+E Polyketide biosynthesis proteins KO #

  Polyketide Biosynthesis Proteins - Streptomyces malaysiensis

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APolyketide synthase (PKS) B Modular type I PKS C cis-AT PKS D Erythronolide PKS D Oleandomycin synthase D Pikromycin PKS D Avermectin PKS D Tylactone synthase D Protomycinolide IV synthase D Niddamycin PKS D Rapamycin PKS E SMALA_8318 type I modular polyketide synthase K16420 rapA_B_C; rapamycin polyketide synthase A/B/C E SMALA_8316 type I modular polyketide synthase K16420 rapA_B_C; rapamycin polyketide synthase A/B/C D Immunomycin PKS D Ansamitocin PKS D Rifamycin PKS D Polyene macrolide PKS D Pimaricinolide synthase D Candicidin PKS D Soraphen PKS D Stigmatellin PKS D Mycolactone PKS D Coelimycin PKS D Aureothin PKS D Spectinabilin PKS D Phthiocerol / Phenolphthiocerol PKS C trans-AT PKS D Bacillanene hybrid PKS-NRPS D Chivosazol hybrid PKS-NRPS E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133] D Macrolactin PKS D Difficidin PKS D Rhizoxin hybrid PKS-NRPS D Myxovirescin hybrid PKS-NRPS E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932] D Albicidin synthase, hybrid PKS-NRPS E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516] E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523] D Etnangien PKS E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193] B Iterative type I PKS C Fungal nonreducing PKS (NR-PKS) C Fungal partially reducing PKS (PR-PKS) C Fungal highly reducing PKS (HR-PKS) C Fungal hybrid type D Zearalenone synthase D Asperfuranone NR/HR-PKS E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2] E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2] C Bacterial type B Type II PKS C C9-C14 cyclized polyketide type D Spore pigment PKS E SMALA_6144 putative polyketide beta-ketoacyl synthase 1 K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-] E SMALA_6142 putative polyketide synthase acyl carrier protein K14669 whiEV; minimal PKS acyl carrier protein E SMALA_6141 putative polyketide cyclase K14670 whiEVI; aromatase E SMALA_6140 putative polyketide synthesis cyclase K14671 whiEVII; cyclase C C7-C14 cyclized polyketide type D Octaketide PKS E SMALA_7388 beta-lactamase K05555 actIV; cyclase [EC:4.-.-.-] D Nonaketide PKS D Decaketide PKS B Type III PKS C Plant type C Fungal type C Bacterial type D SMALA_7737 chalcone and stilbene synthases-like K16424 dpgA; 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246] D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550] D ------ arsC; alkylpyrone synthase [AVN:Avin_29530] B PKS-NRPS hybrid C Bacterial type (modular) D Myxalamid hybrid PKS-NRPS D Myxothiazol hybrid PKS-NRPS E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019] D Coronatine hybrid PKS-NRPS D Microcystin synthetase D Epothilone synthetase D Bleomycin synthetase D Colibactin synthetase C Fungal type (trans-ER, iterative) D Aspyridone synthetase C Fungal type (iterative) # ANonribosomal peptide synthetase (NRPS) B Linear NRPS C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2] C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500] C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000] C ACV synthetase C Bacitracin synthetase C Viomycin synthetase C Pristinamycin I synthetase C Tyrocidine synthetase C Surfactin family lipopeptide synthetase C Iturin family lipopeptide synthetase C Fengycin family lipopeptide synthetase C Arthrofactin type cyclic lipopeptide synthetase C Vancomycin synthetase C Nocardicin synthetase D SMALA_6615 MbtH domain protein K05375 mbtH; MbtH protein D SMALA_0084 MbtH domain protein K05375 mbtH; MbtH protein D SMALA_8104 MbtH-like protein K05375 mbtH; MbtH protein D SMALA_0270 MbtH domain protein K05375 mbtH; MbtH protein D SMALA_8507 MbtH domain protein K05375 mbtH; MbtH protein D SMALA_2691 MbtH domain protein K05375 mbtH; MbtH protein D SMALA_7735 MbtH domain protein K05375 mbtH; MbtH protein D SMALA_5821 MbtH domain protein K05375 mbtH; MbtH protein D SMALA_7574 MbtH-like protein K05375 mbtH; MbtH protein D SMALA_7827 MbtH-like protein K05375 mbtH; MbtH protein C Bialaphos synthetase C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase B Iterative NRPS C Enterobactin synthetase D SMALA_3025 nonribosomal peptide synthetase DhbF K02364 entF; L-serine---[L-seryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.72] C Bacillibactin synthetase C Gramicidin synthetase B Nonlinear NRPS C Yersiniabactin synthetase C Pyochelin synthetase C Mycobactin synthetase C Vibriobactin synthetase C Myxochelin synthetase C Petrobacin synthetase C Syringomycin synthetase C Vanchrobactin synthetase # APolyketide tailoring proteins B Hydrolase B Ketoreductase B Oxygenase C SMALA_0858 3-(3-hydroxyphenyl)propionate hydroxylase K16022 rif19; flavoprotein hydroxylase C SMALA_1351 3-(3-hydroxyphenyl)propionate hydroxylase K16022 rif19; flavoprotein hydroxylase C SMALA_0475 3-(3-hydroxyphenyl)propionate hydroxylase K16022 rif19; flavoprotein hydroxylase C SMALA_8313 cytochrome P450 K16379 fkbD; cytochrome P450 C-9 hydroxylase C SMALA_8312 cytochrome P450 K16379 fkbD; cytochrome P450 C-9 hydroxylase C SMALA_2464 cytochrome P450 hydroxylase K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C SMALA_5783 cytochrome P450 monooxygenase K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C SMALA_5067 epoxide hydrolase domain protein K21159 sgcF; epoxide hydrolase C SMALA_2870 2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase K14253 oxyE; 6-methylpretetramide 4-monooxygenase [EC:1.14.13.232] C SMALA_7753 enoyl-CoA hydratase/isomerase K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] C SMALA_6145 WhiE II-like protein K14673 whiEII; putative monooxygenase C SMALA_6147 polyketide hydroxylase K14672 whiEVIII; putative polyketide hydroxylase B Methylase C SMALA_1273 caffeoyl-CoA O-methyltransferase K16028 asm17; O-methyltransferase C SMALA_0865 caffeoyl-CoA O-methyltransferase K16028 asm17; O-methyltransferase C SMALA_6137 O-methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-] B Glycosyltransferase B Halogenase C SMALA_7763 tryptophan halogenase K16431 cepH; FAD-dependent halogenase [EC:1.14.19.-] B beta-Branched incorporating proteins B Others C SMALA_1272 3-hydroxyacyl-CoA dehydrogenase NAD-binding K16024 asm13; methoxymalonate biosynthesis protein C SMALA_0864 3-hydroxyacyl-CoA dehydrogenase NAD-binding K16024 asm13; methoxymalonate biosynthesis protein C SMALA_1271 ACP methoxymalonate biosynthesis protein K16025 asm14; methoxymalonate biosynthesis acyl carrier protein C SMALA_1179 putative methoxymalonate biosynthesis protein K16025 asm14; methoxymalonate biosynthesis acyl carrier protein C SMALA_1367 putative methoxymalonate biosynthesis acyl carrier protein K16025 asm14; methoxymalonate biosynthesis acyl carrier protein C SMALA_0863 ACP involved in methoymalonyl-ACP biosynthesis for ansamycin K16025 asm14; methoxymalonate biosynthesis acyl carrier protein C SMALA_1270 acyl-CoA dehydrogenase domain protein K16026 asm15; methoxymalonate biosynthesis protein C SMALA_0862 acyl-CoA dehydrogenase domain protein K16026 asm15; methoxymalonate biosynthesis protein C SMALA_1269 FkbH like protein K16027 asm16; methoxymalonate biosynthesis protein C SMALA_0861 FkbH like protein K16027 asm16; methoxymalonate biosynthesis protein C SMALA_0860 carbamoyltransferase K16035 asm21; 7-O-carbamoyltransferase [EC:2.1.3.-] C SMALA_0465 arylamine N-acetyltransferase K15466 rifF; amide synthase C SMALA_0857 N-acetyltransferase K15466 rifF; amide synthase C SMALA_1359 arylamine N-acetyltransferase K15466 rifF; amide synthase C SMALA_1304 flavin reductase domain protein FMN-binding K14631 actVB; flavin reductase ActVB [EC:1.5.1.-] C SMALA_1311 flavin reductase domain protein FMN-binding K14631 actVB; flavin reductase ActVB [EC:1.5.1.-] C SMALA_8317 non-ribosomal peptide synthetase K16378 rapP; pipecolate-incorporating enzyme # ANonribosomal peptide tailoring proteins B Reductase B Thioesterase B Oxygenase B Glycosyltransferase B Aminotransferase C SMALA_7754 GntR family transcriptional regulator K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103] B Others C SMALA_2490 selenocysteine lyase / isopenicillin N epimerase K04127 cefD; isopenicillin-N epimerase [EC:5.1.1.17] C SMALA_0360 FMN-dependent alpha-hydroxy acid dehydrogenase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46] C SMALA_7752 enoyl-CoA hydratase K16425 dpgB; isomerase DpgB C SMALA_7753 enoyl-CoA hydratase/isomerase K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] ! #
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: February 19, 2024