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| Entry | Name | Description | Category | Pathway | Gene |
|---|---|---|---|---|---|
| H00079 | Asthma | ... include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Inhaled allergens encounter antigen presenting cells (APC) that line the airway. Upon recognition of ... | Immune system disease | hsa05310 Asthma |
IL4 [HSA:3565] [KO:K05430] IL4RA [HSA:3566] [KO:K05071] IL13 [HSA:3596] [KO:K05435] FCER1B [HSA:2206] [KO:K08090] TNFA [HSA:7124] [KO:K03156] ADAM33 [HSA:80332] [KO:K08616] CD14 [HSA:929] [KO:K04391] HLA-DRB1 [HSA:3123] [KO:K06752] HLA-DQB1 [HSA:3119] [KO:K06752] HLA-G [HSA:3135] [KO:K06751] ADRB2 [HSA:154] [KO:K04142] ALOX5 [HSA:240] [KO:K00461] CCL11 [HSA:6356] [KO:K16597] MUC7 [HSA:4589] [KO:K13909] SCGB3A2 [HSA:117156] [KO:K25469] (PAFAD) PLA2G7 [HSA:7941] [KO:K01062] (ASRT1) PTGDR [HSA:5729] [KO:K04332] (ASRT5) IRAK3 [HSA:11213] [KO:K04732] (ASRT7) CHI3L1 [HSA:1116] [KO:K17523] |
| H00307 | Vibrio parahaemolyticus infection | Vibrio parahaemolyticus is a Gram-negative halophilic bacterium that naturally inhabits marine and estuarine environments. It is a well-recognized pathogen of both aquatic animals and humans. In the case ... | Bacterial infectious disease | ||
| H00311 |
Legionellosis Legionnaires disease |
... The source of LD is potable water systems that become colonized by the microorganism, transmitted by inhalation of contaminated aerosols and aspiration. Classically, it can cause two different forms of ... | Bacterial infectious disease | hsa05134 Legionellosis | TLR5 [HSA:7100] [KO:K10168] |
| H00328 | Anthrax | ... can occur from infected animals or animal products through three main routes: skin (cutaneous), lung (inhalation) and mouth (gastrointestinal). The disease is rare, but the potential threat of anthrax spores ... | Bacterial infectious disease | ||
| H00342 | Tuberculosis | ... estimated two million deaths each year worldwide, more than from any other single bacterial pathogen. Inhalation is the predominant pathway of infection, making pulmonary tuberculosis the most common form ... | Bacterial infectious disease | hsa05152 Tuberculosis |
IFNG (protection) [HSA:3458] [KO:K04687] IFNGR1 (susceptibility/protection) [HSA:3459] [KO:K05132] IFNGR2 [HSA:3460] [KO:K05133] HLA-DRB1 (susceptibility) [HSA:3123] [KO:K06752] HLA-DQB1 (susceptibility) [HSA:3119] [KO:K06752] SLC11A1 (susceptibility) [HSA:6556] [KO:K12347] VDR (susceptibility) [HSA:7421] [KO:K08539] MBL2 (protection) [HSA:4153] [KO:K03991] CCL2 (susceptibility) [HSA:6347] [KO:K14624] CD209 (susceptibility) [HSA:30835] [KO:K06563] CISH (susceptibility) [HSA:1154] [KO:K04701] IRGM (protection) [HSA:345611] [KO:K14139] SP110 (susceptibility) [HSA:3431] [KO:K24503] TIRAP (protection) [HSA:114609] [KO:K05403] TLR2 (susceptibility) [HSA:7097] [KO:K10159] |
| H00346 |
Extrinsic allergic alveolitis Hypersensitivity pneumonitis |
Extrinsic allergic alveolitis (EAA), also known as hypersensitivity pneumonitis, is caused by repeated inhalation of mainly organic antigens by sensitized subjects. This induces a hypersensitivity response ... | Immune system disease | ||
| H00389 | Hemorrhagic fever with renal syndrome | ... Rodents and Soricomorpha species are natural reservoirs of these viruses, and humans acquire infection by inhaling the excreta of infected animals. HFRS is characterized by renal failure, hemorrhages, and shock ... | Viral infectious disease | ||
| H00402 |
Severe acute respiratory syndrome SARS |
... SARS coronavirus. SARS first emerged in 2002 and gained global from 2002 to 2003. The main mode of transmission of SARS coronavirus is person-to-person spread through inhalation of respiratory droplets. | Viral infectious disease | ||
| H01067 | Proteus mirabilis infection | Proteus mirabilis is a motile gram-negative bacterium within the Enterobacteriaceae, that inhabits the environment. It causes a number of infections including those of the skin, respiratory tract, wounds ... | Bacterial infectious disease | ||
| H01074 | Aeromonas infection | Members of the genus Aeromonas are gram-negative bacteria that inhabit various aquatic environments. It can cause a wide spectrum of disease in humans as well as other animals, with gastroenteritis being ... | Bacterial infectious disease | ||
| H01319 |
Coccidioidomycosis Valley fever |
... Pulmonary symptoms are the most common features. Nearly all cases of coccidioidal pneumonia are self-limited. Infection is caused by inhalation of spores that aerosolizes from disruptions of the soil. | Fungal infectious disease | ||
| H01407 | Capnocytophaga ochracea infection | ... capnophilic (CO2-requiring) organism, originally isolated from a human oral cavity. C. ochracea is a normal inhabitant of the human mouth and other non-oral sites and associated with juvenile and adult periodontitis ... | Bacterial infectious disease | ||
| H01443 | Viridans group streptococcal infection | ... heterogenous group of streptococcal species, are the predominant species of the human oral flora and commonly inhabit other areas of the upper respiratory, gastrointestinal, and female genital tracts. VGS are usually ... | Bacterial infectious disease | ||
| H01444 | Enterococcal infection | ... are Gram-positive, catalase-negative, non-spore-forming, facultative anaerobic bacteria, which usually inhabit the alimentary tract of humans in addition to being isolated from environmental and animal sources ... | Bacterial infectious disease | ||
| H01458 | Nontuberculous mycobacterial infection | ... Mycobacterium leprae are known as nontuberculous mycobacteria (NTM) or atypical mycobacteria. NTM are normal inhabitants of soil and treated water. Although generally of low pathogenicity to humans, NTM can cause ... | Bacterial infectious disease | ||
| H01714 |
Chronic obstructive pulmonary disease (COPD) Emphysema |
... the mainstay of treatment since they improve lung function and reduce acute exacerbations. Long-acting inhaled bronchodilators are recommended as first line treatment for patients with persistent symptoms | Respiratory system disease |
SERPINA1 [HSA:5265] [KO:K03984] HMOX1 [HSA:3162] [KO:K00510] MMP1 [HSA:4312] [KO:K01388] |
|
| H01873 |
Obliterative bronchiolitis Bronchiolitis obliterans |
... infection, usually of adenovirus, whereas OB in adults is more commonly associated with occupational inhalation injuries, hypersensitivity pneumonitis, and autoimmune disorders. In lung transplant recipients ... | Respiratory system disease | ||
| H02386 | Phaeohyphomycosis | ... dematiaceous fungi have been confirmed as agents of phaeohyphomycosis. They are commonly found in the soil and are generally distributed worldwide. Exposure is thought to be from inhalation or minor trauma. | Fungal infectious disease | ||
| H02392 |
Scedosporiosis Pseudoallescheriosis |
... filamentous fungi present in soil, sewage, and polluted waters. Scedosporium apiospermum is the most common agent of scedosporiosis. Infection is acquired through trauma, inhalation and near-drowning. | Fungal infectious disease | ||
| H02393 |
Talaromycosis Penicilliosis |
... Asia, southern China, and northeastern India. It is a major cause of death in patients with advanced HIV infection in these areas. Infections probably occur through inhalation of T. marneffei conidia. | Fungal infectious disease |
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