+D Chaperone KO
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Chaperones and Folding Catalysts - Hydra vulgaris (swiftwater hydra)
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AHeat shock proteins
B HSP110
C 100202835 97 kDa heat shock protein K09485 HSP110; heat shock protein 110kDa
C 100206170 hypoxia up-regulated protein 1 K09486 HYOU1; hypoxia up-regulated 1
B HSP100
C 100202985 caseinolytic peptidase B protein homolog isoform X1 K03695 clpB; ATP-dependent Clp protease ATP-binding subunit ClpB
C 100199421 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1 K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX
B HSP90
C 100199389 heat shock protein HSP 90-alpha K04079 HSP90A; molecular chaperone HtpG
C 101235897 heat shock protein HSP 90-alpha K04079 HSP90A; molecular chaperone HtpG
C 100215003 endoplasmin K09487 HSP90B; heat shock protein 90kDa beta
C 100199347 heat shock protein 75 kDa, mitochondrial K09488 TRAP1; TNF receptor-associated protein 1
B HSP70 / DNAK
C 100203304 heat shock 70 kDa protein K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C 100202286 heat shock 70 kDa protein-like K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C 105844776 heat shock 70 kDa protein-like K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C 124807918 heat shock 70 kDa protein-like K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C 124807919 heat shock 70 kDa protein-like K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C 124807971 heat shock 70 kDa protein-like K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C 124807972 heat shock 70 kDa protein-like K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C 124816626 heat shock 70 kDa protein-like K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C 124816818 heat shock 70 kDa protein-like K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C 100200137 endoplasmic reticulum chaperone BiP K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
C 101240602 heat shock 70 kDa protein 13 K09491 STCH; stress 70 protein chaperone microsome-associated 60kDa protein
C 100201403 stress-70 protein, mitochondrial K04043 dnaK; molecular chaperone DnaK
B HSP60 / Chaperonin
C 100205571 McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin K09492 MKKS; McKusick-Kaufman syndrome protein
C 100210318 T-complex protein 1 subunit alpha K09493 CCT1; T-complex protein 1 subunit alpha
C 100205838 T-complex protein 1 subunit beta K09494 CCT2; T-complex protein 1 subunit beta
C 100208312 T-complex protein 1 subunit gamma K09495 CCT3; T-complex protein 1 subunit gamma
C 100213484 T-complex protein 1 subunit delta K09496 CCT4; T-complex protein 1 subunit delta
C 100198918 T-complex protein 1 subunit epsilon K09497 CCT5; T-complex protein 1 subunit epsilon
C 100211398 T-complex protein 1 subunit zeta K09498 CCT6; T-complex protein 1 subunit zeta
C 100210869 T-complex protein 1 subunit eta K09499 CCT7; T-complex protein 1 subunit eta
C 100201609 T-complex protein 1 subunit theta K09500 CCT8; T-complex protein 1 subunit theta
C 100209426 heat shock protein 60A K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
B HSP47
B HSP40 / DNAJ
C 100201285 dnaJ homolog subfamily A member 1 K09502 DNAJA1; DnaJ homolog subfamily A member 1
C 100211135 dnaJ homolog subfamily A member 3, mitochondrial isoform X2 K09504 DNAJA3; DnaJ homolog subfamily A member 3
C 100207548 dnaJ homolog subfamily C member 21 K09506 DNAJA5; DnaJ homolog subfamily A member 5
C 100214993 dnaJ homolog subfamily B member 4 K09510 DNAJB4; DnaJ homolog subfamily B member 4
C 100213507 dnaJ homolog subfamily B member 9 K09515 DNAJB9; DnaJ homolog subfamily B member 9
C 100209076 dnaJ homolog subfamily B member 11 K09517 DNAJB11; DnaJ homolog subfamily B member 11
C 100207309 dnaJ homolog subfamily B member 12 K09518 DNAJB12; DnaJ homolog subfamily B member 12
C 100201458 dnaJ homolog subfamily B member 13 K09519 DNAJB13; DnaJ homolog subfamily B member 13
C 100202352 dnaJ homolog subfamily C member 1 isoform X1 K09521 DNAJC1; DnaJ homolog subfamily C member 1
C 100206531 dnaJ homolog subfamily C member 2 K09522 DNAJC2; DnaJ homolog subfamily C member 2
C 100208071 dnaJ homolog subfamily C member 3 K09523 DNAJC3; DnaJ homolog subfamily C member 3
C 100196995 dnaJ homolog subfamily C member 5 isoform X2 K09525 DNAJC5; DnaJ homolog subfamily C member 5
C 100197537 dnaJ homolog subfamily C member 7 K09527 DNAJC7; DnaJ homolog subfamily C member 7
C 100214839 dnaJ homolog subfamily C member 8 K09528 DNAJC8; DnaJ homolog subfamily C member 8
C 100215663 dnaJ homolog subfamily C member 9 K09529 DNAJC9; DnaJ homolog subfamily C member 9
C 100206669 dnaJ homolog subfamily C member 10 K09530 DNAJC10; DnaJ homolog subfamily C member 10 [EC:1.8.4.-]
C 101238976 dnaJ homolog subfamily C member 11 K09531 DNAJC11; DnaJ homolog subfamily C member 11
C 100209070 dnaJ homolog subfamily C member 13 K09533 DNAJC13; DnaJ homolog subfamily C member 13
C 101236616 uncharacterized protein LOC101236616 K09534 DNAJC14; DnaJ homolog subfamily C member 14
C 100211445 dnaJ homolog subfamily C member 15 K09535 DNAJC15; DnaJ homolog subfamily C member 15
C 100199979 dnaJ homolog subfamily C member 16 K09536 DNAJC16; DnaJ homolog subfamily C member 16
C 100199341 dnaJ homolog subfamily C member 17 K09537 DNAJC17; DnaJ homolog subfamily C member 17
C 101240236 dnaJ homolog subfamily C member 22 K19370 DNAJC22; DnaJ homolog subfamily C member 22
C 100202859 dnaJ homolog subfamily C member 22 K19370 DNAJC22; DnaJ homolog subfamily C member 22
C 100215612 translocation protein SEC63 homolog K09540 SEC63; translocation protein SEC63
C 100203300 dnaJ homolog subfamily C member 25 homolog K19371 DNAJC25; DnaJ homolog subfamily C member 25
C 100197415 dnaJ homolog subfamily C member 27 K19372 DNAJC27; DnaJ homolog subfamily C member 27
C 101235579 dnaJ homolog subfamily B member 9-like K19374 DNAJC30; DnaJ homolog subfamily C member 30
C 101239636 iron-sulfur cluster co-chaperone protein HscB-like K04082 hscB; molecular chaperone HscB
B HSP33
B HSP24
C 100199526 grpE protein homolog 1, mitochondrial K03687 GRPE; molecular chaperone GrpE
B HSP20
C 100199246 alpha-crystallin B chain-like K09542 CRYAB; crystallin, alpha B
C 100214931 heat shock protein hsp-16.2-like K09542 CRYAB; crystallin, alpha B
C 105843824 uncharacterized protein LOC105843824 K09542 CRYAB; crystallin, alpha B
B HSP15
B HSP10
C 100205882 10 kDa heat shock protein, mitochondrial-like K04078 groES; chaperonin GroES
B GimC
C 100215322 prefoldin subunit 2 K09549 PFDN2; prefoldin subunit 2
C 100197674 prefoldin subunit 4 K09550 PFDN4; prefoldin subunit 4
C 100206278 prefoldin subunit 5 K04797 pfdA; prefoldin alpha subunit
C 100201097 prefoldin subunit 6 K04798 pfdB; prefoldin beta subunit
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AOther chaperones and cochaperones
B Calnexin / calreticulin
C 100210123 calnexin K08054 CANX; calnexin
C 100203010 calreticulin isoform X1 K08057 CALR; calreticulin
B DegP / HtrA
C 101239153 serine protease HTRA2, mitochondrial K08669 HTRA2; HtrA serine peptidase 2 [EC:3.4.21.108]
B AAA proteases
C 100207964 paraplegin K09552 SPG7; spastic paraplegia 7 [EC:3.4.24.-]
C 100199134 AFG3-like protein 2 K08956 AFG3; AFG3 family protein [EC:3.4.24.-]
B PapD
B SecB
B Sti1 / p60
C 100203295 stress-induced-phosphoprotein 1 K09553 STIP1; stress-induced-phosphoprotein 1
B Cdc37 / p50
C 100214820 hsp90 co-chaperone Cdc37 K09554 CDC37; cell division cycle protein 37
B BAG
C 100199450 BAG family molecular chaperone regulator 1 K09555 BAG1; BCL2-associated athanogene 1
B Others
C 100201029 hsc70-interacting protein K09560 ST13; suppressor of tumorigenicity protein 13
C 100210298 E3 ubiquitin-protein ligase CHIP K09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]
C 100203178 hsp70-binding protein 1 isoform X1 K09562 HSPBP1; hsp70-interacting protein
C 100215455 HSPB1-associated protein 1 K19375 HSPBAP1; HSPB1-associated protein 1
C 100210672 protein OPI10 homolog K23327 HIKESHI; protein Hikeshi
C 105843570 uncharacterized protein LOC105843570 isoform X1 K09256 NFKBIL1; NF-kappa-B inhibitor-like protein 1
C 105843117 cysteine and histidine-rich domain-containing protein 1 K16729 CHORDC1; cysteine and histidine-rich domain-containing protein
C 100203735 prolyl 3-hydroxylase 2 isoform X1 K22459 P3H2; procollagen-proline 3-dioxygenase 2 [EC:1.14.11.7]
C 100200804 probable methyltransferase-like protein 23 isoform X1 K23151 METTL23; methyltransferase-like protein 23 [EC:2.1.1.-]
C 100204506 protein unc-45 homolog A K21991 UNC45; protein unc-45
C 100211618 protein canopy 4-like K22816 CNPY3_4; protein canopy 3/4
C 100197977 torsin-1A isoform X1 K22990 TOR1; torsin-1
C 105846662 torsin-1A isoform X1 K22990 TOR1; torsin-1
C 100198975 torsin-1A K22990 TOR1; torsin-1
C 100206552 torsin-1A K22990 TOR1; torsin-1
C 100214232 torsin-1A K22990 TOR1; torsin-1
C 101237515 torsin-1A K22990 TOR1; torsin-1
C 100213741 uncharacterized protein LOC100213741 K23001 TOR1AIP; torsin-1A-interacting protein
C 100215658 small glutamine-rich tetratricopeptide repeat-containing protein alpha K16365 SGTA; small glutamine-rich tetratricopeptide repeat-containing protein alpha
C 101239314 tetratricopeptide repeat protein 1 K24926 TTC1; tetratricopeptide repeat protein 1
C 100206011 tetratricopeptide repeat protein 4 K24927 TTC4; tetratricopeptide repeat protein 4
C 100208570 coiled-coil domain-containing protein 47 K24962 CCDC47; PAT complex subunit CCDC47
C 124806199 PAT complex subunit Asterix-like K24963 WDR83OS; PAT complex subunit Asterix
C 100214375 LDLR chaperone boca isoform X1 K25366 MESD; LRP chaperone MESD
C 100213081 activator of 90 kDa heat shock protein ATPase homolog 1 K26216 AHSA1; activator of Hsp90 ATPase protein 1
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AIntramolecular chaperones
B Subtilisin family
C 100215239 membrane-bound transcription factor site-1 protease isoform X1 K08653 MBTPS1; membrane-bound transcription factor site-1 protease [EC:3.4.21.112]
C 100202203 uncharacterized protein LOC100202203 isoform X1 K01349 FURIN; furin [EC:3.4.21.75]
C 100206357 PC3-like endoprotease variant B K01349 FURIN; furin [EC:3.4.21.75]
C 100205483 neuroendocrine convertase 1 K01359 PCSK1; proprotein convertase subtilisin/kexin type 1 [EC:3.4.21.93]
C 100201910 PC3-like endoprotease variant A isoform X2 K01359 PCSK1; proprotein convertase subtilisin/kexin type 1 [EC:3.4.21.93]
C 100202929 PC3-like endoprotease variant B K01359 PCSK1; proprotein convertase subtilisin/kexin type 1 [EC:3.4.21.93]
C 101237189 proprotein convertase subtilisin/kexin type 6 isoform X1 K08654 PCSK5; proprotein convertase subtilisin/kexin type 5 [EC:3.4.21.-]
C 100206506 proprotein convertase subtilisin/kexin type 7 K08673 PCSK7; proprotein convertase subtilisin/kexin type 7 [EC:3.4.21.-]
C 100213935 tripeptidyl-peptidase 1 K01279 TPP1; tripeptidyl-peptidase I [EC:3.4.14.9]
C 101241465 tripeptidyl-peptidase 2 K01280 TPP2; tripeptidyl-peptidase II [EC:3.4.14.10]
B Papain family
C 100197952 cathepsin B K01363 CTSB; cathepsin B [EC:3.4.22.1]
C 100199148 cathepsin B K01363 CTSB; cathepsin B [EC:3.4.22.1]
C 100207605 dipeptidyl peptidase 1 K01275 CTSC; cathepsin C [EC:3.4.14.1]
C 100205671 dipeptidyl peptidase 1 K01275 CTSC; cathepsin C [EC:3.4.14.1]
C 100197138 procathepsin L-like K01365 CTSL; cathepsin L [EC:3.4.22.15]
C 100206725 procathepsin L-like K01365 CTSL; cathepsin L [EC:3.4.22.15]
C 100198821 cathepsin L1-like precursor K01365 CTSL; cathepsin L [EC:3.4.22.15]
C 100198930 procathepsin L isoform X2 K01365 CTSL; cathepsin L [EC:3.4.22.15]
C 100205451 procathepsin L K01365 CTSL; cathepsin L [EC:3.4.22.15]
C 100207321 procathepsin L K01365 CTSL; cathepsin L [EC:3.4.22.15]
B Other peptidases
B Others
C 100205795 beta-hexosaminidase subunit alpha K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
C 100207986 chitooligosaccharidolytic beta-N-acetylglucosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
C 100213691 beta-hexosaminidase subunit alpha K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
C 100201147 beta-hexosaminidase subunit alpha K12373 HEXA_B; hexosaminidase [EC:3.2.1.52]
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AProtein folding catalysts
B Peptidyl prolyl isomerase
C Cyclophilin
D 100196976 peptidyl-prolyl cis-trans isomerase 5 K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]
D 100197478 peptidyl-prolyl cis-trans isomerase B K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]
D 100198023 peptidyl-prolyl cis-trans isomerase B K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]
D 100209496 peptidyl-prolyl cis-trans isomerase, mitochondrial-like K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]
D 100214516 peptidyl-prolyl cis-trans isomerase E K09564 PPIE; peptidyl-prolyl isomerase E (cyclophilin E) [EC:5.2.1.8]
D 100207023 peptidyl-prolyl cis-trans isomerase G K09566 PPIG; peptidyl-prolyl isomerase G (cyclophilin G) [EC:5.2.1.8]
D 100215508 peptidyl-prolyl cis-trans isomerase H-like K09567 PPIH; peptidyl-prolyl isomerase H (cyclophilin H) [EC:5.2.1.8]
D 101241074 peptidyl-prolyl cis-trans isomerase-like 1 K12733 PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [EC:5.2.1.8]
D 100198050 RING-type E3 ubiquitin-protein ligase PPIL2 K10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]
D 100212570 peptidyl-prolyl cis-trans isomerase-like 3 K12734 PPIL3; peptidyl-prolyl cis-trans isomerase-like 3 [EC:5.2.1.8]
D 100200683 peptidyl-prolyl cis-trans isomerase sig-7-like K12735 PPIL4; peptidyl-prolyl cis-trans isomerase-like 4 [EC:5.2.1.8]
D 100209549 peptidyl-prolyl cis-trans isomerase A2 isoform X1 K12739 PPIL6; peptidyl-prolyl cis-trans isomerase-like 6 [EC:5.2.1.8]
D 100206689 peptidylprolyl isomerase domain and WD repeat-containing protein 1 K12736 PPWD1; peptidylprolyl isomerase domain and WD repeat-containing protein 1 [EC:5.2.1.8]
D 100209513 spliceosome-associated protein CWC27 homolog K12737 SDCCAG10; peptidyl-prolyl cis-trans isomerase SDCCAG10 [EC:5.2.1.8]
D 100211630 E3 SUMO-protein ligase RanBP2-like K12172 RANBP2; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]
C FKBP
D 100208847 peptidyl-prolyl cis-trans isomerase Fkbp12 K09568 FKBP1; FK506-binding protein 1 [EC:5.2.1.8]
D 101241426 peptidyl-prolyl cis-trans isomerase FKBP2 K09569 FKBP2; FK506-binding protein 2 [EC:5.2.1.8]
D 101235335 FK506-binding protein 2-like isoform X1 K09569 FKBP2; FK506-binding protein 2 [EC:5.2.1.8]
D 100197691 peptidyl-prolyl cis-trans isomerase FKBP5 K09571 FKBP4_5; FK506-binding protein 4/5 [EC:5.2.1.8]
D 100214413 inactive peptidyl-prolyl cis-trans isomerase FKBP6 K09572 FKBP6; FK506-binding protein 6 [EC:5.2.1.8]
D 100197695 peptidyl-prolyl cis-trans isomerase FKBP9 K09575 FKBP9_10; FK506-binding protein 9/10 [EC:5.2.1.8]
D 100209086 peptidyl-prolyl cis-trans isomerase FKBP14 K09577 FKBP14; FK506-binding protein 14 [EC:5.2.1.8]
D 100213335 peptidyl-prolyl cis-trans isomerase FKBP14 K09577 FKBP14; FK506-binding protein 14 [EC:5.2.1.8]
D 100202267 FK506-binding protein 2 K09577 FKBP14; FK506-binding protein 14 [EC:5.2.1.8]
D 100213556 FK506-binding protein 2-like K09577 FKBP14; FK506-binding protein 14 [EC:5.2.1.8]
D 100201325 FK506-binding protein 15 isoform X1 K17478 FKBP15; FK506-binding protein 15
D 101235739 peptidyl-prolyl cis-trans isomerase FKBP62-like K20097 FKBPL; FK506-binding protein-like
C Parvulin
D 100205141 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 K09578 PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [EC:5.2.1.8]
D 105845153 peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 K09579 PIN4; peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 [EC:5.2.1.8]
B Protein disulfide isomerase
C 100207025 thioredoxin K03671 TXN; thioredoxin
C 100205970 thioredoxin K03671 TXN; thioredoxin
C 100214065 thioredoxin, mitochondrial K03671 TXN; thioredoxin
C 100206877 thioredoxin K03671 TXN; thioredoxin
C 100203063 glutaredoxin-2, mitochondrial-like K03676 grxC; glutaredoxin 3
C 101237907 glutaredoxin K03676 grxC; glutaredoxin 3
C 100212558 glutaredoxin-related protein 5, mitochondrial K07390 grxD; monothiol glutaredoxin
C 105844872 glutaredoxin domain-containing cysteine-rich protein CG31559 K17479 GRXCR1; glutaredoxin domain-containing cysteine-rich protein 1
C 100203161 protein disulfide-isomerase A3 K08056 PDIA3; protein disulfide-isomerase A3 [EC:5.3.4.1]
C 100204811 protein disulfide-isomerase A4 K09582 PDIA4; protein disulfide-isomerase A4 [EC:5.3.4.1]
C 100203193 protein disulfide-isomerase A6 K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C 100198247 probable protein disulfide-isomerase A6 K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C 100199495 protein disulfide isomerase-like 2-2 isoform X1 K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C 100208732 probable protein disulfide-isomerase A4 isoform X1 K13984 TXNDC5; thioredoxin domain-containing protein 5 [EC:5.3.4.1]
C 100208034 thioredoxin domain-containing protein 5 K13984 TXNDC5; thioredoxin domain-containing protein 5 [EC:5.3.4.1]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: January 25, 2024