+F Repair protein KO
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DNA Repair and Recombination Proteins - Nitrosomonas europaea
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D NE0885 ogt; Methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E NE0056 mutY; HhH-GPD K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E NE2223 nth; HhH-GPD:Iron-sulfur cluster loop (FCL) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D NE2215 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NE1462 dut; dUTPase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D NE0885 ogt; Methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E NE1560 conserved hypothetical protein K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E NE0931 conserved hypothetical protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E NE1398 putative DNA polymerase-related protein, bacteriophage-type K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E NE0981 HhH-GPD K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E NE0056 mutY; HhH-GPD K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E NE2552 mutM; Formamidopyrimidine-DNA glycolase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E NE2223 nth; HhH-GPD:Iron-sulfur cluster loop (FCL) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E NE2192 xthA2; Exodeoxyribonuclease III:Exodeoxyribonuclease III xth K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E NE0023 xthA1; Exodeoxyribonuclease III:Exodeoxyribonuclease III xth K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E NE0010 recJ; recJ: single-stranded-DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E NE1753 lig; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E NE1468 polA; polA; DNA polymerase I protein K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E NE2455 uvrA1; ABC transporter:Excinuclease ABC A subunit K03701 uvrA; excinuclease ABC subunit A
E NE0785 uvrB; Helicase subunit of the DNA excision repair complex K03702 uvrB; excinuclease ABC subunit B
E NE0933 uvrC; uvrC Nuclease subunit of the excinuclease complex K03703 uvrC; excinuclease ABC subunit C
E NE1473 uvrD; UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E NE1468 polA; polA; DNA polymerase I protein K02335 polA; DNA polymerase I [EC:2.7.7.7]
E NE1753 lig; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F NE2046 rpoB; RNA polymerases beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F NE2045 rpoC; RNA polymerase, alpha subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F NE0426 rpoA; Bacterial RNA polymerase, alpha chain K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F NE2255 rpoZ; RNA polymerase omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F NE0008 mfd; mfd: transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E NE1705 mutS; mutS; DNA mismatch repair protein K03555 mutS; DNA mismatch repair protein MutS
E NE0830 DNA mismatch repair protein MutS family, C-terminal domain K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E NE1742 mutL; mutL; DNA mismatch repair protein K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E NE0671 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E NE1172 xseA; xseA; exodeoxyribonuclease vII large subunit protein K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E NE1159 xseB; Exonuclease VII, small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E NE1978 dnaE1; dnaE1; DNA polymerase III (alpha chain) protein K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E NE0002 dnaN; DNA polymerase III, beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E NE0442 holC; putative DNA polymerase III (chi subunit) protein K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E NE1137 holA; putative DNA polymerase III (delta subunit) protein K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E NE2180 holB; putative DNA polymerase III (delta' subunit) protein K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E NE0141 dnaQ; probable DNA polymerase III (epsilon chain) protein K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E NE0433 dnaX; dnaX; DNA polymerase III (subunits tau and gamma) protein K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E NE1753 lig; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E NE1473 uvrD; UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E NE2453 ssb; Single-strand binding protein family K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E NE1932 recA; RecA bacterial DNA recombination protein:AAA ATPase superfamily K03553 recA; recombination protein RecA
E NE0212 ruvA; probable Holliday junction DNA helicase subunit K03550 ruvA; holliday junction DNA helicase RuvA
E NE0213 ruvB; ruvB; holliday junction DNA helicase protein K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E NE0211 ruvC; Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E NE1505 priA; probable priA; primosomal protein N' (replication factor Y) K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E NE0197 conserved hypothetical protein K02686 priB; primosomal replication protein N
E NE0671 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E NE1392 sbcC; ATP/GTP-binding site motif A (P-loop):ABC transporter K03546 sbcC; DNA repair protein SbcC/Rad50
E NE1390 sbcD; Serine/threonine specific protein phosphatase:Exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E NE1932 recA; RecA bacterial DNA recombination protein:AAA ATPase superfamily K03553 recA; recombination protein RecA
E NE1808 radA; sms: DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E NE1850 recG; RecG-like helicases K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E NE2525 possible ATP-dependent DNA helicase RecG-related protein K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E NE0383 conserved hypothetical protein K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E NE0010 recJ; recJ: single-stranded-DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E NE1479 recN; ABC transporter:DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E NE0507 rdgC; putative recombination associated protein rdgC K03554 rdgC; recombination associated protein RdgC
E NE0212 ruvA; probable Holliday junction DNA helicase subunit K03550 ruvA; holliday junction DNA helicase RuvA
E NE0213 ruvB; ruvB; holliday junction DNA helicase protein K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E NE0211 ruvC; Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E NE0111 Protein of unknown function DUF48 K15342 cas1; CRISP-associated protein Cas1
E NE0844 Protein of unknown function DUF48 K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
E NE1392 sbcC; ATP/GTP-binding site motif A (P-loop):ABC transporter K03546 sbcC; DNA repair protein SbcC/Rad50
E NE1390 sbcD; Serine/threonine specific protein phosphatase:Exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
E NE1263 conserved hypothetical protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F NE0332 gyrA; DNA gyrase/topoisomerase IV, subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F NE0003 gyrB; DNA gyrase, subunit B:DNA topoisomerase II gyrB K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
E Supressor
F NE2207 hupB; Bacterial histone-like DNA-binding protein K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F NE0010 recJ; recJ: single-stranded-DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F NE1753 lig; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F NE0875 fis; probable factor-for-inversion-stimulation transcription regulator protein K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F NE0952 ihfA; Bacterial histone-like DNA-binding protein K04764 ihfA; integration host factor subunit alpha
F NE1961 ihfB; Bacterial histone-like DNA-binding protein K05788 ihfB; integration host factor subunit beta
E Supressor
F NE0671 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F NE2564 recQ; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F NE0093 recQ; ATP-dependent DNA helicase K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F NE2520 ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F NE2455 uvrA1; ABC transporter:Excinuclease ABC A subunit K03701 uvrA; excinuclease ABC subunit A
F NE0785 uvrB; Helicase subunit of the DNA excision repair complex K03702 uvrB; excinuclease ABC subunit B
F NE1339 H-NS histone family K03746 hns; DNA-binding protein H-NS
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D NE1219 UMUC family (DNA-repair) K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D NE1932 recA; RecA bacterial DNA recombination protein:AAA ATPase superfamily K03553 recA; recombination protein RecA
D NE1479 recN; ABC transporter:DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D NE2453 ssb; Single-strand binding protein family K03111 ssb; single-strand DNA-binding protein
D NE1931 recX; RecX regulatory protein K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D NE0880 probable ATP-dependent DNA helicase-related protein K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D NE2215 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D NE1462 dut; dUTPase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D NE2423 nrdA; Ribonucleotide reductase large subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D NE2422 nrdB; Ribonucleotide reductase K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024