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Transfer RNA Biogenesis - Methylocaldum marinum
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AEukaryotic type
B 5'processing factors
C Ribonucrease P
B 3'processing and CCA adding factors
C 3'processing factors
D sS8_5228 ribonuclease Z K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D sS8_3723 ribonuclease T2 family protein K01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]
C CCA adding factors
D sS8_3526 tRNA nucleotidyltransferase K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
D sS8_5447 tRNA nucleotidyltransferase K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
B tRNA spricing factors
C tRNA splicing endonuclease complex
C tRNA splicing ligase complex
D sS8_5553 replication factor C subunit K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
D sS8_0085 rtcb protein K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
D sS8_0080 rtcB protein K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
D sS8_5554 uncharacterized protein K24956 ZBTB8OS; protein archease
C Other tRNA splicing factors
B tRNA transport factors
C tRNA export factors
C tRNA import factors
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D sS8_5406 glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D sS8_2677 prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D sS8_3410 isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D sS8_5190 leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D sS8_0649 methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D sS8_4416 arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D sS8_2521 lysine tRNA synthetase, inducible K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D sS8_2294 aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
C Other AARSs
D sS8_2651 alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D sS8_0255 uncharacterized protein K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D sS8_2077 threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D sS8_2042 seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D sS8_1458 cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D sS8_2286 valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D sS8_3211 histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D sS8_2074 phenylalanyl-tRNA synthetase subunit alpha K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D sS8_2072 phenylalanyl-tRNA synthetase subunit beta K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D sS8_4703 tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D sS8_1349 tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
C Trans-editing factors
D sS8_2227 D-tyrosyl-tRNA(Tyr) deacylase K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
C AARS associated factors
D sS8_5374 diadenosine tetraphosphate (Ap4A) hydrolase-like HIT family hydrolase K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
B tRNA modification factors
C Deaminases
C Dihydorouridine synthases
C Methylthiotransferase
C Methyltransferases
D sS8_0309 tRNA (guanine-N(7)-)-methyltransferase K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
C Psudouridine synthases
D sS8_1040 tRNA pseudouridine synthase A K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D sS8_1261 tRNA pseudouridine synthase B K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D sS8_1805 tRNA pseudouridine synthase D K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
C Thiolation factors
D sS8_5518 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D sS8_3216 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D sS8_3438 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D sS8_5435 class V aminotransferase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C KEOPS/EKC complex
C Elongator complex
C Elongator related proteins
C Other tRNA modification factors
D sS8_1513 threonylcarbamoyl-AMP synthase K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D sS8_0301 tRNA delta(2)-isopentenylpyrophosphate transferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D sS8_3754 tRNA modification GTPase TrmE K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
D sS8_3646 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D sS8_5107 selenophosphate synthetase K01008 selD; selenide, water dikinase [EC:2.7.9.3]
B tRNA degradation factors
C TRAMP complex
C Rapid tRNA decay (RTD) pathway factors
D sS8_0658 3'(2'),5'-bisphosphate nucleotidase K01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]
C Other tRNA degradation factors
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AProkaryotic type
B 5'processing factors
C Ribonucrease P
D sS8_4868 UPF0278 family K09006 K09006; RNA-free ribonuclease P [EC:3.1.26.5]
B 3'processing and CCA adding factors
C 3'processing factors
D sS8_5228 ribonuclease Z K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D sS8_3447 ribonuclease T K03683 rnt; ribonuclease T [EC:3.1.13.-]
D sS8_3272 ribonuclease PH K00989 rph; ribonuclease PH [EC:2.7.7.56]
D sS8_4932 ribonuclease D K03684 rnd; ribonuclease D [EC:3.1.13.5]
D sS8_3723 ribonuclease T2 family protein K01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]
C CCA adding factors
D sS8_3526 tRNA nucleotidyltransferase K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
D sS8_5447 tRNA nucleotidyltransferase K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
B tRNA spricing factors
C tRNA splicing endonucleases
C tRNA splicing ligases
D sS8_5553 replication factor C subunit K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
D sS8_0085 rtcb protein K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
D sS8_0080 rtcB protein K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
C Other tRNA splicing factors
D sS8_2654 putative 2'-5' RNA ligase K01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]
D sS8_1646 phosphotransferase KptA/Tpt1 K07559 kptA; putative RNA 2'-phosphotransferase [EC:2.7.1.-]
B tRNA transport factors
C tRNA export factors
D sS8_5336 atp-binding protein K06020 ettA; energy-dependent translational throttle protein EttA
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D sS8_5190 leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D sS8_2677 prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
C Other AARSs
D sS8_4703 tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D sS8_1349 tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D sS8_2077 threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D sS8_3410 isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D sS8_2521 lysine tRNA synthetase, inducible K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D sS8_2651 alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D sS8_2286 valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D sS8_0649 methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D sS8_2042 seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D sS8_2294 aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D sS8_1291 glycyl-tRNA synthetase subunit alpha K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D sS8_1292 glycyl-tRNA synthetase subunit beta K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D sS8_1458 cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D sS8_5406 glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D sS8_4416 arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D sS8_2074 phenylalanyl-tRNA synthetase subunit alpha K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D sS8_2072 phenylalanyl-tRNA synthetase subunit beta K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D sS8_3211 histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D sS8_0255 uncharacterized protein K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D sS8_0429 glutamyl-Q tRNA(Asp) synthetase K01894 gluQ; glutamyl-Q tRNA(Asp) synthetase [EC:6.1.1.-]
D sS8_1459 glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24]
C Trans-editing factors
D sS8_2227 D-tyrosyl-tRNA(Tyr) deacylase K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
B tRNA modification factors
C Deaminases
D sS8_2543 CMP/dCMP deaminase zinc-binding protein K11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]
C Dihydorouridine synthases
D sS8_5605 TIM-barrel protein, yjbN family K05539 dusA; tRNA-dihydrouridine synthase A [EC:1.-.-.-]
D sS8_4395 NifR3 K05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-]
C Methylthiotransferases
D sS8_0601 tRNA-i(6)A37 thiotransferase enzyme MiaB K06168 miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]
D sS8_4787 MiaB-like tRNA modifying enzyme K18707 mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5]
C Methyltransferases
D sS8_0239 strongly similar to SAM-dependent methyltransferase YecO K15256 cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-]
D sS8_4622 methyltransferase K15257 cmoB; tRNA (mo5U34)-methyltransferase [EC:2.1.1.-]
D sS8_2185 SAM-dependent methyltransferase K15257 cmoB; tRNA (mo5U34)-methyltransferase [EC:2.1.1.-]
D sS8_0309 tRNA (guanine-N(7)-)-methyltransferase K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D sS8_2645 tRNA (guanine-N1)-methyltransferase K00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D sS8_3754 tRNA modification GTPase TrmE K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
D sS8_3739 RNA methyltransferase, TrmH family K03214 yfiF; RNA methyltransferase, TrmH family [EC:2.1.1.-]
D sS8_3655 RNA methyltransferase K15396 trmJ; tRNA (cytidine32/uridine32-2'-O)-methyltransferase [EC:2.1.1.200]
D sS8_4660 RNA methyltransferase K03216 trmL; tRNA (cytidine/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]
C Psudouridine synthases
D sS8_1040 tRNA pseudouridine synthase A K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D sS8_1261 tRNA pseudouridine synthase B K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D sS8_3063 pseudouridine synthase K06175 truC; tRNA pseudouridine65 synthase [EC:5.4.99.26]
D sS8_1805 tRNA pseudouridine synthase D K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
C Thiolation factors
D sS8_5345 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]
D sS8_3826 tRNA 2-thiocytidine biosynthesis protein TtcA K14058 ttcA; tRNA 2-thiocytidine biosynthesis protein TtcA
D sS8_0249 uncharacterized protein K04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]
D sS8_1574 uncharacterized protein K04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]
D sS8_5627 sulfur relay protein TusB/DsrH K07237 tusB; tRNA 2-thiouridine synthesizing protein B
D sS8_5626 sulfur relay protein TusC/DsrF K07236 tusC; tRNA 2-thiouridine synthesizing protein C
D sS8_0262 hypothetical protein K07235 tusD; tRNA 2-thiouridine synthesizing protein D [EC:2.8.1.-]
D sS8_5625 intracellular sulfur oxidation protein DsrE K07235 tusD; tRNA 2-thiouridine synthesizing protein D [EC:2.8.1.-]
D sS8_5628 sulfurtransferase tusE K11179 tusE; tRNA 2-thiouridine synthesizing protein E [EC:2.8.1.-]
D sS8_5515 HesB/YadR/YfhF family protein K13628 iscA; iron-sulfur cluster assembly protein
D sS8_3215 HesB/YadR/YfhF family protein K13628 iscA; iron-sulfur cluster assembly protein
D sS8_5429 HesB/YadR/YfhF family protein K13628 iscA; iron-sulfur cluster assembly protein
D sS8_5518 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D sS8_3216 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D sS8_3438 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D sS8_5435 class V aminotransferase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D sS8_0948 glycine cleavage T protein K06980 ygfZ; tRNA-modifying protein YgfZ
D sS8_5476 uncharacterized protein K06980 ygfZ; tRNA-modifying protein YgfZ
C KEOPS/EKC complex
C Other tRNA modification factors
D sS8_3646 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D sS8_0301 tRNA delta(2)-isopentenylpyrophosphate transferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D sS8_5330 S-adenosylmethionine--tRNA ribosyltransferase-isomerase K07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]
D sS8_5399 queuosine biosynthesis protein queC K06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]
D sS8_3887 6-pyruvoyl tetrahydrobiopterin synthase K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
D sS8_1347 6-pyruvoyl tetrahydrobiopterin synthase K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
D sS8_5398 radical activating enzyme K10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]
D sS8_2607 7-cyano-7-deazaguanine reductase K09457 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
D sS8_0296 iron-sulfur cluster binding protein K18979 queG; epoxyqueuosine reductase [EC:1.17.99.6]
D sS8_5107 selenophosphate synthetase K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D sS8_1779 queuine tRNA-ribosyltransferase K00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]
D sS8_1796 tRNA(Ile)-lysidine synthase K04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]
D sS8_5578 universal protein YeaZ K14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB
D sS8_1513 threonylcarbamoyl-AMP synthase K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D sS8_4695 O-sialoglycoprotein endopeptidase K25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234]
D sS8_0298 uncharacterized protein K06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
B tRNA degradation factors
C sS8_2046 ribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1]
C sS8_1259 polynucleotide phosphorylase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: February 29, 2024