+E Polyketide biosynthesis proteins KO #

  Polyketide Biosynthesis Proteins - Streptomyces albireticuli

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APolyketide synthase (PKS) B Modular type I PKS C cis-AT PKS D Erythronolide PKS D Oleandomycin synthase D Pikromycin PKS D Avermectin PKS D Tylactone synthase D Protomycinolide IV synthase D Niddamycin PKS E SMD11_1655 polyketide synthase K16372 nidA1; niddamycin polyketide synthase 1 E SMD11_1653 polyketide synthase module 3 K20786 nidA2; niddamycin polyketide synthase 2 E SMD11_1654 polyketide synthase module 3 K20786 nidA2; niddamycin polyketide synthase 2 E SMD11_1652 polyketide synthase modules 4 and 5 K16373 nidA3; niddamycin polyketide synthase 3 E SMD11_1651 polyketide synthase module 6 K16374 nidA4_5; niddamycin polyketide synthase 4/5 E SMD11_1650 polyketide synthase K16374 nidA4_5; niddamycin polyketide synthase 4/5 D Rapamycin PKS D Immunomycin PKS D Ansamitocin PKS D Rifamycin PKS D Polyene macrolide PKS D Pimaricinolide synthase E SMD11_6574 hypothetical protein K16391 pimS0; pimaricinolide synthase, loading module E SMD11_6571 type I polyketide synthase K19203 pimS1; pimaricinolide synthase PimS1 E SMD11_6567 ScnS2 K19204 pimS2; pimaricinolide synthase PimS2 E SMD11_6568 PimS3 protein K19205 pimS3; pimaricinolide synthase PimS3 E SMD11_6569 polyketide synthase K19206 pimS4; pimaricinolide synthase PimS4 D Candicidin PKS D Soraphen PKS D Stigmatellin PKS D Mycolactone PKS D Coelimycin PKS D Aureothin PKS D Spectinabilin PKS D Phthiocerol / Phenolphthiocerol PKS C trans-AT PKS D Bacillanene hybrid PKS-NRPS D Chivosazol hybrid PKS-NRPS E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133] D Macrolactin PKS D Difficidin PKS D Rhizoxin hybrid PKS-NRPS D Myxovirescin hybrid PKS-NRPS E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932] D Albicidin synthase, hybrid PKS-NRPS E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516] E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523] D Etnangien PKS E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193] B Iterative type I PKS C Fungal nonreducing PKS (NR-PKS) C Fungal partially reducing PKS (PR-PKS) D SMD11_6411 hypothetical protein K15320 ATX; 6-methylsalicylic acid synthase [EC:2.3.1.165] C Fungal highly reducing PKS (HR-PKS) C Fungal hybrid type D Zearalenone synthase D Asperfuranone NR/HR-PKS E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2] E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2] C Bacterial type B Type II PKS C C9-C14 cyclized polyketide type D Spore pigment PKS C C7-C14 cyclized polyketide type D Octaketide PKS E SMD11_0675 actI1; Polyketide beta-ketoacyl synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_6044 actI1; beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_0676 actI2; Polyketide chain length factor WhiE-CLF protein K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_1144 actI2; chain length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_6045 actI2; beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_0677 actI3; Acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E SMD11_1145 actI3; acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E SMD11_6046 actI3; actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E SMD11_0674 actIII; Acetoacetyl-CoA reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E SMD11_1159 actIII; ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E SMD11_6047 actIII; PgaD K12420 actIII; ketoreductase [EC:1.1.1.-] E SMD11_0678 actVII; actinorhodin polyketide synthase bifunctional cyclase/dehydratase K05554 actVII; aromatase [EC:4.2.1.-] E SMD11_1146 actVII; cyclase K05554 actVII; aromatase [EC:4.2.1.-] E SMD11_6048 actVII; cyclase K05554 actVII; aromatase [EC:4.2.1.-] E SMD11_0679 actIV; cyclase K05555 actIV; cyclase [EC:4.-.-.-] E SMD11_5327 actIV; beta-lactamase K05555 actIV; cyclase [EC:4.-.-.-] D Nonaketide PKS E SMD11_0675 actI1; Polyketide beta-ketoacyl synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_6044 actI1; beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_0676 actI2; Polyketide chain length factor WhiE-CLF protein K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_1144 actI2; chain length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_6045 actI2; beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_0677 actI3; Acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E SMD11_1145 actI3; acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E SMD11_6046 actI3; actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E SMD11_0674 actIII; Acetoacetyl-CoA reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E SMD11_1159 actIII; ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E SMD11_6047 actIII; PgaD K12420 actIII; ketoreductase [EC:1.1.1.-] E SMD11_6043 whiEVII; polyketide synthase K15926 jadI; cyclase D Decaketide PKS E SMD11_0675 actI1; Polyketide beta-ketoacyl synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_6044 actI1; beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_0676 actI2; Polyketide chain length factor WhiE-CLF protein K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_1144 actI2; chain length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_6045 actI2; beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E SMD11_0677 actI3; Acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E SMD11_1145 actI3; acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E SMD11_6046 actI3; actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E SMD11_0674 actIII; Acetoacetyl-CoA reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E SMD11_1159 actIII; ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E SMD11_6047 actIII; PgaD K12420 actIII; ketoreductase [EC:1.1.1.-] B Type III PKS C Plant type C Fungal type C Bacterial type D SMD11_3072 phlD; type-III PKS K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233] D SMD11_6467 bpsA; transferase K16167 bpsA; alkylresorcinol/alkylpyrone synthase D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550] D ------ arsC; alkylpyrone synthase [AVN:Avin_29530] B PKS-NRPS hybrid C Bacterial type (modular) D Myxalamid hybrid PKS-NRPS D Myxothiazol hybrid PKS-NRPS E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019] D Coronatine hybrid PKS-NRPS D Microcystin synthetase D Epothilone synthetase D Bleomycin synthetase D Colibactin synthetase C Fungal type (trans-ER, iterative) D Aspyridone synthetase C Fungal type (iterative) # ANonribosomal peptide synthetase (NRPS) B Linear NRPS C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2] C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500] C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000] C ACV synthetase C Bacitracin synthetase C Viomycin synthetase C Pristinamycin I synthetase C Tyrocidine synthetase C Surfactin family lipopeptide synthetase C Iturin family lipopeptide synthetase C Fengycin family lipopeptide synthetase C Arthrofactin type cyclic lipopeptide synthetase C Vancomycin synthetase C Nocardicin synthetase D SMD11_0928 hypothetical protein K05375 mbtH; MbtH protein D SMD11_0621 mbtH; protein mbtH K05375 mbtH; MbtH protein D SMD11_1380 mbtH; MbtH K05375 mbtH; MbtH protein D SMD11_6688 mbtH; antibiotic synthesis protein MbtH K05375 mbtH; MbtH protein D SMD11_6084 mbtH; putative MbtH like protein K05375 mbtH; MbtH protein C Bialaphos synthetase C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase B Iterative NRPS C Enterobactin synthetase D SMD11_1314 entE; enterobactin synthase subunit E K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D SMD11_1311 entF; thioester reductase K02364 entF; L-serine---[L-seryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.72] C Bacillibactin synthetase D SMD11_1314 entE; enterobactin synthase subunit E K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D SMD11_0929 dhbF; peptide synthetase K04780 dhbF; glyine---[glycyl-carrier protein] ligase [EC:6.2.1.66] C Gramicidin synthetase B Nonlinear NRPS C Yersiniabactin synthetase C Pyochelin synthetase C Mycobactin synthetase C Vibriobactin synthetase D SMD11_1314 entE; enterobactin synthase subunit E K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Myxochelin synthetase D SMD11_1314 entE; enterobactin synthase subunit E K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Petrobacin synthetase C Syringomycin synthetase C Vanchrobactin synthetase D SMD11_1314 entE; enterobactin synthase subunit E K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] # APolyketide tailoring proteins B Hydrolase B Ketoreductase C SMD11_6827 hypothetical protein K05556 actVI1; ketoreductase RED1 [EC:1.1.1.-] C SMD11_1158 ketoreductase K14633 gra6; ketoreductase RED2 [EC:1.1.1.-] B Oxygenase C SMD11_6576 cytochrome P450 K16389 amphN; cytochrome P450 monooxygenase C SMD11_6570 penM; cytochrome P450 K16390 amphL; cytochrome P450 monooxygenase C SMD11_0702 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C SMD11_1711 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] B Methylase C SMD11_1646 putative O-methyltransferase K16028 asm17; O-methyltransferase B Glycosyltransferase C SMD11_6578 putative glucosyl transferase K16388 amphDI; polyene glycosyltransferase B Halogenase B beta-Branched incorporating proteins B Others C SMD11_1670 paaH; putative dehydrogenase K16024 asm13; methoxymalonate biosynthesis protein C SMD11_1671 putative acyl carrier protein K16025 asm14; methoxymalonate biosynthesis acyl carrier protein C SMD11_1672 putative dehydrogenase K16026 asm15; methoxymalonate biosynthesis protein C SMD11_1673 putative methoxymalonate biosynthesis protein K16027 asm16; methoxymalonate biosynthesis protein C SMD11_1160 hypothetical protein K14626 actVIA; actinorhodin biosynthesis protein ActVIA C SMD11_0681 actVB; flavin oxidoreductase K14631 actVB; flavin reductase ActVB [EC:1.5.1.-] C SMD11_1393 actVB; FMN-binding flavin reductase domain protein K14631 actVB; flavin reductase ActVB [EC:1.5.1.-] # ANonribosomal peptide tailoring proteins B Reductase B Thioesterase B Oxygenase B Glycosyltransferase C SMD11_6659 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] C SMD11_6727 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] B Aminotransferase B Others ! #
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: February 19, 2024