+C Peptidases and inhibitors KO
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Peptidases and Inhibitors - Variovorax paradoxus B4
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AAspartic peptidases
B Family A1: pepsin family
B Family A2: retropepsin family
B Family A5: thermopsin family
B Family A8: signal peptidase II family
C VAPA_1c13340 lspA; lipoprotein signal peptidase LspA K03101 lspA; signal peptidase II [EC:3.4.23.36]
B Family A22: presenilin family
B Family A24: type IV prepilin peptidase family
C VAPA_1c43800 putative type 4 prepilin-like proteins leader peptide-processing enzyme PilD K02654 pilD; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]
C VAPA_1c16130 putative prepilin type 4 peptidase K02278 cpaA; prepilin peptidase CpaA [EC:3.4.23.43]
C VAPA_1c46180 type IV leader peptidase family K02278 cpaA; prepilin peptidase CpaA [EC:3.4.23.43]
B Family A25: gpr protease family
B Family A26: omptin family
B Family A28
B Family A31: HybD endopeptidase family
B Family A36
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ACysteine peptidases
B Family C1: papain family
B Family C2: calpain family
B Family C3: picornain family
B Family C4: NIa protease family
B Family C5
B Family C9
B Family C10: streptopain family
B Family C11: clostripain family
B Family C12: ubiquitin C-terminal hydrolase family
B Family C13: legumain family
B Family C14: caspase family
B Family C15: pyroglutamyl peptidase I family
C VAPA_1c45370 pcp; pyrrolidone-carboxylate peptidase Pcp K01304 pcp; pyroglutamyl-peptidase [EC:3.4.19.3]
B Family C16
B Family C19: ubiquitin-specific protease family
B Family C25: gingipain family
B Family C26: gamma-glutamyl hydrolase family
C VAPA_1c27940 guaA; GMP synthase GuaA K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
C VAPA_1c54150 peptidase, C26 family K07010 K07010; putative glutamine amidotransferase
B Family C27
B Family C30
B Family C37
B Family C39
B Family C40
B Family C44
C VAPA_1c38890 purF; amidophosphoribosyltransferase PurF K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
C VAPA_1c12110 NADH/NADPH-dependent glutamate synthase, large chain K00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13]
C VAPA_1c10600 glmS; glucosamine--fructose-6-phosphate aminotransferase GlmS K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
B Family C45
B Family C46: hedgehog family
B Family C47: staphopain family
B Family C48: Ulp1 endopeptidase family
B Family C50: separase family
B Family C54: Aut2 peptidase family
B Family C55: YopJ protease family
B Family C56: PfpI endopeptidase family
C VAPA_1c52030 putative intracellular protease, PfpI family K05520 yhbO; deglycase [EC:3.5.1.124]
B Family C57: vaccinia virus I7 peptidase family
B Family C58
B Family C59
B Family C60
B Family C63
B Family C64
B Family C65
B Family C67
B Family C69
B Family C70
B Family C75
B Family C76
B Family C78
B Family C79
B Family C82
B Family C83
B Family C85
B Family C86
B Family C88
B Family C89
B Family C97
B Family C98
B Family C110
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AGlutamic peptidases
B Family G1
B Family G4
B Family G5: prenyl protease 2 family
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AMetallo peptidases
B Family M1
C VAPA_1c39140 pepN; aminopeptidase N K01256 pepN; aminopeptidase N [EC:3.4.11.2]
C VAPA_1c32440 putative zinc metalloprotease, M1 family K01256 pepN; aminopeptidase N [EC:3.4.11.2]
B Family M2
B Family M3
C VAPA_1c23360 oligopeptidase A K01414 prlC; oligopeptidase A [EC:3.4.24.70]
B Family M4: thermolysin family
B Family M5: mycolysin family
B Family M6: immune inhibitor A family
B Family M7: snapalysin family
B Family M8: leishmanolysin family
B Family M9
B Family M10
B Family M12: astacin/adamalysin family
B Family M13: neprilysin family
B Family M14: carboxypeptidase A family
B Family M15: zinc D-Ala-D-Ala carboxypeptidase family
B Family M16: pitrilysin family
C VAPA_1c45460 putative peptidase, M16 family K07263 pqqL; zinc protease [EC:3.4.24.-]
C VAPA_1c45450 putative peptidase, M16 family K07263 pqqL; zinc protease [EC:3.4.24.-]
B Family M17: leucyl aminopeptidase family
C VAPA_1c28290 pepA; putative cytosol aminopeptidase PepA K01255 CARP; leucyl aminopeptidase [EC:3.4.11.1]
B Family M18
B Family M19: membrane dipeptidase family
B Family M20
C VAPA_1c16380 putative glutamate carboxypeptidase K01295 cpg; glutamate carboxypeptidase [EC:3.4.17.11]
C VAPA_1c49950 putative peptidase, M20/M25/M40 family K01295 cpg; glutamate carboxypeptidase [EC:3.4.17.11]
C VAPA_1c48900 putative carboxypeptidase, M20A family K01295 cpg; glutamate carboxypeptidase [EC:3.4.17.11]
C VAPA_1c28450 dapE; succinyl-diaminopimelate desuccinylase DapE K01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]
C VAPA_1c40540 peptidase, ArgE/DapE family K01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]
C VAPA_1c26300 putative carboxypeptidase K13049 PM20D1; carboxypeptidase PM20D1 [EC:3.4.17.-]
C VAPA_1c54890 peptidase, M20 family K01258 pepT; tripeptide aminopeptidase [EC:3.4.11.4]
C VAPA_1c03090 amidohydrolase, peptidase M20 family K01451 hipO; hippurate hydrolase [EC:3.5.1.32]
C VAPA_1c14260 amidohydrolase K01451 hipO; hippurate hydrolase [EC:3.5.1.32]
B Family M23
B Family M24
C VAPA_1c26120 map; methionine aminopeptidase Map K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
C VAPA_2c01280 map; methionine aminopeptidase Map K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
C VAPA_1c54720 pepP; Xaa-Pro aminopeptidase PepP K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]
B Family M26
B Family M27
B Family M28: aminopeptidase Y family
B Family M29: aminopeptidase T family
B Family M32: carboxypeptidase Taq family
B Family M34: anthrax lethal factor family
B Family M35: deuterolysin family
B Family M36: fungalysin family
B Family M38: beta-aspartyl dipeptidase family
B Family M41: FtsH endopeptidase family
C VAPA_1c29280 ftsH; ATP-dependent zinc metalloprotease FtsH K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
C VAPA_2c04860 ftsH; ATP-dependent zinc metalloprotease FtsH K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
B Family M42: glutamyl aminopeptidase family
B Family M43: cytophagalysin family
B Family M44
B Family M48: Ste24 endopeptidase family
C VAPA_1c15740 putative peptidase, M48 family K06013 STE24; STE24 endopeptidase [EC:3.4.24.84]
C VAPA_1c09220 putative peptidase, M48 family K03799 htpX; heat shock protein HtpX [EC:3.4.24.-]
C VAPA_1c53670 peptidase, M48 family K01423 bepA; beta-barrel assembly-enhancing protease [EC:3.4.-.-]
B Family M49: dipeptidyl-peptidase III family
B Family M50: S2P protease family
C VAPA_1c29460 rseP; putative RIP metalloprotease RseP K11749 rseP; regulator of sigma E protease [EC:3.4.24.-]
B Family M54
B Family M55: DppA aminopeptidase family
C VAPA_1c25510 D-aminopeptidase, M55 family K16203 dppA1; D-amino peptidase [EC:3.4.11.-]
B Family M56
B Family M67
B Family M72
B Family M73
B Family M74
B Family M80
B Family M82
C VAPA_1c41390 putative protease, PrsW family K24131 prsW; protease PrsW [EC:3.4.-.-]
B Family M85
B Family M88
B Family M90
C VAPA_1c31630 mtfA; putative transcription factor MtfA K09933 mtfA; MtfA peptidase
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AAsparagine peptide lyases
B Family N1
B Family N8
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AMixed peptidases
B Family P1: DmpA aminopeptidase family
C VAPA_1c25520 peptidase, S58 family K01266 dmpA; D-aminopeptidase [EC:3.4.11.19]
B Family P2
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ASerine peptidases
B Family S1: chymotrypsin family
C VAPA_2c03370 putative serine protease, Do-like protein K04771 degP; serine protease Do [EC:3.4.21.107]
C VAPA_1c25260 putative protease Do K04771 degP; serine protease Do [EC:3.4.21.107]
C VAPA_1c14910 putative Do-like serine protease K04771 degP; serine protease Do [EC:3.4.21.107]
C VAPA_1c12420 degP; putative serine protease DegP K04772 degQ; serine protease DegQ [EC:3.4.21.-]
B Family S3: togavirin family
B Family S6
B Family S7: flavivirin family
B Family S8: subtilisin family
C VAPA_2c01000 putative secreted peptidase K14645 K14645; serine protease [EC:3.4.21.-]
B Family S9: prolyl oligopeptidase family
C VAPA_1c49680 putative prolyl oligopeptidase K01322 PREP; prolyl oligopeptidase [EC:3.4.21.26]
B Family S10
B Family S11: D-Ala-D-Ala carboxypeptidase A family
C VAPA_1c51030 dacA; D-alanyl-D-alanine carboxypeptidase dacA K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C VAPA_1c25140 putative D-alanyl-D-alanine carboxypeptidase K07262 pbpG; serine-type D-Ala-D-Ala endopeptidase (penicillin-binding protein 7) [EC:3.4.21.-]
B Family S12: D-Ala-D-Ala carboxypeptidase B family
B Family S13: D-Ala-D-Ala peptidase C family
C VAPA_1c52800 D-alanyl-D-alanine carboxypeptidase K07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]
B Family S14: ClpP endopeptidase family
C VAPA_1c12720 clpP1; ATP-dependent Clp protease, proteolytic subunit ClpP K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
C VAPA_1c30450 clpP2; ATP-dependent Clp protease, proteolytic subunit ClpP K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
B Family S15
B Family S16: lon protease family
C VAPA_2c03520 lon; Lon protease Lon K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53]
C VAPA_1c30430 ATP-dependent protease K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53]
B Family S21: assemblin family
B Family S24: LexA family
C VAPA_1c29160 lexA; repressor LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
B Family S26: signal peptidase I family
C VAPA_1c14930 putative signal peptidase I LepB K03100 lepB; signal peptidase I [EC:3.4.21.89]
B Family S28
B Family S31
B Family S32
B Family S33
C VAPA_1c31230 putative proline iminopeptidase K01259 pip; proline iminopeptidase [EC:3.4.11.5]
C VAPA_1c11890 putative alpha/beta hydrolase K22369 EPHX4; epoxide hydrolase 4 [EC:3.3.-.-]
B Family S41: C-terminal processing peptidase family
C VAPA_1c42590 C-terminal-processing peptidase K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102]
C VAPA_1c01840 putative peptidase, S41 family K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102]
B Family S45
C VAPA_1c35860 putative penicillin amidase K01434 pac; penicillin G amidase [EC:3.5.1.11]
B Family S49: protease IV family
C VAPA_1c14750 putative peptidase, S49 family K04773 sppA; protease IV [EC:3.4.21.-]
B Family S50
B Family S51
B Family S53
B Family S54: Rhomboid family
B Family S55: SpoIVB peptidase family
B Family S62
B Family S66
C VAPA_1c27560 putative murein tetrapeptide carboxypeptidase K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]
B Family S77: phage prohead processing peptidase family
B Family S78
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AThreonine peptidases
B Family T1: proteasome family
C VAPA_1c09610 hslV; ATP-dependent protease, subunit HslV K01419 hslV; ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2]
C VAPA_1c23420 putative protease K01419 hslV; ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2]
B Family T2
C VAPA_1c25570 putative isoaspartyl peptidase K13051 ASRGL1; L-asparaginase / beta-aspartyl-peptidase [EC:3.5.1.1 3.4.19.5]
B Family T3: gamma-glutamyltransferase family
C VAPA_1c17310 ggt; gamma-glutamyltranspeptidase Ggt K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
C VAPA_1c13200 gamma-glutamyltransferase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
C VAPA_2c09250 gamma-glutamyltranspeptidase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
C VAPA_1c36630 putative gamma-glutamyltransferase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
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APeptidases of unknown catalytic type
B Family U32
B Family U62
C VAPA_1c36670 protein PmbA/TldD K03592 pmbA; PmbA protein
C VAPA_1c09940 tldD; protein TldD K03568 tldD; TldD protein
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APeptidase inhibitors
B Family I1: Kazal family
B Family I2: Kunitz - BPTI family
B Family I4: serpin family
B Family I11: ecotin family
B Family I17: WAP-type family
B Family I25: cystatin family
B Family I27: calpastatin family
B Family I32: IAP family
B Family I34: IA3 family
B Family I35: timp family
B Family I39: alpha2M family
C VAPA_1c14440 alpha-2-macroglobulin family protein K06894 yfhM; alpha-2-macroglobulin
B Family I47: latexin family
B Family I49: proSAAS family
B Family I51: IC family
B Family I57: staphostatin B family
B Family I63
B Family I80
B Family I87
C VAPA_1c23750 hflC; protein HflC K04087 hflC; modulator of FtsH protease HflC
C VAPA_1c23740 hflK; protein HflK K04088 hflK; modulator of FtsH protease HflK
B Family I93
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: May 29, 2024
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Classification taken and modified from MEROPS