+D GENES KO #

  KEGG Orthology (KO) - Sphingobacterium sp. 21

% ! A09100 Metabolism B B 09101 Carbohydrate metabolism C 00010 Glycolysis / Gluconeogenesis [PATH:shg00010] D Sph21_5117 glucokinase K00845 glk; glucokinase [EC:2.7.1.2] D Sph21_1910 ROK family protein K25026 glk; glucokinase [EC:2.7.1.2] D Sph21_0676 Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D Sph21_1062 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_3894 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_3143 Fructose-1,6-bisphosphatase class 1 K03841 FBP; fructose-1,6-bisphosphatase I [EC:3.1.3.11] D Sph21_3994 fructose-bisphosphate aldolase, class II K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D Sph21_3045 triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] D Sph21_3255 Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D Sph21_5090 glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D Sph21_3892 glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D Sph21_0067 glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D Sph21_0066 Phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3] D Sph21_2987 2,3-bisphosphoglycerate-independent phosphoglycerate mutase K15633 gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12] D Sph21_0335 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D Sph21_1354 pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] D Sph21_1149 pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D Sph21_1309 Pyruvate dehydrogenase (acetyl-transferring) K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D Sph21_1150 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] D Sph21_1690 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_3439 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_4787 Mannitol dehydrogenase K13979 yahK; alcohol dehydrogenase (NADP+) [EC:1.1.1.2] D Sph21_5179 acetate/CoA ligase K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1] D Sph21_1348 Aldose 1-epimerase K01785 galM; aldose 1-epimerase [EC:5.1.3.3] D Sph21_1023 Aldose 1-epimerase K01785 galM; aldose 1-epimerase [EC:5.1.3.3] D Sph21_1982 Aldose 1-epimerase K01785 galM; aldose 1-epimerase [EC:5.1.3.3] D Sph21_0595 Aldose 1-epimerase K01785 galM; aldose 1-epimerase [EC:5.1.3.3] D Sph21_2273 HAD-superfamily hydrolase, subfamily IA, variant 3 K20866 yihX; glucose-1-phosphatase [EC:3.1.3.10] D Sph21_2018 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D Sph21_3674 Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) K00131 gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9] D Sph21_3016 Phosphoenolpyruvate carboxykinase (ATP) K01610 pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49] C 00020 Citrate cycle (TCA cycle) [PATH:shg00020] D Sph21_3626 citrate synthase I K01647 CS; citrate synthase [EC:2.3.3.1] D Sph21_2236 aconitate hydratase K01681 ACO; aconitate hydratase [EC:4.2.1.3] D Sph21_0046 aconitate hydratase 1 K01681 ACO; aconitate hydratase [EC:4.2.1.3] D Sph21_0366 isocitrate dehydrogenase, NADP-dependent K00031 IDH1; isocitrate dehydrogenase [EC:1.1.1.42] D Sph21_3146 isocitrate dehydrogenase, NADP-dependent K00031 IDH1; isocitrate dehydrogenase [EC:1.1.1.42] D Sph21_1684 2-oxoglutarate dehydrogenase, E1 subunit K00164 OGDH; 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2] D Sph21_1685 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase K00658 DLST; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61] D Sph21_2539 Dihydrolipoyllysine-residue acetyltransferase K00658 DLST; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61] D Sph21_1690 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_3439 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_2418 succinyl-CoA synthetase, alpha subunit K01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5] D Sph21_3338 Succinyl-CoA ligase (ADP-forming) subunit beta K01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5] D Sph21_1710 succinate CoA transferase K18118 aarC; succinyl-CoA:acetate CoA-transferase [EC:2.8.3.18] D Sph21_1404 succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1] D Sph21_1403 succinate dehydrogenase/fumarate reductase iron-sulfur subunit K00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1] D Sph21_4874 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 sdhC; succinate dehydrogenase cytochrome b subunit D Sph21_1405 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 sdhC; succinate dehydrogenase cytochrome b subunit D Sph21_1523 Fumarate hydratase class II K01679 E4.2.1.2B; fumarate hydratase, class II [EC:4.2.1.2] D Sph21_3933 Malate dehydrogenase K00024 mdh; malate dehydrogenase [EC:1.1.1.37] D Sph21_2252 malate:quinone oxidoreductase K00116 mqo; malate dehydrogenase (quinone) [EC:1.1.5.4] D Sph21_3016 Phosphoenolpyruvate carboxykinase (ATP) K01610 pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49] D Sph21_1149 pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D Sph21_1309 Pyruvate dehydrogenase (acetyl-transferring) K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D Sph21_1150 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] C 00030 Pentose phosphate pathway [PATH:shg00030] D Sph21_0676 Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D Sph21_4277 glucose-6-phosphate 1-dehydrogenase K00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363] D Sph21_4278 6-phosphogluconolactonase K01057 PGLS; 6-phosphogluconolactonase [EC:3.1.1.31] D Sph21_1612 6-phosphogluconolactonase K07404 pgl; 6-phosphogluconolactonase [EC:3.1.1.31] D Sph21_4276 6-phosphogluconate dehydrogenase, decarboxylating K00033 PGD; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343] D Sph21_3089 ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1] D Sph21_2191 transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] D Sph21_2617 Transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] D Sph21_2618 1-deoxy-D-xylulose-5-phosphate synthase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] D Sph21_3915 Transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] D Sph21_3916 Transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] D Sph21_3182 transaldolase K00616 TALDO1; transaldolase [EC:2.2.1.2] D Sph21_2192 transaldolase K00616 TALDO1; transaldolase [EC:2.2.1.2] D Sph21_0015 sugar-phosphate isomerase, RpiB/LacA/LacB family K01808 rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6] D Sph21_4275 sugar-phosphate isomerase, RpiB/LacA/LacB family K01808 rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6] D Sph21_2018 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D Sph21_5156 ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] D Sph21_4580 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] D Sph21_0579 KDPG and KHG aldolase K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] D Sph21_3674 Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) K00131 gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9] D Sph21_3176 3-oxoacyl-(acyl-carrier-protein) reductase K00034 gdh; glucose 1-dehydrogenase [EC:1.1.1.47] D Sph21_2765 Quinoprotein glucose dehydrogenase K00117 gcd; quinoprotein glucose dehydrogenase [EC:1.1.5.2] D Sph21_1253 Gluconolactonase K01053 gnl; gluconolactonase [EC:3.1.1.17] D Sph21_4037 SMP-30/Gluconolaconase/LRE-like region-containing protein K01053 gnl; gluconolactonase [EC:3.1.1.17] D Sph21_4554 Gluconokinase K25031 gntK; gluconokinase [EC:2.7.1.12] D Sph21_0578 PfkB domain protein K00874 kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45] D Sph21_2962 L-seryl-tRNA(ser) selenium transferase protein K17468 dgaE; D-glucosaminate-6-phosphate ammonia-lyase [EC:4.3.1.29] D Sph21_3994 fructose-bisphosphate aldolase, class II K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D Sph21_3143 Fructose-1,6-bisphosphatase class 1 K03841 FBP; fructose-1,6-bisphosphatase I [EC:3.1.3.11] D Sph21_1062 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_3894 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] C 00040 Pentose and glucuronate interconversions [PATH:shg00040] D Sph21_2881 Pectinesterase K01051 E3.1.1.11; pectinesterase [EC:3.1.1.11] D Sph21_2885 Pectinesterase K01051 E3.1.1.11; pectinesterase [EC:3.1.1.11] D Sph21_0475 hypothetical protein K01730 ogl; oligogalacturonide lyase [EC:4.2.2.6] D Sph21_2820 Cupin 2 conserved barrel domain protein K26933 kdgF; unsaturated pyranuronate lyase [EC:4.2.99.25] D Sph21_0728 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase K01815 kduI; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [EC:5.3.1.17] D Sph21_0726 2-deoxy-D-gluconate 3-dehydrogenase K00065 kduD; 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase [EC:1.1.1.127] D Sph21_0575 Uronate isomerase K01812 uxaC; glucuronate isomerase [EC:5.3.1.12] D Sph21_2894 Uronate isomerase K01812 uxaC; glucuronate isomerase [EC:5.3.1.12] D Sph21_2892 Tagaturonate reductase K00041 uxaB; tagaturonate reductase [EC:1.1.1.58] D Sph21_0622 Altronate dehydratase K01685 uxaA; altronate hydrolase [EC:4.2.1.7] D Sph21_2893 Altronate dehydratase K01685 uxaA; altronate hydrolase [EC:4.2.1.7] D Sph21_0576 mannonate dehydratase K01686 uxuA; mannonate dehydratase [EC:4.2.1.8] D Sph21_2004 nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D Sph21_1960 nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D Sph21_1030 L-ribulose-5-phosphate 4-epimerase K03077 araD; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4] D Sph21_3089 ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1] D Sph21_1031 L-arabinose isomerase K01804 araA; L-arabinose isomerase [EC:5.3.1.4] D Sph21_1029 Ribulokinase K00853 araB; L-ribulokinase [EC:2.7.1.16] D Sph21_0610 L-ribulokinase K00853 araB; L-ribulokinase [EC:2.7.1.16] D Sph21_3964 Xylulokinase K00854 xylB; xylulokinase [EC:2.7.1.17] D Sph21_3963 Xylose isomerase K01805 xylA; xylose isomerase [EC:5.3.1.5] D Sph21_0515 Xylose isomerase domain-containing protein TIM barrel K01820 rhaA; L-rhamnose isomerase / sugar isomerase [EC:5.3.1.14 5.3.1.-] D Sph21_0982 Dihydrodipicolinate synthase K22397 yjhH; 2-dehydro-3-deoxy-D-pentonate aldolase [EC:4.1.2.28] D Sph21_2642 fumarylacetoacetate (FAA) hydrolase K14259 kdaD; 2-dehydro-3-deoxy-D-arabinonate dehydratase [EC:4.2.1.141] D Sph21_2641 Aldehyde dehydrogenase (NADP(+)) K13877 aldH; 2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26] D Sph21_0989 Aldehyde dehydrogenase (NADP(+)) K13877 aldH; 2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26] D Sph21_0436 Xylulokinase K22935 XK1; D-ribulokinase [EC:2.7.1.47] D Sph21_0612 L-fucose isomerase K01818 fucI; L-fucose/D-arabinose isomerase [EC:5.3.1.25 5.3.1.3] C 00051 Fructose and mannose metabolism [PATH:shg00051] D Sph21_0933 Endoglucanase H/Glycosyl hydrolase family 26 K01218 gmuG; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78] D Sph21_4785 Fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4] D Sph21_1644 mannose-6-phosphate isomerase type II K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8] D Sph21_3998 Phosphoglucosamine mutase K01840 manB; phosphomannomutase [EC:5.4.2.8] D Sph21_2002 Mannose-1-phosphate guanylyltransferase K00971 manC; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13] D Sph21_1755 GDP-mannose 4,6-dehydratase K01711 gmd; GDPmannose 4,6-dehydratase [EC:4.2.1.47] D Sph21_1941 GDP-mannose 4,6-dehydratase K01711 gmd; GDPmannose 4,6-dehydratase [EC:4.2.1.47] D Sph21_2012 GDP-L-fucose synthase K02377 TSTA3; GDP-L-fucose synthase [EC:1.1.1.271] D Sph21_0612 L-fucose isomerase K01818 fucI; L-fucose/D-arabinose isomerase [EC:5.3.1.25 5.3.1.3] D Sph21_4773 Pyridoxal 4-dehydrogenase K00064 E1.1.1.122; D-threo-aldose 1-dehydrogenase [EC:1.1.1.122] D Sph21_2776 NADP-dependent oxidoreductase domain K00064 E1.1.1.122; D-threo-aldose 1-dehydrogenase [EC:1.1.1.122] D Sph21_0618 3-oxoacyl-(acyl-carrier-protein) reductase K18333 E1.1.1.435; L-fucose dehydrogenase [EC:1.1.1.435] D Sph21_0619 amidohydrolase 2 K07046 E3.1.1.120; L-fucono-1,5-lactonase [EC:3.1.1.120] D Sph21_0515 Xylose isomerase domain-containing protein TIM barrel K01820 rhaA; L-rhamnose isomerase / sugar isomerase [EC:5.3.1.14 5.3.1.-] D Sph21_1062 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_3894 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_3143 Fructose-1,6-bisphosphatase class 1 K03841 FBP; fructose-1,6-bisphosphatase I [EC:3.1.3.11] D Sph21_3963 Xylose isomerase K01805 xylA; xylose isomerase [EC:5.3.1.5] D Sph21_3994 fructose-bisphosphate aldolase, class II K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D Sph21_3045 triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] D Sph21_4784 Fructan beta-fructosidase K03332 fruA; fructan beta-fructosidase [EC:3.2.1.80] D Sph21_0015 sugar-phosphate isomerase, RpiB/LacA/LacB family K01808 rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6] D Sph21_4275 sugar-phosphate isomerase, RpiB/LacA/LacB family K01808 rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6] C 00052 Galactose metabolism [PATH:shg00052] D Sph21_1348 Aldose 1-epimerase K01785 galM; aldose 1-epimerase [EC:5.1.3.3] D Sph21_1023 Aldose 1-epimerase K01785 galM; aldose 1-epimerase [EC:5.1.3.3] D Sph21_1982 Aldose 1-epimerase K01785 galM; aldose 1-epimerase [EC:5.1.3.3] D Sph21_0595 Aldose 1-epimerase K01785 galM; aldose 1-epimerase [EC:5.1.3.3] D Sph21_1349 Galactokinase K00849 galK; galactokinase [EC:2.7.1.6] D Sph21_1050 UDP-glucose 4-epimerase K01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2] D Sph21_2018 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D Sph21_5117 glucokinase K00845 glk; glucokinase [EC:2.7.1.2] D Sph21_1910 ROK family protein K25026 glk; glucokinase [EC:2.7.1.2] D Sph21_2327 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_2338 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_4567 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_2864 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_1975 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_2304 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_1756 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_2646 Beta-galactosidase K12308 bgaB; beta-galactosidase [EC:3.2.1.23] D Sph21_2648 Beta-galactosidase K12308 bgaB; beta-galactosidase [EC:3.2.1.23] D Sph21_4263 carbohydrate binding family 6 K07407 E3.2.1.22B; alpha-galactosidase [EC:3.2.1.22] D Sph21_4066 Alpha-galactosidase K07407 E3.2.1.22B; alpha-galactosidase [EC:3.2.1.22] D Sph21_1062 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_3894 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_4581 Galactonate dehydratase K01684 dgoD; galactonate dehydratase [EC:4.2.1.6] D Sph21_2640 Galactonate dehydratase K01684 dgoD; galactonate dehydratase [EC:4.2.1.6] D Sph21_4583 2-keto-3-deoxy-galactonokinase K00883 dgoK; 2-dehydro-3-deoxygalactonokinase [EC:2.7.1.58] D Sph21_3807 alpha amylase catalytic region K01187 malZ; alpha-glucosidase [EC:3.2.1.20] D Sph21_5140 glycoside hydrolase family 31 K01187 malZ; alpha-glucosidase [EC:3.2.1.20] C 00053 Ascorbate and aldarate metabolism [PATH:shg00053] D Sph21_2004 nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D Sph21_1960 nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D Sph21_0198 Inositol oxygenase K00469 MIOX; inositol oxygenase [EC:1.13.99.1] D Sph21_1253 Gluconolactonase K01053 gnl; gluconolactonase [EC:3.1.1.17] D Sph21_4037 SMP-30/Gluconolaconase/LRE-like region-containing protein K01053 gnl; gluconolactonase [EC:3.1.1.17] D Sph21_4773 Pyridoxal 4-dehydrogenase K00064 E1.1.1.122; D-threo-aldose 1-dehydrogenase [EC:1.1.1.122] D Sph21_2776 NADP-dependent oxidoreductase domain K00064 E1.1.1.122; D-threo-aldose 1-dehydrogenase [EC:1.1.1.122] D Sph21_1030 L-ribulose-5-phosphate 4-epimerase K03077 araD; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4] D Sph21_2642 fumarylacetoacetate (FAA) hydrolase K14259 kdaD; 2-dehydro-3-deoxy-D-arabinonate dehydratase [EC:4.2.1.141] D Sph21_2641 Aldehyde dehydrogenase (NADP(+)) K13877 aldH; 2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26] D Sph21_0989 Aldehyde dehydrogenase (NADP(+)) K13877 aldH; 2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26] C 00500 Starch and sucrose metabolism [PATH:shg00500] D Sph21_3807 alpha amylase catalytic region K01187 malZ; alpha-glucosidase [EC:3.2.1.20] D Sph21_5140 glycoside hydrolase family 31 K01187 malZ; alpha-glucosidase [EC:3.2.1.20] D Sph21_1423 Beta-glucosidase K05349 bglX; beta-glucosidase [EC:3.2.1.21] D Sph21_3133 Beta-glucosidase K05349 bglX; beta-glucosidase [EC:3.2.1.21] D Sph21_3949 beta-galactosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] D Sph21_4498 glycoside hydrolase family 5 K01179 E3.2.1.4; endoglucanase [EC:3.2.1.4] D Sph21_5137 Glucose-1-phosphate adenylyltransferase K00975 glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27] D Sph21_5138 Glycogen synthase K00703 glgA; starch synthase [EC:2.4.1.21] D Sph21_1635 Starch synthase K00703 glgA; starch synthase [EC:2.4.1.21] D Sph21_2180 1,4-alpha-glucan-branching enzyme K00700 GBE1; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18] D Sph21_5139 1,4-alpha-glucan-branching enzyme K00700 GBE1; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18] D Sph21_2181 trehalose synthase K05343 treS; maltose alpha-D-glucosyltransferase / alpha-amylase [EC:5.4.99.16 3.2.1.1] D Sph21_3806 Maltose alpha-D-glucosyltransferase K05343 treS; maltose alpha-D-glucosyltransferase / alpha-amylase [EC:5.4.99.16 3.2.1.1] D Sph21_2182 alpha amylase catalytic region K16147 glgE; starch synthase (maltosyl-transferring) [EC:2.4.99.16] D Sph21_0315 glycogen debranching enzyme GlgX K01214 ISA; isoamylase [EC:3.2.1.68] D Sph21_0314 malto-oligosyltrehalose trehalohydrolase K01236 treZ; maltooligosyltrehalose trehalohydrolase [EC:3.2.1.141] D Sph21_3794 malto-oligosyltrehalose trehalohydrolase K01236 treZ; maltooligosyltrehalose trehalohydrolase [EC:3.2.1.141] D Sph21_1323 trehalose-phosphatase K16055 TPS; trehalose 6-phosphate synthase/phosphatase [EC:2.4.1.15 3.1.3.12] D Sph21_1252 Alpha,alpha-trehalase K01194 TREH; alpha,alpha-trehalase [EC:3.2.1.28] D Sph21_2018 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D Sph21_5117 glucokinase K00845 glk; glucokinase [EC:2.7.1.2] D Sph21_1910 ROK family protein K25026 glk; glucokinase [EC:2.7.1.2] D Sph21_0676 Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D Sph21_4785 Fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4] C 00520 Amino sugar and nucleotide sugar metabolism [PATH:shg00520] D Sph21_2699 Chitinase K01183 E3.2.1.14; chitinase [EC:3.2.1.14] D Sph21_0789 Beta-N-acetylhexosaminidase K01207 nagZ; beta-N-acetylhexosaminidase [EC:3.2.1.52] D Sph21_0790 Beta-N-acetylhexosaminidase K01207 nagZ; beta-N-acetylhexosaminidase [EC:3.2.1.52] D Sph21_3771 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_1083 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_0646 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_0655 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_0656 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_1908 Mannosylglycoprotein endo-beta-mannosidase K15855 csxA; exo-1,4-beta-D-glucosaminidase [EC:3.2.1.165] D Sph21_4115 N-acetylglucosamine-6-phosphate deacetylase K01443 nagA; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25] D Sph21_2846 N-acetylglucosamine-6-phosphate deacetylase K01443 nagA; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25] D Sph21_0371 Glucosamine-6-phosphate deaminase K02564 nagB; glucosamine-6-phosphate deaminase [EC:3.5.99.6] D Sph21_1509 glucosamine-6-phosphate isomerase K02564 nagB; glucosamine-6-phosphate deaminase [EC:3.5.99.6] D Sph21_4785 Fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4] D Sph21_2063 Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] D Sph21_3259 N-acetylmuramic acid 6-phosphate etherase K07106 murQ; N-acetylmuramic acid 6-phosphate etherase [EC:4.2.1.126] D Sph21_3769 Anhydro-N-acetylmuramic acid kinase K09001 anmK; anhydro-N-acetylmuramic acid kinase [EC:2.7.1.170] D Sph21_2929 UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D Sph21_1700 UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] D Sph21_0108 N-acylglucosamine 2-epimerase K01787 RENBP; N-acylglucosamine 2-epimerase [EC:5.1.3.8] D Sph21_4586 N-acetylneuraminate lyase K01639 E4.1.3.3; N-acetylneuraminate lyase [EC:4.1.3.3] D Sph21_1828 UDP-N-acetylglucosamine 2-epimerase K01791 wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14] D Sph21_1811 nucleotide sugar dehydrogenase K02474 wbpO; UDP-N-acetyl-D-glucosamine/UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.136 1.1.1.-] D Sph21_1815 N-acetylneuraminate synthase K18430 legI; N,N'-diacetyllegionaminate synthase [EC:2.5.1.101] D Sph21_1026 alpha-L-arabinofuranosidase domain protein K01209 abfA; alpha-L-arabinofuranosidase [EC:3.2.1.55] D Sph21_1025 alpha-L-arabinofuranosidase domain protein K01209 abfA; alpha-L-arabinofuranosidase [EC:3.2.1.55] D Sph21_4162 glycoside hydrolase family 43 K15921 xynD; arabinoxylan arabinofuranohydrolase [EC:3.2.1.55] D Sph21_2653 Xylan 1,4-beta-xylosidase K01198 xynB; xylan 1,4-beta-xylosidase [EC:3.2.1.37] D Sph21_2647 Xylan 1,4-beta-xylosidase K01198 xynB; xylan 1,4-beta-xylosidase [EC:3.2.1.37] D Sph21_5117 glucokinase K00845 glk; glucokinase [EC:2.7.1.2] D Sph21_1910 ROK family protein K25026 glk; glucokinase [EC:2.7.1.2] D Sph21_2018 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D Sph21_2004 nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D Sph21_1960 nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D Sph21_1349 Galactokinase K00849 galK; galactokinase [EC:2.7.1.6] D Sph21_1050 UDP-glucose 4-epimerase K01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2] D Sph21_0676 Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D Sph21_1644 mannose-6-phosphate isomerase type II K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8] D Sph21_3998 Phosphoglucosamine mutase K01840 manB; phosphomannomutase [EC:5.4.2.8] D Sph21_2002 Mannose-1-phosphate guanylyltransferase K00971 manC; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13] D Sph21_1755 GDP-mannose 4,6-dehydratase K01711 gmd; GDPmannose 4,6-dehydratase [EC:4.2.1.47] D Sph21_1941 GDP-mannose 4,6-dehydratase K01711 gmd; GDPmannose 4,6-dehydratase [EC:4.2.1.47] D Sph21_1813 DegT/DnrJ/EryC1/StrS aminotransferase K13010 per; perosamine synthetase [EC:2.6.1.102] D Sph21_2012 GDP-L-fucose synthase K02377 TSTA3; GDP-L-fucose synthase [EC:1.1.1.271] D Sph21_5137 Glucose-1-phosphate adenylyltransferase K00975 glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27] C 00620 Pyruvate metabolism [PATH:shg00620] D Sph21_5179 acetate/CoA ligase K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1] D Sph21_1149 pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D Sph21_1309 Pyruvate dehydrogenase (acetyl-transferring) K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D Sph21_1150 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] D Sph21_1690 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_3439 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_4787 Mannitol dehydrogenase K13979 yahK; alcohol dehydrogenase (NADP+) [EC:1.1.1.2] D Sph21_1354 pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] D Sph21_2237 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] D Sph21_0012 acetyl-CoA carboxylase, biotin carboxyl carrier protein K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein D Sph21_0013 acetyl-CoA carboxylase, biotin carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14] D Sph21_3995 Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15] D Sph21_1140 Acylphosphatase K01512 acyP; acylphosphatase [EC:3.6.1.7] D Sph21_1710 succinate CoA transferase K18118 aarC; succinyl-CoA:acetate CoA-transferase [EC:2.8.3.18] D Sph21_2205 Pyruvate dehydrogenase (cytochrome) K00156 poxB; pyruvate dehydrogenase (quinone) [EC:1.2.5.1] D Sph21_2899 D-lactate dehydrogenase K03778 ldhA; D-lactate dehydrogenase [EC:1.1.1.28] D Sph21_4107 Glyoxalase/bleomycin resistance protein/dioxygenase K01759 GLO1; lactoylglutathione lyase [EC:4.4.1.5] D Sph21_4356 Glyoxalase/bleomycin resistance protein/dioxygenase K01759 GLO1; lactoylglutathione lyase [EC:4.4.1.5] D Sph21_3587 beta-lactamase domain protein K01069 gloB; hydroxyacylglutathione hydrolase [EC:3.1.2.6] D Sph21_1341 beta-lactamase domain protein K01069 gloB; hydroxyacylglutathione hydrolase [EC:3.1.2.6] D Sph21_3596 Rhodanese-like protein K01069 gloB; hydroxyacylglutathione hydrolase [EC:3.1.2.6] D Sph21_4647 beta-lactamase domain protein K01069 gloB; hydroxyacylglutathione hydrolase [EC:3.1.2.6] D Sph21_2086 malic protein NAD-binding protein K00029 maeB; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40] D Sph21_3933 Malate dehydrogenase K00024 mdh; malate dehydrogenase [EC:1.1.1.37] D Sph21_2252 malate:quinone oxidoreductase K00116 mqo; malate dehydrogenase (quinone) [EC:1.1.5.4] D Sph21_1523 Fumarate hydratase class II K01679 E4.2.1.2B; fumarate hydratase, class II [EC:4.2.1.2] D Sph21_3165 Phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31] D Sph21_3016 Phosphoenolpyruvate carboxykinase (ATP) K01610 pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49] D Sph21_2475 acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D Sph21_2283 2-isopropylmalate synthase K01649 leuA; 2-isopropylmalate synthase [EC:2.3.3.13] C 00630 Glyoxylate and dicarboxylate metabolism [PATH:shg00630] D Sph21_5179 acetate/CoA ligase K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1] D Sph21_3933 Malate dehydrogenase K00024 mdh; malate dehydrogenase [EC:1.1.1.37] D Sph21_3626 citrate synthase I K01647 CS; citrate synthase [EC:2.3.3.1] D Sph21_2236 aconitate hydratase K01681 ACO; aconitate hydratase [EC:4.2.1.3] D Sph21_0046 aconitate hydratase 1 K01681 ACO; aconitate hydratase [EC:4.2.1.3] D Sph21_2475 acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D Sph21_4886 Catalase K03781 katE; catalase [EC:1.11.1.6] D Sph21_5077 Catalase K03781 katE; catalase [EC:1.11.1.6] D Sph21_1533 Catalase K03781 katE; catalase [EC:1.11.1.6] D Sph21_3869 Glyoxylate reductase K00015 gyaR; glyoxylate reductase [EC:1.1.1.26] D Sph21_0666 Glutamate--ammonia ligase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D Sph21_3985 Glutamate--ammonia ligase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D Sph21_1135 Glycine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D Sph21_2084 Glycine dehydrogenase (decarboxylating) K00281 GLDC; glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2] D Sph21_1168 Aminomethyltransferase K00605 gcvT; glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10] D Sph21_1690 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_3439 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_2197 Glycine cleavage system H protein K02437 gcvH; glycine cleavage system H protein D Sph21_3452 Xylose isomerase domain-containing protein TIM barrel K01816 hyi; hydroxypyruvate isomerase [EC:5.3.1.22] D Sph21_4632 glycerate kinase K00865 glxK; glycerate 2-kinase [EC:2.7.1.165] D Sph21_4580 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] D Sph21_0579 KDPG and KHG aldolase K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] D Sph21_1646 formyltetrahydrofolate deformylase K01433 purU; formyltetrahydrofolate deformylase [EC:3.5.1.10] C 00640 Propanoate metabolism [PATH:shg00640] D Sph21_5179 acetate/CoA ligase K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1] D Sph21_1690 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_3439 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_2237 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] D Sph21_0012 acetyl-CoA carboxylase, biotin carboxyl carrier protein K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein D Sph21_0013 acetyl-CoA carboxylase, biotin carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14] D Sph21_3995 Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15] D Sph21_3338 Succinyl-CoA ligase (ADP-forming) subunit beta K01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5] D Sph21_2418 succinyl-CoA synthetase, alpha subunit K01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5] D Sph21_4145 2-methylcitrate synthase/citrate synthase II K01659 prpC; 2-methylcitrate synthase [EC:2.3.3.5] D Sph21_4146 2-methylcitrate dehydratase K01720 prpD; 2-methylcitrate dehydratase [EC:4.2.1.79] D Sph21_4144 methylisocitrate lyase K03417 prpB; methylisocitrate lyase [EC:4.1.3.30] C 00650 Butanoate metabolism [PATH:shg00650] D Sph21_2475 acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D Sph21_3111 3-hydroxybutyryl-CoA dehydrogenase K00074 paaH; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157] D Sph21_0021 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein K07516 fadN; 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] D Sph21_0758 Enoyl-CoA hydratase K01715 crt; enoyl-CoA hydratase [EC:4.2.1.17] D Sph21_1404 succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1] D Sph21_1403 succinate dehydrogenase/fumarate reductase iron-sulfur subunit K00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1] D Sph21_4874 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 sdhC; succinate dehydrogenase cytochrome b subunit D Sph21_1405 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 sdhC; succinate dehydrogenase cytochrome b subunit D Sph21_5246 succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] D Sph21_1710 succinate CoA transferase K18118 aarC; succinyl-CoA:acetate CoA-transferase [EC:2.8.3.18] D Sph21_2967 Hydroxymethylglutaryl-CoA lyase K01640 HMGCL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] D Sph21_4669 3-oxoacid CoA-transferase, A subunit K01028 scoA; 3-oxoacid CoA-transferase subunit A [EC:2.8.3.5] D Sph21_4666 3-oxoacid CoA-transferase, B subunit K01029 scoB; 3-oxoacid CoA-transferase subunit B [EC:2.8.3.5] D Sph21_2289 acetolactate synthase, large subunit, biosynthetic type K01652 E2.2.1.6L; acetolactate synthase I/II/III large subunit [EC:2.2.1.6] D Sph21_2287 acetolactate synthase, small subunit K01653 E2.2.1.6S; acetolactate synthase I/III small subunit [EC:2.2.1.6] C 00660 C5-Branched dibasic acid metabolism [PATH:shg00660] D Sph21_2289 acetolactate synthase, large subunit, biosynthetic type K01652 E2.2.1.6L; acetolactate synthase I/II/III large subunit [EC:2.2.1.6] D Sph21_2287 acetolactate synthase, small subunit K01653 E2.2.1.6S; acetolactate synthase I/III small subunit [EC:2.2.1.6] D Sph21_3338 Succinyl-CoA ligase (ADP-forming) subunit beta K01903 sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5] D Sph21_2418 succinyl-CoA synthetase, alpha subunit K01902 sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5] D Sph21_2770 demethylmenaquinone methyltransferase-like protein K10218 ligK; 4-hydroxy-4-methyl-2-oxoglutarate aldolase [EC:4.1.3.17] D Sph21_2280 (R)-citramalate synthase K09011 cimA; (R)-citramalate synthase [EC:2.3.3.21] D Sph21_2282 3-isopropylmalate dehydratase large subunit K01703 leuC; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35] D Sph21_2281 3-isopropylmalate dehydratase, small subunit K01704 leuD; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35] D Sph21_2279 3-isopropylmalate dehydrogenase K00052 leuB; 3-isopropylmalate dehydrogenase [EC:1.1.1.85] C 00562 Inositol phosphate metabolism [PATH:shg00562] D Sph21_0662 phospholipase C, phosphocholine-specific K01114 plc; phospholipase C [EC:3.1.4.3] D Sph21_1769 phospholipase C, phosphocholine-specific K01114 plc; phospholipase C [EC:3.1.4.3] D Sph21_3623 Inositol-phosphate phosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25] D Sph21_5106 Myo-inositol-1-phosphate synthase K01858 INO1; myo-inositol-1-phosphate synthase [EC:5.5.1.4] D Sph21_4643 phytase K01083 E3.1.3.8; 3-phytase [EC:3.1.3.8] D Sph21_0198 Inositol oxygenase K00469 MIOX; inositol oxygenase [EC:1.13.99.1] D Sph21_0465 oxidoreductase domain protein K00010 iolG; myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase [EC:1.1.1.18 1.1.1.369] D Sph21_3454 oxidoreductase domain protein K00010 iolG; myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase [EC:1.1.1.18 1.1.1.369] D Sph21_0626 Xylose isomerase domain-containing protein TIM barrel K03335 iolE; inosose dehydratase [EC:4.2.1.44] D Sph21_3045 triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] B B 09102 Energy metabolism C 00190 Oxidative phosphorylation [PATH:shg00190] D Sph21_3180 NAD(P)H-quinone oxidoreductase subunit 3 K00330 nuoA; NADH-quinone oxidoreductase subunit A [EC:7.1.1.2] D Sph21_1587 NAD(P)H-quinone oxidoreductase subunit 3 K00330 nuoA; NADH-quinone oxidoreductase subunit A [EC:7.1.1.2] D Sph21_1588 NAD(P)H-quinone oxidoreductase subunit K K00331 nuoB; NADH-quinone oxidoreductase subunit B [EC:7.1.1.2] D Sph21_3179 NAD(P)H-quinone oxidoreductase subunit K K00331 nuoB; NADH-quinone oxidoreductase subunit B [EC:7.1.1.2] D Sph21_3341 NAD(P)H-quinone oxidoreductase subunit J K00332 nuoC; NADH-quinone oxidoreductase subunit C [EC:7.1.1.2] D Sph21_1589 NAD(P)H-quinone oxidoreductase subunit J K00332 nuoC; NADH-quinone oxidoreductase subunit C [EC:7.1.1.2] D Sph21_3340 NAD(P)H-quinone oxidoreductase subunit H K00333 nuoD; NADH-quinone oxidoreductase subunit D [EC:7.1.1.2] D Sph21_1590 NAD(P)H-quinone oxidoreductase subunit H K00333 nuoD; NADH-quinone oxidoreductase subunit D [EC:7.1.1.2] D Sph21_1591 NADH-quinone oxidoreductase, E subunit K00334 nuoE; NADH-quinone oxidoreductase subunit E [EC:7.1.1.2] D Sph21_1592 NADH-quinone oxidoreductase, F subunit K00335 nuoF; NADH-quinone oxidoreductase subunit F [EC:7.1.1.2] D Sph21_1593 NADH dehydrogenase K00336 nuoG; NADH-quinone oxidoreductase subunit G [EC:7.1.1.2] D Sph21_2206 NADH dehydrogenase (quinone) K00337 nuoH; NADH-quinone oxidoreductase subunit H [EC:7.1.1.2] D Sph21_1594 NADH dehydrogenase (quinone) K00337 nuoH; NADH-quinone oxidoreductase subunit H [EC:7.1.1.2] D Sph21_2207 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein K00338 nuoI; NADH-quinone oxidoreductase subunit I [EC:7.1.1.2] D Sph21_1595 NAD(P)H-quinone oxidoreductase subunit I K00338 nuoI; NADH-quinone oxidoreductase subunit I [EC:7.1.1.2] D Sph21_1596 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 nuoJ; NADH-quinone oxidoreductase subunit J [EC:7.1.1.2] D Sph21_2209 NAD(P)H-quinone oxidoreductase subunit 4L K00340 nuoK; NADH-quinone oxidoreductase subunit K [EC:7.1.1.2] D Sph21_1597 NAD(P)H-quinone oxidoreductase subunit 4L K00340 nuoK; NADH-quinone oxidoreductase subunit K [EC:7.1.1.2] D Sph21_2210 proton-translocating NADH-quinone oxidoreductase, chain L K00341 nuoL; NADH-quinone oxidoreductase subunit L [EC:7.1.1.2] D Sph21_1598 proton-translocating NADH-quinone oxidoreductase, chain L K00341 nuoL; NADH-quinone oxidoreductase subunit L [EC:7.1.1.2] D Sph21_2211 proton-translocating NADH-quinone oxidoreductase, chain M K00342 nuoM; NADH-quinone oxidoreductase subunit M [EC:7.1.1.2] D Sph21_1599 proton-translocating NADH-quinone oxidoreductase, chain M K00342 nuoM; NADH-quinone oxidoreductase subunit M [EC:7.1.1.2] D Sph21_2212 NAD(P)H-quinone oxidoreductase subunit 2 K00343 nuoN; NADH-quinone oxidoreductase subunit N [EC:7.1.1.2] D Sph21_1600 NAD(P)H-quinone oxidoreductase subunit 2 K00343 nuoN; NADH-quinone oxidoreductase subunit N [EC:7.1.1.2] D Sph21_2208 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K05578 ndhG; NAD(P)H-quinone oxidoreductase subunit 6 [EC:7.1.1.2] D Sph21_4547 NADH dehydrogenase (ubiquinone) K03885 ndh; NADH:quinone reductase (non-electrogenic) [EC:1.6.5.9] D Sph21_4903 NADH dehydrogenase (ubiquinone) K03885 ndh; NADH:quinone reductase (non-electrogenic) [EC:1.6.5.9] D Sph21_1704 NADH dehydrogenase (ubiquinone) K03885 ndh; NADH:quinone reductase (non-electrogenic) [EC:1.6.5.9] D Sph21_1404 succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1] D Sph21_1403 succinate dehydrogenase/fumarate reductase iron-sulfur subunit K00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1] D Sph21_4874 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 sdhC; succinate dehydrogenase cytochrome b subunit D Sph21_1405 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 sdhC; succinate dehydrogenase cytochrome b subunit D Sph21_1557 Protoheme IX farnesyltransferase K02257 COX10; heme o synthase [EC:2.5.1.141] D Sph21_1560 hypothetical protein K02277 coxD; cytochrome c oxidase subunit IV [EC:7.1.1.9] D Sph21_1558 cytochrome c oxidase, subunit III K02276 coxC; cytochrome c oxidase subunit III [EC:7.1.1.9] D Sph21_1559 cytochrome c oxidase subunit III K02276 coxC; cytochrome c oxidase subunit III [EC:7.1.1.9] D Sph21_1913 cytochrome c oxidase subunit I K02274 coxA; cytochrome c oxidase subunit I [EC:7.1.1.9] D Sph21_1555 cytochrome c oxidase subunit I K02274 coxA; cytochrome c oxidase subunit I [EC:7.1.1.9] D Sph21_1554 cytochrome c oxidase subunit II K02275 coxB; cytochrome c oxidase subunit II [EC:7.1.1.9] D Sph21_1556 cytochrome oxidase assembly K02259 COX15; heme a synthase [EC:1.17.99.9] D Sph21_3527 cytochrome c oxidase, cbb3-type, subunit I K15862 ccoNO; cytochrome c oxidase cbb3-type subunit I/II [EC:7.1.1.9] D Sph21_3529 cytochrome c class I K00406 ccoP; cytochrome c oxidase cbb3-type subunit III D Sph21_1182 cytochrome bd ubiquinol oxidase subunit I K00425 cydA; cytochrome bd ubiquinol oxidase subunit I [EC:7.1.1.7] D Sph21_1183 cytochrome bd ubiquinol oxidase subunit II K00426 cydB; cytochrome bd ubiquinol oxidase subunit II [EC:7.1.1.7] D Sph21_5232 ATP synthase subunit alpha K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1] D Sph21_2292 ATP synthase subunit beta K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1] D Sph21_5231 ATP synthase gamma chain K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma D Sph21_5233 ATP synthase subunit delta K02113 ATPF1D; F-type H+-transporting ATPase subunit delta D Sph21_2291 ATPase, F1 complex, delta/epsilon subunit K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon D Sph21_5236 ATP synthase subunit a K02108 ATPF0A; F-type H+-transporting ATPase subunit a D Sph21_5234 ATP synthase subunit b K02109 ATPF0B; F-type H+-transporting ATPase subunit b D Sph21_5235 ATP synthase subunit c K02110 ATPF0C; F-type H+-transporting ATPase subunit c D Sph21_1602 Inorganic pyrophosphatase K01507 ppa; inorganic pyrophosphatase [EC:3.6.1.1] D Sph21_0532 polyphosphate kinase 1 K00937 ppk1; polyphosphate kinase [EC:2.7.4.1] D Sph21_3169 polyphosphate kinase 1 K00937 ppk1; polyphosphate kinase [EC:2.7.4.1] D Sph21_2713 polyphosphate kinase 2 K22468 ppk2; polyphosphate kinase [EC:2.7.4.34] C 00195 Photosynthesis C 00196 Photosynthesis - antenna proteins C 00710 Carbon fixation in photosynthetic organisms C 00720 Carbon fixation pathways in prokaryotes C 00680 Methane metabolism [PATH:shg00680] D Sph21_1135 Glycine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D Sph21_0335 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D Sph21_3165 Phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31] D Sph21_3933 Malate dehydrogenase K00024 mdh; malate dehydrogenase [EC:1.1.1.37] D Sph21_3994 fructose-bisphosphate aldolase, class II K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D Sph21_3143 Fructose-1,6-bisphosphatase class 1 K03841 FBP; fructose-1,6-bisphosphatase I [EC:3.1.3.11] D Sph21_1062 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_3894 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_2360 protein of unknown function DUF224 cysteine-rich region domain protein K08264 hdrD; heterodisulfide reductase subunit D [EC:1.8.98.1] D Sph21_5179 acetate/CoA ligase K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1] D Sph21_2987 2,3-bisphosphoglycerate-independent phosphoglycerate mutase K15633 gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12] D Sph21_0005 Phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_0434 Phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_0741 amino acid-binding ACT domain protein K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_3091 Phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_3090 Phosphoserine aminotransferase K00831 serC; phosphoserine aminotransferase [EC:2.6.1.52] D Sph21_1338 Phosphosulfolactate synthase K08097 comA; phosphosulfolactate synthase [EC:4.4.1.19] D Sph21_1169 2-phosphosulfolactate phosphatase K05979 comB; 2-phosphosulfolactate phosphatase [EC:3.1.3.71] C 00910 Nitrogen metabolism [PATH:shg00910] D Sph21_3753 major facilitator superfamily MFS_1 K02575 NRT2; MFS transporter, NNP family, nitrate/nitrite transporter D Sph21_3754 Nitrite reductase (NAD(P)H) K00367 narB; ferredoxin-nitrate reductase [EC:1.7.7.2] D Sph21_2694 Nitrate reductase K00372 nasC; assimilatory nitrate reductase catalytic subunit [EC:1.7.99.-] D Sph21_3748 nitrite reductase (NAD(P)H), large subunit K00362 nirB; nitrite reductase (NADH) large subunit [EC:1.7.1.15] D Sph21_3747 nitrite reductase (NAD(P)H), small subunit K00363 nirD; nitrite reductase (NADH) small subunit [EC:1.7.1.15] D Sph21_4164 2-nitropropane dioxygenase K00459 ncd2; nitronate monooxygenase [EC:1.13.12.16] D Sph21_0947 2-nitropropane dioxygenase K00459 ncd2; nitronate monooxygenase [EC:1.13.12.16] D Sph21_2983 Glutamate dehydrogenase (NAD(P)(+)) K00261 GLUD1_2; glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3] D Sph21_3428 Glutamate dehydrogenase (NADP(+)) K00262 E1.4.1.4; glutamate dehydrogenase (NADP+) [EC:1.4.1.4] D Sph21_0666 Glutamate--ammonia ligase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D Sph21_3985 Glutamate--ammonia ligase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D Sph21_3183 Glutamate synthase (ferredoxin) K00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13] D Sph21_3184 glutamate synthase, NADH/NADPH, small subunit K00266 gltD; glutamate synthase (NADPH) small chain [EC:1.4.1.13] D Sph21_2129 carbonic anhydrase K01673 cynT; carbonic anhydrase [EC:4.2.1.1] D Sph21_3973 Carbonate dehydratase K01673 cynT; carbonic anhydrase [EC:4.2.1.1] C 00920 Sulfur metabolism [PATH:shg00920] D Sph21_3195 sulfate adenylyltransferase, large subunit K00956 cysN; sulfate adenylyltransferase subunit 1 [EC:2.7.7.4] D Sph21_3194 sulfate adenylyltransferase, small subunit K00957 cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4] D Sph21_1242 phosphoesterase RecJ domain protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3] D Sph21_3193 Phosphoadenylyl-sulfate reductase (thioredoxin) K00390 cysH; phosphoadenosine phosphosulfate reductase [EC:1.8.4.8 1.8.4.10] D Sph21_4717 Nitrate reductase (NADPH) K17225 soxC; sulfane dehydrogenase subunit SoxC D Sph21_4718 cytochrome c class I K22622 soxD; S-disulfanyl-L-cysteine oxidoreductase SoxD [EC:1.8.2.6] D Sph21_3190 Ferredoxin--nitrite reductase K00392 sir; sulfite reductase (ferredoxin) [EC:1.8.7.1] D Sph21_2030 transferase hexapeptide repeat containing protein K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] D Sph21_4128 Serine O-acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] D Sph21_4638 Cysteine synthase K01738 cysK; cysteine synthase [EC:2.5.1.47] D Sph21_3382 homoserine O-acetyltransferase K00641 metX; homoserine O-acetyltransferase/O-succinyltransferase [EC:2.3.1.31 2.3.1.46] D Sph21_0555 Cystathionine gamma-lyase K10764 metZ; O-succinylhomoserine sulfhydrylase [EC:2.5.1.-] B B 09103 Lipid metabolism C 00061 Fatty acid biosynthesis [PATH:shg00061] D Sph21_2237 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] D Sph21_0012 acetyl-CoA carboxylase, biotin carboxyl carrier protein K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein D Sph21_0013 acetyl-CoA carboxylase, biotin carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14] D Sph21_3995 Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15] D Sph21_3686 hypothetical protein K02078 acpP; acyl carrier protein D Sph21_1356 Acyl carrier protein K02078 acpP; acyl carrier protein D Sph21_1317 malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] D Sph21_0011 3-oxoacyl-(acyl-carrier-protein) synthase 3 K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] D Sph21_2077 Beta-ketoacyl-acyl-carrier-protein synthase III K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] D Sph21_2124 Beta-ketoacyl-acyl-carrier-protein synthase I K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] D Sph21_1357 3-oxoacyl-(acyl-carrier-protein) synthase 2 K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D Sph21_4075 3-oxoacyl-(acyl-carrier-protein) synthase 2 K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D Sph21_0337 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_2703 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_4360 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_2365 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_1541 UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase K16363 lpxC-fabZ; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59] D Sph21_0398 Enoyl-(acyl-carrier-protein) reductase (NADH) K00208 fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10] D Sph21_4113 Acyl-(acyl-carrier-protein) desaturase K03921 FAB2; acyl-[acyl-carrier-protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26] D Sph21_0025 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D Sph21_3308 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] C 00062 Fatty acid elongation C 00071 Fatty acid degradation [PATH:shg00071] D Sph21_2475 acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D Sph21_0020 acetyl-CoA acetyltransferase K00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16] D Sph21_0021 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein K07516 fadN; 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] D Sph21_0824 acyl-CoA dehydrogenase domain-containing protein K00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7] D Sph21_2999 Glutaryl-CoA dehydrogenase K00252 GCDH; glutaryl-CoA dehydrogenase [EC:1.3.8.6] D Sph21_0025 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D Sph21_3308 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D Sph21_1500 Enoyl-CoA hydratase/isomerase K13238 ECI1; Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8] C 00073 Cutin, suberine and wax biosynthesis C 00100 Steroid biosynthesis C 00120 Primary bile acid biosynthesis C 00121 Secondary bile acid biosynthesis C 00140 Steroid hormone biosynthesis C 00561 Glycerolipid metabolism [PATH:shg00561] D Sph21_4632 glycerate kinase K00865 glxK; glycerate 2-kinase [EC:2.7.1.165] D Sph21_4787 Mannitol dehydrogenase K13979 yahK; alcohol dehydrogenase (NADP+) [EC:1.1.1.2] D Sph21_2623 Glycerol kinase K00864 glpK; glycerol kinase [EC:2.7.1.30] D Sph21_2908 Glycerol kinase K00864 glpK; glycerol kinase [EC:2.7.1.30] D Sph21_0010 Phosphate acyltransferase K03621 plsX; phosphate acyltransferase [EC:2.3.1.274] D Sph21_2990 Glycerol-3-phosphate acyltransferase K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] D Sph21_1576 phospholipid/glycerol acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] D Sph21_4263 carbohydrate binding family 6 K07407 E3.2.1.22B; alpha-galactosidase [EC:3.2.1.22] D Sph21_4066 Alpha-galactosidase K07407 E3.2.1.22B; alpha-galactosidase [EC:3.2.1.22] C 00564 Glycerophospholipid metabolism [PATH:shg00564] D Sph21_3880 Glycerol-3-phosphate dehydrogenase (NAD(P)+) K00057 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94] D Sph21_2602 Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) K00057 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94] D Sph21_2909 Glycerol-3-phosphate dehydrogenase K00111 glpA; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3] D Sph21_2990 Glycerol-3-phosphate acyltransferase K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] D Sph21_1576 phospholipid/glycerol acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] D Sph21_0662 phospholipase C, phosphocholine-specific K01114 plc; phospholipase C [EC:3.1.4.3] D Sph21_1769 phospholipase C, phosphocholine-specific K01114 plc; phospholipase C [EC:3.1.4.3] D Sph21_4465 phospholipase A1 K01058 pldA; phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4] D Sph21_2903 glycerophosphoryl diester phosphodiesterase K01126 E3.1.4.46; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46] D Sph21_0438 glycerophosphoryl diester phosphodiesterase K01126 E3.1.4.46; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46] D Sph21_1706 glycerophosphoryl diester phosphodiesterase K01126 E3.1.4.46; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46] D Sph21_1305 phosphatidate cytidylyltransferase K00981 E2.7.7.41; phosphatidate cytidylyltransferase [EC:2.7.7.41] D Sph21_4020 CDP-alcohol phosphatidyltransferase K17103 CHO1; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8] D Sph21_1368 Phosphatidylserine decarboxylase proenzyme K01613 psd; phosphatidylserine decarboxylase [EC:4.1.1.65] D Sph21_4029 phospholipase D/Transphosphatidylase K06131 clsA_B; cardiolipin synthase A/B [EC:2.7.8.-] D Sph21_2155 CDP-alcohol phosphatidyltransferase K08744 CRLS; cardiolipin synthase (CMP-forming) [EC:2.7.8.41] C 00565 Ether lipid metabolism [PATH:shg00565] D Sph21_4465 phospholipase A1 K01058 pldA; phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4] D Sph21_0662 phospholipase C, phosphocholine-specific K01114 plc; phospholipase C [EC:3.1.4.3] D Sph21_1769 phospholipase C, phosphocholine-specific K01114 plc; phospholipase C [EC:3.1.4.3] C 00600 Sphingolipid metabolism [PATH:shg00600] D Sph21_3689 fatty acid desaturase K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] D Sph21_2358 Glucan endo-1,6-beta-glucosidase K01201 GBA; glucosylceramidase [EC:3.2.1.45] D Sph21_2327 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_2338 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_4567 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_2864 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_1975 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_2304 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_1756 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_4240 Steryl-sulfatase K01134 ARSA; arylsulfatase A [EC:3.1.6.8] D Sph21_4558 Cerebroside-sulfatase K01134 ARSA; arylsulfatase A [EC:3.1.6.8] D Sph21_5174 glycosyl hydrolase BNR repeat-containing protein K01186 NEU1; sialidase-1 [EC:3.2.1.18] D Sph21_4587 exo-alpha-sialidase K01186 NEU1; sialidase-1 [EC:3.2.1.18] D Sph21_4589 glycosyl hydrolase BNR repeat-containing protein K01186 NEU1; sialidase-1 [EC:3.2.1.18] D Sph21_4263 carbohydrate binding family 6 K07407 E3.2.1.22B; alpha-galactosidase [EC:3.2.1.22] D Sph21_4066 Alpha-galactosidase K07407 E3.2.1.22B; alpha-galactosidase [EC:3.2.1.22] D Sph21_3771 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_1083 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_0646 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_0655 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_0656 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] C 00590 Arachidonic acid metabolism D Sph21_4465 phospholipase A1 K01058 pldA; phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4] C 00591 Linoleic acid metabolism [PATH:shg00591] D Sph21_4465 phospholipase A1 K01058 pldA; phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4] D Sph21_1254 Linoleoyl-CoA desaturase K00508 E1.14.19.3; linoleoyl-CoA desaturase [EC:1.14.19.3] C 00592 alpha-Linolenic acid metabolism [PATH:shg00592] D Sph21_4465 phospholipase A1 K01058 pldA; phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4] D Sph21_0020 acetyl-CoA acetyltransferase K00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16] C 01040 Biosynthesis of unsaturated fatty acids [PATH:shg01040] D Sph21_4485 fatty acid desaturase K00507 SCD; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1] D Sph21_4113 Acyl-(acyl-carrier-protein) desaturase K03921 FAB2; acyl-[acyl-carrier-protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26] B B 09104 Nucleotide metabolism C 00230 Purine metabolism [PATH:shg00230] D Sph21_2082 NUDIX hydrolase K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-] D Sph21_4472 NUDIX hydrolase K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-] D Sph21_2018 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D Sph21_5156 ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] D Sph21_2214 Amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14] D Sph21_1499 Phosphoribosylamine--glycine ligase K01945 purD; phosphoribosylamine---glycine ligase [EC:6.3.4.13] D Sph21_2384 phosphoribosylglycinamide formyltransferase K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] D Sph21_3859 Phosphoribosylformylglycinamidine synthase K01952 PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3] D Sph21_3984 Phosphoribosylformylglycinamidine cyclo-ligase K01933 purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1] D Sph21_3178 phosphoribosylaminoimidazole carboxylase, ATPase subunit K01589 purK; 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18] D Sph21_3177 phosphoribosylaminoimidazole carboxylase, catalytic subunit K01588 purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18] D Sph21_2531 Phosphoribosylaminoimidazole-succinocarboxamide synthase K01923 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6] D Sph21_3621 adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2] D Sph21_2382 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] D Sph21_2249 Adenine phosphoribosyltransferase K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7] D Sph21_3410 5 nucleotidase deoxy cytosolic type C K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5] D Sph21_3321 Multifunctional protein surE K03787 surE; 5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6] D Sph21_5177 Multifunctional protein surE K03787 surE; 5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6] D Sph21_0349 purine nucleoside phosphorylase I, inosine and guanosine-specific K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1] D Sph21_1367 hypoxanthine phosphoribosyltransferase K00760 hprT; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8] D Sph21_3644 inosine-5'-monophosphate dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205] D Sph21_1241 Nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6] D Sph21_1466 Nucleoside-triphosphatase rdgB K01519 rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66] D Sph21_2239 GMP synthase (glutamine-hydrolyzing) K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] D Sph21_3237 Guanine deaminase K01487 guaD; guanine deaminase [EC:3.5.4.3] D Sph21_1513 Guanylate kinase K00942 gmk; guanylate kinase [EC:2.7.4.8] D Sph21_2913 ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D Sph21_0339 ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D Sph21_2914 Ribonucleoside-diphosphate reductase K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D Sph21_0340 Ribonucleoside-diphosphate reductase K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D Sph21_1251 deoxyguanosinetriphosphate triphosphohydrolase K01129 dgt; dGTPase [EC:3.1.5.1] D Sph21_3499 hypothetical protein K06952 yfdR; 5'-nucleotidase [EC:3.1.3.89] D Sph21_2995 (p)ppGpp synthetase I, SpoT/RelA K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2] D Sph21_3170 Ppx/GppA phosphatase K01524 ppx-gppA; exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC:3.6.1.11 3.6.1.40] D Sph21_4271 putative adenylate/guanylate cyclase K01768 E4.6.1.1; adenylate cyclase [EC:4.6.1.1] D Sph21_2259 adenylate/guanylate cyclase K01768 E4.6.1.1; adenylate cyclase [EC:4.6.1.1] D Sph21_4725 Adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4] D Sph21_2993 Adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4] D Sph21_3513 Deoxyadenosine kinase K15519 dck; deoxyadenosine/deoxycytidine kinase [EC:2.7.1.76 2.7.1.74] D Sph21_2927 AMP nucleosidase K01241 amn; AMP nucleosidase [EC:3.2.2.4] D Sph21_0074 Adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3] D Sph21_4731 metallophosphoesterase K03651 cpdA; 3',5'-cyclic-AMP phosphodiesterase [EC:3.1.4.53] D Sph21_2556 metallophosphoesterase K03651 cpdA; 3',5'-cyclic-AMP phosphodiesterase [EC:3.1.4.53] D Sph21_3195 sulfate adenylyltransferase, large subunit K00956 cysN; sulfate adenylyltransferase subunit 1 [EC:2.7.7.4] D Sph21_3194 sulfate adenylyltransferase, small subunit K00957 cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4] C 00240 Pyrimidine metabolism [PATH:shg00240] D Sph21_1122 carbamoyl-phosphate synthase, large subunit K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] D Sph21_0334 carbamoyl-phosphate synthase, small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] D Sph21_2230 Aspartate carbamoyltransferase K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] D Sph21_5136 dihydroorotase, multifunctional complex type K01465 URA4; dihydroorotase [EC:3.5.2.3] D Sph21_2958 amidohydrolase K01465 URA4; dihydroorotase [EC:3.5.2.3] D Sph21_3886 Allantoinase K01465 URA4; dihydroorotase [EC:3.5.2.3] D Sph21_3536 Dihydroorotate dehydrogenase K00254 DHODH; dihydroorotate dehydrogenase [EC:1.3.5.2] D Sph21_3151 orotate phosphoribosyltransferase K00762 pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10] D Sph21_4018 Orotidine 5'-phosphate decarboxylase K01591 pyrF; orotidine-5'-phosphate decarboxylase [EC:4.1.1.23] D Sph21_1043 uridylate kinase K09903 pyrH; uridylate kinase [EC:2.7.4.22] D Sph21_1241 Nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6] D Sph21_3141 Septum formation protein Maf K06287 yhdE; nucleoside triphosphate pyrophosphatase [EC:3.6.1.-] D Sph21_3519 CTP synthase K01937 pyrG; CTP synthase [EC:6.3.4.2] D Sph21_3135 Cytidylate kinase K00945 cmk; CMP/dCMP kinase [EC:2.7.4.25] D Sph21_4665 Uridine kinase K00876 udk; uridine kinase [EC:2.7.1.48] D Sph21_3410 5 nucleotidase deoxy cytosolic type C K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5] D Sph21_3321 Multifunctional protein surE K03787 surE; 5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6] D Sph21_5177 Multifunctional protein surE K03787 surE; 5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6] D Sph21_3393 purine or other phosphorylase family 1 K00757 udp; uridine phosphorylase [EC:2.4.2.3] D Sph21_0722 phosphoribosyltransferase K00761 upp; uracil phosphoribosyltransferase [EC:2.4.2.9] D Sph21_2231 Uracil phosphoribosyltransferase K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9] D Sph21_1147 phosphoribosyltransferase K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9] D Sph21_0679 deoxycytidine triphosphate deaminase K01494 dcd; dCTP deaminase [EC:3.5.4.13] D Sph21_2913 ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D Sph21_0339 ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D Sph21_2914 Ribonucleoside-diphosphate reductase K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D Sph21_0340 Ribonucleoside-diphosphate reductase K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D Sph21_3499 hypothetical protein K06952 yfdR; 5'-nucleotidase [EC:3.1.3.89] D Sph21_3513 Deoxyadenosine kinase K15519 dck; deoxyadenosine/deoxycytidine kinase [EC:2.7.1.76 2.7.1.74] D Sph21_2216 CMP/dCMP deaminase zinc-binding protein K01493 comEB; dCMP deaminase [EC:3.5.4.12] D Sph21_2373 Thymidine kinase K00857 tdk; thymidine kinase [EC:2.7.1.21] D Sph21_2973 Thymidylate synthase K00560 thyA; thymidylate synthase [EC:2.1.1.45] D Sph21_5208 Serine 3-dehydrogenase K16066 ydfG; 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-] B B 09105 Amino acid metabolism C 00250 Alanine, aspartate and glutamate metabolism [PATH:shg00250] D Sph21_3987 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_3216 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_1297 L-aspartate oxidase K00278 nadB; L-aspartate oxidase [EC:1.4.3.16] D Sph21_1245 L-asparaginase, type I K01424 E3.5.1.1; L-asparaginase [EC:3.5.1.1] D Sph21_0527 Beta-aspartyl-peptidase K13051 ASRGL1; L-asparaginase / beta-aspartyl-peptidase [EC:3.5.1.1 3.4.19.5] D Sph21_3307 asparagine synthase (glutamine-hydrolyzing) K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] D Sph21_3276 Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase K13566 NIT2; omega-amidase [EC:3.5.1.3] D Sph21_1536 Alanine dehydrogenase K00259 ald; alanine dehydrogenase [EC:1.4.1.1] D Sph21_1034 argininosuccinate synthase K01940 argG; argininosuccinate synthase [EC:6.3.4.5] D Sph21_1042 Argininosuccinate lyase K01755 argH; argininosuccinate lyase [EC:4.3.2.1] D Sph21_4725 Adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4] D Sph21_2993 Adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4] D Sph21_3621 adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2] D Sph21_2230 Aspartate carbamoyltransferase K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] D Sph21_5246 succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] D Sph21_3183 Glutamate synthase (ferredoxin) K00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13] D Sph21_3184 glutamate synthase, NADH/NADPH, small subunit K00266 gltD; glutamate synthase (NADPH) small chain [EC:1.4.1.13] D Sph21_2983 Glutamate dehydrogenase (NAD(P)(+)) K00261 GLUD1_2; glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3] D Sph21_3428 Glutamate dehydrogenase (NADP(+)) K00262 E1.4.1.4; glutamate dehydrogenase (NADP+) [EC:1.4.1.4] D Sph21_0351 delta-1-pyrroline-5-carboxylate dehydrogenase K00294 E1.2.1.88; 1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88] D Sph21_0666 Glutamate--ammonia ligase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D Sph21_3985 Glutamate--ammonia ligase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D Sph21_1122 carbamoyl-phosphate synthase, large subunit K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] D Sph21_0334 carbamoyl-phosphate synthase, small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] D Sph21_2063 Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] D Sph21_2214 Amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14] C 00260 Glycine, serine and threonine metabolism [PATH:shg00260] D Sph21_4675 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4] D Sph21_3171 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4] D Sph21_1430 aspartate kinase K12524 thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3] D Sph21_1075 aspartate-semialdehyde dehydrogenase K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] D Sph21_3383 Homoserine dehydrogenase K00003 hom; homoserine dehydrogenase [EC:1.1.1.3] D Sph21_1429 Homoserine kinase K00872 thrB; homoserine kinase [EC:2.7.1.39] D Sph21_1428 threonine synthase K01733 thrC; threonine synthase [EC:4.2.3.1] D Sph21_1477 Threonine aldolase K01620 ltaE; threonine aldolase [EC:4.1.2.48] D Sph21_1135 Glycine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D Sph21_4632 glycerate kinase K00865 glxK; glycerate 2-kinase [EC:2.7.1.165] D Sph21_2987 2,3-bisphosphoglycerate-independent phosphoglycerate mutase K15633 gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12] D Sph21_0005 Phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_0434 Phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_0741 amino acid-binding ACT domain protein K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_3091 Phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_3090 Phosphoserine aminotransferase K00831 serC; phosphoserine aminotransferase [EC:2.6.1.52] D Sph21_5208 Serine 3-dehydrogenase K16066 ydfG; 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-] D Sph21_0050 Glycine C-acetyltransferase K00639 kbl; glycine C-acetyltransferase [EC:2.3.1.29] D Sph21_1459 2-amino-3-ketobutyrate coenzyme A ligase K00639 kbl; glycine C-acetyltransferase [EC:2.3.1.29] D Sph21_2084 Glycine dehydrogenase (decarboxylating) K00281 GLDC; glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2] D Sph21_1168 Aminomethyltransferase K00605 gcvT; glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10] D Sph21_1690 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_3439 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_2197 Glycine cleavage system H protein K02437 gcvH; glycine cleavage system H protein D Sph21_4020 CDP-alcohol phosphatidyltransferase K17103 CHO1; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8] D Sph21_2928 Cysteine synthase K01697 CBS; cystathionine beta-synthase [EC:4.2.1.22] D Sph21_4650 Cystathionine gamma-lyase K01758 CTH; cystathionine gamma-lyase [EC:4.4.1.1] D Sph21_0704 L-serine dehydratase 1 K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17] D Sph21_2278 threonine dehydratase K01754 E4.3.1.19; threonine dehydratase [EC:4.3.1.19] D Sph21_3103 Tryptophan synthase alpha chain K01695 trpA; tryptophan synthase alpha chain [EC:4.2.1.20] D Sph21_3102 Tryptophan synthase beta chain K01696 trpB; tryptophan synthase beta chain [EC:4.2.1.20] C 00270 Cysteine and methionine metabolism [PATH:shg00270] D Sph21_2030 transferase hexapeptide repeat containing protein K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] D Sph21_4128 Serine O-acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] D Sph21_4638 Cysteine synthase K01738 cysK; cysteine synthase [EC:2.5.1.47] D Sph21_4650 Cystathionine gamma-lyase K01758 CTH; cystathionine gamma-lyase [EC:4.4.1.1] D Sph21_1916 Cys/Met metabolism pyridoxal-phosphate-dependent protein K01760 metC; cysteine-S-conjugate beta-lyase [EC:4.4.1.13] D Sph21_2928 Cysteine synthase K01697 CBS; cystathionine beta-synthase [EC:4.2.1.22] D Sph21_0379 methionine synthase K00548 metH; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13] D Sph21_5265 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC:2.1.1.14] D Sph21_1577 S-adenosylmethionine synthase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D Sph21_0870 purine or other phosphorylase family 1 K01243 mtnN; adenosylhomocysteine nucleosidase [EC:3.2.2.9] D Sph21_3037 GAF domain-containing protein K08968 msrC; L-methionine (R)-S-oxide reductase [EC:1.8.4.14] D Sph21_3497 C-5 cytosine-specific DNA methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D Sph21_0901 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D Sph21_1238 Adenosylhomocysteinase K01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1] D Sph21_3677 1-aminocyclopropane-1-carboxylate deaminase K01505 E3.5.99.7; 1-aminocyclopropane-1-carboxylate deaminase [EC:3.5.99.7] D Sph21_4675 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4] D Sph21_3171 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4] D Sph21_1430 aspartate kinase K12524 thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3] D Sph21_1075 aspartate-semialdehyde dehydrogenase K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] D Sph21_3383 Homoserine dehydrogenase K00003 hom; homoserine dehydrogenase [EC:1.1.1.3] D Sph21_3382 homoserine O-acetyltransferase K00641 metX; homoserine O-acetyltransferase/O-succinyltransferase [EC:2.3.1.31 2.3.1.46] D Sph21_3381 O-acetylhomoserine/O-acetylserine sulfhydrylase K01740 metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49] D Sph21_0555 Cystathionine gamma-lyase K10764 metZ; O-succinylhomoserine sulfhydrylase [EC:2.5.1.-] D Sph21_0743 branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D Sph21_3549 Aminodeoxychorismate lyase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D Sph21_4118 Glutathione synthase K01920 gshB; glutathione synthase [EC:6.3.2.3] D Sph21_3987 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_3216 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_3933 Malate dehydrogenase K00024 mdh; malate dehydrogenase [EC:1.1.1.37] D Sph21_0704 L-serine dehydratase 1 K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17] D Sph21_4127 cysteine synthase B K12339 cysM; S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent) [EC:2.5.1.144] D Sph21_0005 Phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_0434 Phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_0741 amino acid-binding ACT domain protein K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_3091 Phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_3090 Phosphoserine aminotransferase K00831 serC; phosphoserine aminotransferase [EC:2.6.1.52] C 00280 Valine, leucine and isoleucine degradation [PATH:shg00280] D Sph21_0743 branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D Sph21_3549 Aminodeoxychorismate lyase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D Sph21_4008 Leucine dehydrogenase K00263 E1.4.1.9; leucine dehydrogenase [EC:1.4.1.9] D Sph21_1690 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_3439 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_0824 acyl-CoA dehydrogenase domain-containing protein K00249 ACADM; acyl-CoA dehydrogenase [EC:1.3.8.7] D Sph21_0020 acetyl-CoA acetyltransferase K00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16] D Sph21_1191 3-hydroxyisobutyrate dehydrogenase K00020 HIBADH; 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31] D Sph21_3285 Methylcrotonoyl-CoA carboxylase K01969 MCCC2; 3-methylcrotonyl-CoA carboxylase beta subunit [EC:6.4.1.4] D Sph21_2967 Hydroxymethylglutaryl-CoA lyase K01640 HMGCL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] D Sph21_4669 3-oxoacid CoA-transferase, A subunit K01028 scoA; 3-oxoacid CoA-transferase subunit A [EC:2.8.3.5] D Sph21_4666 3-oxoacid CoA-transferase, B subunit K01029 scoB; 3-oxoacid CoA-transferase subunit B [EC:2.8.3.5] D Sph21_2475 acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] C 00290 Valine, leucine and isoleucine biosynthesis [PATH:shg00290] D Sph21_2278 threonine dehydratase K01754 E4.3.1.19; threonine dehydratase [EC:4.3.1.19] D Sph21_2280 (R)-citramalate synthase K09011 cimA; (R)-citramalate synthase [EC:2.3.3.21] D Sph21_2282 3-isopropylmalate dehydratase large subunit K01703 leuC; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35] D Sph21_2281 3-isopropylmalate dehydratase, small subunit K01704 leuD; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35] D Sph21_2279 3-isopropylmalate dehydrogenase K00052 leuB; 3-isopropylmalate dehydrogenase [EC:1.1.1.85] D Sph21_2289 acetolactate synthase, large subunit, biosynthetic type K01652 E2.2.1.6L; acetolactate synthase I/II/III large subunit [EC:2.2.1.6] D Sph21_2287 acetolactate synthase, small subunit K01653 E2.2.1.6S; acetolactate synthase I/III small subunit [EC:2.2.1.6] D Sph21_2285 Ketol-acid reductoisomerase K00053 ilvC; ketol-acid reductoisomerase [EC:1.1.1.86] D Sph21_2290 Dihydroxy-acid dehydratase K01687 ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9] D Sph21_0743 branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D Sph21_3549 Aminodeoxychorismate lyase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D Sph21_4008 Leucine dehydrogenase K00263 E1.4.1.9; leucine dehydrogenase [EC:1.4.1.9] D Sph21_2283 2-isopropylmalate synthase K01649 leuA; 2-isopropylmalate synthase [EC:2.3.3.13] C 00300 Lysine biosynthesis [PATH:shg00300] D Sph21_3383 Homoserine dehydrogenase K00003 hom; homoserine dehydrogenase [EC:1.1.1.3] D Sph21_4675 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4] D Sph21_3171 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4] D Sph21_1430 aspartate kinase K12524 thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3] D Sph21_1075 aspartate-semialdehyde dehydrogenase K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] D Sph21_0049 Dihydrodipicolinate synthase K01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] D Sph21_2300 dihydrodipicolinate synthetase K01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] D Sph21_4588 dihydrodipicolinate synthetase K01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] D Sph21_0425 Dihydrodipicolinate reductase K00215 dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8] D Sph21_2428 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase K00674 dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [EC:2.3.1.117] D Sph21_1037 Acetylornithine transaminase K00821 argD; acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17] D Sph21_1106 Diaminopimelate epimerase K01778 dapF; diaminopimelate epimerase [EC:5.1.1.7] D Sph21_1606 LL-diaminopimelate aminotransferase K10206 E2.6.1.83; LL-diaminopimelate aminotransferase [EC:2.6.1.83] D Sph21_3172 diaminopimelate decarboxylase K01586 lysA; diaminopimelate decarboxylase [EC:4.1.1.20] D Sph21_0060 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase K01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13] D Sph21_1352 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate/D-alanyl-D-alanyl ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10] D Sph21_4678 Alanine racemase K01798 alr-murF; Alr-MurF fusion protein [EC:5.1.1.1 6.3.2.10] C 00310 Lysine degradation [PATH:shg00310] D Sph21_1336 L-aminoadipate-semialdehyde dehydrogenase K26061 amaB; L-aminoadipate-semialdehyde dehydrogenase D Sph21_1685 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase K00658 DLST; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61] D Sph21_2539 Dihydrolipoyllysine-residue acetyltransferase K00658 DLST; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61] D Sph21_1690 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_3439 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_2999 Glutaryl-CoA dehydrogenase K00252 GCDH; glutaryl-CoA dehydrogenase [EC:1.3.8.6] D Sph21_2475 acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D Sph21_5246 succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] C 00220 Arginine biosynthesis [PATH:shg00220] D Sph21_1034 argininosuccinate synthase K01940 argG; argininosuccinate synthase [EC:6.3.4.5] D Sph21_1042 Argininosuccinate lyase K01755 argH; argininosuccinate lyase [EC:4.3.2.1] D Sph21_2761 Arginase/agmatinase/formiminoglutamase K01476 rocF; arginase [EC:3.5.3.1] D Sph21_3006 Arginine deiminase K01478 arcA; arginine deiminase [EC:3.5.3.6] D Sph21_0666 Glutamate--ammonia ligase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D Sph21_3985 Glutamate--ammonia ligase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D Sph21_2983 Glutamate dehydrogenase (NAD(P)(+)) K00261 GLUD1_2; glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3] D Sph21_3428 Glutamate dehydrogenase (NADP(+)) K00262 E1.4.1.4; glutamate dehydrogenase (NADP+) [EC:1.4.1.4] D Sph21_3987 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_3216 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_1039 acetylglutamate kinase K00930 argB; acetylglutamate kinase [EC:2.7.2.8] D Sph21_1035 N-acetyl-gamma-glutamyl-phosphate reductase K00145 argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38] D Sph21_1037 Acetylornithine transaminase K00821 argD; acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17] D Sph21_1041 peptidase M20 K01438 argE; acetylornithine deacetylase [EC:3.5.1.16] C 00330 Arginine and proline metabolism [PATH:shg00330] D Sph21_3004 Orn/DAP/Arg decarboxylase 2, C-terminal protein K01585 speA; arginine decarboxylase [EC:4.1.1.19] D Sph21_0332 Agmatine deiminase K10536 aguA; agmatine deiminase [EC:3.5.3.12] D Sph21_0331 N-carbamoylputrescine amidase K12251 aguB; N-carbamoylputrescine amidase [EC:3.5.1.53] D Sph21_2761 Arginase/agmatinase/formiminoglutamase K01476 rocF; arginase [EC:3.5.3.1] D Sph21_1040 pyrroline-5-carboxylate reductase K00286 proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2] D Sph21_2274 Proline dehydrogenase K00318 PRODH; proline dehydrogenase [EC:1.5.5.2] D Sph21_0351 delta-1-pyrroline-5-carboxylate dehydrogenase K00294 E1.2.1.88; 1-pyrroline-5-carboxylate dehydrogenase [EC:1.2.1.88] D Sph21_3653 Glutamate 5-kinase K00931 proB; glutamate 5-kinase [EC:2.7.2.11] D Sph21_3652 Gamma-glutamyl phosphate reductase K00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] D Sph21_4185 alpha/beta hydrolase fold protein K01259 pip; proline iminopeptidase [EC:3.4.11.5] D Sph21_3987 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_3216 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] C 00340 Histidine metabolism [PATH:shg00340] D Sph21_5142 ATP phosphoribosyltransferase K00765 hisG; ATP phosphoribosyltransferase [EC:2.4.2.17] D Sph21_5149 Phosphoribosyl-ATP pyrophosphatase K11755 hisIE; phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase [EC:3.5.4.19 3.6.1.31] D Sph21_5147 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase K01814 hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16] D Sph21_5146 Imidazole glycerol phosphate synthase subunit hisH K02501 hisH; imidazole glycerol-phosphate synthase subunit HisH [EC:4.3.2.10] D Sph21_5148 Imidazole glycerol phosphate synthase subunit hisF K02500 hisF; imidazole glycerol-phosphate synthase subunit HisF [EC:4.3.2.10] D Sph21_5145 Imidazoleglycerol-phosphate dehydratase K01089 hisB; imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase [EC:4.2.1.19 3.1.3.15] D Sph21_5144 Histidinol-phosphate aminotransferase K00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9] D Sph21_5143 Histidinol dehydrogenase K00013 hisD; histidinol dehydrogenase [EC:1.1.1.23] D Sph21_3303 histidine ammonia-lyase K01745 hutH; histidine ammonia-lyase [EC:4.3.1.3] D Sph21_3302 urocanate hydratase K01712 hutU; urocanate hydratase [EC:4.2.1.49] D Sph21_3301 imidazolonepropionase K01468 hutI; imidazolonepropionase [EC:3.5.2.7] D Sph21_3300 Formimidoylglutamase K01479 hutG; formiminoglutamase [EC:3.5.3.8] D Sph21_0739 Arginase/agmatinase/formiminoglutamase K01479 hutG; formiminoglutamase [EC:3.5.3.8] D Sph21_0649 Histidine decarboxylase K01590 hdc; histidine decarboxylase [EC:4.1.1.22] D Sph21_2565 Protein of unknown function DUF2260 K18911 egtD; L-histidine Nalpha-methyltransferase [EC:2.1.1.44] C 00350 Tyrosine metabolism [PATH:shg00350] D Sph21_3987 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_3216 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_5144 Histidinol-phosphate aminotransferase K00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9] D Sph21_5246 succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] C 00360 Phenylalanine metabolism [PATH:shg00360] D Sph21_4119 Oxidoreductase FAD-binding domain protein K02613 paaE; ring-1,2-phenylacetyl-CoA epoxidase subunit PaaE D Sph21_3111 3-hydroxybutyryl-CoA dehydrogenase K00074 paaH; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157] D Sph21_3987 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_3216 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_5144 Histidinol-phosphate aminotransferase K00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9] D Sph21_0987 D-amino-acid dehydrogenase K00285 dadA; D-amino-acid dehydrogenase [EC:1.4.5.1] D Sph21_2594 Catalase-peroxidase K03782 katG; catalase-peroxidase [EC:1.11.1.21] C 00380 Tryptophan metabolism [PATH:shg00380] D Sph21_1685 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase K00658 DLST; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61] D Sph21_2539 Dihydrolipoyllysine-residue acetyltransferase K00658 DLST; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61] D Sph21_1690 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_3439 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_2999 Glutaryl-CoA dehydrogenase K00252 GCDH; glutaryl-CoA dehydrogenase [EC:1.3.8.6] D Sph21_2475 acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D Sph21_4886 Catalase K03781 katE; catalase [EC:1.11.1.6] D Sph21_5077 Catalase K03781 katE; catalase [EC:1.11.1.6] D Sph21_1533 Catalase K03781 katE; catalase [EC:1.11.1.6] D Sph21_2594 Catalase-peroxidase K03782 katG; catalase-peroxidase [EC:1.11.1.21] C 00400 Phenylalanine, tyrosine and tryptophan biosynthesis [PATH:shg00400] D Sph21_0448 3-dehydroquinate synthase K01735 aroB; 3-dehydroquinate synthase [EC:4.2.3.4] D Sph21_2276 3-dehydroquinate synthase K01735 aroB; 3-dehydroquinate synthase [EC:4.2.3.4] D Sph21_3159 3-dehydroquinate dehydratase, type II K03786 aroQ; 3-dehydroquinate dehydratase II [EC:4.2.1.10] D Sph21_5255 Shikimate kinase K00891 aroK; shikimate kinase [EC:2.7.1.71] D Sph21_3220 3-phosphoshikimate 1-carboxyvinyltransferase K00800 aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19] D Sph21_3219 chorismate synthase K01736 aroC; chorismate synthase [EC:4.2.3.5] D Sph21_1506 Anthranilate synthase K01657 trpE; anthranilate synthase component I [EC:4.1.3.27] D Sph21_1507 glutamine amidotransferase of anthranilate synthase K01658 trpG; anthranilate synthase component II [EC:4.1.3.27] D Sph21_3100 Anthranilate phosphoribosyltransferase K00766 trpD; anthranilate phosphoribosyltransferase [EC:2.4.2.18] D Sph21_3101 Phosphoribosylanthranilate isomerase K01817 trpF; phosphoribosylanthranilate isomerase [EC:5.3.1.24] D Sph21_1508 Indole-3-glycerol-phosphate synthase K01609 trpC; indole-3-glycerol phosphate synthase [EC:4.1.1.48] D Sph21_3103 Tryptophan synthase alpha chain K01695 trpA; tryptophan synthase alpha chain [EC:4.2.1.20] D Sph21_3102 Tryptophan synthase beta chain K01696 trpB; tryptophan synthase beta chain [EC:4.2.1.20] D Sph21_3221 3-deoxy-7-phosphoheptulonate synthase K04516 AROA1; chorismate mutase [EC:5.4.99.5] D Sph21_1605 Prephenate dehydrogenase K04517 tyrA2; prephenate dehydrogenase [EC:1.3.1.12] D Sph21_3222 Prephenate dehydratase K04518 pheA2; prephenate dehydratase [EC:4.2.1.51] D Sph21_3987 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_3216 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_5144 Histidinol-phosphate aminotransferase K00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9] B B 09106 Metabolism of other amino acids C 00410 beta-Alanine metabolism [PATH:shg00410] D Sph21_1637 Aspartate 1-decarboxylase K01579 panD; aspartate 1-decarboxylase [EC:4.1.1.11] D Sph21_1636 Pantothenate synthetase K01918 panC; pantoate--beta-alanine ligase [EC:6.3.2.1] C 00430 Taurine and hypotaurine metabolism [PATH:shg00430] D Sph21_3879 gamma-glutamyltransferase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] D Sph21_5118 Gamma-glutamyltransferase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] D Sph21_1536 Alanine dehydrogenase K00259 ald; alanine dehydrogenase [EC:1.4.1.1] C 00440 Phosphonate and phosphinate metabolism D Sph21_3873 beta-lactamase domain protein K06167 phnP; phosphoribosyl 1,2-cyclic phosphate phosphodiesterase [EC:3.1.4.55] C 00450 Selenocompound metabolism [PATH:shg00450] D Sph21_1916 Cys/Met metabolism pyridoxal-phosphate-dependent protein K01760 metC; cysteine-S-conjugate beta-lyase [EC:4.4.1.13] D Sph21_0379 methionine synthase K00548 metH; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13] D Sph21_5265 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC:2.1.1.14] D Sph21_4650 Cystathionine gamma-lyase K01758 CTH; cystathionine gamma-lyase [EC:4.4.1.1] D Sph21_4014 cysteine desulfurase, SufS subfamily K11717 sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16] D Sph21_2969 Ferredoxin--NADP reductase K00384 trxB; thioredoxin reductase (NADPH) [EC:1.8.1.9] D Sph21_3286 thioredoxin reductase K00384 trxB; thioredoxin reductase (NADPH) [EC:1.8.1.9] D Sph21_1480 Thioredoxin domain-containing protein K00384 trxB; thioredoxin reductase (NADPH) [EC:1.8.1.9] D Sph21_3195 sulfate adenylyltransferase, large subunit K00956 cysN; sulfate adenylyltransferase subunit 1 [EC:2.7.7.4] D Sph21_3194 sulfate adenylyltransferase, small subunit K00957 cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4] D Sph21_1427 Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] C 00460 Cyanoamino acid metabolism [PATH:shg00460] D Sph21_1423 Beta-glucosidase K05349 bglX; beta-glucosidase [EC:3.2.1.21] D Sph21_3133 Beta-glucosidase K05349 bglX; beta-glucosidase [EC:3.2.1.21] D Sph21_3949 beta-galactosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] D Sph21_3879 gamma-glutamyltransferase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] D Sph21_5118 Gamma-glutamyltransferase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] D Sph21_1245 L-asparaginase, type I K01424 E3.5.1.1; L-asparaginase [EC:3.5.1.1] D Sph21_0527 Beta-aspartyl-peptidase K13051 ASRGL1; L-asparaginase / beta-aspartyl-peptidase [EC:3.5.1.1 3.4.19.5] D Sph21_1135 Glycine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] C 00470 D-Amino acid metabolism [PATH:shg00470] D Sph21_4678 Alanine racemase K01798 alr-murF; Alr-MurF fusion protein [EC:5.1.1.1 6.3.2.10] D Sph21_3074 D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D Sph21_3157 Glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3] D Sph21_0058 UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] D Sph21_3252 Mandelate racemase/muconate lactonizing protein K19802 ycjG; L-Ala-D/L-Glu epimerase / N-acetyl-D-glutamate racemase [EC:5.1.1.20 5.1.1.25] D Sph21_3543 Muconate cycloisomerase K19802 ycjG; L-Ala-D/L-Glu epimerase / N-acetyl-D-glutamate racemase [EC:5.1.1.20 5.1.1.25] D Sph21_1106 Diaminopimelate epimerase K01778 dapF; diaminopimelate epimerase [EC:5.1.1.7] D Sph21_3172 diaminopimelate decarboxylase K01586 lysA; diaminopimelate decarboxylase [EC:4.1.1.20] D Sph21_0988 4-hydroxyproline epimerase K12658 lhpA; 4-hydroxyproline epimerase [EC:5.1.1.8] D Sph21_0990 Dihydrodipicolinate synthase K21062 lhpC; 1-pyrroline-4-hydroxy-2-carboxylate deaminase [EC:3.5.4.22] D Sph21_2641 Aldehyde dehydrogenase (NADP(+)) K13877 aldH; 2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26] D Sph21_0989 Aldehyde dehydrogenase (NADP(+)) K13877 aldH; 2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26] D Sph21_0987 D-amino-acid dehydrogenase K00285 dadA; D-amino-acid dehydrogenase [EC:1.4.5.1] C 00480 Glutathione metabolism [PATH:shg00480] D Sph21_3879 gamma-glutamyltransferase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] D Sph21_5118 Gamma-glutamyltransferase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] D Sph21_2710 UPF0271 protein ybgL K07160 pxpA; 5-oxoprolinase (ATP-hydrolysing) subunit A [EC:3.5.2.9] D Sph21_4118 Glutathione synthase K01920 gshB; glutathione synthase [EC:6.3.2.3] D Sph21_1641 Membrane alanyl aminopeptidase K01256 pepN; aminopeptidase N [EC:3.4.11.2] D Sph21_0366 isocitrate dehydrogenase, NADP-dependent K00031 IDH1; isocitrate dehydrogenase [EC:1.1.1.42] D Sph21_3146 isocitrate dehydrogenase, NADP-dependent K00031 IDH1; isocitrate dehydrogenase [EC:1.1.1.42] D Sph21_4276 6-phosphogluconate dehydrogenase, decarboxylating K00033 PGD; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343] D Sph21_4277 glucose-6-phosphate 1-dehydrogenase K00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363] D Sph21_2997 glutathione peroxidase K00432 gpx; glutathione peroxidase [EC:1.11.1.9] D Sph21_0032 Peroxiredoxin K00432 gpx; glutathione peroxidase [EC:1.11.1.9] B B 09107 Glycan biosynthesis and metabolism C 00510 N-Glycan biosynthesis C 00513 Various types of N-glycan biosynthesis C 00512 Mucin type O-glycan biosynthesis C 00515 Mannose type O-glycan biosynthesis C 00514 Other types of O-glycan biosynthesis C 00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate C 00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin C 00533 Glycosaminoglycan biosynthesis - keratan sulfate C 00531 Glycosaminoglycan degradation C 00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis C 00601 Glycosphingolipid biosynthesis - lacto and neolacto series C 00603 Glycosphingolipid biosynthesis - globo and isoglobo series C 00604 Glycosphingolipid biosynthesis - ganglio series C 00511 Other glycan degradation [PATH:shg00511] D Sph21_5174 glycosyl hydrolase BNR repeat-containing protein K01186 NEU1; sialidase-1 [EC:3.2.1.18] D Sph21_4587 exo-alpha-sialidase K01186 NEU1; sialidase-1 [EC:3.2.1.18] D Sph21_4589 glycosyl hydrolase BNR repeat-containing protein K01186 NEU1; sialidase-1 [EC:3.2.1.18] D Sph21_2327 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_2338 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_4567 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_2864 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_1975 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_2304 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_1756 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D Sph21_3771 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_1083 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_0646 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_0655 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_0656 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_4307 glycosyl hydrolase 38 domain protein K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24] D Sph21_3374 Alpha-L-fucosidase K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_4700 Alpha-L-fucosidase K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_2860 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_2863 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_2166 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_2056 coagulation factor 5/8 type domain protein K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_0657 Alpha-L-fucosidase K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_3373 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_1768 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_4801 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_0603 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_0729 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_2868 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_2865 Alpha-L-fucosidase K15923 AXY8; alpha-L-fucosidase 2 [EC:3.2.1.51] D Sph21_2882 Alpha-L-fucosidase K15923 AXY8; alpha-L-fucosidase 2 [EC:3.2.1.51] D Sph21_0636 Alpha-L-fucosidase K15923 AXY8; alpha-L-fucosidase 2 [EC:3.2.1.51] D Sph21_2303 Alpha-L-fucosidase K15923 AXY8; alpha-L-fucosidase 2 [EC:3.2.1.51] D Sph21_4157 Alpha-L-fucosidase K15923 AXY8; alpha-L-fucosidase 2 [EC:3.2.1.51] D Sph21_3890 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase K01444 AGA; N4-(beta-N-acetylglucosaminyl)-L-asparaginase [EC:3.5.1.26] D Sph21_2358 Glucan endo-1,6-beta-glucosidase K01201 GBA; glucosylceramidase [EC:3.2.1.45] C 00540 Lipopolysaccharide biosynthesis [PATH:shg00540] D Sph21_1542 acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase K00677 lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129] D Sph21_1541 UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase K16363 lpxC-fabZ; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59] D Sph21_1540 UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase K02536 lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191] D Sph21_1451 metallophosphoesterase K03269 lpxH; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54] D Sph21_5175 lipid-A-disaccharide synthase K00748 lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182] D Sph21_0350 Tetraacyldisaccharide 4'-kinase K00912 lpxK; tetraacyldisaccharide 4'-kinase [EC:2.7.1.130] D Sph21_3363 KpsF/GutQ family protein K06041 kdsD; arabinose-5-phosphate isomerase [EC:5.3.1.13] D Sph21_3365 2-dehydro-3-deoxyphosphooctonate aldolase K01627 kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55] D Sph21_3140 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45] D Sph21_3514 3-deoxy-manno-octulosonate cytidylyltransferase K00979 kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38] D Sph21_1048 Three-deoxy-D-manno-octulosonic-acid transferase domain-containing protein K02527 kdtA; 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.12 2.4.99.13 2.4.99.14 2.4.99.15] D Sph21_4379 lipid A biosynthesis acyltransferase K02517 lpxL; Kdo2-lipid IVA lauroyltransferase/acyltransferase [EC:2.3.1.241 2.3.1.-] D Sph21_1257 lipid A biosynthesis acyltransferase K02517 lpxL; Kdo2-lipid IVA lauroyltransferase/acyltransferase [EC:2.3.1.241 2.3.1.-] D Sph21_3162 lipid A biosynthesis acyltransferase K02517 lpxL; Kdo2-lipid IVA lauroyltransferase/acyltransferase [EC:2.3.1.241 2.3.1.-] D Sph21_4142 Protein of unknown function DUF2219 K09953 lpxR; lipid A 3-O-deacylase [EC:3.1.1.-] D Sph21_3829 cytidyltransferase-related domain protein K03272 gmhC; D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase [EC:2.7.1.167 2.7.7.70] D Sph21_3830 hydrolase, HAD-superfamily, subfamily IIIA K03273 gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83] D Sph21_2429 glycosyl transferase family 9 K02849 waaQ; lipopolysaccharide heptosyltransferase III [EC:2.4.99.25] C 00542 O-Antigen repeat unit biosynthesis [PATH:shg00542] D Sph21_1832 glycosyl transferase family 4 K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D Sph21_1781 glycosyl transferase family 4 K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] C 00541 O-Antigen nucleotide sugar biosynthesis [PATH:shg00541] D Sph21_1050 UDP-glucose 4-epimerase K01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2] D Sph21_2004 nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D Sph21_1960 nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D Sph21_1754 glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D Sph21_1049 UDP-glucuronate decarboxylase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D Sph21_1051 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D Sph21_1566 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] D Sph21_2081 dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] D Sph21_2294 dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] D Sph21_1644 mannose-6-phosphate isomerase type II K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8] D Sph21_3998 Phosphoglucosamine mutase K01840 manB; phosphomannomutase [EC:5.4.2.8] D Sph21_2002 Mannose-1-phosphate guanylyltransferase K00971 manC; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13] D Sph21_1755 GDP-mannose 4,6-dehydratase K01711 gmd; GDPmannose 4,6-dehydratase [EC:4.2.1.47] D Sph21_1941 GDP-mannose 4,6-dehydratase K01711 gmd; GDPmannose 4,6-dehydratase [EC:4.2.1.47] D Sph21_2012 GDP-L-fucose synthase K02377 TSTA3; GDP-L-fucose synthase [EC:1.1.1.271] D Sph21_1813 DegT/DnrJ/EryC1/StrS aminotransferase K13010 per; perosamine synthetase [EC:2.6.1.102] D Sph21_1828 UDP-N-acetylglucosamine 2-epimerase K01791 wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14] D Sph21_1811 nucleotide sugar dehydrogenase K02474 wbpO; UDP-N-acetyl-D-glucosamine/UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.136 1.1.1.-] C 00550 Peptidoglycan biosynthesis [PATH:shg00550] D Sph21_2929 UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D Sph21_1700 UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] D Sph21_0055 UDP-N-acetylmuramate--L-alanine ligase K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8] D Sph21_0058 UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] D Sph21_0060 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase K01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13] D Sph21_3074 D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D Sph21_1352 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate/D-alanyl-D-alanyl ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10] D Sph21_4678 Alanine racemase K01798 alr-murF; Alr-MurF fusion protein [EC:5.1.1.1 6.3.2.10] D Sph21_0039 diacylglycerol kinase K00887 dgkA; undecaprenol kinase [EC:2.7.1.66] D Sph21_5202 Undecaprenyl pyrophosphate synthase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] D Sph21_0549 Undecaprenyl-diphosphatase K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] D Sph21_2431 phosphoesterase PA-phosphatase related protein K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] D Sph21_0059 Phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] D Sph21_0056 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] D Sph21_2295 Monofunctional biosynthetic peptidoglycan transglycosylase K03814 mtgA; monofunctional glycosyltransferase [EC:2.4.99.28] D Sph21_5240 Peptidoglycan glycosyltransferase K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D Sph21_3115 Peptidoglycan glycosyltransferase K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D Sph21_4124 penicillin-binding protein 1C K05367 pbpC; penicillin-binding protein 1C [EC:2.4.99.28] D Sph21_2376 penicillin-binding protein 2 K05515 mrdA; penicillin-binding protein 2 [EC:3.4.16.4] D Sph21_0061 Peptidoglycan glycosyltransferase K03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4] D Sph21_1073 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase K07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-] D Sph21_1614 beta-lactamase K21469 pbp4b; serine-type D-Ala-D-Ala carboxypeptidase [EC:3.4.16.4] C 00552 Teichoic acid biosynthesis [PATH:shg00552] D Sph21_0549 Undecaprenyl-diphosphatase K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] D Sph21_2431 phosphoesterase PA-phosphatase related protein K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] D Sph21_1832 glycosyl transferase family 4 K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D Sph21_1781 glycosyl transferase family 4 K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] C 00571 Lipoarabinomannan (LAM) biosynthesis C 00572 Arabinogalactan biosynthesis - Mycobacterium C 00543 Exopolysaccharide biosynthesis [PATH:shg00543] D Sph21_1956 glycosyl transferase group 1 K03208 wcaI; putative colanic acid biosynthesis glycosyltransferase WcaI D Sph21_1954 transferase hexapeptide repeat containing protein K03818 wcaF; putative colanic acid biosynthesis acetyltransferase WcaF [EC:2.3.1.-] D Sph21_1832 glycosyl transferase family 4 K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D Sph21_1781 glycosyl transferase family 4 K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D Sph21_1942 membrane bound O-acyl transferase MBOAT family protein K19294 algI; alginate O-acetyltransferase complex protein AlgI D Sph21_3331 membrane bound O-acyl transferase MBOAT family protein K19294 algI; alginate O-acetyltransferase complex protein AlgI D Sph21_2030 transferase hexapeptide repeat containing protein K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] D Sph21_4128 Serine O-acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] D Sph21_2071 glycosyl transferase group 1 K13658 gumI; beta-1,4-mannosyltransferase [EC:2.4.1.251] D Sph21_1799 glycosyl transferase group 1 K13658 gumI; beta-1,4-mannosyltransferase [EC:2.4.1.251] D Sph21_1949 exopolysaccharide biosynthesis pyruvyltransferase ExoV K13665 gumL; pyruvyltransferase B B 09108 Metabolism of cofactors and vitamins C 00730 Thiamine metabolism [PATH:shg00730] D Sph21_1387 Phosphomethylpyrimidine synthase K03147 thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17] D Sph21_4500 phosphomethylpyrimidine kinase K00941 thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7] D Sph21_3741 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D Sph21_3019 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D Sph21_3997 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D Sph21_1383 thiazole biosynthesis protein ThiH K03150 thiH; 2-iminoacetate synthase [EC:4.1.99.19] D Sph21_1133 1-deoxy-D-xylulose-5-phosphate synthase K01662 dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7] D Sph21_1384 Thiazole synthase K03149 thiG; thiazole synthase [EC:2.8.1.10] D Sph21_1385 Thiamine-phosphate pyrophosphorylase K00788 thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3] D Sph21_1386 thiamine monophosphate synthase K00788 thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3] D Sph21_1295 thiamine-monophosphate kinase K00946 thiL; thiamine-monophosphate kinase [EC:2.7.4.16] D Sph21_3205 ribosome biogenesis GTPase RsgA K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] D Sph21_1435 ribosome biogenesis GTPase RsgA K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] D Sph21_2898 Alkaline phosphatase K01077 E3.1.3.1; alkaline phosphatase [EC:3.1.3.1] D Sph21_0968 Alkaline phosphatase K01077 E3.1.3.1; alkaline phosphatase [EC:3.1.3.1] D Sph21_0074 Adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3] C 00740 Riboflavin metabolism [PATH:shg00740] D Sph21_0565 3,4-dihydroxy-2-butanone 4-phosphate synthase K14652 ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25] D Sph21_3390 riboflavin biosynthesis protein RibD K11752 ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193] D Sph21_2691 HAD-superfamily hydrolase, subfamily IA, variant 1 K20862 yigB; FMN hydrolase / 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.102 3.1.3.104] D Sph21_5259 6,7-dimethyl-8-ribityllumazine synthase K00794 ribH; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78] D Sph21_3897 riboflavin synthase, alpha subunit K00793 ribE; riboflavin synthase [EC:2.5.1.9] D Sph21_0551 riboflavin biosynthesis protein RibF K11753 ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2] D Sph21_2082 NUDIX hydrolase K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-] D Sph21_4472 NUDIX hydrolase K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-] D Sph21_5119 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03186 ubiX; flavin prenyltransferase [EC:2.5.1.129] C 00750 Vitamin B6 metabolism [PATH:shg00750] D Sph21_3342 Pyridoxine/pyridoxamine 5'-phosphate oxidase K00275 pdxH; pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5] D Sph21_3090 Phosphoserine aminotransferase K00831 serC; phosphoserine aminotransferase [EC:2.6.1.52] D Sph21_1240 Pyridoxine 5'-phosphate synthase K03474 pdxJ; pyridoxine 5-phosphate synthase [EC:2.6.99.2] D Sph21_1428 threonine synthase K01733 thrC; threonine synthase [EC:4.2.3.1] C 00760 Nicotinate and nicotinamide metabolism [PATH:shg00760] D Sph21_1297 L-aspartate oxidase K00278 nadB; L-aspartate oxidase [EC:1.4.3.16] D Sph21_1296 Quinolinate synthase A K03517 nadA; quinolinate synthase [EC:2.5.1.72] D Sph21_2989 nicotinate-nucleotide pyrophosphorylase K00767 nadC; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19] D Sph21_3065 nicotinate phosphoribosyltransferase K00763 pncB; nicotinate phosphoribosyltransferase [EC:6.3.4.21] D Sph21_0349 purine nucleoside phosphorylase I, inosine and guanosine-specific K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1] D Sph21_3410 5 nucleotidase deoxy cytosolic type C K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5] D Sph21_3321 Multifunctional protein surE K03787 surE; 5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6] D Sph21_5177 Multifunctional protein surE K03787 surE; 5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6] D Sph21_1512 nicotinate-nucleotide adenylyltransferase K00969 nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18] D Sph21_5225 NAD+ synthetase K01950 E6.3.5.1; NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1] D Sph21_3731 CinA domain protein K03743 pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42] D Sph21_2153 Nicotinamidase K08281 pncA; nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-] D Sph21_5204 inorganic polyphosphate/ATP-NAD kinase K00858 ppnK; NAD+ kinase [EC:2.7.1.23] D Sph21_1188 (2Fe-2S)-binding domain-containing protein K18029 nicA; nicotinate dehydrogenase subunit A [EC:1.17.2.1] D Sph21_1189 Isoquinoline 1-oxidoreductase K18030 nicB; nicotinate dehydrogenase subunit B [EC:1.17.2.1] D Sph21_5246 succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] C 00770 Pantothenate and CoA biosynthesis [PATH:shg00770] D Sph21_2289 acetolactate synthase, large subunit, biosynthetic type K01652 E2.2.1.6L; acetolactate synthase I/II/III large subunit [EC:2.2.1.6] D Sph21_2287 acetolactate synthase, small subunit K01653 E2.2.1.6S; acetolactate synthase I/III small subunit [EC:2.2.1.6] D Sph21_2285 Ketol-acid reductoisomerase K00053 ilvC; ketol-acid reductoisomerase [EC:1.1.1.86] D Sph21_2290 Dihydroxy-acid dehydratase K01687 ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9] D Sph21_0317 3-methyl-2-oxobutanoate hydroxymethyltransferase K00606 panB; 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11] D Sph21_4591 2-dehydropantoate 2-reductase K00077 panE; 2-dehydropantoate 2-reductase [EC:1.1.1.169] D Sph21_1636 Pantothenate synthetase K01918 panC; pantoate--beta-alanine ligase [EC:6.3.2.1] D Sph21_3443 Pantothenate kinase K00867 coaA; type I pantothenate kinase [EC:2.7.1.33] D Sph21_1762 phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase K13038 coaBC; phosphopantothenoylcysteine decarboxylase / phosphopantothenate---cysteine ligase [EC:4.1.1.36 6.3.2.5] D Sph21_3153 Phosphopantetheine adenylyltransferase K00954 E2.7.7.3A; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3] D Sph21_4003 Dephospho-CoA kinase K00859 coaE; dephospho-CoA kinase [EC:2.7.1.24] D Sph21_0680 4'-phosphopantetheinyl transferase K06133 LYS5; 4'-phosphopantetheinyl transferase [EC:2.7.8.-] D Sph21_1260 hypothetical protein K06133 LYS5; 4'-phosphopantetheinyl transferase [EC:2.7.8.-] D Sph21_0743 branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D Sph21_3549 Aminodeoxychorismate lyase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D Sph21_1637 Aspartate 1-decarboxylase K01579 panD; aspartate 1-decarboxylase [EC:4.1.1.11] C 00780 Biotin metabolism [PATH:shg00780] D Sph21_1357 3-oxoacyl-(acyl-carrier-protein) synthase 2 K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D Sph21_4075 3-oxoacyl-(acyl-carrier-protein) synthase 2 K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D Sph21_0337 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_2703 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_4360 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_2365 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_0398 Enoyl-(acyl-carrier-protein) reductase (NADH) K00208 fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10] D Sph21_3313 8-amino-7-oxononanoate synthase K00652 bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47] D Sph21_3026 Glycine C-acetyltransferase K00652 bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47] D Sph21_3316 adenosylmethionine-8-amino-7-oxononanoate aminotransferase K00833 bioA; adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62] D Sph21_3314 Dethiobiotin synthetase K01935 bioD; dethiobiotin synthetase [EC:6.3.3.3] D Sph21_3315 biotin synthase K01012 bioB; biotin synthase [EC:2.8.1.6] D Sph21_1059 biotin/acetyl-CoA-carboxylase ligase K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] C 00785 Lipoic acid metabolism [PATH:shg00785] D Sph21_0702 Octanoyltransferase K03801 lipB; lipoyl(octanoyl) transferase [EC:2.3.1.181] D Sph21_5263 Lipoyl synthase K03644 lipA; lipoyl synthase [EC:2.8.1.8] D Sph21_1690 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_3439 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_1149 pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D Sph21_1309 Pyruvate dehydrogenase (acetyl-transferring) K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D Sph21_1150 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] D Sph21_1684 2-oxoglutarate dehydrogenase, E1 subunit K00164 OGDH; 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2] D Sph21_1685 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase K00658 DLST; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61] D Sph21_2539 Dihydrolipoyllysine-residue acetyltransferase K00658 DLST; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61] D Sph21_2084 Glycine dehydrogenase (decarboxylating) K00281 GLDC; glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2] D Sph21_1168 Aminomethyltransferase K00605 gcvT; glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10] D Sph21_2197 Glycine cleavage system H protein K02437 gcvH; glycine cleavage system H protein C 00790 Folate biosynthesis [PATH:shg00790] D Sph21_1318 GTP cyclohydrolase 1 K01495 GCH1; GTP cyclohydrolase IA [EC:3.5.4.16] D Sph21_2898 Alkaline phosphatase K01077 E3.1.3.1; alkaline phosphatase [EC:3.1.3.1] D Sph21_0968 Alkaline phosphatase K01077 E3.1.3.1; alkaline phosphatase [EC:3.1.3.1] D Sph21_1748 dihydroneopterin aldolase K01633 folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81] D Sph21_4021 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3] D Sph21_5252 dihydropteroate synthase K00796 folP; dihydropteroate synthase [EC:2.5.1.15] D Sph21_2972 dihydrofolate reductase region K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3] D Sph21_2223 FolC bifunctional protein K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] D Sph21_0565 3,4-dihydroxy-2-butanone 4-phosphate synthase K14652 ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25] D Sph21_2992 Aminodeoxychorismate synthase K01665 pabB; para-aminobenzoate synthetase component I [EC:2.6.1.85] D Sph21_1319 6-pyruvoyl tetrahydropterin synthase and hypothetical protein K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50] D Sph21_2825 transcriptional coactivator/pterin dehydratase K01724 PCBD; 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96] D Sph21_3290 Radical SAM domain protein K10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3] D Sph21_3738 molybdenum cofactor biosynthesis protein A K03639 moaA; GTP 3',8-cyclase [EC:4.1.99.22] D Sph21_5098 molybdopterin biosynthesis MoaE protein K03635 MOCS2B; molybdopterin synthase catalytic subunit [EC:2.8.1.12] D Sph21_0143 molybdopterin biosynthesis MoaE protein K03635 MOCS2B; molybdopterin synthase catalytic subunit [EC:2.8.1.12] D Sph21_3737 molybdenum cofactor synthesis domain protein K03750 moeA; molybdopterin molybdotransferase [EC:2.10.1.1] D Sph21_3752 molybdenum cofactor synthesis domain protein K03750 moeA; molybdopterin molybdotransferase [EC:2.10.1.1] D Sph21_3739 4-diphosphocytidyl-2C-methyl-D-erythritol synthase K07141 mocA; molybdenum cofactor cytidylyltransferase [EC:2.7.7.76] D Sph21_2686 Molybdopterin-guanine dinucleotide biosynthesis protein A K03752 mobA; molybdenum cofactor guanylyltransferase [EC:2.7.7.77] C 00670 One carbon pool by folate [PATH:shg00670] D Sph21_2972 dihydrofolate reductase region K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3] D Sph21_3450 Bifunctional protein folD K01491 folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] D Sph21_1135 Glycine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D Sph21_2384 phosphoribosylglycinamide formyltransferase K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] D Sph21_2382 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] D Sph21_3548 Methionyl-tRNA formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9] D Sph21_1168 Aminomethyltransferase K00605 gcvT; glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10] D Sph21_0379 methionine synthase K00548 metH; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13] D Sph21_2973 Thymidylate synthase K00560 thyA; thymidylate synthase [EC:2.1.1.45] D Sph21_1646 formyltetrahydrofolate deformylase K01433 purU; formyltetrahydrofolate deformylase [EC:3.5.1.10] D Sph21_0381 Methylenetetrahydrofolate reductase (NAD(P)H) K00297 metF; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54] D Sph21_1545 5-formyltetrahydrofolate cyclo-ligase K01934 MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2] C 00830 Retinol metabolism C 00860 Porphyrin metabolism [PATH:shg00860] D Sph21_1436 glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17] D Sph21_5198 Glutamyl-tRNA reductase K02492 hemA; glutamyl-tRNA reductase [EC:1.2.1.70] D Sph21_5195 Glutamate-1-semialdehyde 2,1-aminomutase K01845 hemL; glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8] D Sph21_5196 Porphobilinogen synthase K01698 hemB; porphobilinogen synthase [EC:4.2.1.24] D Sph21_5197 Porphobilinogen deaminase K01749 hemC; hydroxymethylbilane synthase [EC:2.5.1.61] D Sph21_5244 Uroporphyrinogen III synthase HEM4 K01719 hemD; uroporphyrinogen-III synthase [EC:4.2.1.75] D Sph21_5191 Uroporphyrinogen decarboxylase K01599 hemE; uroporphyrinogen decarboxylase [EC:4.1.1.37] D Sph21_3359 Coproporphyrinogen oxidase K00228 CPOX; coproporphyrinogen III oxidase [EC:1.3.3.3] D Sph21_3524 oxygen-independent coproporphyrinogen III oxidase K02495 hemN; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3] D Sph21_5190 Conserved hypothetical protein CHP00701 K08973 hemJ; protoporphyrinogen IX oxidase [EC:1.3.99.-] D Sph21_1071 Ferrochelatase K01772 hemH; protoporphyrin/coproporphyrin ferrochelatase [EC:4.98.1.1 4.99.1.9] D Sph21_3191 uroporphyrin-III C-methyltransferase K02303 cobA; uroporphyrin-III C-methyltransferase [EC:2.1.1.107] D Sph21_0556 uroporphyrin-III C-methyltransferase K02303 cobA; uroporphyrin-III C-methyltransferase [EC:2.1.1.107] D Sph21_3749 hypothetical protein K02303 cobA; uroporphyrin-III C-methyltransferase [EC:2.1.1.107] D Sph21_3750 uroporphyrin-III C-methyltransferase K02303 cobA; uroporphyrin-III C-methyltransferase [EC:2.1.1.107] D Sph21_1557 Protoheme IX farnesyltransferase K02257 COX10; heme o synthase [EC:2.5.1.141] D Sph21_1556 cytochrome oxidase assembly K02259 COX15; heme a synthase [EC:1.17.99.9] D Sph21_2114 Magnesium chelatase K02230 cobN; cobaltochelatase CobN [EC:6.6.1.2] D Sph21_3515 ATP/cobalamin adenosyltransferase K00798 MMAB; cob(I)alamin adenosyltransferase [EC:2.5.1.17] D Sph21_1185 Mg-chelatase subunit ChlI K03405 chlI; magnesium chelatase subunit I [EC:6.6.1.1] C 00130 Ubiquinone and other terpenoid-quinone biosynthesis [PATH:shg00130] D Sph21_5212 4-hydroxybenzoate polyprenyltransferase K03179 ubiA; 4-hydroxybenzoate polyprenyltransferase [EC:2.5.1.39] D Sph21_2218 Carboxylyase-related protein K03182 ubiD; 4-hydroxy-3-polyprenylbenzoate decarboxylase [EC:4.1.1.98] D Sph21_5119 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03186 ubiX; flavin prenyltransferase [EC:2.5.1.129] D Sph21_5210 Ubiquinone/menaquinone biosynthesis methyltransferase ubiE K03183 ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201] D Sph21_3377 protein of unknown function DUF178 K11782 mqnA; chorismate dehydratase [EC:4.2.1.151] D Sph21_3379 putative menaquinone biosynthesis protein K18285 mqnE; aminodeoxyfutalosine synthase [EC:2.5.1.120] D Sph21_1139 amidohydrolase K20810 mqnX; aminodeoxyfutalosine deaminase [EC:3.5.4.40] D Sph21_1320 futalosine nucleosidase K11783 mqnB; futalosine hydrolase [EC:3.2.2.26] D Sph21_3052 FO synthase, subunit 2 K11784 mqnC; cyclic dehypoxanthinyl futalosine synthase [EC:1.21.98.1] D Sph21_1321 protein of unknown function DUF191 K11785 mqnD; 5,8-dihydroxy-2-naphthoate synthase [EC:4.1.99.29] D Sph21_0974 Ribosyldihydronicotinamide dehydrogenase (quinone) K00355 NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2] D Sph21_4230 NAD(P)H dehydrogenase (quinone) K00355 NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2] D Sph21_4322 NAD(P)H dehydrogenase (quinone) K00355 NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2] D Sph21_4192 NmrA family protein K19267 qorB; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2] B B 09109 Metabolism of terpenoids and polyketides C 00900 Terpenoid backbone biosynthesis [PATH:shg00900] D Sph21_1133 1-deoxy-D-xylulose-5-phosphate synthase K01662 dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7] D Sph21_2919 1-deoxy-D-xylulose 5-phosphate reductoisomerase K00099 dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267] D Sph21_3992 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00991 ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60] D Sph21_2977 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase K00919 ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148] D Sph21_1631 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase K01770 ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12] D Sph21_2204 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase K03526 gcpE; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3] D Sph21_1072 hydroxymethylbutenyl pyrophosphate reductase K03527 ispH; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4] D Sph21_2475 acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D Sph21_5119 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03186 ubiX; flavin prenyltransferase [EC:2.5.1.129] D Sph21_3638 Isopentenyl-diphosphate Delta-isomerase K01823 idi; isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2] D Sph21_3092 Geranyltranstransferase K13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29] D Sph21_1116 Trans-hexaprenyltranstransferase K02523 ispB; octaprenyl-diphosphate synthase [EC:2.5.1.90] D Sph21_5202 Undecaprenyl pyrophosphate synthase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] C 00902 Monoterpenoid biosynthesis C 00909 Sesquiterpenoid and triterpenoid biosynthesis C 00904 Diterpenoid biosynthesis C 00906 Carotenoid biosynthesis C 00905 Brassinosteroid biosynthesis C 00981 Insect hormone biosynthesis C 00908 Zeatin biosynthesis C 00903 Limonene degradation C 00907 Pinene, camphor and geraniol degradation [PATH:shg00907] D Sph21_2967 Hydroxymethylglutaryl-CoA lyase K01640 HMGCL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] D Sph21_0020 acetyl-CoA acetyltransferase K00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16] C 01052 Type I polyketide structures C 00522 Biosynthesis of 12-, 14- and 16-membered macrolides C 01051 Biosynthesis of ansamycins D Sph21_2191 transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] D Sph21_2617 Transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] D Sph21_2618 1-deoxy-D-xylulose-5-phosphate synthase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] D Sph21_3915 Transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] D Sph21_3916 Transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] C 01059 Biosynthesis of enediyne antibiotics C 01056 Biosynthesis of type II polyketide backbone C 01057 Biosynthesis of type II polyketide products C 00253 Tetracycline biosynthesis C 00523 Polyketide sugar unit biosynthesis [PATH:shg00523] D Sph21_1754 glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D Sph21_1049 UDP-glucuronate decarboxylase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D Sph21_1051 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D Sph21_1566 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] D Sph21_2081 dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] D Sph21_2294 dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] C 01054 Nonribosomal peptide structures C 01053 Biosynthesis of siderophore group nonribosomal peptides C 01055 Biosynthesis of vancomycin group antibiotics D Sph21_1049 UDP-glucuronate decarboxylase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D Sph21_1051 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] B B 09110 Biosynthesis of other secondary metabolites C 00940 Phenylpropanoid biosynthesis C 00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis C 00941 Flavonoid biosynthesis C 00944 Flavone and flavonol biosynthesis C 00942 Anthocyanin biosynthesis C 00943 Isoflavonoid biosynthesis C 00946 Degradation of flavonoids [PATH:shg00946] D Sph21_1423 Beta-glucosidase K05349 bglX; beta-glucosidase [EC:3.2.1.21] D Sph21_3133 Beta-glucosidase K05349 bglX; beta-glucosidase [EC:3.2.1.21] D Sph21_3949 beta-galactosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] D Sph21_0443 alpha-L-rhamnosidase K05989 ramA; alpha-L-rhamnosidase [EC:3.2.1.40] D Sph21_0463 alpha-L-rhamnosidase K05989 ramA; alpha-L-rhamnosidase [EC:3.2.1.40] D Sph21_2315 alpha-L-rhamnosidase K05989 ramA; alpha-L-rhamnosidase [EC:3.2.1.40] D Sph21_0444 alpha-L-rhamnosidase K05989 ramA; alpha-L-rhamnosidase [EC:3.2.1.40] D Sph21_2325 alpha-L-rhamnosidase K05989 ramA; alpha-L-rhamnosidase [EC:3.2.1.40] D Sph21_2337 alpha-L-rhamnosidase K05989 ramA; alpha-L-rhamnosidase [EC:3.2.1.40] D Sph21_0484 alpha-L-rhamnosidase K05989 ramA; alpha-L-rhamnosidase [EC:3.2.1.40] C 00901 Indole alkaloid biosynthesis C 00403 Indole diterpene alkaloid biosynthesis C 00950 Isoquinoline alkaloid biosynthesis C 00960 Tropane, piperidine and pyridine alkaloid biosynthesis C 00996 Biosynthesis of various alkaloids C 00232 Caffeine metabolism C 00965 Betalain biosynthesis C 00966 Glucosinolate biosynthesis C 00402 Benzoxazinoid biosynthesis C 00311 Penicillin and cephalosporin biosynthesis [PATH:shg00311] D Sph21_0487 Acetyl xylan esterase K01060 cah; cephalosporin-C deacetylase [EC:3.1.1.41] D Sph21_3904 peptidase S45 penicillin amidase K01434 pac; penicillin G amidase [EC:3.5.1.11] C 00332 Carbapenem biosynthesis [PATH:shg00332] D Sph21_3653 Glutamate 5-kinase K00931 proB; glutamate 5-kinase [EC:2.7.2.11] D Sph21_3652 Gamma-glutamyl phosphate reductase K00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] C 00261 Monobactam biosynthesis [PATH:shg00261] D Sph21_3195 sulfate adenylyltransferase, large subunit K00956 cysN; sulfate adenylyltransferase subunit 1 [EC:2.7.7.4] D Sph21_3194 sulfate adenylyltransferase, small subunit K00957 cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4] D Sph21_4675 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4] D Sph21_3171 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4] D Sph21_1430 aspartate kinase K12524 thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3] D Sph21_1075 aspartate-semialdehyde dehydrogenase K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] D Sph21_0049 Dihydrodipicolinate synthase K01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] D Sph21_2300 dihydrodipicolinate synthetase K01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] D Sph21_4588 dihydrodipicolinate synthetase K01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] D Sph21_0425 Dihydrodipicolinate reductase K00215 dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8] C 00331 Clavulanic acid biosynthesis C 00521 Streptomycin biosynthesis [PATH:shg00521] D Sph21_5117 glucokinase K00845 glk; glucokinase [EC:2.7.1.2] D Sph21_1910 ROK family protein K25026 glk; glucokinase [EC:2.7.1.2] D Sph21_2018 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D Sph21_5106 Myo-inositol-1-phosphate synthase K01858 INO1; myo-inositol-1-phosphate synthase [EC:5.5.1.4] D Sph21_3623 Inositol-phosphate phosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25] D Sph21_0465 oxidoreductase domain protein K00010 iolG; myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase [EC:1.1.1.18 1.1.1.369] D Sph21_3454 oxidoreductase domain protein K00010 iolG; myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase [EC:1.1.1.18 1.1.1.369] D Sph21_1754 glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D Sph21_1049 UDP-glucuronate decarboxylase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D Sph21_1051 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D Sph21_1566 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] D Sph21_2081 dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] D Sph21_2294 dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] C 00524 Neomycin, kanamycin and gentamicin biosynthesis D Sph21_5117 glucokinase K00845 glk; glucokinase [EC:2.7.1.2] D Sph21_1910 ROK family protein K25026 glk; glucokinase [EC:2.7.1.2] C 00525 Acarbose and validamycin biosynthesis [PATH:shg00525] D Sph21_1754 glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D Sph21_1049 UDP-glucuronate decarboxylase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D Sph21_1051 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] C 00401 Novobiocin biosynthesis [PATH:shg00401] D Sph21_1605 Prephenate dehydrogenase K04517 tyrA2; prephenate dehydrogenase [EC:1.3.1.12] D Sph21_3987 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_3216 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_5144 Histidinol-phosphate aminotransferase K00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9] C 00404 Staurosporine biosynthesis C 00405 Phenazine biosynthesis D Sph21_1506 Anthranilate synthase K01657 trpE; anthranilate synthase component I [EC:4.1.3.27] D Sph21_1507 glutamine amidotransferase of anthranilate synthase K01658 trpG; anthranilate synthase component II [EC:4.1.3.27] C 00333 Prodigiosin biosynthesis D Sph21_1317 malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] D Sph21_0337 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_2703 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_4360 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_2365 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_0398 Enoyl-(acyl-carrier-protein) reductase (NADH) K00208 fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10] C 00254 Aflatoxin biosynthesis C 00998 Biosynthesis of various antibiotics D Sph21_3686 hypothetical protein K02078 acpP; acyl carrier protein D Sph21_1356 Acyl carrier protein K02078 acpP; acyl carrier protein C 00999 Biosynthesis of various plant secondary metabolites [PATH:shg00999] D Sph21_1577 S-adenosylmethionine synthase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D Sph21_1423 Beta-glucosidase K05349 bglX; beta-glucosidase [EC:3.2.1.21] D Sph21_3133 Beta-glucosidase K05349 bglX; beta-glucosidase [EC:3.2.1.21] D Sph21_3949 beta-galactosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] C 00997 Biosynthesis of various other secondary metabolites B B 09111 Xenobiotics biodegradation and metabolism C 00362 Benzoate degradation [PATH:shg00362] D Sph21_0020 acetyl-CoA acetyltransferase K00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16] D Sph21_1266 Carboxymuconolactone decarboxylase K01607 pcaC; 4-carboxymuconolactone decarboxylase [EC:4.1.1.44] D Sph21_0121 Carboxymuconolactone decarboxylase K01607 pcaC; 4-carboxymuconolactone decarboxylase [EC:4.1.1.44] D Sph21_2770 demethylmenaquinone methyltransferase-like protein K10218 ligK; 4-hydroxy-4-methyl-2-oxoglutarate aldolase [EC:4.1.3.17] D Sph21_0021 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein K07516 fadN; 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] D Sph21_2999 Glutaryl-CoA dehydrogenase K00252 GCDH; glutaryl-CoA dehydrogenase [EC:1.3.8.6] D Sph21_3111 3-hydroxybutyryl-CoA dehydrogenase K00074 paaH; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157] D Sph21_2475 acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] C 00627 Aminobenzoate degradation [PATH:shg00627] D Sph21_1140 Acylphosphatase K01512 acyP; acylphosphatase [EC:3.6.1.7] D Sph21_5119 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03186 ubiX; flavin prenyltransferase [EC:2.5.1.129] C 00364 Fluorobenzoate degradation [PATH:shg00364] D Sph21_2557 Carboxymethylenebutenolidase K01061 E3.1.1.45; carboxymethylenebutenolidase [EC:3.1.1.45] C 00625 Chloroalkane and chloroalkene degradation D Sph21_1746 HAD-superfamily hydrolase, subfamily IA, variant 3 K01560 E3.8.1.2; 2-haloacid dehalogenase [EC:3.8.1.2] C 00361 Chlorocyclohexane and chlorobenzene degradation [PATH:shg00361] D Sph21_2557 Carboxymethylenebutenolidase K01061 E3.1.1.45; carboxymethylenebutenolidase [EC:3.1.1.45] D Sph21_1746 HAD-superfamily hydrolase, subfamily IA, variant 3 K01560 E3.8.1.2; 2-haloacid dehalogenase [EC:3.8.1.2] C 00623 Toluene degradation [PATH:shg00623] D Sph21_2557 Carboxymethylenebutenolidase K01061 E3.1.1.45; carboxymethylenebutenolidase [EC:3.1.1.45] C 00622 Xylene degradation C 00633 Nitrotoluene degradation [PATH:shg00633] D Sph21_4854 12-oxophytodienoate reductase K10680 nemA; N-ethylmaleimide reductase [EC:1.-.-.-] C 00642 Ethylbenzene degradation D Sph21_0020 acetyl-CoA acetyltransferase K00632 fadA; acetyl-CoA acyltransferase [EC:2.3.1.16] C 00643 Styrene degradation C 00791 Atrazine degradation C 00930 Caprolactam degradation D Sph21_1253 Gluconolactonase K01053 gnl; gluconolactonase [EC:3.1.1.17] D Sph21_4037 SMP-30/Gluconolaconase/LRE-like region-containing protein K01053 gnl; gluconolactonase [EC:3.1.1.17] C 00363 Bisphenol degradation C 00621 Dioxin degradation C 00626 Naphthalene degradation C 00624 Polycyclic aromatic hydrocarbon degradation C 00365 Furfural degradation C 00984 Steroid degradation C 00980 Metabolism of xenobiotics by cytochrome P450 C 00982 Drug metabolism - cytochrome P450 C 00983 Drug metabolism - other enzymes B B 09112 Not included in regular maps C 09113 Global maps only # A09120 Genetic Information Processing B B 09121 Transcription C 03020 RNA polymerase [PATH:shg03020] D Sph21_2406 DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] D Sph21_2407 DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] D Sph21_1742 DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] C 03022 Basal transcription factors C 03040 Spliceosome B B 09122 Translation C 03010 Ribosome [PATH:shg03010] D Sph21_3134 RNA binding S1 domain protein K02945 RP-S1; small subunit ribosomal protein S1 D Sph21_1445 ribosomal protein S2 K02967 RP-S2; small subunit ribosomal protein S2 D Sph21_1720 ribosomal protein S3 K02982 RP-S3; small subunit ribosomal protein S3 D Sph21_1741 ribosomal protein S4 K02986 RP-S4; small subunit ribosomal protein S4 D Sph21_1732 ribosomal protein S5 K02988 RP-S5; small subunit ribosomal protein S5 D Sph21_2352 30S ribosomal protein S6 K02990 RP-S6; small subunit ribosomal protein S6 D Sph21_3980 ribosomal protein S7 K02992 RP-S7; small subunit ribosomal protein S7 D Sph21_1729 ribosomal protein S8 K02994 RP-S8; small subunit ribosomal protein S8 D Sph21_1446 ribosomal protein S9 K02996 RP-S9; small subunit ribosomal protein S9 D Sph21_3978 30S ribosomal protein S10 K02946 RP-S10; small subunit ribosomal protein S10 D Sph21_1740 30S ribosomal protein S11 K02948 RP-S11; small subunit ribosomal protein S11 D Sph21_3981 ribosomal protein S12 K02950 RP-S12; small subunit ribosomal protein S12 D Sph21_1739 30S ribosomal protein S13 K02952 RP-S13; small subunit ribosomal protein S13 D Sph21_1728 30S ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14 D Sph21_3076 ribosomal protein S15 K02956 RP-S15; small subunit ribosomal protein S15 D Sph21_1325 30S ribosomal protein S16 K02959 RP-S16; small subunit ribosomal protein S16 D Sph21_1724 30S ribosomal protein S17 K02961 RP-S17; small subunit ribosomal protein S17 D Sph21_2351 30S ribosomal protein S18 K02963 RP-S18; small subunit ribosomal protein S18 D Sph21_1718 ribosomal protein S19 K02965 RP-S19; small subunit ribosomal protein S19 D Sph21_3959 30S ribosomal protein S20 K02968 RP-S20; small subunit ribosomal protein S20 D Sph21_2394 30S ribosomal protein S21 K02970 RP-S21; small subunit ribosomal protein S21 D Sph21_2403 ribosomal protein L1 K02863 RP-L1; large subunit ribosomal protein L1 D Sph21_1717 ribosomal protein L2 K02886 RP-L2; large subunit ribosomal protein L2 D Sph21_1714 50S ribosomal protein L3 K02906 RP-L3; large subunit ribosomal protein L3 D Sph21_1715 ribosomal protein L4/L1e K02926 RP-L4; large subunit ribosomal protein L4 D Sph21_1727 ribosomal protein L5 K02931 RP-L5; large subunit ribosomal protein L5 D Sph21_1730 ribosomal protein L6 K02933 RP-L6; large subunit ribosomal protein L6 D Sph21_2405 50S ribosomal protein L7/L12 K02935 RP-L7; large subunit ribosomal protein L7/L12 D Sph21_2350 50S ribosomal protein L9 K02939 RP-L9; large subunit ribosomal protein L9 D Sph21_2404 50S ribosomal protein L10 K02864 RP-L10; large subunit ribosomal protein L10 D Sph21_2402 ribosomal protein L11 K02867 RP-L11; large subunit ribosomal protein L11 D Sph21_1447 ribosomal protein L13 K02871 RP-L13; large subunit ribosomal protein L13 D Sph21_1725 ribosomal protein L14 K02874 RP-L14; large subunit ribosomal protein L14 D Sph21_1734 ribosomal protein L15 K02876 RP-L15; large subunit ribosomal protein L15 D Sph21_1721 50S ribosomal protein L16 K02878 RP-L16; large subunit ribosomal protein L16 D Sph21_1743 50S ribosomal protein L17 K02879 RP-L17; large subunit ribosomal protein L17 D Sph21_1731 ribosomal protein L18 K02881 RP-L18; large subunit ribosomal protein L18 D Sph21_1328 50S ribosomal protein L19 K02884 RP-L19; large subunit ribosomal protein L19 D Sph21_2966 50S ribosomal protein L20 K02887 RP-L20; large subunit ribosomal protein L20 D Sph21_3305 50S ribosomal protein L21 K02888 RP-L21; large subunit ribosomal protein L21 D Sph21_1719 ribosomal protein L22 K02890 RP-L22; large subunit ribosomal protein L22 D Sph21_1716 Ribosomal protein L25/L23 K02892 RP-L23; large subunit ribosomal protein L23 D Sph21_1726 ribosomal protein L24 K02895 RP-L24; large subunit ribosomal protein L24 D Sph21_5155 50S ribosomal protein L25 K02897 RP-L25; large subunit ribosomal protein L25 D Sph21_3306 50S ribosomal protein L27 K02899 RP-L27; large subunit ribosomal protein L27 D Sph21_5182 50S ribosomal protein L28 K02902 RP-L28; large subunit ribosomal protein L28 D Sph21_1723 ribosomal protein L29 K02904 RP-L29; large subunit ribosomal protein L29 D Sph21_1733 ribosomal protein L30 K02907 RP-L30; large subunit ribosomal protein L30 D Sph21_3043 50S ribosomal protein L31 type B K02909 RP-L31; large subunit ribosomal protein L31 D Sph21_0009 50S ribosomal protein L32 K02911 RP-L32; large subunit ribosomal protein L32 D Sph21_5183 50S ribosomal protein L33 K02913 RP-L33; large subunit ribosomal protein L33 D Sph21_0328 50S ribosomal protein L34 K02914 RP-L34; large subunit ribosomal protein L34 D Sph21_2965 50S ribosomal protein L35 K02916 RP-L35; large subunit ribosomal protein L35 D Sph21_1738 50S ribosomal protein L36 K02919 RP-L36; large subunit ribosomal protein L36 D Sph21_R0009 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D Sph21_R0034 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D Sph21_R0068 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D Sph21_R0015 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D Sph21_R0013 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D Sph21_R0065 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D Sph21_R0037 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D Sph21_R0007 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D Sph21_R0006 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D Sph21_R0064 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D Sph21_R0012 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D Sph21_R0038 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA C 00970 Aminoacyl-tRNA biosynthesis [PATH:shg00970] D Sph21_R0023 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D Sph21_R0036 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D Sph21_R0066 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D Sph21_R0003 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D Sph21_R0044 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D Sph21_R0020 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D Sph21_R0049 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D Sph21_R0021 tRNA-Asn K14220 tRNA-Asn; tRNA Asn D Sph21_R0018 tRNA-Asp K14221 tRNA-Asp; tRNA Asp D Sph21_R0019 tRNA-Asp K14221 tRNA-Asp; tRNA Asp D Sph21_R0046 tRNA-Cys K14222 tRNA-Cys; tRNA Cys D Sph21_R0062 tRNA-Cys K14222 tRNA-Cys; tRNA Cys D Sph21_R0022 tRNA-Cys K14222 tRNA-Cys; tRNA Cys D Sph21_R0058 tRNA-Cys K14222 tRNA-Cys; tRNA Cys D Sph21_R0063 tRNA-Gln K14223 tRNA-Gln; tRNA Gln D Sph21_R0004 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D Sph21_R0005 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D Sph21_R0060 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D Sph21_R0055 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D Sph21_R0028 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D Sph21_R0033 tRNA-His K14226 tRNA-His; tRNA His D Sph21_R0008 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D Sph21_R0014 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D Sph21_R0035 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D Sph21_R0067 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D Sph21_R0041 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D Sph21_R0061 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D Sph21_R0040 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D Sph21_R0054 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D Sph21_R0053 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D Sph21_R0051 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D Sph21_R0052 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D Sph21_R0050 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D Sph21_R0024 tRNA-Met K14230 tRNA-Met; tRNA Met D Sph21_R0011 tRNA-Met K14230 tRNA-Met; tRNA Met D Sph21_R0010 tRNA-Met K14230 tRNA-Met; tRNA Met D Sph21_R0025 tRNA-Phe K14231 tRNA-Phe; tRNA Phe D Sph21_R0017 tRNA-Pro K14232 tRNA-Pro; tRNA Pro D Sph21_R0016 tRNA-Pro K14232 tRNA-Pro; tRNA Pro D Sph21_R0057 tRNA-Pro K14232 tRNA-Pro; tRNA Pro D Sph21_R0059 tRNA-Pro K14232 tRNA-Pro; tRNA Pro D Sph21_R0056 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D Sph21_R0043 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D Sph21_R0039 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D Sph21_R0031 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D Sph21_R0029 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D Sph21_R0026 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D Sph21_R0042 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D Sph21_R0030 tRNA-Trp K14235 tRNA-Trp; tRNA Trp D Sph21_R0027 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr D Sph21_R0002 tRNA-Val K14237 tRNA-Val; tRNA Val D Sph21_R0001 tRNA-Val K14237 tRNA-Val; tRNA Val D Sph21_R0032 tRNA-Val K14237 tRNA-Val; tRNA Val D Sph21_1436 glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17] D Sph21_0772 Glutaminyl-tRNA synthetase K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18] D Sph21_3106 alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7] D Sph21_1132 aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D Sph21_3337 Asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D Sph21_1705 glycyl-tRNA synthetase K01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14] D Sph21_2963 threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3] D Sph21_5220 seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11] D Sph21_1472 cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16] D Sph21_1427 Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] D Sph21_3548 Methionyl-tRNA formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9] D Sph21_2462 Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9] D Sph21_0546 leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D Sph21_0041 Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5] D Sph21_2410 Lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] D Sph21_3007 Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D Sph21_4651 Prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15] D Sph21_1306 Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21] D Sph21_1460 Phenylalanyl-tRNA synthetase alpha chain K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] D Sph21_3955 Phenylalanyl-tRNA synthetase beta chain K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] D Sph21_3907 Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D Sph21_3512 tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] C 03013 Nucleocytoplasmic transport C 03015 mRNA surveillance pathway C 03008 Ribosome biogenesis in eukaryotes B B 09123 Folding, sorting and degradation C 03060 Protein export [PATH:shg03060] D Sph21_1735 preprotein translocase, SecY subunit K03076 secY; preprotein translocase subunit SecY D Sph21_2400 preprotein translocase, SecE subunit K03073 secE; preprotein translocase subunit SecE D Sph21_0751 preprotein translocase, SecG subunit K03075 secG; preprotein translocase subunit SecG D Sph21_2971 protein-export membrane protein SecD K12257 secDF; SecD/SecF fusion protein D Sph21_4005 preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC D Sph21_3520 Membrane protein oxaA K03217 yidC; YidC/Oxa1 family membrane protein insertase D Sph21_0674 Protein translocase subunit secA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D Sph21_1442 signal recognition particle protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] D Sph21_R0045 ffs; SRP RNA; RNA component of signal recognition particle K01983 ffs; SRP RNA D Sph21_5185 signal recognition particle-docking protein FtsY K03110 ftsY; fused signal recognition particle receptor D Sph21_2540 Sec-independent protein translocase protein tatA/E-like protein K03116 tatA; sec-independent protein translocase protein TatA D Sph21_1145 twin-arginine translocation protein, TatA/E family subunit K03116 tatA; sec-independent protein translocase protein TatA D Sph21_2075 Sec-independent protein translocase protein tatA/E-like protein K03116 tatA; sec-independent protein translocase protein TatA D Sph21_0014 Sec-independent protein translocase, TatC subunit K03118 tatC; sec-independent protein translocase protein TatC D Sph21_0424 signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D Sph21_0043 Lipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36] D Sph21_2364 Lipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36] C 04141 Protein processing in endoplasmic reticulum C 04130 SNARE interactions in vesicular transport C 04120 Ubiquitin mediated proteolysis C 04122 Sulfur relay system [PATH:shg04122] D Sph21_3741 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D Sph21_3019 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D Sph21_3997 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D Sph21_3175 tRNA-specific 2-thiouridylase mnmA K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13] D Sph21_5098 molybdopterin biosynthesis MoaE protein K03635 MOCS2B; molybdopterin synthase catalytic subunit [EC:2.8.1.12] D Sph21_0143 molybdopterin biosynthesis MoaE protein K03635 MOCS2B; molybdopterin synthase catalytic subunit [EC:2.8.1.12] D Sph21_3738 molybdenum cofactor biosynthesis protein A K03639 moaA; GTP 3',8-cyclase [EC:4.1.99.22] D Sph21_3735 thiamineS protein K03636 moaD; sulfur-carrier protein D Sph21_2043 UBA/THIF-type NAD/FAD binding protein K21029 moeB; molybdopterin-synthase adenylyltransferase [EC:2.7.7.80] D Sph21_3734 UBA/THIF-type NAD/FAD binding protein K21147 moeZR; sulfur-carrier protein adenylyltransferase/sulfurtransferase [EC:2.7.7.80 2.7.7.- 2.8.1.11 2.8.1.-] D Sph21_1382 UBA/THIF-type NAD/FAD binding protein K21147 moeZR; sulfur-carrier protein adenylyltransferase/sulfurtransferase [EC:2.7.7.80 2.7.7.- 2.8.1.11 2.8.1.-] D Sph21_1388 thiamine biosynthesis protein ThiS K03154 thiS; sulfur carrier protein C 03050 Proteasome C 03018 RNA degradation [PATH:shg03018] D Sph21_0335 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D Sph21_3088 Polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] D Sph21_3885 DEAD/DEAH box helicase domain protein K11927 rhlE; ATP-dependent RNA helicase RhlE [EC:5.6.2.7] D Sph21_0774 DEAD/DEAH box helicase domain protein K11927 rhlE; ATP-dependent RNA helicase RhlE [EC:5.6.2.7] D Sph21_3518 DEAD/DEAH box helicase domain protein K11927 rhlE; ATP-dependent RNA helicase RhlE [EC:5.6.2.7] D Sph21_3093 ribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1] D Sph21_3878 DEAD/DEAH box helicase domain protein K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7] D Sph21_2937 ATP-dependent DNA helicase, RecQ family K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4] D Sph21_3364 ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4] D Sph21_4019 transcription termination factor Rho K03628 rho; transcription termination factor Rho D Sph21_3952 2,3 cyclic-nucleotide 2-phosphodiesterase K18682 rny; ribonucrease Y [EC:3.1.-.-] D Sph21_1062 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_3894 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_1745 Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK D Sph21_0753 60 kDa chaperonin K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D Sph21_0532 polyphosphate kinase 1 K00937 ppk1; polyphosphate kinase [EC:2.7.4.1] D Sph21_3169 polyphosphate kinase 1 K00937 ppk1; polyphosphate kinase [EC:2.7.4.1] D Sph21_2713 polyphosphate kinase 2 K22468 ppk2; polyphosphate kinase [EC:2.7.4.34] D Sph21_2425 polynucleotide adenylyltransferase/metal dependent phosphohydrolase K00970 pcnB; poly(A) polymerase [EC:2.7.7.19] B B 09124 Replication and repair C 03030 DNA replication [PATH:shg03030] D Sph21_3055 Exonuclease RNase T and DNA polymerase III K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D Sph21_3431 DNA polymerase III, epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D Sph21_3922 DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D Sph21_2353 DNA polymerase III, subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D Sph21_0763 DNA polymerase III gamma/tau subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D Sph21_2465 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D Sph21_1712 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D Sph21_3056 replicative DNA helicase K02314 dnaB; replicative DNA helicase [EC:5.6.2.3] D Sph21_0670 DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101] D Sph21_4628 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_5164 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_1131 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_3294 Ribonuclease H K03469 rnhA; ribonuclease HI [EC:3.1.26.4] D Sph21_1167 Ribonuclease H K03470 rnhB; ribonuclease HII [EC:3.1.26.4] D Sph21_1518 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D Sph21_0048 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03410 Base excision repair [PATH:shg03410] D Sph21_0570 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] D Sph21_4011 Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] D Sph21_1130 A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] D Sph21_2724 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] D Sph21_3236 DNA-formamidopyrimidine glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18] D Sph21_5115 HhH-GPD family protein K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21] D Sph21_4366 methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] D Sph21_4849 methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] D Sph21_1495 DNA-3-methyladenine glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] D Sph21_4521 exodeoxyribonuclease III Xth K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2] D Sph21_1390 exodeoxyribonuclease III Xth K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2] D Sph21_1518 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D Sph21_0716 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D Sph21_0048 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03420 Nucleotide excision repair [PATH:shg03420] D Sph21_1343 transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4] D Sph21_5270 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A D Sph21_0558 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A D Sph21_0721 UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B D Sph21_5241 UvrABC system protein C K03703 uvrC; excinuclease ABC subunit C D Sph21_3839 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D Sph21_2931 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D Sph21_1518 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D Sph21_0048 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03430 Mismatch repair [PATH:shg03430] D Sph21_3063 DNA mismatch repair protein mutS K03555 mutS; DNA mismatch repair protein MutS D Sph21_5111 DNA mismatch repair protein MutS domain protein K03555 mutS; DNA mismatch repair protein MutS D Sph21_4670 MutS2 protein K07456 mutS2; DNA mismatch repair protein MutS2 D Sph21_1476 DNA mismatch repair protein mutL K03572 mutL; DNA mismatch repair protein MutL D Sph21_3839 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D Sph21_2931 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D Sph21_1456 Exonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6] D Sph21_1455 Exodeoxyribonuclease 7 small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6] D Sph21_0716 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D Sph21_4628 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_5164 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_1131 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_3922 DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D Sph21_1712 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D Sph21_2353 DNA polymerase III, subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D Sph21_2465 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D Sph21_0763 DNA polymerase III gamma/tau subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D Sph21_3055 Exonuclease RNase T and DNA polymerase III K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D Sph21_3431 DNA polymerase III, epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D Sph21_0048 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03440 Homologous recombination [PATH:shg03440] D Sph21_0716 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D Sph21_4628 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_5164 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_1131 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_5257 DNA replication and repair protein recF K03629 recF; DNA replication and repair protein RecF D Sph21_0038 DNA repair protein recO K03584 recO; DNA repair protein RecO (recombination protein O) D Sph21_3097 Recombination protein recR K06187 recR; recombination protein RecR D Sph21_0569 Protein recA K03553 recA; recombination protein RecA D Sph21_1518 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D Sph21_2087 Holliday junction ATP-dependent DNA helicase ruvA K03550 ruvA; holliday junction DNA helicase RuvA D Sph21_2470 Holliday junction ATP-dependent DNA helicase ruvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4] D Sph21_1573 Crossover junction endodeoxyribonuclease ruvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10] D Sph21_1158 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4] D Sph21_3922 DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D Sph21_1712 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D Sph21_2353 DNA polymerase III, subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D Sph21_2465 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D Sph21_0763 DNA polymerase III gamma/tau subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D Sph21_3055 Exonuclease RNase T and DNA polymerase III K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D Sph21_3431 DNA polymerase III, epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D Sph21_0322 primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4] C 03450 Non-homologous end-joining [PATH:shg03450] D Sph21_3426 DNA repair protein K10979 ku; DNA end-binding protein Ku D Sph21_2578 DNA ligase D K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1] C 03460 Fanconi anemia pathway B B 09126 Chromosome C 03082 ATP-dependent chromatin remodeling C 03083 Polycomb repressive complex B B 09125 Information processing in viruses C 03230 Viral genome structure C 03240 Viral replication C 03250 Viral life cycle - HIV-1 C 03260 Virion - Human immunodeficiency virus C 03271 Virion - Rotavirus C 03262 Virion - Coronavirus C 03261 Virion - Influenza virus C 03263 Virion - Enterovirus C 03264 Virion - Flavivirus C 03265 Virion - Ebolavirus and Lyssavirus C 03266 Virion - Herpesvirus C 03268 Virion - Orthopoxvirus C 03267 Virion - Adenovirus C 03259 Virion - Bacteriophages T4 and T7 C 03258 Virion - Bacteriophage lambda # A09130 Environmental Information Processing B B 09131 Membrane transport C 02010 ABC transporters [PATH:shg02010] D Sph21_2284 ABC transporter related protein K05776 modF; molybdate transport system ATP-binding protein D Sph21_0814 ABC-type glycine betaine transport, periplasmic subunit K02002 proX; glycine betaine/proline transport system substrate-binding protein D Sph21_0815 ABC-type transporter, integral membrane subunit K02001 proW; glycine betaine/proline transport system permease protein D Sph21_0816 glycine betaine/L-proline ABC transporter, ATPase subunit K02000 proV; glycine betaine/proline transport system ATP-binding protein [EC:7.6.2.9] D Sph21_2567 ABC-type glycine betaine transport, periplasmic subunit K05845 opuC; osmoprotectant transport system substrate-binding protein D Sph21_2568 Fe(3+)-transporting ATPase K05847 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9] D Sph21_3069 Mammalian cell entry related domain protein K02067 mlaD; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein D Sph21_2534 Mammalian cell entry related domain protein K02067 mlaD; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein D Sph21_3067 protein of unknown function DUF140 K02066 mlaE; phospholipid/cholesterol/gamma-HCH transport system permease protein D Sph21_1668 protein of unknown function DUF140 K02066 mlaE; phospholipid/cholesterol/gamma-HCH transport system permease protein D Sph21_3068 Sulfate-transporting ATPase K02065 mlaF; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein D Sph21_1667 Sulfate-transporting ATPase K02065 mlaF; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein D Sph21_2619 periplasmic binding protein/LacI transcriptional regulator K10439 rbsB; ribose transport system substrate-binding protein D Sph21_2622 ABC-type transporter, integral membrane subunit K10440 rbsC; ribose transport system permease protein D Sph21_2621 Monosaccharide-transporting ATPase K10441 rbsA; ribose transport system ATP-binding protein [EC:7.5.2.7] D Sph21_4532 ABC-type phosphate transporter substrate-binding component K02040 pstS; phosphate transport system substrate-binding protein D Sph21_4735 phosphate binding protein K02040 pstS; phosphate transport system substrate-binding protein D Sph21_4531 phosphate ABC transporter, inner membrane subunit PstC K02037 pstC; phosphate transport system permease protein D Sph21_4734 phosphate ABC transporter, inner membrane subunit PstC K02037 pstC; phosphate transport system permease protein D Sph21_4530 ABC-type transporter, integral membrane subunit K02038 pstA; phosphate transport system permease protein D Sph21_4733 phosphate ABC transporter, inner membrane subunit PstA K02038 pstA; phosphate transport system permease protein D Sph21_4529 Phosphate-transporting ATPase K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D Sph21_4732 phosphate ABC transporter, ATPase subunit K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D Sph21_4537 lipoprotein, YaeC family K02073 metQ; D-methionine transport system substrate-binding protein D Sph21_4538 ABC-type transporter, integral membrane subunit K02072 metI; D-methionine transport system permease protein D Sph21_4539 Phosphonate-transporting ATPase K02071 metN; D-methionine transport system ATP-binding protein D Sph21_1342 protein of unknown function DUF214 K09808 lolC_E; lipoprotein-releasing system permease protein D Sph21_3547 protein of unknown function DUF214 K09808 lolC_E; lipoprotein-releasing system permease protein D Sph21_3281 Polyamine-transporting ATPase K09810 lolD; lipoprotein-releasing system ATP-binding protein [EC:7.6.2.-] D Sph21_2981 cytochrome c assembly protein K02195 ccmC; heme exporter protein C D Sph21_2980 cytochrome c-type biogenesis protein CcmB K02194 ccmB; heme exporter protein B D Sph21_0564 permease YjgP/YjgQ family protein K07091 lptF; lipopolysaccharide export system permease protein D Sph21_2520 permease YjgP/YjgQ family protein K11720 lptG; lipopolysaccharide export system permease protein D Sph21_0715 Sulfate-transporting ATPase K06861 lptB; lipopolysaccharide export system ATP-binding protein [EC:7.5.2.5] D Sph21_4999 ABC transporter related protein K06861 lptB; lipopolysaccharide export system ATP-binding protein [EC:7.5.2.5] D Sph21_0547 protein of unknown function DUF214 K09811 ftsX; cell division transport system permease protein D Sph21_3122 Sigma 54 interacting domain protein K09812 ftsE; cell division transport system ATP-binding protein D Sph21_4436 Xenobiotic-transporting ATPase K14698 irtA; ATP-binding cassette, subfamily B, bacterial IrtA/YbtP [EC:7.-.-.-] D Sph21_4435 Xenobiotic-transporting ATPase K14699 irtB; ATP-binding cassette, subfamily B, bacterial IrtB/YbtQ [EC:7.-.-.-] D Sph21_1607 Xenobiotic-transporting ATPase K11085 msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:7.5.2.6] D Sph21_4009 Xenobiotic-transporting ATPase K18889 mdlA; ATP-binding cassette, subfamily B, multidrug efflux pump D Sph21_2417 Xenobiotic-transporting ATPase K18890 mdlB; ATP-binding cassette, subfamily B, multidrug efflux pump D Sph21_1895 Xenobiotic-transporting ATPase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter D Sph21_4095 Xenobiotic-transporting ATPase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter D Sph21_0591 Xenobiotic-transporting ATPase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter C 02060 Phosphotransferase system (PTS) C 03070 Bacterial secretion system [PATH:shg03070] D Sph21_3416 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1232 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4138 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_3601 putative outer membrane protein K12340 tolC; outer membrane protein D Sph21_0030 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_0888 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1674 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1758 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4864 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4635 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4057 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1697 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_2971 protein-export membrane protein SecD K12257 secDF; SecD/SecF fusion protein D Sph21_2400 preprotein translocase, SecE subunit K03073 secE; preprotein translocase subunit SecE D Sph21_0751 preprotein translocase, SecG subunit K03075 secG; preprotein translocase subunit SecG D Sph21_1735 preprotein translocase, SecY subunit K03076 secY; preprotein translocase subunit SecY D Sph21_4005 preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC D Sph21_3520 Membrane protein oxaA K03217 yidC; YidC/Oxa1 family membrane protein insertase D Sph21_0674 Protein translocase subunit secA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D Sph21_5185 signal recognition particle-docking protein FtsY K03110 ftsY; fused signal recognition particle receptor D Sph21_1442 signal recognition particle protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] D Sph21_2540 Sec-independent protein translocase protein tatA/E-like protein K03116 tatA; sec-independent protein translocase protein TatA D Sph21_1145 twin-arginine translocation protein, TatA/E family subunit K03116 tatA; sec-independent protein translocase protein TatA D Sph21_2075 Sec-independent protein translocase protein tatA/E-like protein K03116 tatA; sec-independent protein translocase protein TatA D Sph21_0014 Sec-independent protein translocase, TatC subunit K03118 tatC; sec-independent protein translocase protein TatC D Sph21_4834 Rhs element Vgr protein K11904 vgrG; type VI secretion system secreted protein VgrG B B 09132 Signal transduction C 02020 Two-component system [PATH:shg02020] D Sph21_1333 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_1369 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_3420 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_2053 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_4070 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_4737 PAS/PAC sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_4716 response regulator receiver protein K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB D Sph21_3108 two component transcriptional regulator, winged helix family K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP D Sph21_5193 two component transcriptional regulator, winged helix family K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP D Sph21_1570 two component transcriptional regulator, winged helix family K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP D Sph21_2898 Alkaline phosphatase K01077 E3.1.3.1; alkaline phosphatase [EC:3.1.3.1] D Sph21_0968 Alkaline phosphatase K01077 E3.1.3.1; alkaline phosphatase [EC:3.1.3.1] D Sph21_4532 ABC-type phosphate transporter substrate-binding component K02040 pstS; phosphate transport system substrate-binding protein D Sph21_4735 phosphate binding protein K02040 pstS; phosphate transport system substrate-binding protein D Sph21_3618 peptidase S1 and S6 chymotrypsin/Hap K04771 degP; serine protease Do [EC:3.4.21.107] D Sph21_1406 protease Do K04771 degP; serine protease Do [EC:3.4.21.107] D Sph21_2802 efflux transporter, RND family, MFP subunit K07798 cusB; membrane fusion protein, copper/silver efflux system D Sph21_0285 efflux transporter, RND family, MFP subunit K07798 cusB; membrane fusion protein, copper/silver efflux system D Sph21_0286 hypothetical protein K07798 cusB; membrane fusion protein, copper/silver efflux system D Sph21_2803 hypothetical protein K07798 cusB; membrane fusion protein, copper/silver efflux system D Sph21_0288 acriflavin resistance protein K07787 cusA; copper/silver efflux system protein D Sph21_2805 acriflavin resistance protein K07787 cusA; copper/silver efflux system protein D Sph21_4258 Osmosensitive K channel His kinase sensor K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] D Sph21_4254 Potassium-transporting ATPase A chain K01546 kdpA; potassium-transporting ATPase potassium-binding subunit D Sph21_4255 Potassium-transporting ATPase B chain K01547 kdpB; potassium-transporting ATPase ATP-binding subunit [EC:7.2.2.6] D Sph21_4256 Potassium-transporting ATPase C chain K01548 kdpC; potassium-transporting ATPase KdpC subunit D Sph21_1556 cytochrome oxidase assembly K02259 COX15; heme a synthase [EC:1.17.99.9] D Sph21_5130 PAS/PAC sensor signal transduction histidine kinase K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] D Sph21_0001 Chromosomal replication initiator protein dnaA K02313 dnaA; chromosomal replication initiator protein D Sph21_4054 Lysylphosphatidylglycerol synthetase/UPF0104 K14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3] D Sph21_4476 Lantibiotic dehydratase domain protein K20483 nisB; lantibiotic biosynthesis protein D Sph21_0696 Lantibiotic dehydratase domain protein K20483 nisB; lantibiotic biosynthesis protein D Sph21_1090 Lantibiotic dehydratase domain protein K20483 nisB; lantibiotic biosynthesis protein D Sph21_4504 response regulator receiver sensor signal transduction histidine kinase K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3] D Sph21_4123 two component transcriptional regulator, LuxR family K20264 fusR; two-component system, NarL family, response regulator FusR D Sph21_4207 two component transcriptional regulator, LuxR family K20264 fusR; two-component system, NarL family, response regulator FusR D Sph21_2076 integral membrane sensor signal transduction histidine kinase K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3] D Sph21_4952 response regulator receiver protein K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB D Sph21_2093 two component transcriptional regulator, LuxR family K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY D Sph21_3744 two component transcriptional regulator, LuxR family K07692 degU; two-component system, NarL family, response regulator DegU D Sph21_3206 two component transcriptional regulator, LuxR family K07696 nreC; two-component system, NarL family, response regulator NreC D Sph21_0666 Glutamate--ammonia ligase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D Sph21_3985 Glutamate--ammonia ligase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D Sph21_3147 two component, sigma54 specific, transcriptional regulator, Fis family K07713 zraR; two-component system, NtrC family, response regulator HydG D Sph21_1172 two component, sigma54 specific, transcriptional regulator, Fis family K07713 zraR; two-component system, NtrC family, response regulator HydG D Sph21_2475 acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D Sph21_1231 sodium:dicarboxylate symporter K11103 dctA; aerobic C4-dicarboxylate transport protein D Sph21_0330 RNA polymerase, sigma 54 subunit, RpoN K03092 rpoN; RNA polymerase sigma-54 factor D Sph21_4259 multi-sensor signal transduction histidine kinase K11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3] D Sph21_1115 MCP methyltransferase, CheR-type K00575 cheR; chemotaxis protein methyltransferase CheR [EC:2.1.1.80] D Sph21_2156 signal transduction histidine kinase with CheB and CheR activity K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61] D Sph21_2923 CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] D Sph21_2096 CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] D Sph21_2157 putative PAS/PAC sensor protein K11354 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3] D Sph21_3521 PAS/PAC sensor signal transduction histidine kinase K14986 fixL; two-component system, LuxR family, sensor kinase FixL [EC:2.7.13.3] D Sph21_4914 hypothetical protein K10914 crp; CRP/FNR family transcriptional regulator, cyclic AMP receptor protein D Sph21_3527 cytochrome c oxidase, cbb3-type, subunit I K15862 ccoNO; cytochrome c oxidase cbb3-type subunit I/II [EC:7.1.1.9] D Sph21_3529 cytochrome c class I K00406 ccoP; cytochrome c oxidase cbb3-type subunit III D Sph21_1182 cytochrome bd ubiquinol oxidase subunit I K00425 cydA; cytochrome bd ubiquinol oxidase subunit I [EC:7.1.1.7] D Sph21_1183 cytochrome bd ubiquinol oxidase subunit II K00426 cydB; cytochrome bd ubiquinol oxidase subunit II [EC:7.1.1.7] D Sph21_3416 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1232 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4138 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_3601 putative outer membrane protein K12340 tolC; outer membrane protein D Sph21_0030 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_0888 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1674 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1758 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4864 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4635 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4057 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1697 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1958 polysaccharide export protein K01991 wza; polysaccharide biosynthesis/export protein D Sph21_1809 Soluble ligand binding domain K01991 wza; polysaccharide biosynthesis/export protein D Sph21_2025 Soluble ligand binding domain K01991 wza; polysaccharide biosynthesis/export protein D Sph21_1170 protein tyrosine phosphatase K25307 wzb; low molecular weight protein-tyrosine phosphatase [EC:3.1.3.48] D Sph21_1959 capsular exopolysaccharide family K16692 etk-wzc; tyrosine-protein kinase Etk/Wzc [EC:2.7.10.3] D Sph21_2026 capsular exopolysaccharide family K16692 etk-wzc; tyrosine-protein kinase Etk/Wzc [EC:2.7.10.3] D Sph21_1810 capsular exopolysaccharide family K16692 etk-wzc; tyrosine-protein kinase Etk/Wzc [EC:2.7.10.3] D Sph21_1828 UDP-N-acetylglucosamine 2-epimerase K01791 wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14] D Sph21_2881 Pectinesterase K01051 E3.1.1.11; pectinesterase [EC:3.1.1.11] D Sph21_2885 Pectinesterase K01051 E3.1.1.11; pectinesterase [EC:3.1.1.11] D Sph21_4498 glycoside hydrolase family 5 K01179 E3.2.1.4; endoglucanase [EC:3.2.1.4] D Sph21_0486 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_2938 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_2492 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_3403 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_4695 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_0806 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_5020 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1890 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1877 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_2764 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_4232 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_0462 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_2954 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1281 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_4805 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_0843 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1869 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1664 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_0805 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_4857 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_4311 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_4413 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_2833 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_2264 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_2497 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_0972 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_4293 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1778 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1965 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1918 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_0195 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_0489 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_0461 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_0842 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_0804 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_0807 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_0938 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_0971 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_0999 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_1280 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_2834 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_2946 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_2955 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_1870 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_1878 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_2769 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_2778 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_2939 FecR protein K07165 fecR; transmembrane sensor D Sph21_1888 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_2266 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_2493 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_2498 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_1919 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_1927 FecR protein K07165 fecR; transmembrane sensor D Sph21_1966 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_1663 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_1777 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_3402 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_4233 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_4292 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_4310 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_4334 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_4414 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_4804 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_4858 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_4696 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_4705 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor D Sph21_5019 anti-FecI sigma factor, FecR K07165 fecR; transmembrane sensor C 04010 MAPK signaling pathway C 04013 MAPK signaling pathway - fly C 04016 MAPK signaling pathway - plant C 04011 MAPK signaling pathway - yeast C 04012 ErbB signaling pathway C 04014 Ras signaling pathway C 04015 Rap1 signaling pathway C 04310 Wnt signaling pathway C 04330 Notch signaling pathway C 04340 Hedgehog signaling pathway C 04341 Hedgehog signaling pathway - fly C 04350 TGF-beta signaling pathway C 04390 Hippo signaling pathway C 04391 Hippo signaling pathway - fly C 04392 Hippo signaling pathway - multiple species C 04370 VEGF signaling pathway C 04371 Apelin signaling pathway C 04630 JAK-STAT signaling pathway C 04064 NF-kappa B signaling pathway C 04668 TNF signaling pathway C 04066 HIF-1 signaling pathway C 04068 FoxO signaling pathway C 04020 Calcium signaling pathway C 04070 Phosphatidylinositol signaling system C 04072 Phospholipase D signaling pathway C 04071 Sphingolipid signaling pathway C 04024 cAMP signaling pathway C 04022 cGMP-PKG signaling pathway C 04151 PI3K-Akt signaling pathway C 04152 AMPK signaling pathway C 04150 mTOR signaling pathway C 04075 Plant hormone signal transduction B B 09133 Signaling molecules and interaction C 04080 Neuroactive ligand-receptor interaction C 04060 Cytokine-cytokine receptor interaction C 04061 Viral protein interaction with cytokine and cytokine receptor C 04512 ECM-receptor interaction C 04514 Cell adhesion molecules # A09140 Cellular Processes B B 09141 Transport and catabolism C 04144 Endocytosis C 04145 Phagosome C 04142 Lysosome C 04146 Peroxisome C 04140 Autophagy - animal C 04138 Autophagy - yeast C 04136 Autophagy - other C 04137 Mitophagy - animal C 04139 Mitophagy - yeast C 04148 Efferocytosis D Sph21_2761 Arginase/agmatinase/formiminoglutamase K01476 rocF; arginase [EC:3.5.3.1] B B 09143 Cell growth and death C 04110 Cell cycle C 04111 Cell cycle - yeast C 04112 Cell cycle - Caulobacter C 04113 Meiosis - yeast C 04114 Oocyte meiosis C 04210 Apoptosis C 04214 Apoptosis - fly C 04215 Apoptosis - multiple species C 04216 Ferroptosis C 04217 Necroptosis C 04115 p53 signaling pathway C 04218 Cellular senescence B B 09144 Cellular community - eukaryotes C 04510 Focal adhesion C 04520 Adherens junction C 04530 Tight junction C 04540 Gap junction C 04550 Signaling pathways regulating pluripotency of stem cells B B 09145 Cellular community - prokaryotes C 02024 Quorum sensing [PATH:shg02024] D Sph21_1506 Anthranilate synthase K01657 trpE; anthranilate synthase component I [EC:4.1.3.27] D Sph21_1507 glutamine amidotransferase of anthranilate synthase K01658 trpG; anthranilate synthase component II [EC:4.1.3.27] D Sph21_4123 two component transcriptional regulator, LuxR family K20264 fusR; two-component system, NarL family, response regulator FusR D Sph21_4207 two component transcriptional regulator, LuxR family K20264 fusR; two-component system, NarL family, response regulator FusR D Sph21_0025 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D Sph21_3308 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D Sph21_4914 hypothetical protein K10914 crp; CRP/FNR family transcriptional regulator, cyclic AMP receptor protein D Sph21_0933 Endoglucanase H/Glycosyl hydrolase family 26 K01218 gmuG; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78] D Sph21_3390 riboflavin biosynthesis protein RibD K11752 ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193] D Sph21_0423 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_2826 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_2599 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_1488 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_4896 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_1895 Xenobiotic-transporting ATPase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter D Sph21_4095 Xenobiotic-transporting ATPase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter D Sph21_0591 Xenobiotic-transporting ATPase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter D Sph21_1896 secretion protein HlyD family protein K20345 blpB; membrane fusion protein, peptide pheromone/bacteriocin exporter D Sph21_4094 secretion protein HlyD family protein K20345 blpB; membrane fusion protein, peptide pheromone/bacteriocin exporter D Sph21_3520 Membrane protein oxaA K03217 yidC; YidC/Oxa1 family membrane protein insertase D Sph21_2971 protein-export membrane protein SecD K12257 secDF; SecD/SecF fusion protein D Sph21_2400 preprotein translocase, SecE subunit K03073 secE; preprotein translocase subunit SecE D Sph21_0751 preprotein translocase, SecG subunit K03075 secG; preprotein translocase subunit SecG D Sph21_1735 preprotein translocase, SecY subunit K03076 secY; preprotein translocase subunit SecY D Sph21_4005 preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC D Sph21_0674 Protein translocase subunit secA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D Sph21_5185 signal recognition particle-docking protein FtsY K03110 ftsY; fused signal recognition particle receptor D Sph21_1442 signal recognition particle protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] D Sph21_3744 two component transcriptional regulator, LuxR family K07692 degU; two-component system, NarL family, response regulator DegU D Sph21_0662 phospholipase C, phosphocholine-specific K01114 plc; phospholipase C [EC:3.1.4.3] D Sph21_1769 phospholipase C, phosphocholine-specific K01114 plc; phospholipase C [EC:3.1.4.3] D Sph21_4476 Lantibiotic dehydratase domain protein K20483 nisB; lantibiotic biosynthesis protein D Sph21_0696 Lantibiotic dehydratase domain protein K20483 nisB; lantibiotic biosynthesis protein D Sph21_1090 Lantibiotic dehydratase domain protein K20483 nisB; lantibiotic biosynthesis protein C 05111 Biofilm formation - Vibrio cholerae C 02025 Biofilm formation - Pseudomonas aeruginosa C 02026 Biofilm formation - Escherichia coli B B 09142 Cell motility C 02030 Bacterial chemotaxis [PATH:shg02030] D Sph21_2619 periplasmic binding protein/LacI transcriptional regulator K10439 rbsB; ribose transport system substrate-binding protein D Sph21_2923 CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] D Sph21_2096 CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] D Sph21_2156 signal transduction histidine kinase with CheB and CheR activity K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61] D Sph21_1115 MCP methyltransferase, CheR-type K00575 cheR; chemotaxis protein methyltransferase CheR [EC:2.1.1.80] D Sph21_2444 OmpA/MotB domain protein K02557 motB; chemotaxis protein MotB D Sph21_1565 OmpA/MotB domain protein K02557 motB; chemotaxis protein MotB C 02040 Flagellar assembly [PATH:shg02040] D Sph21_2444 OmpA/MotB domain protein K02557 motB; chemotaxis protein MotB D Sph21_1565 OmpA/MotB domain protein K02557 motB; chemotaxis protein MotB D Sph21_4481 RNA polymerase, sigma 70 subunit, RpoD subfamily K03086 rpoD; RNA polymerase primary sigma factor D Sph21_3256 RNA polymerase, sigma 70 subunit, RpoD subfamily K03086 rpoD; RNA polymerase primary sigma factor D Sph21_0330 RNA polymerase, sigma 54 subunit, RpoN K03092 rpoN; RNA polymerase sigma-54 factor C 04814 Motor proteins C 04820 Cytoskeleton in muscle cells D Sph21_0335 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] C 04810 Regulation of actin cytoskeleton # A09150 Organismal Systems B B 09151 Immune system C 04640 Hematopoietic cell lineage C 04610 Complement and coagulation cascades C 04611 Platelet activation C 04613 Neutrophil extracellular trap formation C 04620 Toll-like receptor signaling pathway C 04624 Toll and Imd signaling pathway C 04621 NOD-like receptor signaling pathway C 04622 RIG-I-like receptor signaling pathway C 04623 Cytosolic DNA-sensing pathway C 04625 C-type lectin receptor signaling pathway C 04650 Natural killer cell mediated cytotoxicity C 04612 Antigen processing and presentation C 04660 T cell receptor signaling pathway C 04658 Th1 and Th2 cell differentiation C 04659 Th17 cell differentiation C 04657 IL-17 signaling pathway C 04662 B cell receptor signaling pathway C 04664 Fc epsilon RI signaling pathway C 04666 Fc gamma R-mediated phagocytosis C 04670 Leukocyte transendothelial migration C 04672 Intestinal immune network for IgA production C 04062 Chemokine signaling pathway B B 09152 Endocrine system C 04911 Insulin secretion C 04910 Insulin signaling pathway C 04922 Glucagon signaling pathway C 04923 Regulation of lipolysis in adipocytes C 04920 Adipocytokine signaling pathway C 03320 PPAR signaling pathway C 04929 GnRH secretion C 04912 GnRH signaling pathway C 04913 Ovarian steroidogenesis C 04915 Estrogen signaling pathway C 04914 Progesterone-mediated oocyte maturation C 04917 Prolactin signaling pathway C 04921 Oxytocin signaling pathway C 04926 Relaxin signaling pathway C 04935 Growth hormone synthesis, secretion and action C 04918 Thyroid hormone synthesis C 04919 Thyroid hormone signaling pathway C 04928 Parathyroid hormone synthesis, secretion and action C 04916 Melanogenesis C 04924 Renin secretion C 04614 Renin-angiotensin system C 04925 Aldosterone synthesis and secretion C 04927 Cortisol synthesis and secretion B B 09153 Circulatory system C 04260 Cardiac muscle contraction C 04261 Adrenergic signaling in cardiomyocytes C 04270 Vascular smooth muscle contraction B B 09154 Digestive system C 04970 Salivary secretion C 04971 Gastric acid secretion C 04972 Pancreatic secretion C 04976 Bile secretion C 04973 Carbohydrate digestion and absorption C 04974 Protein digestion and absorption C 04975 Fat digestion and absorption C 04979 Cholesterol metabolism C 04977 Vitamin digestion and absorption C 04980 Cobalamin transport and metabolism [PATH:shg04980] D Sph21_3515 ATP/cobalamin adenosyltransferase K00798 MMAB; cob(I)alamin adenosyltransferase [EC:2.5.1.17] D Sph21_0379 methionine synthase K00548 metH; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13] C 04978 Mineral absorption B B 09155 Excretory system C 04962 Vasopressin-regulated water reabsorption C 04960 Aldosterone-regulated sodium reabsorption C 04961 Endocrine and other factor-regulated calcium reabsorption C 04964 Proximal tubule bicarbonate reclamation C 04966 Collecting duct acid secretion B B 09156 Nervous system C 04724 Glutamatergic synapse C 04727 GABAergic synapse C 04725 Cholinergic synapse C 04728 Dopaminergic synapse C 04726 Serotonergic synapse C 04720 Long-term potentiation C 04730 Long-term depression C 04723 Retrograde endocannabinoid signaling C 04721 Synaptic vesicle cycle C 04722 Neurotrophin signaling pathway B B 09157 Sensory system C 04744 Phototransduction C 04745 Phototransduction - fly C 04740 Olfactory transduction C 04742 Taste transduction C 04750 Inflammatory mediator regulation of TRP channels B B 09158 Development and regeneration C 04320 Dorso-ventral axis formation C 04360 Axon guidance C 04361 Axon regeneration C 04380 Osteoclast differentiation B B 09149 Aging C 04211 Longevity regulating pathway C 04212 Longevity regulating pathway - worm C 04213 Longevity regulating pathway - multiple species B B 09159 Environmental adaptation C 04710 Circadian rhythm C 04713 Circadian entrainment C 04711 Circadian rhythm - fly C 04712 Circadian rhythm - plant C 04714 Thermogenesis C 04626 Plant-pathogen interaction # A09160 Human Diseases B B 09161 Cancer: overview C 05200 Pathways in cancer C 05202 Transcriptional misregulation in cancer C 05206 MicroRNAs in cancer C 05205 Proteoglycans in cancer C 05204 Chemical carcinogenesis - DNA adducts C 05207 Chemical carcinogenesis - receptor activation C 05208 Chemical carcinogenesis - reactive oxygen species C 05203 Viral carcinogenesis C 05230 Central carbon metabolism in cancer C 05231 Choline metabolism in cancer C 05235 PD-L1 expression and PD-1 checkpoint pathway in cancer B B 09162 Cancer: specific types C 05210 Colorectal cancer C 05212 Pancreatic cancer C 05225 Hepatocellular carcinoma C 05226 Gastric cancer C 05214 Glioma C 05216 Thyroid cancer C 05221 Acute myeloid leukemia C 05220 Chronic myeloid leukemia C 05217 Basal cell carcinoma C 05218 Melanoma C 05211 Renal cell carcinoma C 05219 Bladder cancer C 05215 Prostate cancer C 05213 Endometrial cancer C 05224 Breast cancer C 05222 Small cell lung cancer C 05223 Non-small cell lung cancer B B 09172 Infectious disease: viral C 05166 Human T-cell leukemia virus 1 infection C 05170 Human immunodeficiency virus 1 infection C 05161 Hepatitis B C 05160 Hepatitis C C 05171 Coronavirus disease - COVID-19 C 05164 Influenza A C 05162 Measles C 05168 Herpes simplex virus 1 infection C 05163 Human cytomegalovirus infection C 05167 Kaposi sarcoma-associated herpesvirus infection C 05169 Epstein-Barr virus infection C 05165 Human papillomavirus infection B B 09171 Infectious disease: bacterial C 05110 Vibrio cholerae infection C 05120 Epithelial cell signaling in Helicobacter pylori infection C 05130 Pathogenic Escherichia coli infection C 05132 Salmonella infection C 05131 Shigellosis C 05135 Yersinia infection C 05133 Pertussis C 05134 Legionellosis C 05150 Staphylococcus aureus infection C 05152 Tuberculosis C 05100 Bacterial invasion of epithelial cells B B 09174 Infectious disease: parasitic C 05146 Amoebiasis C 05144 Malaria C 05145 Toxoplasmosis C 05140 Leishmaniasis C 05142 Chagas disease C 05143 African trypanosomiasis B B 09163 Immune disease C 05310 Asthma C 05322 Systemic lupus erythematosus C 05323 Rheumatoid arthritis C 05320 Autoimmune thyroid disease C 05321 Inflammatory bowel disease C 05330 Allograft rejection C 05332 Graft-versus-host disease C 05340 Primary immunodeficiency B B 09164 Neurodegenerative disease C 05010 Alzheimer disease C 05012 Parkinson disease C 05014 Amyotrophic lateral sclerosis C 05016 Huntington disease C 05017 Spinocerebellar ataxia C 05020 Prion disease C 05022 Pathways of neurodegeneration - multiple diseases B B 09165 Substance dependence C 05030 Cocaine addiction C 05031 Amphetamine addiction C 05032 Morphine addiction C 05033 Nicotine addiction C 05034 Alcoholism B B 09166 Cardiovascular disease C 05417 Lipid and atherosclerosis C 05418 Fluid shear stress and atherosclerosis C 05410 Hypertrophic cardiomyopathy C 05412 Arrhythmogenic right ventricular cardiomyopathy C 05414 Dilated cardiomyopathy C 05415 Diabetic cardiomyopathy C 05416 Viral myocarditis B B 09167 Endocrine and metabolic disease C 04930 Type II diabetes mellitus C 04940 Type I diabetes mellitus C 04950 Maturity onset diabetes of the young C 04936 Alcoholic liver disease C 04932 Non-alcoholic fatty liver disease C 04931 Insulin resistance C 04933 AGE-RAGE signaling pathway in diabetic complications C 04934 Cushing syndrome B B 09175 Drug resistance: antimicrobial C 01501 beta-Lactam resistance [PATH:shg01501] D Sph21_0789 Beta-N-acetylhexosaminidase K01207 nagZ; beta-N-acetylhexosaminidase [EC:3.2.1.52] D Sph21_0790 Beta-N-acetylhexosaminidase K01207 nagZ; beta-N-acetylhexosaminidase [EC:3.2.1.52] D Sph21_1235 peptidase M56 BlaR1 K02172 blaR1; bla regulator protein blaR1 D Sph21_1402 TonB family protein K02172 blaR1; bla regulator protein blaR1 D Sph21_3629 peptidase M56 BlaR1 K02172 blaR1; bla regulator protein blaR1 D Sph21_1401 transcriptional repressor, CopY family K02171 blaI; BlaI family transcriptional regulator, penicillinase repressor D Sph21_3628 transcriptional repressor, CopY family K02171 blaI; BlaI family transcriptional regulator, penicillinase repressor D Sph21_1236 transcriptional repressor, CopY family K02171 blaI; BlaI family transcriptional regulator, penicillinase repressor D Sph21_3633 transcriptional regulator, TetR family K18136 acrR; TetR/AcrR family transcriptional regulator, multidrug resistance operon repressor D Sph21_2629 regulatory protein TetR K18136 acrR; TetR/AcrR family transcriptional regulator, multidrug resistance operon repressor D Sph21_2597 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_3635 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1124 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1486 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_0028 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1696 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_4059 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_4898 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_0029 acriflavin resistance protein K18138 acrB; multidrug efflux pump D Sph21_0423 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_2826 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_2599 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_1488 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_4896 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_3416 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1232 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4138 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_3601 putative outer membrane protein K12340 tolC; outer membrane protein D Sph21_0030 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_0888 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1674 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1758 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4864 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4635 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4057 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1697 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_5240 Peptidoglycan glycosyltransferase K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D Sph21_3115 Peptidoglycan glycosyltransferase K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D Sph21_2376 penicillin-binding protein 2 K05515 mrdA; penicillin-binding protein 2 [EC:3.4.16.4] D Sph21_0061 Peptidoglycan glycosyltransferase K03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4] D Sph21_3243 Beta-lactamase K17837 bla2; metallo-beta-lactamase class B [EC:3.5.2.6] D Sph21_2800 Beta-lactamase K17838 oxa; beta-lactamase class D [EC:3.5.2.6] C 01502 Vancomycin resistance [PATH:shg01502] D Sph21_3074 D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D Sph21_4678 Alanine racemase K01798 alr-murF; Alr-MurF fusion protein [EC:5.1.1.1 6.3.2.10] D Sph21_1352 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate/D-alanyl-D-alanyl ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10] D Sph21_0059 Phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] D Sph21_0056 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] C 01503 Cationic antimicrobial peptide (CAMP) resistance [PATH:shg01503] D Sph21_2535 cell wall hydrolase/autolysin K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] D Sph21_2536 cell wall hydrolase/autolysin K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] D Sph21_3618 peptidase S1 and S6 chymotrypsin/Hap K04771 degP; serine protease Do [EC:3.4.21.107] D Sph21_1406 protease Do K04771 degP; serine protease Do [EC:3.4.21.107] D Sph21_2597 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_3635 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1124 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1486 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_0028 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1696 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_4059 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_4898 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_0029 acriflavin resistance protein K18138 acrB; multidrug efflux pump D Sph21_3416 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1232 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4138 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_3601 putative outer membrane protein K12340 tolC; outer membrane protein D Sph21_0030 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_0888 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1674 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1758 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4864 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4635 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4057 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1697 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1542 acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase K00677 lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129] D Sph21_4054 Lysylphosphatidylglycerol synthetase/UPF0104 K14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3] B B 09176 Drug resistance: antineoplastic C 01521 EGFR tyrosine kinase inhibitor resistance C 01524 Platinum drug resistance C 01523 Antifolate resistance C 01522 Endocrine resistance # A09180 Brite Hierarchies B B 09181 Protein families: metabolism C 01000 Enzymes [BR:shg01000] C 01001 Protein kinases [BR:shg01001] D Sph21_3073 PASTA domain containing protein K12132 prkC; eukaryotic-like serine/threonine-protein kinase [EC:2.7.11.1] D Sph21_4943 serine/threonine protein kinase K08884 K08884; serine/threonine protein kinase, bacterial [EC:2.7.11.1] D Sph21_1959 capsular exopolysaccharide family K16692 etk-wzc; tyrosine-protein kinase Etk/Wzc [EC:2.7.10.3] D Sph21_2026 capsular exopolysaccharide family K16692 etk-wzc; tyrosine-protein kinase Etk/Wzc [EC:2.7.10.3] D Sph21_1810 capsular exopolysaccharide family K16692 etk-wzc; tyrosine-protein kinase Etk/Wzc [EC:2.7.10.3] D Sph21_1333 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_1369 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_3420 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_2053 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_4070 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_4737 PAS/PAC sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_4258 Osmosensitive K channel His kinase sensor K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] D Sph21_5130 PAS/PAC sensor signal transduction histidine kinase K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] D Sph21_4504 response regulator receiver sensor signal transduction histidine kinase K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3] D Sph21_2076 integral membrane sensor signal transduction histidine kinase K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3] D Sph21_0719 histidine kinase K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3] D Sph21_3722 PAS/PAC sensor signal transduction histidine kinase K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3] D Sph21_4122 histidine kinase K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3] D Sph21_4526 histidine kinase K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3] D Sph21_0854 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_0695 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_0874 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_3408 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_2387 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_2097 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4046 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4225 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4375 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4814 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4478 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4640 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4744 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4259 multi-sensor signal transduction histidine kinase K11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3] D Sph21_2257 integral membrane sensor signal transduction histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3] D Sph21_2045 multi-sensor signal transduction multi-kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3] D Sph21_2157 putative PAS/PAC sensor protein K11354 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3] D Sph21_3521 PAS/PAC sensor signal transduction histidine kinase K14986 fixL; two-component system, LuxR family, sensor kinase FixL [EC:2.7.13.3] D Sph21_1936 signal transduction histidine kinase K00936 pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3] D Sph21_2355 Diverse 7TM receptor transmembrane region K20971 ladS; two-component system, sensor histidine kinase LadS D Sph21_1112 response regulator receiver sensor signal transduction histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] D Sph21_2041 response regulator receiver sensor signal transduction histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] C 01009 Protein phosphatases and associated proteins [BR:shg01009] D Sph21_1238 Adenosylhomocysteinase K01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1] D Sph21_1062 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_3894 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_3254 Heat shock protein Hsp90 K04079 HSP90A; molecular chaperone HtpG D Sph21_2810 HSP90 family protein K04079 HSP90A; molecular chaperone HtpG D Sph21_0860 hypothetical protein K20074 prpC; PPM family protein phosphatase [EC:3.1.3.16] C 01002 Peptidases and inhibitors [BR:shg01002] D Sph21_0043 Lipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36] D Sph21_2364 Lipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36] D Sph21_5158 peptidase C1A papain K01372 BLMH; bleomycin hydrolase [EC:3.4.22.40] D Sph21_2239 GMP synthase (glutamine-hydrolyzing) K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] D Sph21_0664 peptidase C26 K07010 K07010; putative glutamine amidotransferase D Sph21_1895 Xenobiotic-transporting ATPase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter D Sph21_4095 Xenobiotic-transporting ATPase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter D Sph21_0591 Xenobiotic-transporting ATPase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter D Sph21_1148 NLP/P60 protein K13694 mepS; murein DD-endopeptidase / murein LD-carboxypeptidase [EC:3.4.-.- 3.4.17.13] D Sph21_3889 NLP/P60 protein K20742 ykfC; gamma-D-glutamyl-L-lysine dipeptidyl-peptidase [EC:3.4.14.13] D Sph21_3003 NLP/P60 protein K20742 ykfC; gamma-D-glutamyl-L-lysine dipeptidyl-peptidase [EC:3.4.14.13] D Sph21_2214 Amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14] D Sph21_3183 Glutamate synthase (ferredoxin) K00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13] D Sph21_2063 Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] D Sph21_3307 asparagine synthase (glutamine-hydrolyzing) K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] D Sph21_0357 intracellular protease, PfpI family K05520 yhbO; deglycase [EC:3.5.1.124] D Sph21_0760 ErfK/YbiS/YcfS/YnhG family protein K21470 ycbB; L,D-transpeptidase YcbB D Sph21_0360 ErfK/YbiS/YcfS/YnhG family protein K21470 ycbB; L,D-transpeptidase YcbB D Sph21_1304 Abortive infection protein K07052 K07052; CAAX protease family protein D Sph21_4440 hypothetical protein K07052 K07052; CAAX protease family protein D Sph21_4226 Abortive infection protein K07052 K07052; CAAX protease family protein D Sph21_4824 Abortive infection protein K07052 K07052; CAAX protease family protein D Sph21_1641 Membrane alanyl aminopeptidase K01256 pepN; aminopeptidase N [EC:3.4.11.2] D Sph21_4033 Oligopeptidase A K01284 dcp; peptidyl-dipeptidase Dcp [EC:3.4.15.5] D Sph21_5215 oligoendopeptidase, M3 family K08602 pepF; oligoendopeptidase F [EC:3.4.24.-] D Sph21_4637 Endothelin-converting enzyme 1 K07386 pepO; putative endopeptidase [EC:3.4.24.-] D Sph21_0519 peptidase M16 domain protein K07263 pqqL; zinc protease [EC:3.4.24.-] D Sph21_3675 peptidase M16 domain protein K07263 pqqL; zinc protease [EC:3.4.24.-] D Sph21_3676 peptidase M16 domain protein K07263 pqqL; zinc protease [EC:3.4.24.-] D Sph21_2875 peptidase M19 renal dipeptidase K01273 DPEP; membrane dipeptidase [EC:3.4.13.19] D Sph21_1081 Membrane dipeptidase K01273 DPEP; membrane dipeptidase [EC:3.4.13.19] D Sph21_1379 peptidase T K01258 pepT; tripeptide aminopeptidase [EC:3.4.11.4] D Sph21_5015 peptidase dimerization domain protein K12941 abgB; aminobenzoyl-glutamate utilization protein B D Sph21_1736 methionine aminopeptidase, type I K01265 map; methionyl aminopeptidase [EC:3.4.11.18] D Sph21_4274 methionine aminopeptidase, type I K01265 map; methionyl aminopeptidase [EC:3.4.11.18] D Sph21_4613 methionine aminopeptidase, type I K01265 map; methionyl aminopeptidase [EC:3.4.11.18] D Sph21_0992 peptidase M24 K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9] D Sph21_3545 peptidase M24 K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9] D Sph21_2671 Glutamate carboxypeptidase II K01301 NAALAD; N-acetylated-alpha-linked acidic dipeptidase [EC:3.4.17.21] D Sph21_1057 ATP-dependent metalloprotease FtsH K08956 AFG3; AFG3 family protein [EC:3.4.24.-] D Sph21_0775 peptidase M48 Ste24p K07387 K07387; metalloprotease [EC:3.4.24.-] D Sph21_5218 Dipeptidyl-peptidase III K01277 DPP3; dipeptidyl-peptidase III [EC:3.4.14.4] D Sph21_2920 membrane-associated zinc metalloprotease K11749 rseP; regulator of sigma E protease [EC:3.4.24.-] D Sph21_1235 peptidase M56 BlaR1 K02172 blaR1; bla regulator protein blaR1 D Sph21_1402 TonB family protein K02172 blaR1; bla regulator protein blaR1 D Sph21_3629 peptidase M56 BlaR1 K02172 blaR1; bla regulator protein blaR1 D Sph21_3673 protein of unknown function DUF980 K09933 mtfA; MtfA peptidase D Sph21_3618 peptidase S1 and S6 chymotrypsin/Hap K04771 degP; serine protease Do [EC:3.4.21.107] D Sph21_1406 protease Do K04771 degP; serine protease Do [EC:3.4.21.107] D Sph21_0572 peptidase S8 and S53 subtilisin kexin sedolisin K13274 wprA; cell wall-associated protease [EC:3.4.21.-] D Sph21_1453 Prolyl oligopeptidase K01322 PREP; prolyl oligopeptidase [EC:3.4.21.26] D Sph21_2473 Dipeptidyl-peptidase IV K01278 DPP4; dipeptidyl-peptidase 4 [EC:3.4.14.5] D Sph21_0993 Dipeptidyl-peptidase IV K01278 DPP4; dipeptidyl-peptidase 4 [EC:3.4.14.5] D Sph21_1246 Oligopeptidase B K01354 ptrB; oligopeptidase B [EC:3.4.21.83] D Sph21_1614 beta-lactamase K21469 pbp4b; serine-type D-Ala-D-Ala carboxypeptidase [EC:3.4.16.4] D Sph21_1073 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase K07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-] D Sph21_2925 ATP-dependent Clp protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] D Sph21_2814 ATP-dependent Clp protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] D Sph21_3481 peptidase S14 ClpP K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] D Sph21_2984 anti-sigma H sporulation factor, LonB K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53] D Sph21_0424 signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D Sph21_4185 alpha/beta hydrolase fold protein K01259 pip; proline iminopeptidase [EC:3.4.11.5] D Sph21_1361 carboxyl-terminal protease K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102] D Sph21_0376 carboxyl-terminal protease K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102] D Sph21_1397 carboxyl-terminal protease K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102] D Sph21_3271 peptidase S41 K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102] D Sph21_1002 peptidase S41 K08676 tri; tricorn protease [EC:3.4.21.-] D Sph21_3616 peptidase S41 K08676 tri; tricorn protease [EC:3.4.21.-] D Sph21_3904 peptidase S45 penicillin amidase K01434 pac; penicillin G amidase [EC:3.5.1.11] D Sph21_4022 signal peptide peptidase SppA, 67K type K04773 sppA; protease IV [EC:3.4.21.-] D Sph21_1475 Peptidase S54, rhomboid domain K07059 K07059; rhomboid family protein D Sph21_1474 Peptidase S54, rhomboid domain K07059 K07059; rhomboid family protein D Sph21_3230 Peptidase S54, rhomboid domain K07059 K07059; rhomboid family protein D Sph21_3887 peptidase U61 LD-carboxypeptidase A K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13] D Sph21_1426 peptidase U61 LD-carboxypeptidase A K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13] D Sph21_2183 peptidase U61 LD-carboxypeptidase A K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13] D Sph21_0527 Beta-aspartyl-peptidase K13051 ASRGL1; L-asparaginase / beta-aspartyl-peptidase [EC:3.5.1.1 3.4.19.5] D Sph21_3879 gamma-glutamyltransferase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] D Sph21_5118 Gamma-glutamyltransferase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] D Sph21_4125 alpha-2-macroglobulin domain protein K06894 yfhM; alpha-2-macroglobulin C 01003 Glycosyltransferases [BR:shg01003] D Sph21_2471 Dolichyl-phosphate beta-D-mannosyltransferase K00721 DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83] D Sph21_5138 Glycogen synthase K00703 glgA; starch synthase [EC:2.4.1.21] D Sph21_1635 Starch synthase K00703 glgA; starch synthase [EC:2.4.1.21] D Sph21_2295 Monofunctional biosynthetic peptidoglycan transglycosylase K03814 mtgA; monofunctional glycosyltransferase [EC:2.4.99.28] D Sph21_4124 penicillin-binding protein 1C K05367 pbpC; penicillin-binding protein 1C [EC:2.4.99.28] D Sph21_5240 Peptidoglycan glycosyltransferase K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D Sph21_3115 Peptidoglycan glycosyltransferase K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D Sph21_1832 glycosyl transferase family 4 K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D Sph21_1781 glycosyl transferase family 4 K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D Sph21_2071 glycosyl transferase group 1 K13658 gumI; beta-1,4-mannosyltransferase [EC:2.4.1.251] D Sph21_1799 glycosyl transferase group 1 K13658 gumI; beta-1,4-mannosyltransferase [EC:2.4.1.251] D Sph21_1323 trehalose-phosphatase K16055 TPS; trehalose 6-phosphate synthase/phosphatase [EC:2.4.1.15 3.1.3.12] C 01005 Lipopolysaccharide biosynthesis proteins [BR:shg01005] D Sph21_1542 acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase K00677 lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129] D Sph21_5175 lipid-A-disaccharide synthase K00748 lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182] D Sph21_1541 UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase K16363 lpxC-fabZ; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59] D Sph21_1540 UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase K02536 lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191] D Sph21_1451 metallophosphoesterase K03269 lpxH; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54] D Sph21_0350 Tetraacyldisaccharide 4'-kinase K00912 lpxK; tetraacyldisaccharide 4'-kinase [EC:2.7.1.130] D Sph21_4379 lipid A biosynthesis acyltransferase K02517 lpxL; Kdo2-lipid IVA lauroyltransferase/acyltransferase [EC:2.3.1.241 2.3.1.-] D Sph21_1257 lipid A biosynthesis acyltransferase K02517 lpxL; Kdo2-lipid IVA lauroyltransferase/acyltransferase [EC:2.3.1.241 2.3.1.-] D Sph21_3162 lipid A biosynthesis acyltransferase K02517 lpxL; Kdo2-lipid IVA lauroyltransferase/acyltransferase [EC:2.3.1.241 2.3.1.-] D Sph21_4142 Protein of unknown function DUF2219 K09953 lpxR; lipid A 3-O-deacylase [EC:3.1.1.-] D Sph21_1048 Three-deoxy-D-manno-octulosonic-acid transferase domain-containing protein K02527 kdtA; 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.12 2.4.99.13 2.4.99.14 2.4.99.15] D Sph21_3365 2-dehydro-3-deoxyphosphooctonate aldolase K01627 kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55] D Sph21_3514 3-deoxy-manno-octulosonate cytidylyltransferase K00979 kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38] D Sph21_3140 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45] D Sph21_3363 KpsF/GutQ family protein K06041 kdsD; arabinose-5-phosphate isomerase [EC:5.3.1.13] D Sph21_2429 glycosyl transferase family 9 K02849 waaQ; lipopolysaccharide heptosyltransferase III [EC:2.4.99.25] D Sph21_3830 hydrolase, HAD-superfamily, subfamily IIIA K03273 gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83] D Sph21_3829 cytidyltransferase-related domain protein K03272 gmhC; D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase [EC:2.7.1.167 2.7.7.70] D Sph21_1832 glycosyl transferase family 4 K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D Sph21_1781 glycosyl transferase family 4 K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] C 01011 Peptidoglycan biosynthesis and degradation proteins [BR:shg01011] D Sph21_2929 UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D Sph21_1700 UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] D Sph21_0055 UDP-N-acetylmuramate--L-alanine ligase K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8] D Sph21_0058 UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] D Sph21_0060 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase K01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13] D Sph21_4678 Alanine racemase K01798 alr-murF; Alr-MurF fusion protein [EC:5.1.1.1 6.3.2.10] D Sph21_3074 D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D Sph21_3157 Glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3] D Sph21_3887 peptidase U61 LD-carboxypeptidase A K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13] D Sph21_1426 peptidase U61 LD-carboxypeptidase A K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13] D Sph21_2183 peptidase U61 LD-carboxypeptidase A K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13] D Sph21_0059 Phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] D Sph21_0056 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] D Sph21_0549 Undecaprenyl-diphosphatase K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] D Sph21_2431 phosphoesterase PA-phosphatase related protein K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] D Sph21_5240 Peptidoglycan glycosyltransferase K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D Sph21_3115 Peptidoglycan glycosyltransferase K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D Sph21_4124 penicillin-binding protein 1C K05367 pbpC; penicillin-binding protein 1C [EC:2.4.99.28] D Sph21_2376 penicillin-binding protein 2 K05515 mrdA; penicillin-binding protein 2 [EC:3.4.16.4] D Sph21_0061 Peptidoglycan glycosyltransferase K03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4] D Sph21_1073 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase K07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-] D Sph21_1614 beta-lactamase K21469 pbp4b; serine-type D-Ala-D-Ala carboxypeptidase [EC:3.4.16.4] D Sph21_2295 Monofunctional biosynthetic peptidoglycan transglycosylase K03814 mtgA; monofunctional glycosyltransferase [EC:2.4.99.28] D Sph21_0760 ErfK/YbiS/YcfS/YnhG family protein K21470 ycbB; L,D-transpeptidase YcbB D Sph21_0360 ErfK/YbiS/YcfS/YnhG family protein K21470 ycbB; L,D-transpeptidase YcbB D Sph21_1148 NLP/P60 protein K13694 mepS; murein DD-endopeptidase / murein LD-carboxypeptidase [EC:3.4.-.- 3.4.17.13] D Sph21_1146 Lytic transglycosylase catalytic K08307 mltD; peptidoglycan lytic transglycosylase D [EC:4.2.2.29] D Sph21_5271 Lytic transglycosylase catalytic K08307 mltD; peptidoglycan lytic transglycosylase D [EC:4.2.2.29] D Sph21_3072 aminodeoxychorismate lyase K07082 mltG; peptidoglycan lytic transglycosylase G [EC:4.2.2.29] D Sph21_2421 rare lipoprotein A K03642 rlpA; peptidoglycan lytic transglycosylase [EC:4.2.2.29] D Sph21_2535 cell wall hydrolase/autolysin K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] D Sph21_2536 cell wall hydrolase/autolysin K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] C 01004 Lipid biosynthesis proteins [BR:shg01004] D Sph21_1317 malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] D Sph21_0011 3-oxoacyl-(acyl-carrier-protein) synthase 3 K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] D Sph21_2077 Beta-ketoacyl-acyl-carrier-protein synthase III K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] D Sph21_2124 Beta-ketoacyl-acyl-carrier-protein synthase I K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] D Sph21_1357 3-oxoacyl-(acyl-carrier-protein) synthase 2 K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D Sph21_4075 3-oxoacyl-(acyl-carrier-protein) synthase 2 K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D Sph21_0337 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_2703 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_4360 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_2365 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D Sph21_1541 UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase K16363 lpxC-fabZ; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59] D Sph21_0398 Enoyl-(acyl-carrier-protein) reductase (NADH) K00208 fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10] D Sph21_3075 acyl-ACP thioesterase K12500 tesC; thioesterase III [EC:3.1.2.-] D Sph21_4485 fatty acid desaturase K00507 SCD; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1] D Sph21_4113 Acyl-(acyl-carrier-protein) desaturase K03921 FAB2; acyl-[acyl-carrier-protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26] D Sph21_1254 Linoleoyl-CoA desaturase K00508 E1.14.19.3; linoleoyl-CoA desaturase [EC:1.14.19.3] D Sph21_3689 fatty acid desaturase K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] D Sph21_5179 acetate/CoA ligase K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1] D Sph21_0025 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D Sph21_3308 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D Sph21_0010 Phosphate acyltransferase K03621 plsX; phosphate acyltransferase [EC:2.3.1.274] D Sph21_2990 Glycerol-3-phosphate acyltransferase K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] D Sph21_1576 phospholipid/glycerol acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] C 01008 Polyketide biosynthesis proteins C 01006 Prenyltransferases [BR:shg01006] D Sph21_3092 Geranyltranstransferase K13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29] D Sph21_1116 Trans-hexaprenyltranstransferase K02523 ispB; octaprenyl-diphosphate synthase [EC:2.5.1.90] D Sph21_5202 Undecaprenyl pyrophosphate synthase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] D Sph21_2423 tRNA dimethylallyltransferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75] D Sph21_1617 tRNA dimethylallyltransferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75] D Sph21_5212 4-hydroxybenzoate polyprenyltransferase K03179 ubiA; 4-hydroxybenzoate polyprenyltransferase [EC:2.5.1.39] D Sph21_1557 Protoheme IX farnesyltransferase K02257 COX10; heme o synthase [EC:2.5.1.141] C 01007 Amino acid related enzymes [BR:shg01007] D Sph21_1436 glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17] D Sph21_0772 Glutaminyl-tRNA synthetase K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18] D Sph21_3907 Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D Sph21_3512 tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] D Sph21_1472 cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16] D Sph21_3007 Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D Sph21_1427 Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] D Sph21_0041 Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5] D Sph21_2462 Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9] D Sph21_0546 leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D Sph21_2410 Lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] D Sph21_1132 aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D Sph21_3337 Asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D Sph21_1306 Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21] D Sph21_1705 glycyl-tRNA synthetase K01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14] D Sph21_5220 seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11] D Sph21_4651 Prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15] D Sph21_2963 threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3] D Sph21_3106 alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7] D Sph21_1460 Phenylalanyl-tRNA synthetase alpha chain K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] D Sph21_3955 Phenylalanyl-tRNA synthetase beta chain K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] D Sph21_3987 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_3216 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1] D Sph21_3277 Kynurenine--oxoglutarate transaminase K14287 ybdL; methionine transaminase [EC:2.6.1.88] D Sph21_1606 LL-diaminopimelate aminotransferase K10206 E2.6.1.83; LL-diaminopimelate aminotransferase [EC:2.6.1.83] D Sph21_5144 Histidinol-phosphate aminotransferase K00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9] D Sph21_0050 Glycine C-acetyltransferase K00639 kbl; glycine C-acetyltransferase [EC:2.3.1.29] D Sph21_1459 2-amino-3-ketobutyrate coenzyme A ligase K00639 kbl; glycine C-acetyltransferase [EC:2.3.1.29] D Sph21_3313 8-amino-7-oxononanoate synthase K00652 bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47] D Sph21_3026 Glycine C-acetyltransferase K00652 bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47] D Sph21_3678 L-lysine 6-transaminase K03918 lat; L-lysine 6-transaminase [EC:2.6.1.36] D Sph21_1037 Acetylornithine transaminase K00821 argD; acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17] D Sph21_3316 adenosylmethionine-8-amino-7-oxononanoate aminotransferase K00833 bioA; adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62] D Sph21_5195 Glutamate-1-semialdehyde 2,1-aminomutase K01845 hemL; glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8] D Sph21_0743 branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D Sph21_3549 Aminodeoxychorismate lyase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D Sph21_3090 Phosphoserine aminotransferase K00831 serC; phosphoserine aminotransferase [EC:2.6.1.52] D Sph21_1813 DegT/DnrJ/EryC1/StrS aminotransferase K13010 per; perosamine synthetase [EC:2.6.1.102] C 00199 Cytochrome P450 C 00194 Photosynthesis proteins [BR:shg00194] D Sph21_2291 ATPase, F1 complex, delta/epsilon subunit K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon D Sph21_2292 ATP synthase subunit beta K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1] D Sph21_5231 ATP synthase gamma chain K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma D Sph21_5232 ATP synthase subunit alpha K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1] D Sph21_5233 ATP synthase subunit delta K02113 ATPF1D; F-type H+-transporting ATPase subunit delta D Sph21_5234 ATP synthase subunit b K02109 ATPF0B; F-type H+-transporting ATPase subunit b D Sph21_5235 ATP synthase subunit c K02110 ATPF0C; F-type H+-transporting ATPase subunit c D Sph21_5236 ATP synthase subunit a K02108 ATPF0A; F-type H+-transporting ATPase subunit a B B 09182 Protein families: genetic information processing C 03000 Transcription factors [BR:shg03000] D Sph21_3497 C-5 cytosine-specific DNA methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D Sph21_0901 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D Sph21_4390 transcriptional regulator, AraC family K02508 hpaA; AraC family transcriptional regulator, 4-hydroxyphenylacetate 3-monooxygenase operon regulatory protein D Sph21_0822 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_0919 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_1265 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_0910 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_3597 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_2672 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_2678 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_2872 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_3024 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_2491 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_2503 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_1926 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_2271 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_1985 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_1416 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4188 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4204 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4342 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4364 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4753 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4764 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4766 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4788 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4793 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4865 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4894 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4444 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4449 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4517 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_5002 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_5006 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_4988 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_0128 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_0131 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_3758 transcriptional regulator, AraC family K18954 pobR; AraC family transcriptional regulator, transcriptional activator of pobA D Sph21_0878 transcriptional regulator, AraC family K20968 exsA; AraC family transcriptional regulator, exoenzyme S synthesis regulatory protein ExsA D Sph21_0943 transcriptional regulator, AraC family K20968 exsA; AraC family transcriptional regulator, exoenzyme S synthesis regulatory protein ExsA D Sph21_1484 Helix-turn-helix, AraC domain K20968 exsA; AraC family transcriptional regulator, exoenzyme S synthesis regulatory protein ExsA D Sph21_4867 transcriptional regulator, AraC family K20968 exsA; AraC family transcriptional regulator, exoenzyme S synthesis regulatory protein ExsA D Sph21_4443 transcriptional regulator, AraC family K20968 exsA; AraC family transcriptional regulator, exoenzyme S synthesis regulatory protein ExsA D Sph21_4997 Helix-turn-helix, AraC domain K20968 exsA; AraC family transcriptional regulator, exoenzyme S synthesis regulatory protein ExsA D Sph21_0277 transcriptional regulator, AraC family K07506 K07506; AraC family transcriptional regulator D Sph21_3232 transcriptional regulator, AraC family K07506 K07506; AraC family transcriptional regulator D Sph21_4272 methylated-DNA/protein-cysteine methyltransferase K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63] D Sph21_2783 transcriptional regulator, AraC family K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63] D Sph21_1915 transcriptional regulator, LysR family K03576 metR; LysR family transcriptional regulator, regulator for metE and metH D Sph21_1534 transcriptional regulator, LysR family K04761 oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator D Sph21_1063 transcriptional regulator, LysR family K21900 cysL; LysR family transcriptional regulator, transcriptional activator of the cysJI operon D Sph21_4074 transcriptional regulator, LysR family K21900 cysL; LysR family transcriptional regulator, transcriptional activator of the cysJI operon D Sph21_0430 transcriptional regulator, DeoR family K02081 agaR; DeoR family transcriptional regulator, aga operon transcriptional repressor D Sph21_2910 transcriptional regulator, DeoR family K02081 agaR; DeoR family transcriptional regulator, aga operon transcriptional repressor D Sph21_3847 transcriptional regulator, DeoR family K22103 glcR; DeoR family transcriptional regulator, carbon catabolite repression regulator D Sph21_3899 transcriptional regulator, LacI family K02529 galR; LacI family transcriptional regulator, galactose operon repressor D Sph21_4799 transcriptional regulator, LacI family K02529 galR; LacI family transcriptional regulator, galactose operon repressor D Sph21_0370 transcriptional regulator, LacI family K02529 galR; LacI family transcriptional regulator, galactose operon repressor D Sph21_0574 transcriptional regulator, LacI family K02529 galR; LacI family transcriptional regulator, galactose operon repressor D Sph21_0605 transcriptional regulator, LacI family K02529 galR; LacI family transcriptional regulator, galactose operon repressor D Sph21_0731 transcriptional regulator, LacI family K02529 galR; LacI family transcriptional regulator, galactose operon repressor D Sph21_2839 transcriptional regulator, LacI family K02529 galR; LacI family transcriptional regulator, galactose operon repressor D Sph21_3966 transcriptional regulator, LacI family K02529 galR; LacI family transcriptional regulator, galactose operon repressor D Sph21_2879 transcriptional regulator, LacI family K02529 galR; LacI family transcriptional regulator, galactose operon repressor D Sph21_1909 periplasmic binding protein/LacI transcriptional regulator K02529 galR; LacI family transcriptional regulator, galactose operon repressor D Sph21_5120 transcriptional regulator, LacI family K02529 galR; LacI family transcriptional regulator, galactose operon repressor D Sph21_0199 transcriptional regulator, LacI family K02529 galR; LacI family transcriptional regulator, galactose operon repressor D Sph21_4247 transcriptional regulator, GntR family with UTRA sensor domain K03710 K03710; GntR family transcriptional regulator D Sph21_2741 regulatory protein GntR HTH K05799 pdhR; GntR family transcriptional regulator, transcriptional repressor for pyruvate dehydrogenase complex D Sph21_3311 transcriptional regulator, GntR family with aminotransferase domain K00375 K00375; GntR family transcriptional regulator / MocR family aminotransferase D Sph21_0539 transcriptional regulator, GntR family with aminotransferase domain K00375 K00375; GntR family transcriptional regulator / MocR family aminotransferase D Sph21_3633 transcriptional regulator, TetR family K18136 acrR; TetR/AcrR family transcriptional regulator, multidrug resistance operon repressor D Sph21_2629 regulatory protein TetR K18136 acrR; TetR/AcrR family transcriptional regulator, multidrug resistance operon repressor D Sph21_4359 regulatory protein TetR K16137 nemR; TetR/AcrR family transcriptional regulator, transcriptional repressor for nem operon D Sph21_4372 regulatory protein TetR K16137 nemR; TetR/AcrR family transcriptional regulator, transcriptional repressor for nem operon D Sph21_1842 regulatory protein TetR K16137 nemR; TetR/AcrR family transcriptional regulator, transcriptional repressor for nem operon D Sph21_2452 transcriptional regulator, TetR family K16137 nemR; TetR/AcrR family transcriptional regulator, transcriptional repressor for nem operon D Sph21_4614 transcriptional regulator, TetR family K16137 nemR; TetR/AcrR family transcriptional regulator, transcriptional repressor for nem operon D Sph21_5034 regulatory protein TetR K16137 nemR; TetR/AcrR family transcriptional regulator, transcriptional repressor for nem operon D Sph21_1308 transcriptional regulator, AsnC family K03718 asnC; Lrp/AsnC family transcriptional regulator, regulator for asnA, asnC and gidA D Sph21_0528 transcriptional regulator, AsnC family K03719 lrp; Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein D Sph21_2789 transcriptional regulator, AsnC family K03719 lrp; Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein D Sph21_4012 transcriptional regulator, AsnC family K03719 lrp; Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein D Sph21_2743 regulatory protein MarR K03712 marR; MarR family transcriptional regulator, multiple antibiotic resistance protein MarR D Sph21_0022 regulatory protein MarR K23775 ohrR; MarR family transcriptional regulator, organic hydroperoxide resistance regulator D Sph21_3094 ferric uptake regulator, Fur family K03711 fur; Fur family transcriptional regulator, ferric uptake regulator D Sph21_4616 ferric-uptake regulator K03711 fur; Fur family transcriptional regulator, ferric uptake regulator D Sph21_2994 ferric uptake regulator, Fur family K03711 fur; Fur family transcriptional regulator, ferric uptake regulator D Sph21_4914 hypothetical protein K10914 crp; CRP/FNR family transcriptional regulator, cyclic AMP receptor protein D Sph21_3585 transcriptional regulator, Crp/Fnr family K01420 fnr; CRP/FNR family transcriptional regulator, anaerobic regulatory protein D Sph21_4221 putative transcriptional regulator, Crp/Fnr family K01420 fnr; CRP/FNR family transcriptional regulator, anaerobic regulatory protein D Sph21_2613 putative transcriptional regulator, Crp/Fnr family K21562 flp; CRP/FNR family transcriptional regulator, anaerobic regulatory protein D Sph21_4726 putative transcriptional regulator, Crp/Fnr family K21562 flp; CRP/FNR family transcriptional regulator, anaerobic regulatory protein D Sph21_0218 regulatory protein ArsR K21903 cadC; ArsR family transcriptional regulator, lead/cadmium/zinc/bismuth-responsive transcriptional repressor D Sph21_0235 regulatory protein ArsR K22298 smtB; ArsR family transcriptional regulator, zinc-responsive transcriptional repressor D Sph21_1350 transcriptional regulator, PadR-like family K10947 K10947; PadR family transcriptional regulator D Sph21_0318 iron (metal) dependent repressor, DtxR family K03709 troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator D Sph21_1401 transcriptional repressor, CopY family K02171 blaI; BlaI family transcriptional regulator, penicillinase repressor D Sph21_3628 transcriptional repressor, CopY family K02171 blaI; BlaI family transcriptional regulator, penicillinase repressor D Sph21_1236 transcriptional repressor, CopY family K02171 blaI; BlaI family transcriptional regulator, penicillinase repressor D Sph21_1059 biotin/acetyl-CoA-carboxylase ligase K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] D Sph21_0442 transcriptional regulator, XRE family K18831 higA; HTH-type transcriptional regulator / antitoxin HigA D Sph21_3773 hypothetical protein K22301 opcR; HTH-type transcriptional regulator, osmoprotectant uptake regulator D Sph21_4881 sigma54 specific transcriptional regulator, Fis family K15836 fhlA; formate hydrogenlyase transcriptional activator D Sph21_4885 sigma54 specific transcriptional regulator, Fis family K15836 fhlA; formate hydrogenlyase transcriptional activator D Sph21_4888 sigma54 specific transcriptional regulator, Fis family K15836 fhlA; formate hydrogenlyase transcriptional activator D Sph21_0427 parB-like partition protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein D Sph21_2544 hypothetical protein K03973 pspC; phage shock protein C D Sph21_1670 phage shock protein C, PspC K03973 pspC; phage shock protein C D Sph21_5167 GreA/GreB family elongation factor K06140 rnk; regulator of nucleoside diphosphate kinase D Sph21_2231 Uracil phosphoribosyltransferase K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9] D Sph21_1147 phosphoribosyltransferase K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9] D Sph21_5105 FMN-binding negative transcriptional regulator K07734 paiB; transcriptional regulator D Sph21_3343 protein of unknown function DUF179 K07735 algH; putative transcriptional regulator D Sph21_0042 DnaK suppressor protein K06204 dksA; RNA polymerase-binding transcription factor D Sph21_0064 Protein mraZ K03925 mraZ; transcriptional regulator MraZ C 03021 Transcription machinery [BR:shg03021] D Sph21_1742 DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] D Sph21_2406 DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] D Sph21_2407 DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] D Sph21_4481 RNA polymerase, sigma 70 subunit, RpoD subfamily K03086 rpoD; RNA polymerase primary sigma factor D Sph21_3256 RNA polymerase, sigma 70 subunit, RpoD subfamily K03086 rpoD; RNA polymerase primary sigma factor D Sph21_4656 RNA polymerase, sigma-24 subunit, ECF subfamily K03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily D Sph21_3917 RNA polymerase, sigma-24 subunit, ECF subfamily K03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily D Sph21_2131 RNA polymerase, sigma-24 subunit, ECF subfamily K03088 rpoE; RNA polymerase sigma-70 factor, ECF subfamily D Sph21_0486 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_2938 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_2492 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_3403 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_4695 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_0806 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_5020 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1890 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1877 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_2764 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_4232 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_0462 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_2954 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1281 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_4805 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_0843 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1869 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1664 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_0805 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_4857 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_4311 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_4413 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_2833 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_2264 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_2497 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_0972 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_4293 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1778 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1965 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_1918 RNA polymerase, sigma-24 subunit, ECF subfamily K23514 fecI; RNA polymerase sigma-19 factor, ECF subfamily D Sph21_0330 RNA polymerase, sigma 54 subunit, RpoN K03092 rpoN; RNA polymerase sigma-54 factor D Sph21_1609 NusA antitermination factor K02600 nusA; transcription termination/antitermination protein NusA D Sph21_4007 NusB antitermination factor K03625 nusB; transcription antitermination protein NusB D Sph21_2401 NusG antitermination factor K02601 nusG; transcription termination/antitermination protein NusG D Sph21_2532 anti-anti-sigma factor K04749 rsbV; anti-sigma B factor antagonist D Sph21_0042 DnaK suppressor protein K06204 dksA; RNA polymerase-binding transcription factor D Sph21_1571 transcription elongation factor GreA K03624 greA; transcription elongation factor GreA D Sph21_4019 transcription termination factor Rho K03628 rho; transcription termination factor Rho C 03019 Messenger RNA biogenesis [BR:shg03019] D Sph21_1127 ribonuclease, Rne/Rng family K08301 rng; ribonuclease G [EC:3.1.26.-] D Sph21_1358 Ribonuclease 3 K03685 rnc; ribonuclease III [EC:3.1.26.3] D Sph21_3952 2,3 cyclic-nucleotide 2-phosphodiesterase K18682 rny; ribonucrease Y [EC:3.1.-.-] D Sph21_3093 ribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1] D Sph21_3885 DEAD/DEAH box helicase domain protein K11927 rhlE; ATP-dependent RNA helicase RhlE [EC:5.6.2.7] D Sph21_0774 DEAD/DEAH box helicase domain protein K11927 rhlE; ATP-dependent RNA helicase RhlE [EC:5.6.2.7] D Sph21_3518 DEAD/DEAH box helicase domain protein K11927 rhlE; ATP-dependent RNA helicase RhlE [EC:5.6.2.7] D Sph21_3878 DEAD/DEAH box helicase domain protein K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7] D Sph21_2937 ATP-dependent DNA helicase, RecQ family K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4] D Sph21_3364 ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4] D Sph21_0335 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D Sph21_3088 Polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] D Sph21_4019 transcription termination factor Rho K03628 rho; transcription termination factor Rho D Sph21_1062 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_3894 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D Sph21_1745 Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK D Sph21_0753 60 kDa chaperonin K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D Sph21_0532 polyphosphate kinase 1 K00937 ppk1; polyphosphate kinase [EC:2.7.4.1] D Sph21_3169 polyphosphate kinase 1 K00937 ppk1; polyphosphate kinase [EC:2.7.4.1] D Sph21_2713 polyphosphate kinase 2 K22468 ppk2; polyphosphate kinase [EC:2.7.4.34] D Sph21_2425 polynucleotide adenylyltransferase/metal dependent phosphohydrolase K00970 pcnB; poly(A) polymerase [EC:2.7.7.19] D Sph21_1998 ATP-dependent helicase HrpB K03579 hrpB; ATP-dependent RNA helicase HrpB [EC:5.6.2.6] C 03041 Spliceosome C 03011 Ribosome [BR:shg03011] D Sph21_3134 RNA binding S1 domain protein K02945 RP-S1; small subunit ribosomal protein S1 D Sph21_1445 ribosomal protein S2 K02967 RP-S2; small subunit ribosomal protein S2 D Sph21_1720 ribosomal protein S3 K02982 RP-S3; small subunit ribosomal protein S3 D Sph21_1741 ribosomal protein S4 K02986 RP-S4; small subunit ribosomal protein S4 D Sph21_1732 ribosomal protein S5 K02988 RP-S5; small subunit ribosomal protein S5 D Sph21_2352 30S ribosomal protein S6 K02990 RP-S6; small subunit ribosomal protein S6 D Sph21_3980 ribosomal protein S7 K02992 RP-S7; small subunit ribosomal protein S7 D Sph21_1729 ribosomal protein S8 K02994 RP-S8; small subunit ribosomal protein S8 D Sph21_1446 ribosomal protein S9 K02996 RP-S9; small subunit ribosomal protein S9 D Sph21_3978 30S ribosomal protein S10 K02946 RP-S10; small subunit ribosomal protein S10 D Sph21_1740 30S ribosomal protein S11 K02948 RP-S11; small subunit ribosomal protein S11 D Sph21_3981 ribosomal protein S12 K02950 RP-S12; small subunit ribosomal protein S12 D Sph21_1739 30S ribosomal protein S13 K02952 RP-S13; small subunit ribosomal protein S13 D Sph21_1728 30S ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14 D Sph21_3076 ribosomal protein S15 K02956 RP-S15; small subunit ribosomal protein S15 D Sph21_1325 30S ribosomal protein S16 K02959 RP-S16; small subunit ribosomal protein S16 D Sph21_1724 30S ribosomal protein S17 K02961 RP-S17; small subunit ribosomal protein S17 D Sph21_2351 30S ribosomal protein S18 K02963 RP-S18; small subunit ribosomal protein S18 D Sph21_1718 ribosomal protein S19 K02965 RP-S19; small subunit ribosomal protein S19 D Sph21_3959 30S ribosomal protein S20 K02968 RP-S20; small subunit ribosomal protein S20 D Sph21_2394 30S ribosomal protein S21 K02970 RP-S21; small subunit ribosomal protein S21 D Sph21_2458 hypothetical protein K19033 PSRP4; 30S ribosomal protein S31 D Sph21_2403 ribosomal protein L1 K02863 RP-L1; large subunit ribosomal protein L1 D Sph21_1717 ribosomal protein L2 K02886 RP-L2; large subunit ribosomal protein L2 D Sph21_1714 50S ribosomal protein L3 K02906 RP-L3; large subunit ribosomal protein L3 D Sph21_1715 ribosomal protein L4/L1e K02926 RP-L4; large subunit ribosomal protein L4 D Sph21_1727 ribosomal protein L5 K02931 RP-L5; large subunit ribosomal protein L5 D Sph21_1730 ribosomal protein L6 K02933 RP-L6; large subunit ribosomal protein L6 D Sph21_2350 50S ribosomal protein L9 K02939 RP-L9; large subunit ribosomal protein L9 D Sph21_2404 50S ribosomal protein L10 K02864 RP-L10; large subunit ribosomal protein L10 D Sph21_2402 ribosomal protein L11 K02867 RP-L11; large subunit ribosomal protein L11 D Sph21_2405 50S ribosomal protein L7/L12 K02935 RP-L7; large subunit ribosomal protein L7/L12 D Sph21_1447 ribosomal protein L13 K02871 RP-L13; large subunit ribosomal protein L13 D Sph21_1725 ribosomal protein L14 K02874 RP-L14; large subunit ribosomal protein L14 D Sph21_1734 ribosomal protein L15 K02876 RP-L15; large subunit ribosomal protein L15 D Sph21_1721 50S ribosomal protein L16 K02878 RP-L16; large subunit ribosomal protein L16 D Sph21_1743 50S ribosomal protein L17 K02879 RP-L17; large subunit ribosomal protein L17 D Sph21_1731 ribosomal protein L18 K02881 RP-L18; large subunit ribosomal protein L18 D Sph21_1328 50S ribosomal protein L19 K02884 RP-L19; large subunit ribosomal protein L19 D Sph21_2966 50S ribosomal protein L20 K02887 RP-L20; large subunit ribosomal protein L20 D Sph21_3305 50S ribosomal protein L21 K02888 RP-L21; large subunit ribosomal protein L21 D Sph21_1719 ribosomal protein L22 K02890 RP-L22; large subunit ribosomal protein L22 D Sph21_1716 Ribosomal protein L25/L23 K02892 RP-L23; large subunit ribosomal protein L23 D Sph21_1726 ribosomal protein L24 K02895 RP-L24; large subunit ribosomal protein L24 D Sph21_3306 50S ribosomal protein L27 K02899 RP-L27; large subunit ribosomal protein L27 D Sph21_5182 50S ribosomal protein L28 K02902 RP-L28; large subunit ribosomal protein L28 D Sph21_1723 ribosomal protein L29 K02904 RP-L29; large subunit ribosomal protein L29 D Sph21_1733 ribosomal protein L30 K02907 RP-L30; large subunit ribosomal protein L30 D Sph21_3043 50S ribosomal protein L31 type B K02909 RP-L31; large subunit ribosomal protein L31 D Sph21_0009 50S ribosomal protein L32 K02911 RP-L32; large subunit ribosomal protein L32 D Sph21_5183 50S ribosomal protein L33 K02913 RP-L33; large subunit ribosomal protein L33 D Sph21_0328 50S ribosomal protein L34 K02914 RP-L34; large subunit ribosomal protein L34 D Sph21_2965 50S ribosomal protein L35 K02916 RP-L35; large subunit ribosomal protein L35 D Sph21_1738 50S ribosomal protein L36 K02919 RP-L36; large subunit ribosomal protein L36 D Sph21_5155 50S ribosomal protein L25 K02897 RP-L25; large subunit ribosomal protein L25 D Sph21_R0006 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D Sph21_R0064 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D Sph21_R0012 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D Sph21_R0038 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D Sph21_R0009 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D Sph21_R0034 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D Sph21_R0068 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D Sph21_R0015 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D Sph21_R0013 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D Sph21_R0065 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D Sph21_R0037 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D Sph21_R0007 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA C 03009 Ribosome biogenesis [BR:shg03009] D Sph21_1358 Ribonuclease 3 K03685 rnc; ribonuclease III [EC:3.1.26.3] D Sph21_0363 GTP-binding protein Era-like-protein K03595 era; GTPase D Sph21_0075 GTPase obg K03979 obgE; GTPase [EC:3.6.5.-] D Sph21_0042 DnaK suppressor protein K06204 dksA; RNA polymerase-binding transcription factor D Sph21_1609 NusA antitermination factor K02600 nusA; transcription termination/antitermination protein NusA D Sph21_4007 NusB antitermination factor K03625 nusB; transcription antitermination protein NusB D Sph21_2401 NusG antitermination factor K02601 nusG; transcription termination/antitermination protein NusG D Sph21_0006 Ribosomal RNA small subunit methyltransferase A K02528 ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182] D Sph21_2241 Fmu (Sun) domain protein K03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176] D Sph21_3154 Conserved hypothetical protein CHP00095 K08316 rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171] D Sph21_1604 Ribosomal RNA small subunit methyltransferase E K09761 rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193] D Sph21_2523 Ribosomal RNA small subunit methyltransferase G K03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170] D Sph21_0063 Ribosomal RNA small subunit methyltransferase H K03438 mraW; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199] D Sph21_5221 Ribosomal RNA small subunit methyltransferase I K07056 rsmI; 16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198] D Sph21_1497 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase K07056 rsmI; 16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198] D Sph21_3057 RNA methyltransferase, TrmH family, group 3 K03218 rlmB; 23S rRNA (guanosine2251-2'-O)-methyltransferase [EC:2.1.1.185] D Sph21_0344 Ribosomal RNA large subunit methyltransferase H K00783 rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177] D Sph21_1086 PUA domain containing protein K06969 rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191] D Sph21_1666 SAM dependent methyltransferase K06969 rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191] D Sph21_1331 rRNA (guanine-N(2)-)-methyltransferase K25137 rlmL; 23S rRNA (guanine2445-N2)-methyltransferase [EC:2.1.1.173] D Sph21_1138 Ribosomal RNA large subunit methyltransferase N K06941 rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192] D Sph21_1250 RNA methyltransferase, TrmA family K03215 rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190] D Sph21_5272 pseudouridine synthase Rsu K06178 rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22] D Sph21_3110 pseudouridine synthase K06179 rluC; 23S rRNA pseudouridine955/2504/2580 synthase [EC:5.4.99.24] D Sph21_3550 pseudouridine synthase, RluA family K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] D Sph21_2297 pseudouridine synthase K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] D Sph21_1986 pseudouridine synthase K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] D Sph21_3982 alpha-L-glutamate ligase, RimK family K05844 rimK; ribosomal protein S6--L-glutamate ligase [EC:6.3.2.-] D Sph21_1326 Ribosome maturation factor rimM K02860 rimM; 16S rRNA processing protein RimM D Sph21_5186 Ribosomal protein S12 methylthiotransferase rimO K14441 rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4] D Sph21_3046 Ribosomal protein L11 methyltransferase K02687 prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-] D Sph21_1127 ribonuclease, Rne/Rng family K08301 rng; ribonuclease G [EC:3.1.26.-] D Sph21_0764 Holliday junction resolvase K07447 ruvX; putative pre-16S rRNA nuclease [EC:3.1.-.-] D Sph21_3878 DEAD/DEAH box helicase domain protein K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7] D Sph21_3205 ribosome biogenesis GTPase RsgA K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] D Sph21_1435 ribosome biogenesis GTPase RsgA K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] D Sph21_0369 GTP-binding protein engA K03977 engA; GTPase D Sph21_1159 GTP-binding proten HflX K03665 hflX; GTPase D Sph21_2426 Sua5/YciO/YrdC/YwlC family protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87] D Sph21_2995 (p)ppGpp synthetase I, SpoT/RelA K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2] D Sph21_1160 Ribosome-binding factor A K02834 rbfA; ribosome-binding factor A D Sph21_1610 Ribosome maturation factor rimP K09748 rimP; ribosome maturation factor RimP D Sph21_2275 RNA-binding S4 domain protein K14761 rlbA; ribosome-associated protein D Sph21_1058 iojap-like protein K09710 ybeB; ribosome-associated protein D Sph21_1292 metalloprotease ybeY K07042 ybeY; probable rRNA maturation factor D Sph21_2398 ribosomal subunit interface protein K05808 hpf; ribosome hibernation promoting factor D Sph21_3129 GTP-binding protein YchF K06942 ychF; ribosome-binding ATPase D Sph21_0008 protein of unknown function DUF177 K07040 yceD; DUF177 domain-containing protein C 03016 Transfer RNA biogenesis [BR:shg03016] D Sph21_2533 Ribonuclease Z K00784 rnz; ribonuclease Z [EC:3.1.26.11] D Sph21_5037 protein of unknown function UPF0027 K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8] D Sph21_1436 glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17] D Sph21_4651 Prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15] D Sph21_0041 Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5] D Sph21_0546 leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D Sph21_1427 Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] D Sph21_0772 Glutaminyl-tRNA synthetase K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18] D Sph21_3007 Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D Sph21_2410 Lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] D Sph21_1132 aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D Sph21_3106 alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7] D Sph21_3337 Asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D Sph21_1705 glycyl-tRNA synthetase K01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14] D Sph21_2963 threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3] D Sph21_5220 seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11] D Sph21_1472 cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16] D Sph21_2462 Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9] D Sph21_1306 Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21] D Sph21_1460 Phenylalanyl-tRNA synthetase alpha chain K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] D Sph21_3955 Phenylalanyl-tRNA synthetase beta chain K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] D Sph21_3907 Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D Sph21_3512 tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] D Sph21_1380 D-tyrosyl-tRNA(Tyr) deacylase K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96] D Sph21_1572 histidine triad (HIT) protein K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-] D Sph21_1084 tRNA (guanine-N(7)-)-methyltransferase K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33] D Sph21_2416 tRNA pseudouridine synthase A K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12] D Sph21_0550 tRNA pseudouridine synthase B K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25] D Sph21_3741 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D Sph21_3019 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D Sph21_3997 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D Sph21_2426 Sua5/YciO/YrdC/YwlC family protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87] D Sph21_2423 tRNA dimethylallyltransferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75] D Sph21_1617 tRNA dimethylallyltransferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75] D Sph21_4135 tRNA modification GTPase mnmE K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-] D Sph21_1300 tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme D Sph21_0327 Ribonuclease P protein component K03536 rnpA; ribonuclease P protein component [EC:3.1.26.5] D Sph21_R0048 rnpB; RNA component of RNaseP K01978 rnpB; M1 RNA D Sph21_0410 ATP-binding cassette protein, ChvD family K06020 ettA; energy-dependent translational throttle protein EttA D Sph21_1067 CMP/dCMP deaminase zinc-binding protein K11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33] D Sph21_1303 TIM-barrel protein, nifR3 family K05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-] D Sph21_0747 (Dimethylallyl)adenosine tRNA methylthiotransferase miaB K06168 miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3] D Sph21_3053 MiaB-like tRNA modifying enzyme K18707 mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5] D Sph21_2817 Methyltransferase type 11 K15256 cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-] D Sph21_2217 Methyltransferase type 12 K15256 cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-] D Sph21_1327 tRNA (guanine-N(1)-)-methyltransferase K00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228] D Sph21_3639 methyltransferase small K15460 yfiC; tRNA1Val (adenine37-N6)-methyltransferase [EC:2.1.1.223] D Sph21_3187 tRNA/rRNA methyltransferase (SpoU) K03437 spoU; RNA methyltransferase, TrmH family D Sph21_3175 tRNA-specific 2-thiouridylase mnmA K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13] D Sph21_0004 iron-sulfur cluster assembly accessory protein K13628 iscA; iron-sulfur cluster assembly protein D Sph21_3018 iron-sulfur cluster assembly accessory protein K13628 iscA; iron-sulfur cluster assembly protein D Sph21_4132 tRNA-hydroxylase K06169 miaE; tRNA 2-(methylsulfanyl)-N6-isopentenyladenosine37 hydroxylase [EC:1.14.99.69] D Sph21_3991 S-adenosylmethionine:tRNA ribosyltransferase-isomerase K07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17] D Sph21_1319 6-pyruvoyl tetrahydropterin synthase and hypothetical protein K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50] D Sph21_3290 Radical SAM domain protein K10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3] D Sph21_3535 iron-sulfur cluster binding protein K18979 queG; epoxyqueuosine reductase [EC:1.17.99.6] D Sph21_2521 Queuine tRNA-ribosyltransferase K00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29] D Sph21_1620 tRNA(Ile)-lysidine synthase K04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19] D Sph21_0325 universal protein YeaZ K14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB D Sph21_0567 O-sialoglycoprotein endopeptidase K25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234] D Sph21_1537 Uncharacterized protein family UPF0079, ATPase K06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE D Sph21_3659 UBA/THIF-type NAD/FAD binding protein K22132 tcdA; tRNA threonylcarbamoyladenosine dehydratase D Sph21_3093 ribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1] D Sph21_3088 Polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] D Sph21_4405 PilT protein domain protein K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-] D Sph21_1840 PilT protein domain protein K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-] C 03012 Translation factors [BR:shg03012] D Sph21_1579 translation initiation factor SUI1 K03113 EIF1; translation initiation factor 1 D Sph21_1608 translation initiation factor IF-2 K02519 infB; translation initiation factor IF-2 D Sph21_2964 Translation initiation factor IF-3 K02520 infC; translation initiation factor IF-3 D Sph21_3537 ABC transporter related protein K06158 ABCF3; ATP-binding cassette, subfamily F, member 3 D Sph21_1444 Elongation factor Ts K02357 tsf; elongation factor Ts D Sph21_2399 translation elongation factor Tu K02358 tuf; elongation factor Tu D Sph21_3979 translation elongation factor G K02355 fusA; elongation factor G D Sph21_1449 Peptide chain release factor 1 K02835 prfA; peptide chain release factor 1 D Sph21_1431 Ribosome-recycling factor K02838 frr; ribosome recycling factor D Sph21_3389 protein-(glutamine-N5) methyltransferase, release factor-specific K02493 hemK; release factor glutamine methyltransferase [EC:2.1.1.297] D Sph21_5154 Peptidyl-tRNA hydrolase K01056 PTH1; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29] D Sph21_1737 Translation initiation factor IF-1 K02518 infA; translation initiation factor IF-1 D Sph21_1544 Elongation factor P K02356 efp; elongation factor P D Sph21_0678 hypothetical protein K02836 prfB; peptide chain release factor 2 D Sph21_3645 peptide chain release factor 3 K02837 prfC; peptide chain release factor 3 D Sph21_3136 Class I peptide chain release factor K15034 yaeJ; ribosome-associated protein C 03110 Chaperones and folding catalysts [BR:shg03110] D Sph21_3149 ATP-dependent chaperone ClpB K03695 clpB; ATP-dependent Clp protease ATP-binding subunit ClpB D Sph21_4843 ATPase AAA-2 domain protein K03695 clpB; ATP-dependent Clp protease ATP-binding subunit ClpB D Sph21_0409 ATPase AAA-2 domain protein K03696 clpC; ATP-dependent Clp protease ATP-binding subunit ClpC D Sph21_2926 Sigma 54 interacting domain protein K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX D Sph21_3254 Heat shock protein Hsp90 K04079 HSP90A; molecular chaperone HtpG D Sph21_2810 HSP90 family protein K04079 HSP90A; molecular chaperone HtpG D Sph21_1745 Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK D Sph21_0753 60 kDa chaperonin K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D Sph21_3120 Chaperone protein dnaJ K03686 dnaJ; molecular chaperone DnaJ D Sph21_0783 chaperone DnaJ domain protein K05516 cbpA; curved DNA-binding protein D Sph21_3121 Protein grpE K03687 GRPE; molecular chaperone GrpE D Sph21_3240 heat shock protein Hsp20 K13993 HSP20; HSP20 family protein D Sph21_0002 heat shock protein Hsp20 K13993 HSP20; HSP20 family protein D Sph21_2858 heat shock protein Hsp20 K13993 HSP20; HSP20 family protein D Sph21_2432 RNA-binding S4 domain protein K04762 hslR; ribosome-associated heat shock protein Hsp15 D Sph21_0752 10 kDa chaperonin K04078 groES; chaperonin GroES D Sph21_4573 Chaperonin Cpn10 K04078 groES; chaperonin GroES D Sph21_3618 peptidase S1 and S6 chymotrypsin/Hap K04771 degP; serine protease Do [EC:3.4.21.107] D Sph21_1406 protease Do K04771 degP; serine protease Do [EC:3.4.21.107] D Sph21_1057 ATP-dependent metalloprotease FtsH K08956 AFG3; AFG3 family protein [EC:3.4.24.-] D Sph21_5236 ATP synthase subunit a K02108 ATPF0A; F-type H+-transporting ATPase subunit a D Sph21_2742 hypothetical protein K06006 cpxP; periplasmic protein CpxP/Spy D Sph21_0572 peptidase S8 and S53 subtilisin kexin sedolisin K13274 wprA; cell wall-associated protease [EC:3.4.21.-] D Sph21_3771 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_1083 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_0646 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_0655 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_0656 Beta-N-acetylhexosaminidase K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] D Sph21_0347 peptidyl-prolyl cis-trans isomerase cyclophilin type K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8] D Sph21_1410 PpiC-type peptidyl-prolyl cis-trans isomerase K03770 ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8] D Sph21_1243 peptidylprolyl isomerase FKBP-type K03772 fkpA; FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [EC:5.2.1.8] D Sph21_2681 peptidylprolyl isomerase FKBP-type K03772 fkpA; FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [EC:5.2.1.8] D Sph21_1679 peptidylprolyl isomerase FKBP-type K03772 fkpA; FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [EC:5.2.1.8] D Sph21_3948 peptidylprolyl isomerase FKBP-type K03773 fklB; FKBP-type peptidyl-prolyl cis-trans isomerase FklB [EC:5.2.1.8] D Sph21_3541 peptidylprolyl isomerase FKBP-type K03775 slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8] D Sph21_1470 PpiC-type peptidyl-prolyl cis-trans isomerase K03771 surA; peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8] D Sph21_3592 thioredoxin K03671 TXN; thioredoxin D Sph21_3201 thioredoxin K03671 TXN; thioredoxin D Sph21_3921 thioredoxin K03671 TXN; thioredoxin D Sph21_0821 Thioredoxin domain-containing protein K03671 TXN; thioredoxin D Sph21_2911 glutaredoxin K03671 TXN; thioredoxin C 04131 Membrane trafficking [BR:shg04131] D Sph21_1241 Nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6] D Sph21_4307 glycosyl hydrolase 38 domain protein K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24] D Sph21_3255 Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D Sph21_5090 glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D Sph21_3892 glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D Sph21_0067 glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D Sph21_1354 pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] D Sph21_3254 Heat shock protein Hsp90 K04079 HSP90A; molecular chaperone HtpG D Sph21_2810 HSP90 family protein K04079 HSP90A; molecular chaperone HtpG D Sph21_2942 major facilitator superfamily MFS_1 K06902 UMF1; MFS transporter, UMF1 family D Sph21_0985 protein of unknown function DUF500 K20523 SH3YL1; SH3 domain-containing YSC84-like protein 1 C 04121 Ubiquitin system [BR:shg04121] C 03051 Proteasome [BR:shg03051] D Sph21_3254 Heat shock protein Hsp90 K04079 HSP90A; molecular chaperone HtpG D Sph21_2810 HSP90 family protein K04079 HSP90A; molecular chaperone HtpG C 03032 DNA replication proteins [BR:shg03032] D Sph21_3294 Ribonuclease H K03469 rnhA; ribonuclease HI [EC:3.1.26.4] D Sph21_3497 C-5 cytosine-specific DNA methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D Sph21_0901 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D Sph21_2104 histone family protein DNA-binding protein K03530 hupB; DNA-binding protein HU-beta D Sph21_1129 histone family protein DNA-binding protein K03530 hupB; DNA-binding protein HU-beta D Sph21_0001 Chromosomal replication initiator protein dnaA K02313 dnaA; chromosomal replication initiator protein D Sph21_3056 replicative DNA helicase K02314 dnaB; replicative DNA helicase [EC:5.6.2.3] D Sph21_0670 DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101] D Sph21_4628 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_5164 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_1131 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_3922 DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D Sph21_1712 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D Sph21_2465 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D Sph21_0763 DNA polymerase III gamma/tau subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D Sph21_3055 Exonuclease RNase T and DNA polymerase III K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D Sph21_3431 DNA polymerase III, epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D Sph21_2353 DNA polymerase III, subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D Sph21_1167 Ribonuclease H K03470 rnhB; ribonuclease HII [EC:3.1.26.4] D Sph21_1518 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D Sph21_0048 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] D Sph21_3360 DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] D Sph21_2460 DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] D Sph21_1654 DNA topoisomerase (ATP-hydrolyzing) K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] D Sph21_1645 DNA topoisomerase type IIA subunit B region 2 domain protein K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] D Sph21_3683 DNA topoisomerase K03168 topA; DNA topoisomerase I [EC:5.6.2.1] D Sph21_3174 DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1] D Sph21_3672 DNA topoisomerase K03169 topB; DNA topoisomerase III [EC:5.6.2.1] D Sph21_3610 DNA topoisomerase III K03169 topB; DNA topoisomerase III [EC:5.6.2.1] C 03036 Chromosome and associated proteins [BR:shg03036] D Sph21_3497 C-5 cytosine-specific DNA methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D Sph21_0901 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D Sph21_1358 Ribonuclease 3 K03685 rnc; ribonuclease III [EC:3.1.26.3] D Sph21_2104 histone family protein DNA-binding protein K03530 hupB; DNA-binding protein HU-beta D Sph21_1129 histone family protein DNA-binding protein K03530 hupB; DNA-binding protein HU-beta D Sph21_0783 chaperone DnaJ domain protein K05516 cbpA; curved DNA-binding protein D Sph21_0001 Chromosomal replication initiator protein dnaA K02313 dnaA; chromosomal replication initiator protein D Sph21_4661 Ferritin Dps family protein K04047 dps; starvation-inducible DNA-binding protein D Sph21_0781 Ferritin Dps family protein K04047 dps; starvation-inducible DNA-binding protein D Sph21_0528 transcriptional regulator, AsnC family K03719 lrp; Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein D Sph21_2789 transcriptional regulator, AsnC family K03719 lrp; Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein D Sph21_4012 transcriptional regulator, AsnC family K03719 lrp; Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein D Sph21_3274 chromosome segregation protein SMC K03529 smc; chromosome segregation protein D Sph21_1134 chromosome segregation and condensation protein ScpA K05896 scpA; segregation and condensation protein A D Sph21_3051 chromosome segregation and condensation protein, ScpB K06024 scpB; segregation and condensation protein B D Sph21_0053 cell division protein FtsA K03590 ftsA; cell division protein FtsA D Sph21_3122 Sigma 54 interacting domain protein K09812 ftsE; cell division transport system ATP-binding protein D Sph21_0061 Peptidoglycan glycosyltransferase K03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4] D Sph21_3876 cell division protein FtsK/SpoIIIE K03466 ftsK; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family D Sph21_0054 hypothetical protein K03589 ftsQ; cell division protein FtsQ D Sph21_0057 cell cycle protein K03588 ftsW; cell division protein FtsW D Sph21_0547 protein of unknown function DUF214 K09811 ftsX; cell division transport system permease protein D Sph21_0052 cell division protein FtsZ K03531 ftsZ; cell division protein FtsZ D Sph21_3953 hypothetical protein K09888 zapA; cell division protein ZapA D Sph21_2535 cell wall hydrolase/autolysin K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] D Sph21_2536 cell wall hydrolase/autolysin K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] D Sph21_2597 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_3635 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1124 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1486 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_0028 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1696 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_4059 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_4898 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_2379 cell shape determining protein, MreB/Mrl family K03569 mreB; rod shape-determining protein MreB and related proteins D Sph21_2378 Rod shape-determining protein MreC K03570 mreC; rod shape-determining protein MreC D Sph21_2375 rod shape-determining protein RodA K05837 rodA; rod shape determining protein RodA D Sph21_0428 Cobyrinic acid ac-diamide synthase K03496 parA; chromosome partitioning protein D Sph21_0427 parB-like partition protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein D Sph21_1654 DNA topoisomerase (ATP-hydrolyzing) K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] D Sph21_1645 DNA topoisomerase type IIA subunit B region 2 domain protein K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] D Sph21_1300 tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme D Sph21_2523 Ribosomal RNA small subunit methyltransferase G K03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170] D Sph21_2397 Tyrosine recombinase xerC K03733 xerC; integrase/recombinase XerC D Sph21_2551 Tyrosine recombinase xerC K04763 xerD; integrase/recombinase XerD D Sph21_0303 integrase family protein K04763 xerD; integrase/recombinase XerD D Sph21_3457 integrase family protein K04763 xerD; integrase/recombinase XerD D Sph21_1365 ATPase-like, ParA/MinD K03593 mrp; ATP-binding protein involved in chromosome partitioning D Sph21_5211 GTP-binding protein engB K03978 engB; GTP-binding protein C 03400 DNA repair and recombination proteins [BR:shg03400] D Sph21_1680 Deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] D Sph21_4011 Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] D Sph21_2724 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] D Sph21_1130 A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] D Sph21_0570 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] D Sph21_1546 S1/P1 nuclease K05986 NUCS; nuclease S1 [EC:3.1.30.1] D Sph21_2716 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] D Sph21_3895 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] D Sph21_1028 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] D Sph21_2933 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] D Sph21_2363 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] D Sph21_4272 methylated-DNA/protein-cysteine methyltransferase K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63] D Sph21_2783 transcriptional regulator, AraC family K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63] D Sph21_5115 HhH-GPD family protein K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21] D Sph21_4366 methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] D Sph21_4849 methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] D Sph21_1495 DNA-3-methyladenine glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] D Sph21_3236 DNA-formamidopyrimidine glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18] D Sph21_4521 exodeoxyribonuclease III Xth K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2] D Sph21_1390 exodeoxyribonuclease III Xth K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2] D Sph21_4105 Endonuclease V K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7] D Sph21_0716 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D Sph21_0048 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] D Sph21_1518 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D Sph21_5270 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A D Sph21_0558 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A D Sph21_0721 UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B D Sph21_5241 UvrABC system protein C K03703 uvrC; excinuclease ABC subunit C D Sph21_3839 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D Sph21_2931 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D Sph21_2406 DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] D Sph21_2407 DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] D Sph21_1742 DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] D Sph21_1343 transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4] D Sph21_3063 DNA mismatch repair protein mutS K03555 mutS; DNA mismatch repair protein MutS D Sph21_5111 DNA mismatch repair protein MutS domain protein K03555 mutS; DNA mismatch repair protein MutS D Sph21_4670 MutS2 protein K07456 mutS2; DNA mismatch repair protein MutS2 D Sph21_1476 DNA mismatch repair protein mutL K03572 mutL; DNA mismatch repair protein MutL D Sph21_1456 Exonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6] D Sph21_1455 Exodeoxyribonuclease 7 small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6] D Sph21_3922 DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D Sph21_1712 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D Sph21_2465 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D Sph21_0763 DNA polymerase III gamma/tau subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D Sph21_3055 Exonuclease RNase T and DNA polymerase III K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D Sph21_3431 DNA polymerase III, epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D Sph21_2353 DNA polymerase III, subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D Sph21_4628 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_5164 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_1131 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_0962 DNA mismatch endonuclease Vsr K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-] D Sph21_0569 Protein recA K03553 recA; recombination protein RecA D Sph21_2087 Holliday junction ATP-dependent DNA helicase ruvA K03550 ruvA; holliday junction DNA helicase RuvA D Sph21_2470 Holliday junction ATP-dependent DNA helicase ruvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4] D Sph21_1573 Crossover junction endodeoxyribonuclease ruvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10] D Sph21_0322 primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4] D Sph21_3865 SMC domain protein K03546 sbcC; DNA repair protein SbcC/Rad50 D Sph21_3866 nuclease SbcCD, D subunit K03547 sbcD; DNA repair protein SbcD/Mre11 D Sph21_1126 DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms D Sph21_5257 DNA replication and repair protein recF K03629 recF; DNA replication and repair protein RecF D Sph21_1158 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4] D Sph21_0038 DNA repair protein recO K03584 recO; DNA repair protein RecO (recombination protein O) D Sph21_3097 Recombination protein recR K06187 recR; recombination protein RecR D Sph21_0396 DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N) D Sph21_1752 protein of unknown function DUF853 NPT hydrolase K06915 herA; DNA double-strand break repair helicase HerA and related ATPase D Sph21_3426 DNA repair protein K10979 ku; DNA end-binding protein Ku D Sph21_2578 DNA ligase D K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1] D Sph21_3360 DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] D Sph21_2460 DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] D Sph21_3683 DNA topoisomerase K03168 topA; DNA topoisomerase I [EC:5.6.2.1] D Sph21_3174 DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1] D Sph21_2104 histone family protein DNA-binding protein K03530 hupB; DNA-binding protein HU-beta D Sph21_1129 histone family protein DNA-binding protein K03530 hupB; DNA-binding protein HU-beta D Sph21_2937 ATP-dependent DNA helicase, RecQ family K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4] D Sph21_3364 ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4] D Sph21_3197 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7] D Sph21_3429 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7] D Sph21_3244 hypothetical protein K14160 imuA; protein ImuA D Sph21_3245 cytosolic protein K14161 imuB; protein ImuB D Sph21_4679 regulatory protein RecX K03565 recX; regulatory protein D Sph21_4023 PHP domain protein K02347 polX; DNA polymerase (family X) D Sph21_1109 DEAD/H associated domain protein K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4] D Sph21_2913 ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D Sph21_0339 ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D Sph21_2914 Ribonucleoside-diphosphate reductase K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D Sph21_0340 Ribonucleoside-diphosphate reductase K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D Sph21_1242 phosphoesterase RecJ domain protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3] C 03029 Mitochondrial biogenesis [BR:shg03029] D Sph21_1608 translation initiation factor IF-2 K02519 infB; translation initiation factor IF-2 D Sph21_2964 Translation initiation factor IF-3 K02520 infC; translation initiation factor IF-3 D Sph21_1444 Elongation factor Ts K02357 tsf; elongation factor Ts D Sph21_2399 translation elongation factor Tu K02358 tuf; elongation factor Tu D Sph21_3979 translation elongation factor G K02355 fusA; elongation factor G D Sph21_0363 GTP-binding protein Era-like-protein K03595 era; GTPase D Sph21_3907 Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D Sph21_0546 leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D Sph21_1132 aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D Sph21_1705 glycyl-tRNA synthetase K01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14] D Sph21_3007 Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D Sph21_2508 Endonuclease I K01173 ENDOG; endonuclease G, mitochondrial D Sph21_4628 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_5164 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_1131 single-strand binding protein K03111 ssb; single-strand DNA-binding protein D Sph21_5201 outer membrane protein assembly complex, YaeT protein K07277 SAM50; outer membrane protein insertion porin family D Sph21_3188 surface antigen (D15) K07277 SAM50; outer membrane protein insertion porin family D Sph21_1745 Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK D Sph21_3121 Protein grpE K03687 GRPE; molecular chaperone GrpE D Sph21_0753 60 kDa chaperonin K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D Sph21_0752 10 kDa chaperonin K04078 groES; chaperonin GroES D Sph21_4573 Chaperonin Cpn10 K04078 groES; chaperonin GroES D Sph21_3120 Chaperone protein dnaJ K03686 dnaJ; molecular chaperone DnaJ D Sph21_3741 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D Sph21_3019 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D Sph21_3997 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D Sph21_2968 ferredoxin K22071 FDX2; ferredoxin-2, mitochondrial D Sph21_3622 Scaffold protein Nfu/NifU K22074 NFU1; NFU1 iron-sulfur cluster scaffold homolog, mitochondrial D Sph21_1365 ATPase-like, ParA/MinD K03593 mrp; ATP-binding protein involved in chromosome partitioning D Sph21_1557 Protoheme IX farnesyltransferase K02257 COX10; heme o synthase [EC:2.5.1.141] D Sph21_1556 cytochrome oxidase assembly K02259 COX15; heme a synthase [EC:1.17.99.9] D Sph21_3520 Membrane protein oxaA K03217 yidC; YidC/Oxa1 family membrane protein insertase D Sph21_1561 electron transport protein SCO1/SenC K07152 SCO1; protein SCO1 D Sph21_3346 electron transport protein SCO1/SenC K07152 SCO1; protein SCO1 D Sph21_4299 electron transport protein SCO1/SenC K07152 SCO1; protein SCO1 D Sph21_3254 Heat shock protein Hsp90 K04079 HSP90A; molecular chaperone HtpG D Sph21_2810 HSP90 family protein K04079 HSP90A; molecular chaperone HtpG B B 09183 Protein families: signaling and cellular processes C 02000 Transporters [BR:shg02000] D Sph21_4436 Xenobiotic-transporting ATPase K14698 irtA; ATP-binding cassette, subfamily B, bacterial IrtA/YbtP [EC:7.-.-.-] D Sph21_4435 Xenobiotic-transporting ATPase K14699 irtB; ATP-binding cassette, subfamily B, bacterial IrtB/YbtQ [EC:7.-.-.-] D Sph21_1607 Xenobiotic-transporting ATPase K11085 msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:7.5.2.6] D Sph21_4009 Xenobiotic-transporting ATPase K18889 mdlA; ATP-binding cassette, subfamily B, multidrug efflux pump D Sph21_2417 Xenobiotic-transporting ATPase K18890 mdlB; ATP-binding cassette, subfamily B, multidrug efflux pump D Sph21_0538 Xenobiotic-transporting ATPase K06147 ABCB-BAC; ATP-binding cassette, subfamily B, bacterial D Sph21_0698 Xenobiotic-transporting ATPase K06147 ABCB-BAC; ATP-binding cassette, subfamily B, bacterial D Sph21_3761 Xenobiotic-transporting ATPase K06147 ABCB-BAC; ATP-binding cassette, subfamily B, bacterial D Sph21_0909 Xenobiotic-transporting ATPase K06147 ABCB-BAC; ATP-binding cassette, subfamily B, bacterial D Sph21_3760 Xenobiotic-transporting ATPase K06147 ABCB-BAC; ATP-binding cassette, subfamily B, bacterial D Sph21_1895 Xenobiotic-transporting ATPase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter D Sph21_4095 Xenobiotic-transporting ATPase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter D Sph21_0591 Xenobiotic-transporting ATPase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter D Sph21_1301 ABC transporter related protein K15738 uup; ABC transport system ATP-binding/permease protein D Sph21_2284 ABC transporter related protein K05776 modF; molybdate transport system ATP-binding protein D Sph21_0814 ABC-type glycine betaine transport, periplasmic subunit K02002 proX; glycine betaine/proline transport system substrate-binding protein D Sph21_0815 ABC-type transporter, integral membrane subunit K02001 proW; glycine betaine/proline transport system permease protein D Sph21_0816 glycine betaine/L-proline ABC transporter, ATPase subunit K02000 proV; glycine betaine/proline transport system ATP-binding protein [EC:7.6.2.9] D Sph21_2567 ABC-type glycine betaine transport, periplasmic subunit K05845 opuC; osmoprotectant transport system substrate-binding protein D Sph21_2568 Fe(3+)-transporting ATPase K05847 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9] D Sph21_2619 periplasmic binding protein/LacI transcriptional regulator K10439 rbsB; ribose transport system substrate-binding protein D Sph21_2622 ABC-type transporter, integral membrane subunit K10440 rbsC; ribose transport system permease protein D Sph21_2621 Monosaccharide-transporting ATPase K10441 rbsA; ribose transport system ATP-binding protein [EC:7.5.2.7] D Sph21_3069 Mammalian cell entry related domain protein K02067 mlaD; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein D Sph21_2534 Mammalian cell entry related domain protein K02067 mlaD; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein D Sph21_3067 protein of unknown function DUF140 K02066 mlaE; phospholipid/cholesterol/gamma-HCH transport system permease protein D Sph21_1668 protein of unknown function DUF140 K02066 mlaE; phospholipid/cholesterol/gamma-HCH transport system permease protein D Sph21_3068 Sulfate-transporting ATPase K02065 mlaF; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein D Sph21_1667 Sulfate-transporting ATPase K02065 mlaF; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein D Sph21_2339 extracellular solute-binding protein family 1 K02027 ABC.MS.S; multiple sugar transport system substrate-binding protein D Sph21_2342 extracellular solute-binding protein family 1 K02027 ABC.MS.S; multiple sugar transport system substrate-binding protein D Sph21_4532 ABC-type phosphate transporter substrate-binding component K02040 pstS; phosphate transport system substrate-binding protein D Sph21_4735 phosphate binding protein K02040 pstS; phosphate transport system substrate-binding protein D Sph21_4531 phosphate ABC transporter, inner membrane subunit PstC K02037 pstC; phosphate transport system permease protein D Sph21_4734 phosphate ABC transporter, inner membrane subunit PstC K02037 pstC; phosphate transport system permease protein D Sph21_4530 ABC-type transporter, integral membrane subunit K02038 pstA; phosphate transport system permease protein D Sph21_4733 phosphate ABC transporter, inner membrane subunit PstA K02038 pstA; phosphate transport system permease protein D Sph21_4529 Phosphate-transporting ATPase K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D Sph21_4732 phosphate ABC transporter, ATPase subunit K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D Sph21_4537 lipoprotein, YaeC family K02073 metQ; D-methionine transport system substrate-binding protein D Sph21_4538 ABC-type transporter, integral membrane subunit K02072 metI; D-methionine transport system permease protein D Sph21_4539 Phosphonate-transporting ATPase K02071 metN; D-methionine transport system ATP-binding protein D Sph21_3278 ABC transporter substrate binding protein K01989 K01989; putative tryptophan/tyrosine transport system substrate-binding protein D Sph21_3279 ABC-type transporter, integral membrane subunit K05832 K05832; putative tryptophan/tyrosine transport system permease protein D Sph21_3280 Phosphonate-transporting ATPase K05833 K05833; putative tryptophan/tyrosine transport system ATP-binding protein D Sph21_3700 ABC-type transporter, periplasmic subunit K25132 hmuT; heme transport system substrate-binding protein D Sph21_3701 ABC-type transporter, integral membrane subunit K25133 hmuU; heme transport system permease protein D Sph21_3702 Phosphonate-transporting ATPase K10834 hmuV; heme transport system ATP-binding protein [EC:7.6.2.5] D Sph21_0411 hypothetical protein K02016 ABC.FEV.S; iron complex transport system substrate-binding protein D Sph21_0564 permease YjgP/YjgQ family protein K07091 lptF; lipopolysaccharide export system permease protein D Sph21_2520 permease YjgP/YjgQ family protein K11720 lptG; lipopolysaccharide export system permease protein D Sph21_0715 Sulfate-transporting ATPase K06861 lptB; lipopolysaccharide export system ATP-binding protein [EC:7.5.2.5] D Sph21_4999 ABC transporter related protein K06861 lptB; lipopolysaccharide export system ATP-binding protein [EC:7.5.2.5] D Sph21_1709 gliding-associated putative ABC transporter substrate-binding component GldG K25151 gldF; gliding motility-associated transport system permease protein D Sph21_1707 Sulfate-transporting ATPase K25152 gldA; gliding motility-associated transport system ATP-binding protein D Sph21_4079 ABC-2 type transporter K25180 ybhR; drug efflux transport system permease protein D Sph21_4080 ABC-2 type transporter K25181 ybhS; drug efflux transport system permease protein D Sph21_4082 Sulfate-transporting ATPase K25182 ybhF; drug efflux transport system ATP-binding protein D Sph21_4081 Sulfate-transporting ATPase K25182 ybhF; drug efflux transport system ATP-binding protein D Sph21_4083 biotin/lipoyl attachment domain-containing protein K25183 ybhG; membrane fusion protein YbhG D Sph21_1342 protein of unknown function DUF214 K09808 lolC_E; lipoprotein-releasing system permease protein D Sph21_3547 protein of unknown function DUF214 K09808 lolC_E; lipoprotein-releasing system permease protein D Sph21_3281 Polyamine-transporting ATPase K09810 lolD; lipoprotein-releasing system ATP-binding protein [EC:7.6.2.-] D Sph21_2981 cytochrome c assembly protein K02195 ccmC; heme exporter protein C D Sph21_2980 cytochrome c-type biogenesis protein CcmB K02194 ccmB; heme exporter protein B D Sph21_0547 protein of unknown function DUF214 K09811 ftsX; cell division transport system permease protein D Sph21_3122 Sigma 54 interacting domain protein K09812 ftsE; cell division transport system ATP-binding protein D Sph21_2719 ABC-type transport, permease protein K01992 ABC-2.P; ABC-2 type transport system permease protein D Sph21_3117 ABC transporter, permease protein, putative K01992 ABC-2.P; ABC-2 type transport system permease protein D Sph21_3766 membrane protein K01992 ABC-2.P; ABC-2 type transport system permease protein D Sph21_3118 Fe(3+)-transporting ATPase K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D Sph21_2718 Phosphonate-transporting ATPase K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D Sph21_0787 Fe(3+)-transporting ATPase K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D Sph21_3767 ABC transporter related protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D Sph21_2591 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_3413 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1069 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1178 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1198 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1200 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_3990 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_0828 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_0844 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_0965 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1209 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1210 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1176 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1177 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1179 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1199 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1214 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1221 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1225 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1226 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1227 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_1228 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_2610 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_4314 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_4358 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_4388 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_4774 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_4981 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein D Sph21_3414 Phosphonate-transporting ATPase K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D Sph21_3516 Phosphonate-transporting ATPase K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D Sph21_1175 Phosphonate-transporting ATPase K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D Sph21_2590 Phosphonate-transporting ATPase K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D Sph21_1229 Phosphonate-transporting ATPase K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D Sph21_4016 FeS assembly ATPase SufC K09013 sufC; Fe-S cluster assembly ATP-binding protein D Sph21_1448 MATE efflux family protein K26939 norM; MATE family, multidrug efflux pump D Sph21_1223 MATE efflux family protein K26939 norM; MATE family, multidrug efflux pump D Sph21_0109 sugar transporter K02100 araE; MFS transporter, SP family, arabinose:H+ symporter D Sph21_4246 sugar transporter K02100 araE; MFS transporter, SP family, arabinose:H+ symporter D Sph21_4794 sugar transporter K02100 araE; MFS transporter, SP family, arabinose:H+ symporter D Sph21_4108 glucose/galactose transporter K02429 fucP; MFS transporter, FHS family, L-fucose permease D Sph21_0624 L-fucose transporter K02429 fucP; MFS transporter, FHS family, L-fucose permease D Sph21_0611 L-fucose transporter K02429 fucP; MFS transporter, FHS family, L-fucose permease D Sph21_2345 L-fucose transporter K02429 fucP; MFS transporter, FHS family, L-fucose permease D Sph21_2845 glucose/galactose transporter K02429 fucP; MFS transporter, FHS family, L-fucose permease D Sph21_1439 glucose/galactose transporter K02429 fucP; MFS transporter, FHS family, L-fucose permease D Sph21_3058 nucleoside transporter K11537 xapB; MFS transporter, NHS family, xanthosine permease D Sph21_2391 General substrate transporter K03761 kgtP; MFS transporter, MHS family, alpha-ketoglutarate permease D Sph21_2895 major facilitator superfamily MFS_1 K08191 exuT; MFS transporter, ACS family, aldohexuronate transporter D Sph21_4582 major facilitator superfamily MFS_1 K08194 dgoT; MFS transporter, ACS family, D-galactonate transporter D Sph21_3753 major facilitator superfamily MFS_1 K02575 NRT2; MFS transporter, NNP family, nitrate/nitrite transporter D Sph21_0362 major facilitator superfamily MFS_1 K08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein D Sph21_0952 major facilitator superfamily MFS_1 K07552 bcr; MFS transporter, DHA1 family, multidrug resistance protein D Sph21_1192 major facilitator superfamily MFS_1 K08156 araJ; MFS transporter, DHA1 family, arabinose polymer utilization protein D Sph21_1676 drug resistance transporter, EmrB/QacA subfamily K03446 emrB; MFS transporter, DHA2 family, multidrug resistance protein D Sph21_3688 drug resistance transporter, EmrB/QacA subfamily K03446 emrB; MFS transporter, DHA2 family, multidrug resistance protein D Sph21_1760 hypothetical protein K03446 emrB; MFS transporter, DHA2 family, multidrug resistance protein D Sph21_4862 hypothetical protein K03446 emrB; MFS transporter, DHA2 family, multidrug resistance protein D Sph21_0890 hypothetical protein K03446 emrB; MFS transporter, DHA2 family, multidrug resistance protein D Sph21_4553 major facilitator superfamily MFS_1 K08217 mef; MFS transporter, DHA3 family, macrolide efflux protein D Sph21_3853 major facilitator superfamily MFS_1 K08223 fsr; MFS transporter, FSR family, fosmidomycin resistance protein D Sph21_2942 major facilitator superfamily MFS_1 K06902 UMF1; MFS transporter, UMF1 family D Sph21_5112 MIP family channel protein K06188 aqpZ; aquaporin Z D Sph21_2907 major intrinsic protein K02440 glpF; glycerol uptake facilitator D Sph21_2213 ammonium transporter K03320 amt; ammonium transporter, Amt family D Sph21_3223 ammonium transporter K03320 amt; ammonium transporter, Amt family D Sph21_0643 von Willebrand factor type A K07114 yfbK; Ca-activated chloride channel homolog D Sph21_1186 von Willebrand factor type A K07114 yfbK; Ca-activated chloride channel homolog D Sph21_3746 formate/nitrite transporter K21993 fdhC; formate transporter D Sph21_0329 Large-conductance mechanosensitive channel K03282 mscL; large conductance mechanosensitive channel D Sph21_2838 MscS Mechanosensitive ion channel K05802 mscK; potassium-dependent mechanosensitive channel D Sph21_4028 MscS Mechanosensitive ion channel K03442 mscS; small conductance mechanosensitive channel D Sph21_0671 MscS Mechanosensitive ion channel K16053 ybdG; miniconductance mechanosensitive channel D Sph21_4296 magnesium transporter K06213 mgtE; magnesium transporter D Sph21_3970 magnesium transporter K06213 mgtE; magnesium transporter D Sph21_2444 OmpA/MotB domain protein K02557 motB; chemotaxis protein MotB D Sph21_1565 OmpA/MotB domain protein K02557 motB; chemotaxis protein MotB D Sph21_2226 MotA/TolQ/ExbB proton channel K03561 exbB; biopolymer transport protein ExbB D Sph21_1580 MotA/TolQ/ExbB proton channel K03561 exbB; biopolymer transport protein ExbB D Sph21_2225 Biopolymer transport protein ExbD/TolR K03559 exbD; biopolymer transport protein ExbD D Sph21_2078 Mg2 transporter protein CorA family protein K03284 corA; magnesium transporter D Sph21_1335 hypothetical protein K08994 yneE; ion channel-forming bestrophin family protein D Sph21_2916 hypothetical protein K08994 yneE; ion channel-forming bestrophin family protein D Sph21_3974 hypothetical protein K08994 yneE; ion channel-forming bestrophin family protein D Sph21_0291 hypothetical protein K08364 merP; periplasmic mercuric ion binding protein D Sph21_3679 protein of unknown function DUF21 K03699 tlyC; magnesium and cobalt exporter, CNNM family D Sph21_1603 protein of unknown function DUF21 K03699 tlyC; magnesium and cobalt exporter, CNNM family D Sph21_0352 phosphate-selective porin O and P K07221 oprO_P; phosphate-selective porin OprO and OprP D Sph21_1156 OmpA/MotB domain protein K03286 TC.OOP; OmpA-OmpF porin, OOP family D Sph21_3211 OmpA/MotB domain protein K03286 TC.OOP; OmpA-OmpF porin, OOP family D Sph21_2414 OmpA/MotB domain protein K03286 TC.OOP; OmpA-OmpF porin, OOP family D Sph21_3650 TonB-dependent receptor K16092 btuB; vitamin B12 transporter D Sph21_3961 TonB-dependent receptor K16092 btuB; vitamin B12 transporter D Sph21_0583 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_0477 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_0497 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_0388 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_0460 TonB-dependent receptor K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_0929 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_1008 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_1279 TonB-dependent receptor K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_3882 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_2660 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_2842 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_2949 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_3925 TonB-dependent receptor K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_2857 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_2888 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_2779 TonB-dependent receptor K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_2905 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_1900 TonB-dependent receptor K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_2267 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_2649 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_1967 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_1662 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_1990 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_1419 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_2054 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_2372 TonB-dependent receptor K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_4291 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_4309 TonB-dependent receptor K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_4760 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_4798 TonB-dependent receptor K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_4803 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_4917 TonB-dependent receptor K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_4707 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_4722 TonB-dependent receptor K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_5060 TonB-dependent receptor K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_5087 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_0154 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_5121 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_5123 TonB-dependent receptor K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_4245 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_3902 TonB-dependent receptor plug K21573 susC; TonB-dependent starch-binding outer membrane protein SusC D Sph21_3699 TonB-dependent receptor K16089 TC.FEV.OM2; outer membrane receptor for ferrienterochelin and colicins D Sph21_2773 TonB-dependent receptor plug K16089 TC.FEV.OM2; outer membrane receptor for ferrienterochelin and colicins D Sph21_0222 TonB-dependent receptor plug K16089 TC.FEV.OM2; outer membrane receptor for ferrienterochelin and colicins D Sph21_3398 TonB-dependent siderophore receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_5170 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_0139 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_1184 TonB-dependent siderophore receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_1248 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_2111 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_5065 TonB-dependent siderophore receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_2546 outer membrane insertion C-terminal signal K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_2549 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_2572 TonB-dependent siderophore receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_0924 TonB-dependent siderophore receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_2683 TonB-dependent siderophore receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_5107 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_2676 TonB-dependent receptor plug K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_1011 TonB-dependent siderophore receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_3131 TonB-dependent receptor plug K02014 TC.FEV.OM; iron complex outermembrane recepter protein D Sph21_0287 outer membrane protein-like protein K15725 czcC; outer membrane protein, heavy metal efflux system D Sph21_2804 outer membrane protein-like protein K15725 czcC; outer membrane protein, heavy metal efflux system D Sph21_3967 outer membrane efflux protein K15725 czcC; outer membrane protein, heavy metal efflux system D Sph21_3416 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1232 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4138 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_3601 putative outer membrane protein K12340 tolC; outer membrane protein D Sph21_0030 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_0888 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1674 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1758 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4864 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4635 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4057 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1697 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_0423 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_2826 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_2599 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_1488 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_4896 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_1958 polysaccharide export protein K01991 wza; polysaccharide biosynthesis/export protein D Sph21_1809 Soluble ligand binding domain K01991 wza; polysaccharide biosynthesis/export protein D Sph21_2025 Soluble ligand binding domain K01991 wza; polysaccharide biosynthesis/export protein D Sph21_5201 outer membrane protein assembly complex, YaeT protein K07277 SAM50; outer membrane protein insertion porin family D Sph21_3188 surface antigen (D15) K07277 SAM50; outer membrane protein insertion porin family D Sph21_1764 outer membrane assembly lipoprotein YfiO K05807 bamD; outer membrane protein assembly factor BamD D Sph21_3898 major facilitator superfamily MFS_1 K16211 malY; maltose/moltooligosaccharide transporter D Sph21_3777 amino acid permease-associated region K11734 aroP; aromatic amino acid transport protein AroP D Sph21_0667 ethanolamine transporter K16238 eat; ethanolamine permease D Sph21_4000 zinc/iron permease K16267 zipB; zinc and cadmium transporter D Sph21_3969 heavy metal efflux pump, CzcA family K15726 czcA; heavy metal efflux system protein D Sph21_0225 heavy metal efflux pump, CzcA family K15726 czcA; heavy metal efflux system protein D Sph21_3351 heavy metal efflux pump, CzcA family K15726 czcA; heavy metal efflux system protein D Sph21_0894 heavy metal efflux pump, CzcA family K15726 czcA; heavy metal efflux system protein D Sph21_3665 heavy metal efflux pump, CzcA family K15726 czcA; heavy metal efflux system protein D Sph21_0288 acriflavin resistance protein K07787 cusA; copper/silver efflux system protein D Sph21_2805 acriflavin resistance protein K07787 cusA; copper/silver efflux system protein D Sph21_0029 acriflavin resistance protein K18138 acrB; multidrug efflux pump D Sph21_3287 small multidrug resistance protein K11741 sugE; quaternary ammonium compound-resistance protein SugE D Sph21_3667 protein of unknown function DUF6 transmembrane K15269 pecM; probable blue pigment (indigoidine) exporter D Sph21_0517 RhaT l-rhamnose-proton symport 2 K02856 rhaT; L-rhamnose-H+ transport protein D Sph21_4236 RarD protein, DMT superfamily transporter K05786 rarD; chloramphenicol-sensitive protein RarD D Sph21_5125 gluconate transporter K06155 gntT; Gnt-I system high-affinity gluconate transporter D Sph21_4418 L-lactate transport K03303 lutP; lactate permease D Sph21_3249 choline/carnitine/betaine transporter K02168 betT; choline/glycine/proline betaine transport protein D Sph21_1231 sodium:dicarboxylate symporter K11103 dctA; aerobic C4-dicarboxylate transport protein D Sph21_0081 Na(+)/H(+) antiporter nhaA K03313 nhaA; Na+:H+ antiporter, NhaA family D Sph21_3226 Na(+)/H(+) antiporter nhaA K03313 nhaA; Na+:H+ antiporter, NhaA family D Sph21_2791 Na+/H+ antiporter K24163 nhaK; monovalent cation/hydrogen antiporter D Sph21_2575 Na+/H+ antiporter K24163 nhaK; monovalent cation/hydrogen antiporter D Sph21_2242 sodium/hydrogen exchanger K03316 nhaP; Na+:H+ antiporter D Sph21_3145 sodium/hydrogen exchanger K26730 napA; Na+:H+ antiporter D Sph21_3856 sodium/hydrogen exchanger K26731 CHX; K+:H+ antiporter D Sph21_5266 TrkA-C domain protein K07228 khtT; K+:H+ antiporter subunit KhtT D Sph21_5267 sodium/hydrogen exchanger K26732 khtU; K+:H+ antiporter subunit KhtU D Sph21_3022 Cl-channel voltage-gated family protein K03281 clcA; chloride channel protein, CIC family D Sph21_3235 Cl-channel voltage-gated family protein K03281 clcA; chloride channel protein, CIC family D Sph21_0179 Cl-channel voltage-gated family protein K03281 clcA; chloride channel protein, CIC family D Sph21_5099 Chromate transporter K07240 chrA; chromate transporter D Sph21_5100 Chromate transporter K07240 chrA; chromate transporter D Sph21_0301 sulfate transporter K03321 TC.SULP; sulfate permease, SulP family D Sph21_2702 sulphate transporter K03321 TC.SULP; sulfate permease, SulP family D Sph21_2367 Manganese transport protein mntH K03322 mntH; manganese transport protein D Sph21_2855 natural resistance-associated macrophage protein K03322 mntH; manganese transport protein D Sph21_0231 arsenical-resistance protein K03325 ACR3; arsenite transporter D Sph21_4778 arsenical-resistance protein K03325 ACR3; arsenite transporter D Sph21_3008 NADH dehydrogenase (quinone) K05565 mnhA; multicomponent Na+:H+ antiporter subunit A D Sph21_3009 Na+/H+ antiporter MnhB subunit-related protein K05566 mnhB; multicomponent Na+:H+ antiporter subunit B D Sph21_3010 NADH-ubiquinone oxidoreductase chain 4L K05567 mnhC; multicomponent Na+:H+ antiporter subunit C D Sph21_3011 NADH dehydrogenase (quinone) K05568 mnhD; multicomponent Na+:H+ antiporter subunit D D Sph21_3012 cation antiporter K05569 mnhE; multicomponent Na+:H+ antiporter subunit E D Sph21_3013 multiple resistance and pH regulation protein F K05570 mnhF; multicomponent Na+:H+ antiporter subunit F D Sph21_3014 monovalent cation/proton antiporter, MnhG/PhaG subunit K05571 mnhG; multicomponent Na+:H+ antiporter subunit G D Sph21_5056 Auxin Efflux Carrier K24180 mleP; malate permease and related proteins D Sph21_3910 Low affinity potassium transport system protein kup K03549 kup; KUP system potassium uptake protein D Sph21_2243 multiple antibiotic resistance (MarC)-related protein K05595 marC; multiple antibiotic resistance protein D Sph21_0057 cell cycle protein K03588 ftsW; cell division protein FtsW D Sph21_1583 TonB family protein K03832 tonB; periplasmic protein TonB D Sph21_3333 TonB family protein K03832 tonB; periplasmic protein TonB D Sph21_3844 OmpA/MotB domain protein K03640 pal; peptidoglycan-associated lipoprotein D Sph21_2245 Pyrophosphate-energized proton pump K15987 hppA; K(+)-stimulated pyrophosphate-energized sodium pump [EC:7.2.3.1] D Sph21_0889 secretion protein HlyD family protein K03543 emrA; membrane fusion protein, multidrug efflux system D Sph21_1759 secretion protein HlyD family protein K03543 emrA; membrane fusion protein, multidrug efflux system D Sph21_4863 secretion protein HlyD family protein K03543 emrA; membrane fusion protein, multidrug efflux system D Sph21_1675 secretion protein HlyD family protein K03543 emrA; membrane fusion protein, multidrug efflux system D Sph21_0226 efflux transporter, RND family, MFP subunit K15727 czcB; membrane fusion protein, heavy metal efflux system D Sph21_3968 efflux transporter, RND family, MFP subunit K15727 czcB; membrane fusion protein, heavy metal efflux system D Sph21_0893 efflux transporter, RND family, MFP subunit K15727 czcB; membrane fusion protein, heavy metal efflux system D Sph21_3664 efflux transporter, RND family, MFP subunit K15727 czcB; membrane fusion protein, heavy metal efflux system D Sph21_3353 efflux transporter, RND family, MFP subunit K15727 czcB; membrane fusion protein, heavy metal efflux system D Sph21_2802 efflux transporter, RND family, MFP subunit K07798 cusB; membrane fusion protein, copper/silver efflux system D Sph21_0285 efflux transporter, RND family, MFP subunit K07798 cusB; membrane fusion protein, copper/silver efflux system D Sph21_0286 hypothetical protein K07798 cusB; membrane fusion protein, copper/silver efflux system D Sph21_2803 hypothetical protein K07798 cusB; membrane fusion protein, copper/silver efflux system D Sph21_2597 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_3635 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1124 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1486 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_0028 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1696 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_4059 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_4898 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1896 secretion protein HlyD family protein K20345 blpB; membrane fusion protein, peptide pheromone/bacteriocin exporter D Sph21_4094 secretion protein HlyD family protein K20345 blpB; membrane fusion protein, peptide pheromone/bacteriocin exporter D Sph21_1959 capsular exopolysaccharide family K16692 etk-wzc; tyrosine-protein kinase Etk/Wzc [EC:2.7.10.3] D Sph21_2026 capsular exopolysaccharide family K16692 etk-wzc; tyrosine-protein kinase Etk/Wzc [EC:2.7.10.3] D Sph21_1810 capsular exopolysaccharide family K16692 etk-wzc; tyrosine-protein kinase Etk/Wzc [EC:2.7.10.3] D Sph21_3901 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4721 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1001 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0389 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_5059 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0491 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_5122 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_5172 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2357 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2950 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2887 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_5086 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4249 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1886 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4467 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4244 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2948 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1661 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4860 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0601 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4290 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0089 tetratricopeptide domain protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1003 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4916 hypothetical protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1013 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2747 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1921 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1976 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4308 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2331 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0106 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0840 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0193 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1899 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_5124 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1883 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1880 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1929 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1420 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2659 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4416 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1278 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2780 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2371 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4761 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2268 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1094 RagB/SusD domain protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0616 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4332 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0496 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0459 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0476 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0632 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1262 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1872 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1991 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_3881 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0265 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0479 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0809 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1773 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1775 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2495 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2836 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2843 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2856 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2862 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2889 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2941 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4797 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_5017 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_3267 hypothetical protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0582 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1968 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2751 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0481 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4698 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_3926 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1007 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1853 hypothetical protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2650 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4262 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4708 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0940 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0928 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2904 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2055 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4802 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0153 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0635 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1096 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2630 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0432 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_0802 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_1648 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_2307 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_3263 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4235 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_4747 RagB/SusD domain-containing protein K21572 susD; starch-binding outer membrane protein, SusD/RagB family D Sph21_3670 nicotinamide mononucleotide transporter PnuC K03811 pnuC; nicotinamide mononucleotide transporter D Sph21_2199 FeoA family protein K04758 feoA; ferrous iron transport protein A D Sph21_2200 ferrous iron transport protein B K04759 feoB; ferrous iron transport protein B D Sph21_3138 cytochrome c assembly protein K02198 ccmF; cytochrome c-type biogenesis protein CcmF D Sph21_3774 MgtC/SapB transporter K07507 mgtC; putative Mg2+ transporter-C (MgtC) family protein D Sph21_5268 MgtC/SapB transporter K07507 mgtC; putative Mg2+ transporter-C (MgtC) family protein C 02044 Secretion system [BR:shg02044] D Sph21_3416 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1232 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4138 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_3601 putative outer membrane protein K12340 tolC; outer membrane protein D Sph21_0030 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_0888 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1674 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1758 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4864 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4635 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4057 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1697 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_2248 DNA uptake protein and related DNA-binding protein-like protein K02237 comEA; competence protein ComEA D Sph21_2216 CMP/dCMP deaminase zinc-binding protein K01493 comEB; dCMP deaminase [EC:3.5.4.12] D Sph21_2936 ComEC/Rec2-related protein K02238 comEC; competence protein ComEC D Sph21_4395 beta-lactamase domain protein K02238 comEC; competence protein ComEC D Sph21_4834 Rhs element Vgr protein K11904 vgrG; type VI secretion system secreted protein VgrG D Sph21_0674 Protein translocase subunit secA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D Sph21_2971 protein-export membrane protein SecD K12257 secDF; SecD/SecF fusion protein D Sph21_2400 preprotein translocase, SecE subunit K03073 secE; preprotein translocase subunit SecE D Sph21_0751 preprotein translocase, SecG subunit K03075 secG; preprotein translocase subunit SecG D Sph21_1735 preprotein translocase, SecY subunit K03076 secY; preprotein translocase subunit SecY D Sph21_1442 signal recognition particle protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] D Sph21_5185 signal recognition particle-docking protein FtsY K03110 ftsY; fused signal recognition particle receptor D Sph21_4005 preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC D Sph21_3520 Membrane protein oxaA K03217 yidC; YidC/Oxa1 family membrane protein insertase D Sph21_2540 Sec-independent protein translocase protein tatA/E-like protein K03116 tatA; sec-independent protein translocase protein TatA D Sph21_1145 twin-arginine translocation protein, TatA/E family subunit K03116 tatA; sec-independent protein translocase protein TatA D Sph21_2075 Sec-independent protein translocase protein tatA/E-like protein K03116 tatA; sec-independent protein translocase protein TatA D Sph21_0014 Sec-independent protein translocase, TatC subunit K03118 tatC; sec-independent protein translocase protein TatC C 02042 Bacterial toxins [BR:shg02042] D Sph21_3679 protein of unknown function DUF21 K03699 tlyC; magnesium and cobalt exporter, CNNM family D Sph21_1603 protein of unknown function DUF21 K03699 tlyC; magnesium and cobalt exporter, CNNM family D Sph21_0662 phospholipase C, phosphocholine-specific K01114 plc; phospholipase C [EC:3.1.4.3] D Sph21_1769 phospholipase C, phosphocholine-specific K01114 plc; phospholipase C [EC:3.1.4.3] C 02022 Two-component system [BR:shg02022] D Sph21_1333 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_1369 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_3420 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_2053 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_4070 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_4737 PAS/PAC sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] D Sph21_4716 response regulator receiver protein K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB D Sph21_3108 two component transcriptional regulator, winged helix family K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP D Sph21_5193 two component transcriptional regulator, winged helix family K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP D Sph21_1570 two component transcriptional regulator, winged helix family K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP D Sph21_4258 Osmosensitive K channel His kinase sensor K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] D Sph21_5130 PAS/PAC sensor signal transduction histidine kinase K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] D Sph21_1638 two component transcriptional regulator, winged helix family K02483 K02483; two-component system, OmpR family, response regulator D Sph21_4471 response regulator receiver protein K02483 K02483; two-component system, OmpR family, response regulator D Sph21_4504 response regulator receiver sensor signal transduction histidine kinase K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3] D Sph21_4123 two component transcriptional regulator, LuxR family K20264 fusR; two-component system, NarL family, response regulator FusR D Sph21_4207 two component transcriptional regulator, LuxR family K20264 fusR; two-component system, NarL family, response regulator FusR D Sph21_2076 integral membrane sensor signal transduction histidine kinase K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3] D Sph21_4952 response regulator receiver protein K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB D Sph21_2093 two component transcriptional regulator, LuxR family K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY D Sph21_3744 two component transcriptional regulator, LuxR family K07692 degU; two-component system, NarL family, response regulator DegU D Sph21_3206 two component transcriptional regulator, LuxR family K07696 nreC; two-component system, NarL family, response regulator NreC D Sph21_0719 histidine kinase K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3] D Sph21_3722 PAS/PAC sensor signal transduction histidine kinase K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3] D Sph21_4122 histidine kinase K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3] D Sph21_4526 histidine kinase K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3] D Sph21_0854 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_0695 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_0874 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_3408 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_2387 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_2097 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4046 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4225 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4375 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4814 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4478 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4640 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_4744 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3] D Sph21_2386 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_0653 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_2098 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_0130 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_0873 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_0967 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_4045 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_4376 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_4745 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_0258 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_0855 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_0694 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_3409 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_1859 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_3208 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_4224 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_4477 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_4641 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator D Sph21_3147 two component, sigma54 specific, transcriptional regulator, Fis family K07713 zraR; two-component system, NtrC family, response regulator HydG D Sph21_1172 two component, sigma54 specific, transcriptional regulator, Fis family K07713 zraR; two-component system, NtrC family, response regulator HydG D Sph21_4259 multi-sensor signal transduction histidine kinase K11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3] D Sph21_2257 integral membrane sensor signal transduction histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3] D Sph21_2045 multi-sensor signal transduction multi-kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3] D Sph21_4268 two component, sigma54 specific, transcriptional regulator, Fis family K02481 flgR; two-component system, NtrC family, response regulator D Sph21_2923 CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] D Sph21_2096 CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] D Sph21_2156 signal transduction histidine kinase with CheB and CheR activity K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61] D Sph21_2157 putative PAS/PAC sensor protein K11354 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3] D Sph21_3521 PAS/PAC sensor signal transduction histidine kinase K14986 fixL; two-component system, LuxR family, sensor kinase FixL [EC:2.7.13.3] D Sph21_1936 signal transduction histidine kinase K00936 pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3] D Sph21_1935 two component transcriptional regulator, LytTR family K22010 pdtaR; two-component system, response regulator PdtaR D Sph21_2355 Diverse 7TM receptor transmembrane region K20971 ladS; two-component system, sensor histidine kinase LadS D Sph21_1112 response regulator receiver sensor signal transduction histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] D Sph21_2041 response regulator receiver sensor signal transduction histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3] C 02035 Bacterial motility proteins [BR:shg02035] D Sph21_1115 MCP methyltransferase, CheR-type K00575 cheR; chemotaxis protein methyltransferase CheR [EC:2.1.1.80] D Sph21_2923 CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] D Sph21_2096 CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] D Sph21_2156 signal transduction histidine kinase with CheB and CheR activity K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61] D Sph21_2444 OmpA/MotB domain protein K02557 motB; chemotaxis protein MotB D Sph21_1565 OmpA/MotB domain protein K02557 motB; chemotaxis protein MotB C 03037 Cilium and associated proteins C 04812 Cytoskeleton proteins [BR:shg04812] D Sph21_2379 cell shape determining protein, MreB/Mrl family K03569 mreB; rod shape-determining protein MreB and related proteins D Sph21_0052 cell division protein FtsZ K03531 ftsZ; cell division protein FtsZ D Sph21_0053 cell division protein FtsA K03590 ftsA; cell division protein FtsA D Sph21_0428 Cobyrinic acid ac-diamide synthase K03496 parA; chromosome partitioning protein D Sph21_0427 parB-like partition protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein C 04147 Exosome [BR:shg04147] D Sph21_3254 Heat shock protein Hsp90 K04079 HSP90A; molecular chaperone HtpG D Sph21_2810 HSP90 family protein K04079 HSP90A; molecular chaperone HtpG D Sph21_0335 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D Sph21_3255 Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D Sph21_5090 glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D Sph21_3892 glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D Sph21_0067 glyceraldehyde-3-phosphate dehydrogenase, type I K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D Sph21_0066 Phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3] D Sph21_1354 pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] D Sph21_2875 peptidase M19 renal dipeptidase K01273 DPEP; membrane dipeptidase [EC:3.4.13.19] D Sph21_1081 Membrane dipeptidase K01273 DPEP; membrane dipeptidase [EC:3.4.13.19] D Sph21_1481 Peroxiredoxin K03386 PRDX2_4; peroxiredoxin 2/4 [EC:1.11.1.24] D Sph21_0753 60 kDa chaperonin K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D Sph21_1745 Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK D Sph21_0676 Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D Sph21_2473 Dipeptidyl-peptidase IV K01278 DPP4; dipeptidyl-peptidase 4 [EC:3.4.14.5] D Sph21_0993 Dipeptidyl-peptidase IV K01278 DPP4; dipeptidyl-peptidase 4 [EC:3.4.14.5] D Sph21_1253 Gluconolactonase K01053 gnl; gluconolactonase [EC:3.1.1.17] D Sph21_4037 SMP-30/Gluconolaconase/LRE-like region-containing protein K01053 gnl; gluconolactonase [EC:3.1.1.17] D Sph21_3644 inosine-5'-monophosphate dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205] D Sph21_2399 translation elongation factor Tu K02358 tuf; elongation factor Tu D Sph21_1572 histidine triad (HIT) protein K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-] D Sph21_0025 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D Sph21_3308 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D Sph21_2475 acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D Sph21_1238 Adenosylhomocysteinase K01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1] D Sph21_0074 Adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3] D Sph21_2249 Adenine phosphoribosyltransferase K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7] D Sph21_1042 Argininosuccinate lyase K01755 argH; argininosuccinate lyase [EC:4.3.2.1] D Sph21_1034 argininosuccinate synthase K01940 argG; argininosuccinate synthase [EC:6.3.4.5] D Sph21_4650 Cystathionine gamma-lyase K01758 CTH; cystathionine gamma-lyase [EC:4.4.1.1] D Sph21_3143 Fructose-1,6-bisphosphatase class 1 K03841 FBP; fructose-1,6-bisphosphatase I [EC:3.1.3.11] D Sph21_3374 Alpha-L-fucosidase K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_4700 Alpha-L-fucosidase K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_2860 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_2863 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_2166 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_2056 coagulation factor 5/8 type domain protein K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_0657 Alpha-L-fucosidase K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_3373 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_1768 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_4801 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_0603 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_0729 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_2868 glycoside hydrolase family 29 (alpha-L-fucosidase) K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] D Sph21_1349 Galactokinase K00849 galK; galactokinase [EC:2.7.1.6] D Sph21_2180 1,4-alpha-glucan-branching enzyme K00700 GBE1; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18] D Sph21_5139 1,4-alpha-glucan-branching enzyme K00700 GBE1; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18] D Sph21_2623 Glycerol kinase K00864 glpK; glycerol kinase [EC:2.7.1.30] D Sph21_2908 Glycerol kinase K00864 glpK; glycerol kinase [EC:2.7.1.30] D Sph21_0666 Glutamate--ammonia ligase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D Sph21_3985 Glutamate--ammonia ligase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D Sph21_5196 Porphobilinogen synthase K01698 hemB; porphobilinogen synthase [EC:4.2.1.24] D Sph21_2825 transcriptional coactivator/pterin dehydratase K01724 PCBD; 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96] D Sph21_2898 Alkaline phosphatase K01077 E3.1.3.1; alkaline phosphatase [EC:3.1.3.1] D Sph21_0968 Alkaline phosphatase K01077 E3.1.3.1; alkaline phosphatase [EC:3.1.3.1] D Sph21_0005 Phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_0434 Phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_0741 amino acid-binding ACT domain protein K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_3091 Phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] D Sph21_2382 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] D Sph21_1690 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_3439 dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D Sph21_3060 Electron transfer flavoprotein alpha subunit K03522 fixB; electron transfer flavoprotein alpha subunit D Sph21_2983 Glutamate dehydrogenase (NAD(P)(+)) K00261 GLUD1_2; glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3] D Sph21_4277 glucose-6-phosphate 1-dehydrogenase K00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363] D Sph21_3045 triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] C 02048 Prokaryotic defense system [BR:shg02048] D Sph21_3497 C-5 cytosine-specific DNA methylase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D Sph21_0901 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D Sph21_0585 Domain of unknown function DUF1813 HSP20-like protein K19048 symE; toxic protein SymE D Sph21_2679 addiction module toxin, Txe/YoeB family K19158 yoeB; toxin YoeB [EC:3.1.-.-] D Sph21_2544 hypothetical protein K03973 pspC; phage shock protein C D Sph21_1670 phage shock protein C, PspC K03973 pspC; phage shock protein C D Sph21_0442 transcriptional regulator, XRE family K18831 higA; HTH-type transcriptional regulator / antitoxin HigA D Sph21_4405 PilT protein domain protein K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-] D Sph21_1840 PilT protein domain protein K18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-] D Sph21_0052 cell division protein FtsZ K03531 ftsZ; cell division protein FtsZ D Sph21_2379 cell shape determining protein, MreB/Mrl family K03569 mreB; rod shape-determining protein MreB and related proteins D Sph21_1654 DNA topoisomerase (ATP-hydrolyzing) K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] D Sph21_1645 DNA topoisomerase type IIA subunit B region 2 domain protein K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] D Sph21_1436 glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17] D Sph21_3741 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D Sph21_3019 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D Sph21_3997 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] C 04030 G protein-coupled receptors C 04050 Cytokine receptors C 04054 Pattern recognition receptors C 03310 Nuclear receptors C 04040 Ion channels [BR:shg04040] C 04031 GTP-binding proteins C 04052 Cytokines and neuropeptides C 04515 Cell adhesion molecules C 04090 CD molecules [BR:shg04090] D Sph21_2473 Dipeptidyl-peptidase IV K01278 DPP4; dipeptidyl-peptidase 4 [EC:3.4.14.5] D Sph21_0993 Dipeptidyl-peptidase IV K01278 DPP4; dipeptidyl-peptidase 4 [EC:3.4.14.5] C 01504 Antimicrobial resistance genes [BR:shg01504] D Sph21_2136 GCN5-related N-acetyltransferase K03395 aac3-I; aminoglycoside 3-N-acetyltransferase I [EC:2.3.1.60] D Sph21_3199 adenylyltransferase K05593 aadK; aminoglycoside 6-adenylyltransferase [EC:2.7.7.-] D Sph21_0362 major facilitator superfamily MFS_1 K08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein D Sph21_4553 major facilitator superfamily MFS_1 K08217 mef; MFS transporter, DHA3 family, macrolide efflux protein D Sph21_1822 hypothetical protein K18234 vat; virginiamycin A acetyltransferase [EC:2.3.1.-] D Sph21_4488 chloramphenicol acetyltransferase K19271 catA; chloramphenicol O-acetyltransferase type A [EC:2.3.1.28] D Sph21_3786 Chloramphenicol O-acetyltransferase K19271 catA; chloramphenicol O-acetyltransferase type A [EC:2.3.1.28] D Sph21_1235 peptidase M56 BlaR1 K02172 blaR1; bla regulator protein blaR1 D Sph21_1402 TonB family protein K02172 blaR1; bla regulator protein blaR1 D Sph21_3629 peptidase M56 BlaR1 K02172 blaR1; bla regulator protein blaR1 D Sph21_1401 transcriptional repressor, CopY family K02171 blaI; BlaI family transcriptional regulator, penicillinase repressor D Sph21_3628 transcriptional repressor, CopY family K02171 blaI; BlaI family transcriptional regulator, penicillinase repressor D Sph21_1236 transcriptional repressor, CopY family K02171 blaI; BlaI family transcriptional regulator, penicillinase repressor D Sph21_4054 Lysylphosphatidylglycerol synthetase/UPF0104 K14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3] D Sph21_2597 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_3635 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1124 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1486 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_0028 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_1696 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_4059 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_4898 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system D Sph21_0029 acriflavin resistance protein K18138 acrB; multidrug efflux pump D Sph21_0423 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_2826 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_2599 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_1488 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_4896 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system D Sph21_3416 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1232 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4138 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_3601 putative outer membrane protein K12340 tolC; outer membrane protein D Sph21_0030 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_0888 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1674 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1758 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4864 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4635 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_4057 outer membrane efflux protein K12340 tolC; outer membrane protein D Sph21_1697 outer membrane efflux protein K12340 tolC; outer membrane protein C 00535 Proteoglycans C 00536 Glycosaminoglycan binding proteins C 00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:shg00537] D Sph21_2898 Alkaline phosphatase K01077 E3.1.3.1; alkaline phosphatase [EC:3.1.3.1] D Sph21_0968 Alkaline phosphatase K01077 E3.1.3.1; alkaline phosphatase [EC:3.1.3.1] D Sph21_1252 Alpha,alpha-trehalase K01194 TREH; alpha,alpha-trehalase [EC:3.2.1.28] D Sph21_2875 peptidase M19 renal dipeptidase K01273 DPEP; membrane dipeptidase [EC:3.4.13.19] D Sph21_1081 Membrane dipeptidase K01273 DPEP; membrane dipeptidase [EC:3.4.13.19] C 04091 Lectins C 04990 Domain-containing proteins not elsewhere classified B B 09185 Viral protein families C 03200 Viral proteins C 03210 Viral fusion proteins B B 09184 RNA family C 03100 Non-coding RNAs [BR:shg03100] D Sph21_R0023 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D Sph21_R0036 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D Sph21_R0066 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D Sph21_R0003 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D Sph21_R0044 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D Sph21_R0020 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D Sph21_R0049 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D Sph21_R0021 tRNA-Asn K14220 tRNA-Asn; tRNA Asn D Sph21_R0018 tRNA-Asp K14221 tRNA-Asp; tRNA Asp D Sph21_R0019 tRNA-Asp K14221 tRNA-Asp; tRNA Asp D Sph21_R0046 tRNA-Cys K14222 tRNA-Cys; tRNA Cys D Sph21_R0062 tRNA-Cys K14222 tRNA-Cys; tRNA Cys D Sph21_R0022 tRNA-Cys K14222 tRNA-Cys; tRNA Cys D Sph21_R0058 tRNA-Cys K14222 tRNA-Cys; tRNA Cys D Sph21_R0063 tRNA-Gln K14223 tRNA-Gln; tRNA Gln D Sph21_R0004 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D Sph21_R0005 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D Sph21_R0060 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D Sph21_R0055 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D Sph21_R0028 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D Sph21_R0033 tRNA-His K14226 tRNA-His; tRNA His D Sph21_R0008 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D Sph21_R0014 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D Sph21_R0035 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D Sph21_R0067 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D Sph21_R0041 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D Sph21_R0061 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D Sph21_R0040 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D Sph21_R0054 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D Sph21_R0053 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D Sph21_R0051 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D Sph21_R0052 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D Sph21_R0050 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D Sph21_R0024 tRNA-Met K14230 tRNA-Met; tRNA Met D Sph21_R0011 tRNA-Met K14230 tRNA-Met; tRNA Met D Sph21_R0010 tRNA-Met K14230 tRNA-Met; tRNA Met D Sph21_R0025 tRNA-Phe K14231 tRNA-Phe; tRNA Phe D Sph21_R0017 tRNA-Pro K14232 tRNA-Pro; tRNA Pro D Sph21_R0016 tRNA-Pro K14232 tRNA-Pro; tRNA Pro D Sph21_R0057 tRNA-Pro K14232 tRNA-Pro; tRNA Pro D Sph21_R0059 tRNA-Pro K14232 tRNA-Pro; tRNA Pro D Sph21_R0056 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D Sph21_R0043 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D Sph21_R0039 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D Sph21_R0031 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D Sph21_R0029 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D Sph21_R0026 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D Sph21_R0042 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D Sph21_R0030 tRNA-Trp K14235 tRNA-Trp; tRNA Trp D Sph21_R0027 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr D Sph21_R0002 tRNA-Val K14237 tRNA-Val; tRNA Val D Sph21_R0001 tRNA-Val K14237 tRNA-Val; tRNA Val D Sph21_R0032 tRNA-Val K14237 tRNA-Val; tRNA Val D Sph21_R0009 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D Sph21_R0034 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D Sph21_R0068 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D Sph21_R0015 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D Sph21_R0013 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D Sph21_R0065 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D Sph21_R0037 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D Sph21_R0007 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D Sph21_R0006 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D Sph21_R0064 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D Sph21_R0012 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D Sph21_R0038 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D Sph21_R0045 ffs; SRP RNA; RNA component of signal recognition particle K01983 ffs; SRP RNA D Sph21_R0048 rnpB; RNA component of RNaseP K01978 rnpB; M1 RNA D Sph21_R0047 ssrA; tmRNA as predicted by Rfam (RF00023), score 128.59 K15035 ssrA; transfer-messenger RNA # A09190 Not Included in Pathway or Brite B B 09191 Unclassified: metabolism C 99980 Enzymes with EC numbers D Sph21_0127 Methylglyoxal reductase (NADPH-dependent) K06221 dkgA; 2,5-diketo-D-gluconate reductase A [EC:1.1.1.346] D Sph21_0981 4-hydroxythreonine-4-phosphate dehydrogenase K22024 pdxA2; 4-phospho-D-threonate 3-dehydrogenase / 4-phospho-D-erythronate 3-dehydrogenase [EC:1.1.1.408 1.1.1.409] D Sph21_3423 NADP-dependent oxidoreductase domain K19265 gpr; L-glyceraldehyde 3-phosphate reductase [EC:1.1.1.-] D Sph21_3642 glucose-methanol-choline oxidoreductase K26059 gtd1; glucoside 3-dehydrogenase (cytochrome c) catalytic subunit [EC:1.1.2.11] D Sph21_0176 glucose-methanol-choline oxidoreductase K26059 gtd1; glucoside 3-dehydrogenase (cytochrome c) catalytic subunit [EC:1.1.2.11] D Sph21_4576 glucose sorbosone dehydrogenase K21430 yliI; aldose sugar dehydrogenase [EC:1.1.5.-] D Sph21_2849 Quinoprotein glucose dehydrogenase K21430 yliI; aldose sugar dehydrogenase [EC:1.1.5.-] D Sph21_3823 F420-dependent oxidoreductase, G6PDH family K15510 fgd1; coenzyme F420-dependent glucose-6-phosphate dehydrogenase [EC:1.1.98.2] D Sph21_1047 short-chain dehydrogenase/reductase SDR K11166 DHRS7B; dehydrogenase/reductase SDR family member 7B [EC:1.1.-.-] D Sph21_4281 Isoquinoline 1-oxidoreductase K07302 iorA; isoquinoline 1-oxidoreductase subunit alpha [EC:1.3.99.16] D Sph21_0135 Isoquinoline 1-oxidoreductase K07302 iorA; isoquinoline 1-oxidoreductase subunit alpha [EC:1.3.99.16] D Sph21_4754 Isoquinoline 1-oxidoreductase K07302 iorA; isoquinoline 1-oxidoreductase subunit alpha [EC:1.3.99.16] D Sph21_4282 Aldehyde dehydrogenase (pyrroloquinoline-quinone) K07303 iorB; isoquinoline 1-oxidoreductase subunit beta [EC:1.3.99.16] D Sph21_0134 Aldehyde dehydrogenase (pyrroloquinoline-quinone) K07303 iorB; isoquinoline 1-oxidoreductase subunit beta [EC:1.3.99.16] D Sph21_4756 Isoquinoline 1-oxidoreductase K07303 iorB; isoquinoline 1-oxidoreductase subunit beta [EC:1.3.99.16] D Sph21_0187 NADP oxidoreductase coenzyme F420-dependent K06988 fno; 8-hydroxy-5-deazaflavin:NADPH oxidoreductase [EC:1.5.1.40] D Sph21_3554 NAD(P)H quinone oxidoreductase, PIG3 family K00344 qor; NADPH:quinone reductase [EC:1.6.5.5] D Sph21_4155 zinc-binding alcohol dehydrogenase family protein K00344 qor; NADPH:quinone reductase [EC:1.6.5.5] D Sph21_2665 NAD(P)H dehydrogenase (quinone) K03923 mdaB; NADPH dehydrogenase (quinone) [EC:1.6.5.10] D Sph21_2625 FMN-dependent NADH-azoreductase K01118 acpD; FMN-dependent NADH-azoreductase [EC:1.7.1.17] D Sph21_4746 FMN-dependent NADH-azoreductase K01118 acpD; FMN-dependent NADH-azoreductase [EC:1.7.1.17] D Sph21_4866 FMN-dependent NADH-azoreductase K01118 acpD; FMN-dependent NADH-azoreductase [EC:1.7.1.17] D Sph21_4316 FMN-dependent NADH-azoreductase K01118 acpD; FMN-dependent NADH-azoreductase [EC:1.7.1.17] D Sph21_3181 FAD-dependent pyridine nucleotide-disulfide oxidoreductase K26960 bdr; bacillithiol disulfide reductase [EC:1.8.1.-] D Sph21_2152 cytochrome c class I K19713 tsdA; thiosulfate dehydrogenase [EC:1.8.2.2] D Sph21_1064 Peptide methionine sulfoxide reductase msrA K07304 msrA; peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11] D Sph21_1655 Peptide methionine sulfoxide reductase msrA K07304 msrA; peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11] D Sph21_2419 methionine-R-sulfoxide reductase K07305 msrB; peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12] D Sph21_5042 Cytochrome-c peroxidase K00428 E1.11.1.5; cytochrome c peroxidase [EC:1.11.1.5] D Sph21_2189 Catalase K07217 ydbD; manganese catalase [EC:1.11.1.6] D Sph21_4992 Chloride peroxidase K00433 cpo; non-heme chloroperoxidase [EC:1.11.1.10] D Sph21_5248 Chloride peroxidase K00433 cpo; non-heme chloroperoxidase [EC:1.11.1.10] D Sph21_3914 Peroxiredoxin K03564 BCP; thioredoxin-dependent peroxiredoxin [EC:1.11.1.24] D Sph21_4522 thiol peroxidase K11065 tpx; thioredoxin-dependent peroxiredoxin [EC:1.11.1.24] D Sph21_3871 Peroxidase K24158 prx; thioredoxin-dependent peroxiredoxin [EC:1.11.1.24] D Sph21_1843 peroxiredoxin, OsmC subfamily K04063 osmC; lipoyl-dependent peroxiredoxin [EC:1.11.1.28] D Sph21_0383 peroxiredoxin, OsmC subfamily K04063 osmC; lipoyl-dependent peroxiredoxin [EC:1.11.1.28] D Sph21_4065 peroxiredoxin, OsmC subfamily K04063 osmC; lipoyl-dependent peroxiredoxin [EC:1.11.1.28] D Sph21_0298 Pirin domain protein K06911 PIR; quercetin 2,3-dioxygenase [EC:1.13.11.24] D Sph21_2612 Pirin domain protein K06911 PIR; quercetin 2,3-dioxygenase [EC:1.13.11.24] D Sph21_2512 Nitric oxide dioxygenase K05916 hmp; nitric oxide dioxygenase [EC:1.14.12.17] D Sph21_3029 fatty acid hydroxylase K19703 FA2H; 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase [EC:1.14.18.6] D Sph21_4486 fatty acid desaturase K23054 desC; sn-1 stearoyl-lipid 9-desaturase [EC:1.14.19.28] D Sph21_2220 Ferritin Dps family protein K02217 ftnA; ferritin [EC:1.16.3.2] D Sph21_0232 protein tyrosine phosphatase K03741 arsC; arsenate reductase (thioredoxin) [EC:1.20.4.4] D Sph21_4779 protein tyrosine phosphatase K03741 arsC; arsenate reductase (thioredoxin) [EC:1.20.4.4] D Sph21_4351 short-chain dehydrogenase/reductase SDR K14189 dltE; uncharacterized oxidoreductase [EC:1.-.-.-] D Sph21_0320 Protein-L-isoaspartate O-methyltransferase K00573 E2.1.1.77; protein-L-isoaspartate(D-aspartate) O-methyltransferase [EC:2.1.1.77] D Sph21_1489 Protein-L-isoaspartate O-methyltransferase K00573 E2.1.1.77; protein-L-isoaspartate(D-aspartate) O-methyltransferase [EC:2.1.1.77] D Sph21_3687 Cyclopropane-fatty-acyl-phospholipid synthase K00574 cfa; cyclopropane-fatty-acyl-phospholipid synthase [EC:2.1.1.79] D Sph21_4519 Trans-aconitate 2-methyltransferase K00598 tam; trans-aconitate 2-methyltransferase [EC:2.1.1.144] D Sph21_1038 N-acetylornithine carbamoyltransferase K13043 argF; N-succinyl-L-ornithine transcarbamylase [EC:2.1.3.11] D Sph21_3825 Carbamoyltransferase K00612 nodU; carbamoyltransferase [EC:2.1.3.-] D Sph21_2821 GCN5-related N-acetyltransferase K22441 paiA; diamine N-acetyltransferase [EC:2.3.1.57] D Sph21_4751 GCN5-related N-acetyltransferase K22441 paiA; diamine N-acetyltransferase [EC:2.3.1.57] D Sph21_4060 Arylamine N-acetyltransferase K00675 nhoA; N-hydroxyarylamine O-acetyltransferase [EC:2.3.1.118] D Sph21_5223 Apolipoprotein N-acyltransferase K03820 lnt; apolipoprotein N-acyltransferase [EC:2.3.1.269] D Sph21_3395 GCN5-related N-acetyltransferase K03827 yjaB; putative acetyltransferase [EC:2.3.1.-] D Sph21_0544 GCN5-related N-acetyltransferase K03828 yjgM; putative acetyltransferase [EC:2.3.1.-] D Sph21_0668 glutamine cyclotransferase K22757 QCT; glutaminyl-peptide cyclotransferase [EC:2.3.2.5] D Sph21_1161 leucyl/phenylalanyl-tRNA/protein transferase K00684 aat; leucyl/phenylalanyl-tRNA---protein transferase [EC:2.3.2.6] D Sph21_2601 HAD-superfamily hydrolase, subfamily IIB K03692 E2.4.1.213; glucosylglycerol-phosphate synthase [EC:2.4.1.213] D Sph21_0930 glycosidase related protein K16212 mgp; 4-O-beta-D-mannosyl-D-glucose phosphorylase [EC:2.4.1.281] D Sph21_5081 Glycosyl hydrolase family 32 domain protein K20885 K20885; beta-1,2-mannobiose phosphorylase / 1,2-beta-oligomannan phosphorylase [EC:2.4.1.339 2.4.1.340] D Sph21_1613 glycosyl transferase group 1 K00754 bshA; L-malate glycosyltransferase [EC:2.4.1.-] D Sph21_1827 glycosyl transferase group 1 K00754 bshA; L-malate glycosyltransferase [EC:2.4.1.-] D Sph21_3937 glycosyl transferase group 1 K00754 bshA; L-malate glycosyltransferase [EC:2.4.1.-] D Sph21_1547 deoxyhypusine synthase K00809 DHPS; deoxyhypusine synthase [EC:2.5.1.46] D Sph21_3624 prolipoprotein diacylglyceryl transferase K13292 lgt; phosphatidylglycerol---prolipoprotein diacylglyceryl transferase [EC:2.5.1.145] D Sph21_3095 Prolipoprotein diacylglyceryl transferase K13292 lgt; phosphatidylglycerol---prolipoprotein diacylglyceryl transferase [EC:2.5.1.145] D Sph21_3453 ApbE family lipoprotein K03734 apbE; FAD:protein FMN transferase [EC:2.7.1.180] D Sph21_0980 hypothetical protein K22129 dtnK; D-threonate/D-erythronate kinase [EC:2.7.1.219 2.7.1.220] D Sph21_2162 type III effector Hrp-dependent outer domain protein K23247 oiaK; 3-oxoisoapionate kinase [EC:2.7.1.231] D Sph21_3225 RNA-directed DNA polymerase (Reverse transcriptase) K00986 ltrA; RNA-directed DNA polymerase [EC:2.7.7.49] D Sph21_1233 Conserved hypothetical protein CHP00159 K18672 dacA; diadenylate cyclase [EC:2.7.7.85] D Sph21_2340 Formyl-CoA transferase K18702 uctC; CoA:oxalate CoA-transferase [EC:2.8.3.19] D Sph21_2341 Formyl-CoA transferase K18702 uctC; CoA:oxalate CoA-transferase [EC:2.8.3.19] D Sph21_4286 Sialate O-acetylesterase K05970 SIAE; sialate O-acetylesterase [EC:3.1.1.53] D Sph21_2348 Sialate O-acetylesterase K05970 SIAE; sialate O-acetylesterase [EC:3.1.1.53] D Sph21_2657 protein of unknown function DUF303 acetylesterase K05970 SIAE; sialate O-acetylesterase [EC:3.1.1.53] D Sph21_0469 lipolytic protein G-D-S-L family K15530 RGAE; rhamnogalacturonan acetylesterase [EC:3.1.1.86] D Sph21_5022 Appr-1-p processing domain protein K23518 MACROD; O-acetyl-ADP-ribose deacetylase [EC:3.1.1.106] D Sph21_0445 glycoside hydrolase family 2 sugar binding protein K25010 GE; (4-O-methyl)-D-glucuronate---lignin esterase [EC:3.1.1.117] D Sph21_2346 glycoside hydrolase family 2 sugar binding protein K25010 GE; (4-O-methyl)-D-glucuronate---lignin esterase [EC:3.1.1.117] D Sph21_4324 Carboxylesterase type B K03929 pnbA; para-nitrobenzyl esterase [EC:3.1.1.-] D Sph21_0122 Carboxylesterase K03929 pnbA; para-nitrobenzyl esterase [EC:3.1.1.-] D Sph21_0202 Carboxylesterase type B K03929 pnbA; para-nitrobenzyl esterase [EC:3.1.1.-] D Sph21_3071 4-hydroxybenzoyl-CoA thioesterase K07107 ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-] D Sph21_0003 thioesterase superfamily protein K07107 ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-] D Sph21_4856 hypothetical protein K07107 ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-] D Sph21_4549 thioesterase-like protein K07107 ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-] D Sph21_1835 capsular polysaccharide biosynthesis protein K01104 E3.1.3.48; protein-tyrosine phosphatase [EC:3.1.3.48] D Sph21_2000 capsular polysaccharide biosynthesis protein K01104 E3.1.3.48; protein-tyrosine phosphatase [EC:3.1.3.48] D Sph21_4026 putative phosphohistidine phosphatase, SixA K08296 sixA; phosphohistidine phosphatase [EC:3.1.3.-] D Sph21_2478 7TM receptor with intracellular metal dependent phosphohydrolase K07037 pgpH; cyclic-di-AMP phosphodiesterase PgpH [EC:3.1.4.-] D Sph21_3658 TatD-related deoxyribonuclease K03424 tatD; TatD DNase family protein [EC:3.1.21.-] D Sph21_1244 hydrolase, TatD family K03424 tatD; TatD DNase family protein [EC:3.1.21.-] D Sph21_4279 nuclease (SNase domain-containing protein) K01174 nuc; micrococcal nuclease [EC:3.1.31.1] D Sph21_2656 Endo-1,4-beta-xylanase K01181 E3.2.1.8; endo-1,4-beta-xylanase [EC:3.2.1.8] D Sph21_0594 glycoside hydrolase family 43 K06113 abnA; arabinan endo-1,5-alpha-L-arabinosidase [EC:3.2.1.99] D Sph21_0593 glycoside hydrolase family 43 K06113 abnA; arabinan endo-1,5-alpha-L-arabinosidase [EC:3.2.1.99] D Sph21_1452 Mannosylglycoprotein endo-beta-mannosidase K18577 EBM; mannosylglycoprotein endo-beta-mannosidase [EC:3.2.1.152] D Sph21_2891 glycosyl hydrolase family 88 K15532 yteR; unsaturated rhamnogalacturonyl hydrolase [EC:3.2.1.172] D Sph21_0495 glycosyl hydrolase family 88 K15532 yteR; unsaturated rhamnogalacturonyl hydrolase [EC:3.2.1.172] D Sph21_0796 glycosyl hydrolase family 88 K15532 yteR; unsaturated rhamnogalacturonyl hydrolase [EC:3.2.1.172] D Sph21_0942 glycosyl hydrolase family 88 K15532 yteR; unsaturated rhamnogalacturonyl hydrolase [EC:3.2.1.172] D Sph21_3924 glycoside hydrolase family 31 K01811 xylS; alpha-D-xyloside xylohydrolase [EC:3.2.1.177] D Sph21_0725 glycosyl hydrolase family 88 K18581 ugl; unsaturated chondroitin disaccharide hydrolase [EC:3.2.1.180] D Sph21_0730 glycosyl hydrolase family 88 K18581 ugl; unsaturated chondroitin disaccharide hydrolase [EC:3.2.1.180] D Sph21_2869 glycosyl hydrolase family 88 K18581 ugl; unsaturated chondroitin disaccharide hydrolase [EC:3.2.1.180] D Sph21_2781 glycosyl hydrolase family 88 K18581 ugl; unsaturated chondroitin disaccharide hydrolase [EC:3.2.1.180] D Sph21_4419 glycosyl hydrolase family 88 K18581 ugl; unsaturated chondroitin disaccharide hydrolase [EC:3.2.1.180] D Sph21_4699 glycosyl hydrolase family 88 K18581 ugl; unsaturated chondroitin disaccharide hydrolase [EC:3.2.1.180] D Sph21_0797 glycoside hydrolase family 16 K20832 EN3GAL; galactan endo-beta-1,3-galactanase [EC:3.2.1.181] D Sph21_4796 glycosidase related protein K21065 E3.2.1.197; beta-1,2-mannosidase [EC:3.2.1.197] D Sph21_0614 hypothetical protein K27494 exoMA1; D-arabinan exo alpha-(1,3)/(1,5)-arabinofuranosidase (non-reducing end) [EC:3.2.1.225] D Sph21_0771 N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD K01447 xlyAB; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] D Sph21_1256 Peptide deformylase K01462 PDF; peptide deformylase [EC:3.5.1.88] D Sph21_1163 Peptide deformylase K01462 PDF; peptide deformylase [EC:3.5.1.88] D Sph21_4139 polysaccharide deacetylase K22278 pgdA; peptidoglycan-N-acetylglucosamine deacetylase [EC:3.5.1.104] D Sph21_2998 LmbE family protein K01463 bshB1; N-acetylglucosamine malate deacetylase 1 [EC:3.5.1.-] D Sph21_1157 endoribonuclease L-PSP K09022 ridA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10] D Sph21_0834 Endoribonuclease L-PSP K09022 ridA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10] D Sph21_2959 Endoribonuclease L-PSP K09022 ridA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10] D Sph21_4229 Endoribonuclease L-PSP K09022 ridA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10] D Sph21_2107 nucleoside diphosphate pyrophosphatase K12945 nudK; GDP-mannose pyrophosphatase NudK [EC:3.6.1.-] D Sph21_0712 ATPase associated with various cellular activities AAA_3 K03924 moxR; MoxR-like ATPase [EC:3.6.3.-] D Sph21_2161 Ribulose-bisphosphate carboxylase K01559 oiaT; 3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase [EC:3.7.1.28] D Sph21_5264 YjeF-related protein K23997 nnr; ADP-dependent NAD(P)H-hydrate dehydratase / NAD(P)H-hydrate epimerase [EC:4.2.1.136 5.1.99.6] D Sph21_0932 N-acylglucosamine 2-epimerase K16213 cbe; cellobiose epimerase [EC:5.1.3.11] D Sph21_4585 Kelch repeat type 1-containing protein K17948 nanM; N-acetylneuraminate epimerase [EC:5.1.3.24] D Sph21_0467 L-rhamnose 1-epimerase K03534 rhaM; L-rhamnose mutarotase [EC:5.1.3.32] D Sph21_0623 protein of unknown function DUF718 K03534 rhaM; L-rhamnose mutarotase [EC:5.1.3.32] D Sph21_3047 UDP-N-acetylmuramate--L-alanine ligase K02558 mpl; UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase [EC:6.3.2.45] D Sph21_0281 copper-translocating P-type ATPase K01533 copB; P-type Cu2+ transporter [EC:7.2.2.9] D Sph21_0283 heavy metal translocating P-type ATPase K01533 copB; P-type Cu2+ transporter [EC:7.2.2.9] D Sph21_4251 copper-translocating P-type ATPase K01533 copB; P-type Cu2+ transporter [EC:7.2.2.9] D Sph21_3663 heavy metal translocating P-type ATPase K01534 zntA; Zn2+/Cd2+-exporting ATPase [EC:7.2.2.12 7.2.2.21] D Sph21_0227 heavy metal translocating P-type ATPase K01534 zntA; Zn2+/Cd2+-exporting ATPase [EC:7.2.2.12 7.2.2.21] C 99981 Carbohydrate metabolism D Sph21_5205 CBS domain containing protein K04767 acuB; acetoin utilization protein AcuB D Sph21_0660 protein of unknown function DUF224 cysteine-rich region domain protein K18928 lldE; L-lactate dehydrogenase complex protein LldE D Sph21_2943 protein of unknown function DUF224 cysteine-rich region domain protein K18928 lldE; L-lactate dehydrogenase complex protein LldE D Sph21_0017 Lactate utilization protein B/C K18929 lldF; L-lactate dehydrogenase complex protein LldF D Sph21_0659 Lactate utilization protein B/C K18929 lldF; L-lactate dehydrogenase complex protein LldF D Sph21_1056 Lactate utilization protein B/C K00782 lldG; L-lactate dehydrogenase complex protein LldG D Sph21_0658 Lactate utilization protein B/C K00782 lldG; L-lactate dehydrogenase complex protein LldG D Sph21_5187 UPF0747 protein K22136 bshC; bacillithiol synthase D Sph21_3640 twin-arginine translocation pathway signal K26060 gtd2; glucoside 3-dehydrogenase (cytochrome c) hitch-hiker subunit C 99982 Energy metabolism D Sph21_1065 NADPH:quinone reductase K13955 yogA; zinc-binding alcohol dehydrogenase/oxidoreductase D Sph21_3061 Electron transfer flavoprotein alpha/beta-subunit K03521 fixA; electron transfer flavoprotein beta subunit D Sph21_3248 protein of unknown function DUF1458 K09165 K09165; dodecin C 99983 Lipid metabolism C 99984 Nucleotide metabolism D Sph21_2912 NrdI protein K03647 nrdI; protein involved in ribonucleotide reduction C 99985 Amino acid metabolism D Sph21_0779 Glyoxalase/bleomycin resistance protein/dioxygenase K08234 yaeR; glyoxylase I family protein D Sph21_4672 protein of unknown function UPF0001 K06997 yggS; PLP dependent protein D Sph21_1017 acetyltransferase, putative K22479 argA; N-acetyltransferase C 99986 Glycan metabolism D Sph21_5161 hypothetical protein K07027 K07027; glycosyltransferase 2 family protein C 99987 Cofactor metabolism C 99988 Secondary metabolism D Sph21_0877 phospholipase/Carboxylesterase K03932 lpqC; polyhydroxybutyrate depolymerase D Sph21_0429 NADPH-dependent FMN reductase K19784 chrR; chromate reductase, NAD(P)H dehydrogenase (quinone) C 99999 Others D Sph21_2797 metallophosphoesterase K22390 ACP7; acid phosphatase type 7 D Sph21_1922 metallophosphoesterase K22390 ACP7; acid phosphatase type 7 D Sph21_0645 Glyoxalase/bleomycin resistance protein/dioxygenase K15975 K15975; glyoxalase family protein D Sph21_1425 DoxX family protein K15977 K15977; putative oxidoreductase D Sph21_3128 DoxX family protein K15977 K15977; putative oxidoreductase D Sph21_4126 DoxX family protein K15977 K15977; putative oxidoreductase D Sph21_4183 DoxX family protein K15977 K15977; putative oxidoreductase D Sph21_5093 DoxX family protein K15977 K15977; putative oxidoreductase D Sph21_0644 phospholipase/Carboxylesterase K06999 K06999; phospholipase/carboxylesterase D Sph21_1234 protein of unknown function DUF1094 K26958 brxA_B; bacilliredoxin D Sph21_5261 hypothetical protein K26959 brxC; monothiol bacilliredoxin B B 09192 Unclassified: genetic information processing C 99973 Transcription D Sph21_4687 cold-shock DNA-binding domain protein K03704 cspA; cold shock protein D Sph21_3870 cold-shock DNA-binding domain protein K03704 cspA; cold shock protein D Sph21_0773 cold-shock DNA-binding domain protein K03704 cspA; cold shock protein D Sph21_2125 cold-shock DNA-binding domain protein K03704 cspA; cold shock protein D Sph21_4482 Cold-shock protein DNA-binding protein K03704 cspA; cold shock protein D Sph21_2541 Tex-like protein K06959 tex; protein Tex C 99974 Translation D Sph21_2526 beta-lactamase domain protein K07576 K07576; metallo-beta-lactamase family protein D Sph21_1107 RNA procession exonuclease K07577 K07577; putative mRNA 3-end processing factor D Sph21_4002 RNA procession exonuclease-like protein K07577 K07577; putative mRNA 3-end processing factor C 99975 Protein processing D Sph21_2457 protein of unknown function DUF306 Meta and HslJ K03668 hslJ; heat shock protein HslJ D Sph21_1502 ATP-dependent Clp protease adaptor protein ClpS K06891 clpS; ATP-dependent Clp protease adaptor protein ClpS D Sph21_2924 trigger factor K03545 tig; trigger factor D Sph21_0319 SsrA-binding protein K03664 smpB; SsrA-binding protein D Sph21_1443 Mg chelatase, subunit ChlI K07391 comM; magnesium chelatase family protein D Sph21_3442 OsmC family protein K07397 yhfA; putative redox protein D Sph21_0554 OsmC family protein K07397 yhfA; putative redox protein D Sph21_3328 selT/selW/selH selenoprotein domain-containing protein K07401 K07401; selenoprotein W-related protein D Sph21_3740 Xanthine dehydrogenase K07402 xdhC; xanthine dehydrogenase accessory factor D Sph21_0137 Xanthine dehydrogenase K07402 xdhC; xanthine dehydrogenase accessory factor D Sph21_4662 protein of unknown function DUF107 K07403 nfeD; membrane-bound serine protease (ClpP class) C 99976 Replication and repair D Sph21_1496 Methylated-DNA-(protein)-cysteine S-methyltransferase DNA binding protein K07443 ybaZ; methylated-DNA-protein-cysteine methyltransferase related protein D Sph21_3957 DNA repair protein RadC K03630 radC; DNA repair protein RadC D Sph21_1294 RmuC-domain protein K09760 rmuC; DNA recombination protein RmuC D Sph21_0297 SMC domain protein K07459 ybjD; putative ATP-dependent endonuclease of the OLD family D Sph21_0669 UPF0102 protein yraN K07460 yraN; putative endonuclease D Sph21_1864 Excinuclease ABC C subunit domain protein K07461 K07461; putative endonuclease D Sph21_1482 Excinuclease ABC C subunit domain protein K07461 K07461; putative endonuclease D Sph21_3113 hypothetical protein K07461 K07461; putative endonuclease D Sph21_2524 DNA protecting protein DprA K04096 smf; DNA processing protein D Sph21_1359 AAA ATPase central domain protein K07478 ycaJ; putative ATPase D Sph21_4173 hypothetical protein K07483 K07483; transposase D Sph21_4929 IS66 Orf2 family protein K07484 K07484; transposase D Sph21_4930 transposase IS66 K07484 K07484; transposase D Sph21_5071 IS66 Orf2 family protein K07484 K07484; transposase D Sph21_5072 transposase IS66 K07484 K07484; transposase D Sph21_0164 transposase IS66 K07484 K07484; transposase D Sph21_0113 transposase IS204/IS1001/IS1096/IS1165 family protein K07485 K07485; transposase D Sph21_0033 transposase IS204/IS1001/IS1096/IS1165 family protein K07485 K07485; transposase D Sph21_0311 transposase IS204/IS1001/IS1096/IS1165 family protein K07485 K07485; transposase D Sph21_0365 transposase IS204/IS1001/IS1096/IS1165 family protein K07485 K07485; transposase D Sph21_0485 transposase IS116/IS110/IS902 family protein K07486 K07486; transposase D Sph21_0414 transposase IS116/IS110/IS902 family protein K07486 K07486; transposase D Sph21_0637 transposase IS116/IS110/IS902 family protein K07486 K07486; transposase D Sph21_1861 transposase IS116/IS110/IS902 family protein K07486 K07486; transposase D Sph21_2897 transposase IS116/IS110/IS902 family protein K07486 K07486; transposase D Sph21_1651 transposase IS116/IS110/IS902 family protein K07486 K07486; transposase D Sph21_1652 transposase IS116/IS110/IS902 family protein K07486 K07486; transposase D Sph21_2336 transposase IS116/IS110/IS902 family protein K07486 K07486; transposase D Sph21_1469 transposase IS116/IS110/IS902 family protein K07486 K07486; transposase D Sph21_3272 transposase IS116/IS110/IS902 family protein K07486 K07486; transposase D Sph21_3397 transposase IS116/IS110/IS902 family protein K07486 K07486; transposase D Sph21_4984 transposase IS116/IS110/IS902 family protein K07486 K07486; transposase C 99979 Viral proteins C 99998 Others D Sph21_3588 Rhodanese-like protein K03972 pspE; phage shock protein E D Sph21_1521 Uncharacterized protein family UPF0133 K09747 ebfC; nucleoid-associated protein EbfC D Sph21_1683 cryptochrome, DASH family K25656 cry; cryptochrome B B 09193 Unclassified: signaling and cellular processes C 99977 Transport D Sph21_0931 sugar (Glycoside-Pentoside-Hexuronide) transporter K03292 TC.GPH; glycoside/pentoside/hexuronide:cation symporter, GPH family D Sph21_2244 amino acid permease-associated region K03294 TC.APA; basic amino acid/polyamine antiporter, APA family D Sph21_2247 amino acid permease-associated region K03294 TC.APA; basic amino acid/polyamine antiporter, APA family D Sph21_1019 amino acid permease-associated region K03294 TC.APA; basic amino acid/polyamine antiporter, APA family D Sph21_3909 amino acid permease-associated region K03294 TC.APA; basic amino acid/polyamine antiporter, APA family D Sph21_3706 amino acid permease-associated region K03294 TC.APA; basic amino acid/polyamine antiporter, APA family D Sph21_0422 transporter, hydrophobe/amphiphile efflux-1 (HAE1) family K03296 TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family D Sph21_1487 transporter, hydrophobe/amphiphile efflux-1 (HAE1) family K03296 TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family D Sph21_1695 acriflavin resistance protein K03296 TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family D Sph21_2598 transporter, hydrophobe/amphiphile efflux-1 (HAE1) family K03296 TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family D Sph21_2827 transporter, hydrophobe/amphiphile efflux-1 (HAE1) family K03296 TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family D Sph21_4897 transporter, hydrophobe/amphiphile efflux-1 (HAE1) family K03296 TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family D Sph21_1123 transporter, hydrophobe/amphiphile efflux-1 (HAE1) family K03296 TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family D Sph21_2472 amino acid/peptide transporter K03305 TC.POT; proton-dependent oligopeptide transporter, POT family D Sph21_1012 amino acid/peptide transporter K03305 TC.POT; proton-dependent oligopeptide transporter, POT family D Sph21_1371 phosphate transporter K03306 TC.PIT; inorganic phosphate transporter, PiT family D Sph21_2299 SSS sodium solute transporter superfamily K03307 TC.SSS; solute:Na+ symporter, SSS family D Sph21_1347 SSS sodium solute transporter superfamily K03307 TC.SSS; solute:Na+ symporter, SSS family D Sph21_2335 SSS sodium solute transporter superfamily K03307 TC.SSS; solute:Na+ symporter, SSS family D Sph21_4265 Na+/solute symporter K03307 TC.SSS; solute:Na+ symporter, SSS family D Sph21_0979 SSS sodium solute transporter superfamily K03307 TC.SSS; solute:Na+ symporter, SSS family D Sph21_0197 SSS sodium solute transporter superfamily K03307 TC.SSS; solute:Na+ symporter, SSS family D Sph21_1032 SSS sodium solute transporter superfamily K03307 TC.SSS; solute:Na+ symporter, SSS family D Sph21_1997 SSS sodium solute transporter superfamily K03307 TC.SSS; solute:Na+ symporter, SSS family D Sph21_1463 Na+/solute symporter K03307 TC.SSS; solute:Na+ symporter, SSS family D Sph21_0204 amino acid carrier protein K03310 TC.AGCS; alanine or glycine:cation symporter, AGCS family D Sph21_2164 Bile acid:sodium symporter K03453 TC.BASS; bile acid:Na+ symporter, BASS family D Sph21_2638 Bile acid:sodium symporter K03453 TC.BASS; bile acid:Na+ symporter, BASS family D Sph21_2961 Bile acid:sodium symporter K03453 TC.BASS; bile acid:Na+ symporter, BASS family C 99978 Cell growth D Sph21_2711 urea amidolyase related protein K06350 kipA; antagonist of KipI D Sph21_2712 Conserved hypothetical protein CHP00370 K06351 kipI; inhibitor of KinA D Sph21_0114 Resolvase domain K06400 spoIVCA; site-specific DNA recombinase D Sph21_0294 Resolvase domain K06400 spoIVCA; site-specific DNA recombinase D Sph21_3555 Resolvase domain K06400 spoIVCA; site-specific DNA recombinase D Sph21_4630 Resolvase domain K06400 spoIVCA; site-specific DNA recombinase D Sph21_4631 Resolvase domain K06400 spoIVCA; site-specific DNA recombinase D Sph21_1144 Peptidase M23 K22719 envC; murein hydrolase activator C 99993 Cell motility D Sph21_3647 hypothetical protein K07337 K07337; penicillin-binding protein activator C 99995 Signaling proteins D Sph21_1911 carbon starvation protein CstA K06200 cstA; carbon starvation protein D Sph21_1630 GTP-binding protein TypA K06207 typA; GTP-binding protein D Sph21_2530 PhoH family protein K06217 phoH; phosphate starvation-inducible protein PhoH and related proteins D Sph21_5126 putative signal transduction protein with CBS domains K07182 K07182; CBS domain-containing protein C 99992 Structural proteins D Sph21_5199 outer membrane chaperone Skp (OmpH) K06142 hlpA; outer membrane protein D Sph21_5200 outer membrane chaperone Skp (OmpH) K06142 hlpA; outer membrane protein D Sph21_2459 outer membrane chaperone Skp (OmpH) K06142 hlpA; outer membrane protein D Sph21_3388 glycoside hydrolase family 25 K07273 acm; lysozyme D Sph21_3415 efflux transporter, RND family, MFP subunit K02005 ABC.CD.TX; HlyD family secretion protein D Sph21_1173 efflux transporter, RND family, MFP subunit K02005 ABC.CD.TX; HlyD family secretion protein D Sph21_4137 efflux transporter, RND family, MFP subunit K02005 ABC.CD.TX; HlyD family secretion protein D Sph21_2483 Inner membrane CreD family protein K06143 creD; inner membrane protein C 99994 Others D Sph21_1117 integral membrane protein, TerC family K05794 terC; tellurite resistance protein TerC D Sph21_3891 Copper homeostasis protein cutC K06201 cutC; copper homeostasis protein D Sph21_1302 ApaG domain protein K06195 apaG; ApaG protein D Sph21_0230 Flavin-containing monooxygenase-like protein K07222 K07222; putative flavoprotein involved in K+ transport D Sph21_4956 hypothetical protein K26994 sdpA; sporulation delaying protein A D Sph21_4958 HTTM domain protein K26995 sdpB; sporulation delaying protein B B B 09194 Poorly characterized C 99996 General function prediction only D Sph21_1206 GCN5-related N-acetyltransferase K02348 elaA; ElaA protein D Sph21_1068 export-related chaperone CsaA K06878 K06878; tRNA-binding protein D Sph21_1394 hypothetical protein K06886 glbN; hemoglobin D Sph21_4097 Patatin K07001 K07001; NTE family protein D Sph21_0723 HAD superfamily (subfamily IA) hydrolase, TIGR02254 K07025 K07025; putative hydrolase of the HAD superfamily D Sph21_2193 HAD-superfamily hydrolase, subfamily IA, variant 3 K07025 K07025; putative hydrolase of the HAD superfamily D Sph21_4017 FeS assembly protein SufB K09014 sufB; Fe-S cluster assembly protein SufB D Sph21_4015 FeS assembly protein SufD K09015 sufD; Fe-S cluster assembly protein SufD D Sph21_3070 ribonuclease BN K07058 K07058; membrane protein D Sph21_2110 ribonuclease BN K07058 K07058; membrane protein D Sph21_1535 ribonuclease BN K07058 K07058; membrane protein D Sph21_4013 Fe-S metabolism associated SufE K02426 sufE; cysteine desulfuration protein SufE D Sph21_1417 UPF0176 protein yceA K07146 K07146; UPF0176 protein D Sph21_4503 Glyoxalase/bleomycin resistance protein/dioxygenase K04750 phnB; PhnB protein D Sph21_0201 NADPH-dependent FMN reductase K11811 arsH; arsenical resistance protein ArsH D Sph21_0734 LemA family protein K03744 lemA; LemA protein D Sph21_2202 hypothetical protein K02742 sprT; SprT protein D Sph21_1713 SNARE associated Golgi protein-related protein K03975 dedA; membrane-associated protein D Sph21_2758 SNARE associated Golgi protein-related protein K03975 dedA; membrane-associated protein D Sph21_1601 SNARE associated Golgi protein-related protein K03975 dedA; membrane-associated protein D Sph21_4491 SNARE associated Golgi protein-related protein K03975 dedA; membrane-associated protein D Sph21_4312 protein of unknown function DUF202 K00389 yidH; putative membrane protein D Sph21_1611 membrane protein of unknown function K08972 K08972; putative membrane protein D Sph21_1562 protein of unknown function DUF420 K08976 K08976; putative membrane protein D Sph21_2184 putative outer membrane protein K08995 K08995; putative membrane protein D Sph21_3834 hypothetical protein K08995 K08995; putative membrane protein D Sph21_2101 outer membrane protein-like protein K08995 K08995; putative membrane protein D Sph21_1219 PhnA protein K06193 phnA; protein PhnA D Sph21_4752 protein of unknown function DUF417 K21741 rclC; reactive chlorine resistance protein C C 99997 Function unknown D Sph21_5076 Ankyrin K06867 K06867; uncharacterized protein D Sph21_1924 ankyrin K06867 K06867; uncharacterized protein D Sph21_1202 Ankyrin K06867 K06867; uncharacterized protein D Sph21_2545 Ankyrin K06867 K06867; uncharacterized protein D Sph21_2448 Ankyrin K06867 K06867; uncharacterized protein D Sph21_0688 Radical SAM domain protein K06871 K06871; uncharacterized protein D Sph21_0736 protein of unknown function DUF477 K06872 K06872; uncharacterized protein D Sph21_1539 metal dependent phosphohydrolase K06885 K06885; uncharacterized protein D Sph21_3339 metal dependent phosphohydrolase K06885 K06885; uncharacterized protein D Sph21_3542 protein of unknown function DUF255 K06888 K06888; uncharacterized protein D Sph21_0120 hypothetical protein K06889 K06889; uncharacterized protein D Sph21_2461 hypothetical protein K06889 K06889; uncharacterized protein D Sph21_2784 alpha/beta superfamily hydrolase K06889 K06889; uncharacterized protein D Sph21_4563 hypothetical protein K06893 K06893; uncharacterized protein D Sph21_4361 hypothetical protein K06893 K06893; uncharacterized protein D Sph21_4400 hypothetical protein K06893 K06893; uncharacterized protein D Sph21_2662 protein of unknown function DUF296 K06934 K06934; uncharacterized protein D Sph21_1329 metal dependent phosphohydrolase K06950 K06950; uncharacterized protein D Sph21_1110 metallophosphoesterase K06953 K06953; uncharacterized protein D Sph21_1293 peptidase membrane zinc metallopeptidase K06973 K06973; uncharacterized protein D Sph21_2611 GCN5-related N-acetyltransferase K06975 K06975; uncharacterized protein D Sph21_2698 acetyltransferase K06975 K06975; uncharacterized protein D Sph21_2808 hydrolase CocE/NonD family protein K06978 K06978; uncharacterized protein D Sph21_4724 Succinylglutamate desuccinylase/aspartoacylase K06987 K06987; uncharacterized protein D Sph21_4502 glyoxalase/bleomycin resistance protein/dioxygenase K06996 K06996; uncharacterized protein D Sph21_2108 Glyoxalase/bleomycin resistance protein/dioxygenase K06996 K06996; uncharacterized protein D Sph21_2115 pyridoxamine 5'-phosphate oxidase-related FMN-binding protein K07005 K07005; uncharacterized protein D Sph21_2720 pyridoxamine 5'-phosphate oxidase-related FMN-binding protein K07006 K07006; uncharacterized protein D Sph21_1288 esterase K07017 K07017; uncharacterized protein D Sph21_0180 esterase K07017 K07017; uncharacterized protein D Sph21_2921 Glyoxalase/bleomycin resistance protein/dioxygenase K07032 K07032; uncharacterized protein D Sph21_0450 TatD-related deoxyribonuclease K07051 K07051; uncharacterized protein D Sph21_2233 protein of unknown function zinc metallopeptidase K07054 K07054; uncharacterized protein D Sph21_1873 protein of unknown function DUF132 K07063 K07063; uncharacterized protein D Sph21_4392 protein of unknown function DUF132 K07063 K07063; uncharacterized protein D Sph21_1681 domain of unknown function DUF1731 K07071 K07071; uncharacterized protein D Sph21_1208 DNA polymerase beta domain protein region K07075 K07075; uncharacterized protein D Sph21_3192 siroheme synthase K07090 K07090; uncharacterized protein D Sph21_0140 protein of unknown function DUF81 K07090 K07090; uncharacterized protein D Sph21_3586 protein of unknown function DUF81 K07090 K07090; uncharacterized protein D Sph21_3736 protein of unknown function DUF81 K07090 K07090; uncharacterized protein D Sph21_3867 protein of unknown function DUF81 K07090 K07090; uncharacterized protein D Sph21_3142 phosphodiesterase, MJ0936 family K07095 K07095; uncharacterized protein D Sph21_0177 metallophosphoesterase K07098 K07098; uncharacterized protein D Sph21_1070 metallophosphoesterase K07098 K07098; uncharacterized protein D Sph21_3593 protein of unknown function DUF395 YeeE/YedE K07112 K07112; uncharacterized protein D Sph21_3594 protein of unknown function DUF395 YeeE/YedE K07112 K07112; uncharacterized protein D Sph21_0188 NAD-dependent epimerase/dehydratase K07118 K07118; uncharacterized protein D Sph21_2177 Estradiol 17-beta-dehydrogenase K07124 K07124; uncharacterized protein D Sph21_2409 short-chain dehydrogenase/reductase SDR K07124 K07124; uncharacterized protein D Sph21_2811 Sel1 domain protein repeat-containing protein K07126 K07126; uncharacterized protein D Sph21_0845 AAA family ATPase K07133 K07133; uncharacterized protein D Sph21_0848 AAA ATPase K07133 K07133; uncharacterized protein D Sph21_4403 hypothetical protein K07133 K07133; uncharacterized protein D Sph21_4408 hypothetical protein K07133 K07133; uncharacterized protein D Sph21_0400 hypothetical protein K07133 K07133; uncharacterized protein D Sph21_0827 hypothetical protein K07133 K07133; uncharacterized protein D Sph21_0733 HI0933 family protein K07137 K07137; uncharacterized protein D Sph21_4109 Conserved hypothetical protein CHP01212 K07139 K07139; uncharacterized protein D Sph21_2154 MOSC domain containing protein K07140 K07140; MOSC domain-containing protein D Sph21_1999 protein of unknown function DUF418 K07148 K07148; uncharacterized protein D Sph21_0147 protein of unknown function DUF418 K07148 K07148; uncharacterized protein D Sph21_0274 protein of unknown function DUF418 K07148 K07148; uncharacterized protein D Sph21_1377 protein of unknown function DUF164 K07164 K07164; uncharacterized protein D Sph21_0326 UPF0161 protein yidD K08998 K08998; uncharacterized protein D Sph21_3059 protein of unknown function DUF151 K08999 K08999; uncharacterized protein D Sph21_4106 protein of unknown function DUF763 K09003 K09003; uncharacterized protein D Sph21_2151 hypothetical protein K09004 K09004; uncharacterized protein D Sph21_5207 GatB/YqeY domain-containing protein K09117 K09117; uncharacterized protein D Sph21_3352 protein of unknown function DUF190 K09137 K09137; uncharacterized protein D Sph21_3334 protein of unknown function DUF1684 K09164 K09164; uncharacterized protein D Sph21_4703 protein of unknown function DUF1349 K09702 K09702; uncharacterized protein D Sph21_2819 Uncharacterized conserved protein UCP028846 K09704 K09704; uncharacterized protein D Sph21_0413 protein of unknown function DUF458, RNase H-like protein K09776 K09776; uncharacterized protein D Sph21_0217 protein of unknown function DUF808 K09781 K09781; uncharacterized protein D Sph21_3532 integral membrane protein K09792 K09792; uncharacterized protein D Sph21_0044 protein of unknown function DUF541 K09807 K09807; uncharacterized protein D Sph21_3326 RNA binding S1 domain protein K00243 K00243; uncharacterized protein D Sph21_3646 hypothetical protein K09859 K09859; uncharacterized protein D Sph21_2203 UPF0502 protein yceH K09915 K09915; uncharacterized protein D Sph21_4267 protein of unknown function DUF486 K09922 K09922; uncharacterized protein D Sph21_4328 hypothetical protein K09932 K09932; uncharacterized protein D Sph21_3668 protein of unknown function DUF1508 K09946 K09946; uncharacterized protein D Sph21_1344 hypothetical protein K09954 K09954; uncharacterized protein D Sph21_4710 protein of unknown function DUF1680 K09955 K09955; uncharacterized protein D Sph21_4284 protein of unknown function DUF1680 K09955 K09955; uncharacterized protein D Sph21_2347 protein of unknown function DUF1680 K09955 K09955; uncharacterized protein D Sph21_0921 protein of unknown function DUF1680 K09955 K09955; uncharacterized protein D Sph21_4347 protein of unknown function DUF1348 K09958 K09958; uncharacterized protein D Sph21_1454 GumN family protein K09973 K09973; uncharacterized protein D Sph21_2563 hypothetical protein K09981 K09981; uncharacterized protein D Sph21_5114 Protein of unknown function DUF2086 K09990 K09990; uncharacterized protein D Sph21_2277 Crp/FNR family transcriptional regulator K09992 K09992; uncharacterized protein D Sph21_0629 hypothetical protein K09992 K09992; uncharacterized protein D Sph21_1370 putative phosphate transport regulator K07220 K07220; uncharacterized protein ! #
#[ KO | BRITE | KEGG2 | KEGG ]
#Last updated: May 26, 2024