+F Repair protein KO
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DNA Repair and Recombination Proteins - Lactococcus lactis subsp. lactis KF147
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D LLKF_0509 ogt; O6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E LLKF_0228 ung; Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E LLKF_0854 mutY; A/G-specific adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E LLKF_1099 nth; Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D LLKF_2499 yxbC; Hydrolase, MutT/nudix family K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LLKF_1147 mutX; Phosphohydrolase, MutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LLKF_0171 dut; Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D LLKF_1513 pp247; Phage protein, dUTP diphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D LLKF_0509 ogt; O6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D LLKF_0510 adaA; Methylphosphotriester-DNA alkyltransferase K13530 adaA; AraC family transcriptional regulator, regulatory protein of adaptative response / methylphosphotriester-DNA alkyltransferase methyltransferase [EC:2.1.1.-]
C BER (base exicision repair)
D DNA glycosylases
E LLKF_0228 ung; Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E LLKF_0854 mutY; A/G-specific adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E LLKF_1148 tag; DNA-3-methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E LLKF_0408 mutM; Formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E LLKF_1099 nth; Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E LLKF_0811 exoA; Exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E LLKF_0626 recJ; Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E LLKF_0471 ligA; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E LLKF_2390 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E LLKF_2011 uvrA; Excinuclease ABC, subunit A K03701 uvrA; excinuclease ABC subunit A
E LLKF_0540 uvrB; Excinuclease ABC, subunit B K03702 uvrB; excinuclease ABC subunit B
E LLKF_0853 uvrC; Excinuclease ABC, subunit C K03703 uvrC; excinuclease ABC subunit C
E LLKF_1146 pcrA; ATP-dependent DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LLKF_2390 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E LLKF_0471 ligA; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F LLKF_1973 rpoB; DNA-directed RNA polymerase, beta chain K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F LLKF_1972 rpoC; DNA-directed RNA polymerase, beta prime chain K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F LLKF_2321 rpoA; DNA-directed RNA polymerase, alpha chain K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F LLKF_0628 rpoE; DNA-directed RNA polymerase, delta chain K03048 rpoE; DNA-directed RNA polymerase subunit delta
F LLKF_2091 rpoZ; DNA-directed RNA polymerase, omega chain K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F LLKF_0014 mfd; Transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E LLKF_2482 mutS; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
E LLKF_1802 mutS; DNA mismatch repair protein MutS K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E LLKF_2480 mutL; DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E LLKF_0873 xseA; Exodeoxyribonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E LLKF_0874 xseB; Exodeoxyribonuclease VII, small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E LLKF_0500 dnaE; DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E LLKF_2374 polC; DNA polymerase III, alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E LLKF_0002 dnaN; DNA polymerase III, beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E LLKF_1811 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E LLKF_0451 holB; DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E LLKF_1011 dnaQ; DNA polymerase III, epsilon chain K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E LLKF_2439 dnaH; DNA polymerase III subunit, gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E LLKF_0471 ligA; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E LLKF_1146 pcrA; ATP-dependent DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LLKF_0444 ssbA; Single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein
E LLKF_2435 ssbB; Single strand binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E LLKF_1911 recD; Exodeoxyribonuclease V, alpha chain K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E LLKF_0409 recA; DNA-dependent recombination protein RecA, ATPase, AAA family K03553 recA; recombination protein RecA
E LLKF_1284 recA; Recombinase RecA, C-terminal fragement K03553 recA; recombination protein RecA
E LLKF_2479 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E LLKF_2478 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E LLKF_2090 priA; Primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E LLKF_1410 sbcC; Exonuclease, subunit C K03546 sbcC; DNA repair protein SbcC/Rad50
E LLKF_1411 sbcD; Exonuclease, subunit D K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E LLKF_0409 recA; DNA-dependent recombination protein RecA, ATPase, AAA family K03553 recA; recombination protein RecA
E LLKF_1284 recA; Recombinase RecA, C-terminal fragement K03553 recA; recombination protein RecA
E LLKF_2309 radA; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E LLKF_2159 recF; DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E LLKF_2512 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E LLKF_0626 recJ; Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E LLKF_0033 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E LLKF_0395 recR; Recombination protein recR K06187 recR; recombination protein RecR
E LLKF_0880 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E LLKF_0522 recU; Recombination protein RecU K03700 recU; recombination protein U
E LLKF_2479 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E LLKF_2478 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
D AddAB pathway proteins
E LLKF_0004 rexA; ATP-dependent nuclease, subunit A K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E LLKF_0003 rexB; ATP-dependent nuclease, subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
D Archaeal homologous recombinant proteins
E LLKF_1410 sbcC; Exonuclease, subunit C K03546 sbcC; DNA repair protein SbcC/Rad50
E LLKF_1411 sbcD; Exonuclease, subunit D K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F LLKF_1138 gyrA; DNA gyrase, subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F LLKF_0933 gyrB; DNA gyrase, subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F LLKF_1274 topA; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F LLKF_0506 hslA; DNA-binding protein HU, histone-like protein K03530 hupB; DNA-binding protein HU-beta
F LLKF_0901 hslB; DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F LLKF_1526 pp260; Phage protein K07455 recT; recombination protein RecT
F LLKF_0626 recJ; Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F LLKF_0033 recO; DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F LLKF_0395 recR; Recombination protein recR K06187 recR; recombination protein RecR
F LLKF_0471 ligA; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F LLKF_1982 recQ; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F LLKF_2011 uvrA; Excinuclease ABC, subunit A K03701 uvrA; excinuclease ABC subunit A
F LLKF_0540 uvrB; Excinuclease ABC, subunit B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D LLKF_2215 dinP; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D LLKF_0567 umuC; ImpB/MucB/SamB family protein K03502 umuC; DNA polymerase V
D LLKF_p0005 hypothetical protein K03502 umuC; DNA polymerase V
C Other SOS response factors
D LLKF_0409 recA; DNA-dependent recombination protein RecA, ATPase, AAA family K03553 recA; recombination protein RecA
D LLKF_1284 recA; Recombinase RecA, C-terminal fragement K03553 recA; recombination protein RecA
D LLKF_0880 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D LLKF_0444 ssbA; Single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein
D LLKF_2435 ssbB; Single strand binding protein K03111 ssb; single-strand DNA-binding protein
D LLKF_2427 recX; Regulatory protein RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D LLKF_2024 dinG; ATP-dependent DNA helicase/DNA polymerase III, epsilon subunit K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D LLKF_2499 yxbC; Hydrolase, MutT/nudix family K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LLKF_1147 mutX; Phosphohydrolase, MutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LLKF_0171 dut; Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D LLKF_1513 pp247; Phage protein, dUTP diphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D LLKF_1004 nrdE; Ribonucleoside-diphosphate reductase, alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D LLKF_1003 nrdF; Ribonucleoside-diphosphate reductase, beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D LLKF_0755 yheB; Phosphoesterase, DHH family K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024