+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Micromonospora chalcea
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
D Chivosazol hybrid PKS-NRPS
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
D Difficidin PKS
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2]
C Bacterial type
D PVK74_00340 type I polyketide synthase K15314 sgcE; enediyne polyketide synthase
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
E PVK74_07700 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-]
E PVK74_07710 SRPBCC family protein K14670 whiEVI; aromatase
E PVK74_07730 TcmI family type II polyketide cyclase K14671 whiEVII; cyclase
E PVK74_07740 TcmI family type II polyketide cyclase K14671 whiEVII; cyclase
E PVK74_08340 TcmI family type II polyketide cyclase K14671 whiEVII; cyclase
C C7-C14 cyclized polyketide type
D Octaketide PKS
E PVK74_07695 beta-ketoacyl synthase N-terminal-like domain-containing protein K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
D Nonaketide PKS
E PVK74_07695 beta-ketoacyl synthase N-terminal-like domain-containing protein K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
D Decaketide PKS
E PVK74_07695 beta-ketoacyl synthase N-terminal-like domain-containing protein K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D PVK74_04190 MbtH family NRPS accessory protein K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
C Bacillibactin synthetase
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
C Mycobactin synthetase
C Vibriobactin synthetase
C Myxochelin synthetase
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
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APolyketide tailoring proteins
B Hydrolase
C PVK74_00335 acyl-CoA thioesterase K15315 sgcE10; enediyne core biosynthesis thioesterase
B Ketoreductase
B Oxygenase
C PVK74_10380 bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase K16022 rif19; flavoprotein hydroxylase
C PVK74_22400 alpha/beta fold hydrolase K21159 sgcF; epoxide hydrolase
C PVK74_07705 cupin domain-containing protein K14673 whiEII; putative monooxygenase
B Methylase
C PVK74_09000 methyltransferase K20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]
B Glycosyltransferase
C PVK74_00285 DUF1205 domain-containing protein K21259 calG3; calicheamicinone 4-hydroxyamino-4,6-dideoxy-alpha-D-glucosyltransferase [EC:2.4.1.-]
B Halogenase
B beta-Branched incorporating proteins
B Others
C PVK74_00355 DUF1702 family protein K21161 sgcE3; enediyne biosynthesis protein E3
C PVK74_00350 CRTAC1 family protein K21162 sgcE4; enediyne biosynthesis protein E4
C PVK74_00345 enediyne biosynthesis protein K21163 sgcE5; enediyne biosynthesis protein E5
C PVK74_00415 homocysteine S-methyltransferase family protein K21169 calE2; enediyne biosynthesis protein CalE2
C PVK74_00385 50S ribosomal protein L11 methyltransferase K21170 calE3; enediyne biosynthesis protein CalE3
C PVK74_00405 cysteine desulfurase K21171 calE4; enediyne biosynthesis protein CalE4
C PVK74_00315 class I SAM-dependent methyltransferase K21172 calE5; enediyne biosynthesis protein CalE5
C PVK74_00410 PLP-dependent aspartate aminotransferase family protein K21173 calE6; methionine gamma-lyase
C PVK74_00425 aminotransferase class V-fold PLP-dependent enzyme K21174 calE9; enediyne biosynthesis protein CalE9
C PVK74_00055 flavin reductase family protein K21185 sgcE6; flavin reductase
C PVK74_00330 flavin reductase family protein K21185 sgcE6; flavin reductase
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ANonribosomal peptide tailoring proteins
B Reductase
B Thioesterase
B Oxygenase
B Glycosyltransferase
C PVK74_10465 glycosyltransferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]
B Aminotransferase
C PVK74_07580 PLP-dependent aminotransferase family protein K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103]
B Others
C PVK74_28195 aminotransferase class V-fold PLP-dependent enzyme K04127 cefD; isopenicillin-N epimerase [EC:5.1.1.17]
C PVK74_08625 acyl-CoA dehydrogenase family protein K16104 vioJ; 2,3-diaminopropionyl alpha,beta-desaturase
C PVK74_07655 hppD; 4-hydroxyphenylpyruvate dioxygenase K16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46]
C PVK74_07585 alpha-hydroxy acid oxidase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]
C PVK74_09870 alpha-hydroxy acid oxidase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: February 19, 2024