]
E P423_21105 uvrD; DNA-dependent helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E P423_26155 helicase UvrD K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E P423_21455 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E P423_13380 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E P423_20245 ligB; NAD-dependent DNA ligase LigB K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F P423_22105 rpoB; DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F P423_22110 DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F P423_18445 DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F P423_20255 rpoZ; DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F P423_05985 transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E P423_14975 DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E P423_23225 DNA mismatch repair protein K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
E P423_15655 DNA mismatch repair protein K03573 mutH; DNA mismatch repair protein MutH
D DNA exonucleases
E P423_11440 sbcB; exonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E P423_13760 xseA; exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E P423_02145 exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
E P423_09780 exodeoxyribonuclease X K10857 exoX; exodeoxyribonuclease X [EC:3.1.11.-]
D DNA polymerase III holoenzyme
E P423_00980 dnaE; DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E P423_20550 DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E P423_23710 DNA polymerase III subunit chi K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E P423_03140 holA; DNA polymerase III subunit delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E P423_05910 DNA polymerase III subunit delta' K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E P423_01145 DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E P423_02390 DNA polymerase III subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E P423_24830 DNA polymerase III subunit psi K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
E P423_09770 DNA polymerase III subunit theta K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7]
D DNA ligase
E P423_13380 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E P423_20245 ligB; NAD-dependent DNA ligase LigB K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E P423_21105 uvrD; DNA-dependent helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E P423_26155 helicase UvrD K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E P423_25685 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E P423_22580 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E P423_25355 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E P423_14565 DNA methyltransferase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E P423_04965 DNA methyltransferase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E P423_18880 DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E P423_10650 very short patch repair endonuclease K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E P423_15600 recB; exonuclease V subunit beta K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E P423_15610 recC; exonuclease V subunit gamma K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E P423_15595 recD; exonuclease V subunit alpha K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E P423_14780 recA; recombinase RecA K03553 recA; recombination protein RecA
E P423_09890 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E P423_09885 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E P423_09900 ruvC; Holliday junction resolvase K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E P423_10915 endodeoxyribonuclease K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E P423_07185 endodeoxyribonuclease K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E P423_14485 crossover junction endodeoxyribonuclease K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E P423_06220 crossover junction endodeoxyribonuclease RusA K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E P423_21820 primosome assembly protein PriA K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E P423_23385 primosomal replication protein N K02686 priB; primosomal replication protein N
E P423_02375 primosomal replication protein N'' K04067 priC; primosomal replication protein N''
E P423_24775 primosomal protein DnaI K02317 dnaT; DNA replication protein DnaT
E P423_11440 sbcB; exonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E P423_02020 exonuclease subunit SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E P423_02025 exonuclease subunit SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E P423_14780 recA; recombinase RecA K03553 recA; recombination protein RecA
E P423_24925 DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E P423_20545 recF; recombinase F K03629 recF; DNA replication and repair protein RecF
E P423_20270 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E P423_15875 ssDNA exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E P423_14030 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E P423_02400 recR; recombinase RecR K06187 recR; recombination protein RecR
E P423_14280 recombinase K03631 recN; DNA repair protein RecN (Recombination protein N)
E P423_02005 rdgC; recombinase K03554 rdgC; recombination associated protein RdgC
E P423_09890 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E P423_09885 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E P423_09900 ruvC; Holliday junction resolvase K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E P423_12275 hypothetical protein K19789 radD; DNA repair protein RadD
D Archaeal homologous recombinant proteins
E P423_02020 exonuclease subunit SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E P423_02025 exonuclease subunit SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
E P423_23730 hypothetical protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F P423_12500 DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F P423_20540 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F P423_07520 topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F P423_22170 transcriptional regulator K05787 hupA; DNA-binding protein HU-alpha
F P423_02240 transcriptional regulator K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F P423_15875 ssDNA exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F P423_14030 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F P423_02400 recR; recombinase RecR K06187 recR; recombination protein RecR
F P423_13380 ligA; NAD-dependent DNA ligase LigA K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
F P423_20245 ligB; NAD-dependent DNA ligase LigB K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F P423_18275 fis; Fis family transcriptional regulator K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F P423_09130 ihfA; integration host factor subunit alpha K04764 ihfA; integration host factor subunit alpha
F P423_05070 ihfB; integration host factor subunit beta K05788 ihfB; integration host factor subunit beta
E Supressor
F P423_11440 sbcB; exonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F P423_19140 ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F P423_21155 ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F P423_22575 excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F P423_03855 excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
F P423_06995 DNA-binding protein K03746 hns; DNA-binding protein H-NS
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D P423_01420 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D P423_06530 DNA polymerase V subunit UmuC K03502 umuC; DNA polymerase V
D P423_06525 DNA polymerase V subunit UmuD K03503 umuD; DNA polymerase V [EC:3.4.21.-]
C Other SOS response factors
D P423_14780 recA; recombinase RecA K03553 recA; recombination protein RecA
D P423_22430 LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D P423_14490 LexA family transcriptional regulator K01356 lexA; repressor LexA [EC:3.4.21.88]
D P423_14280 recombinase K03631 recN; DNA repair protein RecN (Recombination protein N)
D P423_00300 DNA polymerase II K02336 polB; DNA polymerase II [EC:2.7.7.7]
D P423_25685 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D P423_22580 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D P423_25355 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D P423_05720 DNA damage-inducible protein I K12149 dinI; DNA-damage-inducible protein I
D P423_14775 recX; recombination protein RecX K03565 recX; regulatory protein
D P423_00705 hypothetical protein K24088 rpnC; recombination-promoting nuclease RpnC [EC:3.1.21.-]
D P423_24670 transposase K24089 rpnD; recombination-promoting nuclease RpnD [EC:3.1.21.-]
D P423_12565 hypothetical protein K24090 rpnE; recombination-promoting nuclease RpnE
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D P423_20910 ATP-dependent DNA helicase Rep K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D P423_05290 helD; DNA helicase IV K03658 helD; DNA helicase IV [EC:5.6.2.4]
D P423_03965 dinG; ATP-dependent DNA helicase DinG K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D P423_09590 ATP-dependent helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D P423_00510 nucleoside triphosphate pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D P423_20215 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D P423_12515 ribonucleotide-diphosphate reductase subunit alpha K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D P423_14650 ribonucleotide-diphosphate reductase subunit alpha K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D P423_12520 ribonucleotide-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D P423_14655 ribonucleotide-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024