+F Repair protein KO
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DNA Repair and Recombination Proteins - Mycobacterium canettii CIPT 140070008
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D BN43_30411 ogt; Methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E BN43_40686 ung; Putative uracil-DNA glycosylase Ung (UDG) K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E BN43_30807 mpg; Putative 3-methyladenine DNA glycosylase Mpg K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E BN43_90091 mutY; Putative adenine glycosylase MutY K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E BN43_90179 nth; Putative endonuclease III Nth (DNA-(apurinic or apyrimidinic site) lyase) (AP lyase) (AP endonuclease class I) (Endodeoxyribonuclease (Apurinic or Apyrimidinic)) (Deoxyribonuclease (Apurinic or Apyrimidinic)) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E BN43_20312 ercc; Putative ATP-dependent DNA helicase ErcC3 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D BN43_30227 mutT; Putative mutator protein MutT (7, 8-dihydro-8-oxoguanine-triphosphatase) (8-OXO-DGTPASE) K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BN43_10446 mutT; Putative mutator protein MutT3 (7, 8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase) K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BN43_30708 Conserved protein of unknown function K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BN43_40370 dut; Putative deoxyuridine 5'-triphosphate nucleotidohydrolase Dut (dUTPase) (dUTP pyrophosphatase) (deoxyuridine 5'-triphosphatase) (dUTP diphosphatase) (deoxyuridine-triphosphatase) K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D BN43_30411 ogt; Methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E BN43_40686 ung; Putative uracil-DNA glycosylase Ung (UDG) K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E BN43_30335 Conserved protein of unknown function K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E BN43_30807 mpg; Putative 3-methyladenine DNA glycosylase Mpg K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E BN43_90091 mutY; Putative adenine glycosylase MutY K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E BN43_30279 tagA; Putative DNA-3-methyladenine glycosylase 1 (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine glycosidase I) K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E BN43_20419 Putative formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E BN43_40632 fpg; Putative formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E BN43_40126 Putative DNA glycosylase K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E BN43_60313 nei; Putative endonuclease VIII Nei K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E BN43_90179 nth; Putative endonuclease III Nth (DNA-(apurinic or apyrimidinic site) lyase) (AP lyase) (AP endonuclease class I) (Endodeoxyribonuclease (Apurinic or Apyrimidinic)) (Deoxyribonuclease (Apurinic or Apyrimidinic)) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E BN43_10461 Exodeoxyribonuclease III protein XthA (Exonuclease III) K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E BN43_20098 end; Putative endonuclease IV End (endodeoxyribonuclease IV) (apurinase) K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
D DNA ligase
E BN43_40728 ligA; Putative DNA ligase [NAD dependent] LigA (polydeoxyribonucleotide synthase [NAD+]) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E BN43_30746 polA; Putative DNA polymerase I PolA K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E BN43_30755 uvrA; Putative excinuclease ABC (subunit A-DNA-binding ATPase) UvrA K03701 uvrA; excinuclease ABC subunit A
E BN43_30750 uvrB; Putative excinuclease ABC (subunit B-helicase) UvrB K03702 uvrB; excinuclease ABC subunit B
E BN43_30528 uvrC; Putative excinuclease ABC (subunit C-nuclease) UvrC K03703 uvrC; excinuclease ABC subunit C
E BN43_20426 uvrD; Putative ATP-dependent DNA helicase II UvrD1 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E BN43_60198 uvrD; Putative ATP-dependent DNA helicase II UvrD2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E BN43_60202 Putative ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E BN43_30746 polA; Putative DNA polymerase I PolA K02335 polA; DNA polymerase I [EC:2.7.7.7]
E BN43_40728 ligA; Putative DNA ligase [NAD dependent] LigA (polydeoxyribonucleotide synthase [NAD+]) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F BN43_20094 rpoB; DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F BN43_20095 rpoC; DNA-directed RNA polymerase (beta' chain) RpoC (transcriptase beta' chain) (RNA polymerase beta' subunit) K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F BN43_70125 rpoA; Putative DNA-directed RNA polymerase (alpha chain) RpoA (transcriptase alpha chain) (RNA polymerase alpha subunit) (DNA-directed RNA nucleotidyltransferase) K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F BN43_30498 rpoZ; DNA-directed RNA polymerase (omega chain) RpoZ (transcriptase omega chain) (RNA polymerase omega subunit) K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F BN43_30048 mfd; Putative transcription-repair coupling factor Mfd (TRCF) K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
E BN43_30165 xseA; Exodeoxyribonuclease VII large subunit XseA (Exonuclease VII large subunit) K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E BN43_30164 xseB; Exodeoxyribonuclease VII small subunit XseB (Exonuclease VII small subunit) K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E BN43_30673 dnaE; Putative DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E BN43_10003 dnaN; DNA polymerase III (Beta chain) DnaN (DNA nucleotidyltransferase) K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E BN43_40066 Conserved protein of unknown function K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E BN43_90145 DNA polymerase K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E BN43_90219 dnaQ; Putative DNA Polymerase III (epsilon subunit) DnaQ K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E BN43_31424 Conserved protein of unknown function K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E BN43_90229 dnaZX; DNA polymerase III (subunit gamma/tau) DnaZ/X K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E BN43_40728 ligA; Putative DNA ligase [NAD dependent] LigA (polydeoxyribonucleotide synthase [NAD+]) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E BN43_20426 uvrD; Putative ATP-dependent DNA helicase II UvrD1 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E BN43_60198 uvrD; Putative ATP-dependent DNA helicase II UvrD2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E BN43_60202 Putative ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E BN43_10063 ssb; Putative single-strand binding protein Ssb (helix-destabilizing protein) K03111 ssb; single-strand DNA-binding protein
E BN43_40141 Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E BN43_20052 recB; Exodeoxyribonuclease V beta chain K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E BN43_20053 recC; Putative exonuclease V (gamma chain) RecC (exodeoxyribonuclease V gamma chain)(exodeoxyribonuclease V polypeptide) K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E BN43_20051 recD; Putative exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide) K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E BN43_40419 recA; Protein RecA K03553 recA; recombination protein RecA
E BN43_40268 ruvA; Putative holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E BN43_40267 ruvB; Putative holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E BN43_40269 ruvC; Component of RuvABC resolvasome, endonuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E BN43_30510 priA; Putative primosomal protein N' PriA (Replication factor Y) K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D RecFOR pathway proteins
E BN43_40419 recA; Protein RecA K03553 recA; recombination protein RecA
E BN43_90087 radA; DNA repair protein RadA (DNA repair protein SMS) K04485 radA; DNA repair protein RadA/Sms
E BN43_10004 recF; DNA replication and repair protein RecF (single-strand DNA binding protein) K03629 recF; DNA replication and repair protein RecF
E BN43_40683 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E BN43_40006 recO; Putative DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E BN43_90223 recR; Recombination protein RecR K06187 recR; recombination protein RecR
E BN43_30816 recN; Putative DNA repair protein RecN (recombination protein N) K03631 recN; DNA repair protein RecN (Recombination protein N)
E BN43_40268 ruvA; Putative holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E BN43_40267 ruvB; Putative holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E BN43_40269 ruvC; Component of RuvABC resolvasome, endonuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E BN43_40512 Putative CRISPR-associated deoxyribonuclease/nuclease Cas1/Cas4 K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
E BN43_40177 Conserved protein of unknown function K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E BN43_20407 Conserved protein of unknown function K10979 ku; DNA end-binding protein Ku
E BN43_20408 Putative ATP dependent DNA ligase (ATP dependent polydeoxyribonucleotide synthase) (thermostable DNA ligase) (ATP dependent polynucleotide ligase) (SEALase) (DNA repair enzyme) (DNA joinase) K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F BN43_10007 gyrA; DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F BN43_10006 gyrB; DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F BN43_90147 topA; DNA topoisomerase I TopA (Omega-Protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (Type I DNA topoisomerase) (Nicking-closing enzyme) (TOPO I) K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F BN43_40695 hupB; Putative DNA-binding protein Hu homolog HupB (histone-like protein) (HLP) (21-kDa laminin-2-binding protein) K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F BN43_40006 recO; Putative DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F BN43_90223 recR; Recombination protein RecR K06187 recR; recombination protein RecR
F BN43_40728 ligA; Putative DNA ligase [NAD dependent] LigA (polydeoxyribonucleotide synthase [NAD+]) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F BN43_30755 uvrA; Putative excinuclease ABC (subunit A-DNA-binding ATPase) UvrA K03701 uvrA; excinuclease ABC subunit A
F BN43_30750 uvrB; Putative excinuclease ABC (subunit B-helicase) UvrB K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D BN43_30663 dinB; DNA polymerase IV DinX (POL IV 1) (DNA nucleotidyltransferase (DNA-directed)) K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D BN43_60040 dinP; Putative DNA-damage-inducible protein P DinP (DNA polymerase V) (Pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D BN43_40419 recA; Protein RecA K03553 recA; recombination protein RecA
D BN43_40401 lexA; LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D BN43_30816 recN; Putative DNA repair protein RecN (recombination protein N) K03631 recN; DNA repair protein RecN (Recombination protein N)
D BN43_70046 Conserved protein of unknown function K14161 imuB; protein ImuB
D BN43_70027 dnaE; Error-prone DNA polymerase K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D BN43_10063 ssb; Putative single-strand binding protein Ssb (helix-destabilizing protein) K03111 ssb; single-strand DNA-binding protein
D BN43_40141 Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D BN43_40418 recX; Regulatory protein RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D BN43_30428 dinG; ATP-dependent helicase DinG K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D BN43_60312 lhr; Putative ATP-dependent helicase Lhr (large helicase-related protein) K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D BN43_30227 mutT; Putative mutator protein MutT (7, 8-dihydro-8-oxoguanine-triphosphatase) (8-OXO-DGTPASE) K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BN43_10446 mutT; Putative mutator protein MutT3 (7, 8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase) K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BN43_30708 Conserved protein of unknown function K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BN43_40693 mutT; Putative hydrolase MutT1 K23258 mutT1; 8-oxo-(d)GTP phosphatase [EC:3.6.1.69]
D BN43_30820 Nudix hydrolase K01554 K01554; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D BN43_40370 dut; Putative deoxyuridine 5'-triphosphate nucleotidohydrolase Dut (dUTPase) (dUTP pyrophosphatase) (deoxyuridine 5'-triphosphatase) (dUTP diphosphatase) (deoxyuridine-triphosphatase) K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D BN43_10622 nrdZ; Putative ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleoside reductase) K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D BN43_60034 nrdE; Ribonucleoside-diphosphate reductase 2, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D BN43_60031 nrdF; Ribonucleoside-diphosphate reductase 2, beta subunit, ferritin-like K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D BN43_10262 nrdB; Putative ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D BN43_31144 nrdF; Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D BN43_40527 Conserved protein of unknown function K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024