+C Kinase KO
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Protein Kinases - Necator americanus (New World hookworm)
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ASerine/threonine kinases: AGC group
B PKA family
C NECAME_14910 kinase domain protein K04345 PKA; protein kinase A [EC:2.7.11.11]
C NECAME_17311 SH2 domain protein K04345 PKA; protein kinase A [EC:2.7.11.11]
C NECAME_02475 putative protein kinase A catalytic subunit K19584 PRKX; protein kinase X [EC:2.7.11.11]
C NECAME_02713 hypothetical protein K19584 PRKX; protein kinase X [EC:2.7.11.11]
B PKG family
B PKC family [OT]
C NECAME_11125 phorbol esters/diacylglycerol binding domain protein K18050 PRKCE; novel protein kinase C epsilon type [EC:2.7.11.13]
C NECAME_06658 kinase domain protein K06069 PRKCI; atypical protein kinase C iota type [EC:2.7.11.13]
B PKN family
B AUR family [OT]
C NECAME_11871 kinase domain protein K11481 AURKA; aurora kinase A [EC:2.7.11.1]
C NECAME_13182 kinase domain protein K11479 AURKB; aurora kinase B [EC:2.7.11.1]
B PDK1 family
C NECAME_04827 hypothetical protein K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
B AKT/PKB family
C NECAME_06436 kinase domain protein K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
B SGK family [OT]
C NECAME_00087 kinase domain protein K13302 SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
C NECAME_00088 kinase domain protein K13302 SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
B RSK family [OT]
C NECAME_06412 kinase domain protein K04373 RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
C NECAME_04800 kinase domain protein K04445 RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]
C NECAME_09870 kinase domain protein K04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
C NECAME_12208 MIT domain protein K20839 RSKL; ribosomal protein S6 kinase-like
B NDR family
C NECAME_03210 kinase domain protein K08790 STK38; serine/threonine kinase 38 [EC:2.7.11.1]
B MAST family [OT]
C NECAME_14074 kinase domain protein K08789 MAST; MAST-subfamily protein kinase [EC:2.7.11.37]
B YANK family
C NECAME_00849 hypothetical protein K08793 STK32; serine/threonine kinase 32 [EC:2.7.11.1]
B DMPK family [OT]
B GRK family [OT]
C NECAME_16586 kinase domain protein K00910 ADRBK; beta-adrenergic-receptor kinase [EC:2.7.11.15]
C NECAME_08066 kinase domain protein K08291 GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]
B Other
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ASerine/threonine kinases: CAMK group
B CAMK1 family [OT]
B CAMK2 family
C NECAME_05847 hypothetical protein K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
B CAMKL family
C NECAME_04996 hypothetical protein K08796 BRSK; BR serine/threonine kinase [EC:2.7.11.1]
C NECAME_14937 kinase domain protein K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
C NECAME_14939 kinase domain protein K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
C NECAME_09582 kinase domain protein K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
C NECAME_08849 kinase domain protein K08798 MARK; MAP/microtubule affinity-regulating kinase [EC:2.7.11.1]
C NECAME_17225 kinase domain protein K08799 MELK; maternal embryonic leucine zipper kinase [EC:2.7.11.1]
C NECAME_10734 kinase domain protein K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
C NECAME_02169 kinase domain protein K08802 SNRK; SNF related kinase [EC:2.7.11.1]
C NECAME_04758 kinase domain protein K07298 STK11; serine/threonine-protein kinase 11 [EC:2.7.11.1]
B DAPK family
C NECAME_01413 death domain protein K08803 DAPK; death-associated protein kinase [EC:2.7.11.1]
B DCAMKL family
C NECAME_15901 kinase domain protein K08805 DCLK1_2; doublecortin-like kinase 1/2 [EC:2.7.11.1]
B MAPKAPK family [OT]
C NECAME_13078 kinase domain protein K04443 MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
C NECAME_04156 kinase domain protein K04372 MKNK; MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]
B MLCK family
C NECAME_00034 kinase domain protein K00907 MYLK; myosin-light-chain kinase [EC:2.7.11.18]
C NECAME_01255 hypothetical protein K12567 TTN; titin [EC:2.7.11.1]
B PHK family
C NECAME_03497 kinase domain protein K00871 PHKG; phosphorylase kinase gamma subunit [EC:2.7.11.19]
B PIM family [OT]
B PKD family
B PSK family
C NECAME_10644 hypothetical protein K08808 PSKH; protein serine kinase H [EC:2.7.11.1]
B RAD53 family
C NECAME_12459 kinase domain protein K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
B Trio family [OT]
B TSSK family
B CDPK family
B CASK family
C NECAME_08350 variant SH3 domain protein K06103 CASK; calcium/calmodulin-dependent serine protein kinase [EC:2.7.11.1]
B Trbl family
B Other
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ASerine/threonine kinases: CK1 group
B CK1 family [OT]
C NECAME_03501 putative casein kinase I isoform alpha K08957 CSNK1A; casein kinase 1, alpha [EC:2.7.11.1]
C NECAME_01424 kinase domain protein K08958 CSNK1G; casein kinase 1, gamma [EC:2.7.11.1]
B TTBK family
C NECAME_13398 hypothetical protein K08815 TTBK; tau tubulin kinase [EC:2.7.11.26]
B VRK family
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ASerine/threonine kinases: CMGC group
B CDK family
C NECAME_09786 kinase domain protein K08817 CCRK; cell cycle related kinase [EC:2.7.11.22]
C NECAME_01824 kinase domain protein K08818 CDC2L; cell division cycle 2-like [EC:2.7.11.22]
C NECAME_12986 kinase domain protein K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C NECAME_11256 hypothetical protein K02090 CDK5; cyclin-dependent kinase 5 [EC:2.7.11.22]
C NECAME_03745 kinase domain protein K02208 CDK8_11; cyclin-dependent kinase 8/11 [EC:2.7.11.22 2.7.11.23]
C NECAME_13386 kinase domain protein K02211 CDK9; cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]
C NECAME_13466 kinase domain protein K08819 CDK12_13; cyclin-dependent kinase 12/13 [EC:2.7.11.22 2.7.11.23]
C NECAME_10991 kinase domain protein K08821 CDK14; cyclin-dependent kinase 14 [EC:2.7.11.22]
B MAPK family [OT]
C NECAME_10005 kinase domain protein K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
C NECAME_10006 Mitogen-activated protein kinase 1 family protein K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
C NECAME_12008 kinase domain protein K19603 MAPK15; mitogen-activated protein kinase 15 [EC:2.7.11.24]
C NECAME_10255 kinase domain protein K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
C NECAME_09782 kinase domain protein K04441 P38; p38 MAP kinase [EC:2.7.11.24]
B GSK family [OT]
C NECAME_10523 kinase domain protein K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
C NECAME_03830 hypothetical protein K03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
B CLK family
C NECAME_09765 hypothetical protein K08823 CLK2_3; dual specificity protein kinase CLK2/3 [EC:2.7.12.1]
B CDKL family
C NECAME_09971 kinase domain protein K08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]
B DYRK family [OT]
C NECAME_16777 hypothetical protein K08825 DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1]
C NECAME_08997 kinase domain protein K18669 DYRK2_3_4; dual specificity tyrosine-phosphorylation-regulated kinase 2/3/4 [EC:2.7.12.1]
C NECAME_03318 kinase domain protein K08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]
C NECAME_04369 kinase domain protein K08827 PRPF4B; serine/threonine-protein kinase PRP4 [EC:2.7.11.1]
B RCK family [OT]
C NECAME_01617 kinase domain protein K08829 MAK; male germ cell-associated kinase [EC:2.7.11.22]
B SRPK family [OT]
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ASerine/threonine kinases: STE group
B STE7 family
C NECAME_05191 kinase domain protein K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
C NECAME_08069 kinase domain protein K04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
C NECAME_00159 kinase domain protein K04433 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
C NECAME_02715 kinase domain protein K04431 MAP2K7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
C NECAME_13299 hypothetical protein K04431 MAP2K7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
B STE20 family
C NECAME_10182 kinase domain protein K08835 OXSR1; serine/threonine-protein kinase OSR1/STK39 [EC:2.7.11.1]
C NECAME_03198 hypothetical protein K08836 SLK; STE20-like kinase [EC:2.7.11.1]
C NECAME_15037 hypothetical protein K08271 STRADA; STE20-related kinase adapter protein alpha
C NECAME_03244 kinase domain protein K08838 STK24_25_MST4; serine/threonine-protein kinase 24/25/MST4 [EC:2.7.11.1]
B STE11 family
C NECAME_10109 kinase domain protein K04421 MAP3K3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]
B Other
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ASerine/threonine kinases: TKL group
B IRAK family
C NECAME_08104 hypothetical protein K04730 IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
B LISK family [OT]
B LRRK family
B MLK family
C NECAME_07201 hypothetical protein K04427 MAP3K7; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
C NECAME_00333 kinase domain protein K04417 MAP3K9; mitogen-activated protein kinase kinase kinase 9 [EC:2.7.11.25]
C NECAME_11795 ankyrin repeat protein K06272 ILK; integrin-linked kinase [EC:2.7.11.1]
B RAF family [OT]
C NECAME_16277 kinase domain protein K04365 BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
C NECAME_04601 phorbol esters/diacylglycerol binding domain protein K18529 KSR2; kinase suppressor of Ras 2 [EC:2.7.11.1]
B RIPK family [OT]
B Other
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ASerine/threonine kinases: Other
B RGC family [OT]
C NECAME_11953 adenylate/guanylate cyclase catalytic domain protein K12323 ANPRA; atrial natriuretic peptide receptor A [EC:4.6.1.2]
B BUB family
B Bud32 family
C NECAME_14495 Kae1-associated kinase Bud32 K08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]
B CAMKK family
C NECAME_15838 kinase domain protein K07359 CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 [EC:2.7.11.17]
B CDC7 family
C NECAME_14599 hypothetical protein K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
B CK2 family
C NECAME_14772 hypothetical protein K03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]
B Haspin family
C NECAME_14987 hypothetical protein K16315 GSG2; serine/threonine-protein kinase haspin [EC:2.7.11.1]
B IKK family [OT]
B IRE family
C NECAME_12100 kinase domain protein K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]
B MOS family
B NAK family [OT]
C NECAME_07303 kinase domain protein K08853 AAK; AP2-associated kinase [EC:2.7.11.1]
C NECAME_01473 hypothetical protein K08855 GAK; cyclin G-associated kinase [EC:2.7.11.1]
C NECAME_17031 hypothetical protein K08856 STK16; serine/threonine kinase 16 [EC:2.7.11.1]
B NEK family
C NECAME_13564 kinase domain protein K20876 NEK7; serine/threonine-protein kinase Nek7 [EC:2.7.11.34]
C NECAME_02185 hypothetical protein K20877 NEK8; serine/threonine-protein kinase Nek8 [EC:2.7.11.1]
B NKF1 family
C NECAME_15470 hypothetical protein K08858 SBK; serine/threonine-protein kinase SBK [EC:2.7.11.1]
B NKF2 family
C NECAME_12182 hypothetical protein K05688 PINK1; PTEN induced putative kinase 1 [EC:2.7.11.1]
B NKF3 family
B NKF4 family
B NKF5 family
B NRBP family
C NECAME_14792 hypothetical protein K08875 NRBP; nuclear receptor-binding protein
B PEK family [OT]
C NECAME_02684 hypothetical protein K16194 EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]
B PLK family [OT]
C NECAME_11948 kinase domain protein K06631 PLK1; polo-like kinase 1 [EC:2.7.11.21]
C NECAME_09217 kinase domain protein K06631 PLK1; polo-like kinase 1 [EC:2.7.11.21]
C NECAME_13476 kinase domain protein K08863 PLK4; polo-like kinase 4 [EC:2.7.11.21]
B SCY1 family [OT]
C NECAME_05620 HEAT repeat protein K08876 SCYL1; SCY1-like protein 1
C NECAME_01186 HEAT repeat protein K17542 SCYL3; SCY1-like protein 3
B Slob family
B TBCK family
C NECAME_01176 TBC domain protein K17544 TBCK; TBC domain-containing protein kinase-like protein
B TLK family
C NECAME_05650 kinase domain protein K08864 TLK; tousled-like kinase [EC:2.7.11.1]
B TOPK family
B TTK family
C NECAME_10130 kinase domain protein K08866 TTK; serine/threonine-protein kinase TTK/MPS1 [EC:2.7.12.1]
B ULK family [OT]
C NECAME_05912 kinase domain protein K08269 ULK2; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
B VPS15 family
B WEE family
C NECAME_09333 kinase domain protein K06633 PKMYT; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:2.7.11.1]
C NECAME_12987 hypothetical protein K06633 PKMYT; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:2.7.11.1]
B Wnk family
C NECAME_06208 hypothetical protein K08867 WNK; WNK lysine deficient protein kinase [EC:2.7.11.1]
B ABC1 family
C NECAME_13222 ABC1 family protein K08869 ADCK; aarF domain-containing kinase
C NECAME_15692 ABC1 family protein K08869 ADCK; aarF domain-containing kinase
C NECAME_11186 ABC1 family protein K08869 ADCK; aarF domain-containing kinase
B Alpha family [OT]
C NECAME_09662 MHCK/EF2 kinase domain protein K08292 EEF2K; elongation factor 2 kinase [EC:2.7.11.20]
B BCR family
B BRD family [OT]
C NECAME_01181 Bromodomain protein K08871 BRD2; bromodomain-containing protein 2
B FAST family
B G11 family
B H11 family
B PDHK family [OT]
C NECAME_00928 ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein K00898 PDK2_3_4; pyruvate dehydrogenase kinase 2/3/4 [EC:2.7.11.2]
B PIKK family [OT]
B RIO family [OT]
C NECAME_11998 RIO1 family protein K07178 RIOK1; RIO kinase 1 [EC:2.7.11.1]
C NECAME_02786 RIO1 family protein K07179 RIOK2; RIO kinase 2 [EC:2.7.11.1]
C NECAME_15087 RIO1 family protein K08872 RIOK3; RIO kinase 3 [EC:2.7.11.1]
B TAF1 family
B TIF1 family [OT]
B Other
B Bacterial family
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AReceptor serine/threonine kinases (RSTK): TKL group
B TGFBR1 family [OT]
C NECAME_03193 hypothetical protein K13578 BMPR1B; bone morphogenetic protein receptor type-1B [EC:2.7.11.30]
C NECAME_04333 kinase domain protein K04674 TGFBR1; TGF-beta receptor type-1 [EC:2.7.11.30]
B TGFBR2 family [OT]
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AReceptor tyrosine kinases (RTK)
B EGFR family [OT]
C NECAME_12048 receptor L domain protein K04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]
B INSR family [OT]
B PDGFR family [OT]
B FGFR family [OT]
B VEGFR family [OT]
C NECAME_00008 immunoglobulin domain protein K05096 FLT1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
B MET family
B TRK family [OT]
B EPH family [OT]
B AXL family
B ALK family
B TIE family
B ROR family
C NECAME_13434 kringle domain protein K05123 ROR2; receptor tyrosine kinase-like orphan receptor 2 [EC:2.7.10.1]
B DDR family
B RET family
B ROS family
B CCK family
B RYK family
B MUSK family
B LMR family [OT]
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ANon-receptor tyrosine kinases
B ABL family
C NECAME_06130 SH2 domain protein K06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
B ACK family
B CSK family
C NECAME_14656 SH2 domain protein K05728 CSK; c-src tyrosine kinase [EC:2.7.10.2]
B FAK family
B FES family
C NECAME_05150 protein tyrosine kinase K08889 FER; tyrosine-protein kinase Fer [EC:2.7.10.2]
C NECAME_10975 SH2 domain protein K08889 FER; tyrosine-protein kinase Fer [EC:2.7.10.2]
B JAK family [OT]
B SRC family
C NECAME_08560 tyrosine-protein kinase transforming protein Src K08892 FRK; fyn-related kinase [EC:2.7.10.2]
C NECAME_07204 putative tyrosine-protein kinase transforming protein Src K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
B TEC family
B SYK family
B Other
B Bacterial
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AHistidine kinases
B OmpR family
B NarL family
B Spo family [OT]
B CitB family [OT]
B LytTR family [OT]
B NtrC family
B CheA family [OT]
B Cell cycle family [OT]
B Lux family [OT]
B LuxR family [OT]
B Other
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: June 3, 2024
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Classification taken and modified from Hanks (2003)