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Name |
Description |
Object |
Legend |
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hsa04520
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Adherens junction |
...n E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskelet... |
...AC3) 5879 (RAC1), 5880 (RAC2), 5881 (RAC3) 998 (CDC42) 60 (ACTB), 71 (ACTG1) 60 (ACTB), 71 (ACTG1) 1... |
...MW-PTP RhoA RhoA WAVE IRSp53 WASP NWASP Rac Rac Cdc42 Actin Actin α-Catenin ZO-1 ZO-1 Vinculin Vincu... |
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hsa04360
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Axon guidance |
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a var... |
...IT3) 9353 (SLIT2) 6585 (SLIT1) 5747 (PTK2) 998 (CDC42) 6093 (ROCK1), 9475 (ROCK2) 10298 (PAK4), 1068... |
...AT CaN Netrin-G1 Netrin-4 Slit3 Slit2 Slit1 FAK Cdc42 ROCK PAK RhoA RhoA Regulation of actin cytoske... |
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hsa04530
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Tight junction |
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion th... |
...4552 (PARD6G), 84612 (PARD6B) 10207 (PATJ) 998 (CDC42) 6794 (STK11) 57530 (CGN) 7074 (TIAM1) 55114 (... |
PAR6 PATJ Cdc42 TIGHT JUNCTION Inside Paracellular space LKB1 Cingulin Tiam1 Decreased paracellul... |
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hsa05100
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Bacterial invasion of epithelial cells |
Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellu... |
...3) 5879 (RAC1) 999 (CDH1) 79658 (ARHGAP10) 998 (CDC42) 6714 (SRC) 2017 (CTTN), 3059 (HCLS1) 3678 (IT... |
... SipC β-catenin α-catenin Rac E-cadherin ARHGAP Cdc42 Src Cortactin Integrin Arp2/3 actin Rho GTPase... |
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hsa05130
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Pathogenic Escherichia coli infection |
Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic ... |
...093 (ROCK1), 9475 (ROCK2) 100506658 (OCLN) 998 (CDC42) 25 (ABL1), 2534 (FYN) 8976 (WASL) 100132463 (... |
...pG Phosphatidylethanolamine Cortactin ROCK OCLN Cdc42 EspF c-Fyn/c-Abl N-WASP EspF CLDN ITGB1 Nck GE... |
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hsa05131
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Shigellosis |
Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enter... |
...S1) 6714 (SRC) 63916 (ELMO2), 9844 (ELMO1) 998 (CDC42) 10163 (WASF2), 8936 (WASF1) 10092 (ARPC5), 10... |
... transcript Rac1 Dock180 Crk Cortactin Src ELMO Cdc42 WAVE Arp2/3 ROCK mDia1 IpgB1 RhoA Filopodia fo... |
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hsa04010
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MAPK signaling pathway |
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in... |
...K5) 5879 (RAC1), 5880 (RAC2), 5881 (RAC3), 998 (CDC42) 5058 (PAK1), 5062 (PAK2) 10746 (MAP3K2), 4215... |
...CASP CD14 TGFBR FAS IL1R TNFR TGFB IL1 TNF PRAK Cdc42/Rac PAK1/2 MEKK2/3 JIP1/2 MLK3 MKK7 JNK MKK4 C... |
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hsa04014
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Ras signaling pathway |
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating c... |
...5601 (MAPK9), 5602 (MAPK10) 10928 (RALBP1) 998 (CDC42) 5879 (RAC1), 5880 (RAC2), 5881 (RAC3) 1001370... |
... DAG IP3 BAD BCL-X IKK NFκB AFX FasL JNK RalBP1 CDC42 Rac PLA ELK ETS RAB5 Calcium signaling pathway... |
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hsa04015
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Rap1 signaling pathway |
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction fo... |
...PRKD1) 889 (KRIT1) 6714 (SRC) 9855 (FARP2) 998 (CDC42) 22808 (MRAS) 9771 (RAPGEF5) 5906 (RAP1A), 590... |
... Vav2 Tiam Rac PAR3 Arap3 Rho PKD1 Krit Src FRG Cdc42 M-ras Repac Rap1 CD-GEFIII CD-GEFI GPCR Gi/o C... |
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hsa04062
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Chemokine signaling pathway |
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon... |
...VAV3), 7409 (VAV1), 7410 (VAV2) 3702 (ITK) 998 (CDC42) 107 (ADCY1), 108 (ADCY2), 109 (ADCY3), 111 (A... |
...n ROCK Jak-STAT signaling pathway Vav Itk Cdc42 RasGRP2 Rap1 WASP PKC ROS production Par3 PKCζ... |
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hsa04144
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Endocytosis |
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins... |
...), 9525 (VPS4B) 51534 (VTA1) 51510 (CHMP5) 998 (CDC42) 5584 (PRKCI), 5590 (PRKCZ) 50855 (PARD6A), 84... |
...A-ATPase Clathrin-independent endocytosis CHMP5 CDC42 aPKC PAR6 PAR3 uncoating disassembly of ESCRT... |
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hsa04370
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VEGF signaling pathway |
There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelia... |
...5-trisphosphate) C01312 (Prostaglandin I2) 998 (CDC42) 3791 (KDR) 5335 (PLCG1), 5336 (PLCG2) 56848 (... |
Cdc42 DAG Calcium signaling pathway Focal adhesion MAPK signaling pathway VEGFR2 PLCγ SPK PIP PGI CO... |
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hsa04510
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Focal adhesion |
Cell-matrix adhesions play essential roles in important biological processes including cell motility... |
...10), 8516 (ITGA8) 2316 (FLNA), 2317 (FLNB) 998 (CDC42) 340156 (MYLK4), 4638 (MYLK), 85366 (MYLK2), 9... |
...action MAPK signaling pathway ITGB ITGA Filamin Cdc42 PIP PIP MLCK MLC mDia1 MLCP ROCK Akt/PKB PDK1 ... |
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hsa04660
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T cell receptor signaling pathway |
Activation of T lymphocytes is a key event for an efficient response of the immune system. It requir... |
...AV3), 7409 (VAV1), 7410 (VAV2) 387 (RHOA), 998 (CDC42) 10298 (PAK4), 106821730 (BUB1B-PAK6), 5058 (P... |
...s AP1 NFAT CaN ITK PLC-γ1 GRB2 LAT GADS VAV Rho/Cdc42 PAK NCK SLP-76 ZAP70 CD3ε CD3δ TCRβ TCRα CD3ζ ... |
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hsa04666
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Fc gamma R-mediated phagocytosis |
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction o... |
... (ACTR3B), 653857 (ACTR3C), 81873 (ARPC5L) 998 (CDC42) 7454 (WAS) 1793 (DOCK1) 1398 (CRK), 1399 (CRK... |
...MEK ERK1/2 cPLA2 Akt p70S6K Vav Rac WAVE Arp2/3 Cdc42 WASP PIP DOCK180 CrkII PLD PAK1 VASP LIMK Cofi... |
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hsa04670
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Leukocyte transendothelial migration |
Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. ... |
...L10) 6093 (ROCK1), 9475 (ROCK2) 387 (RHOA) 998 (CDC42) 3676 (ITGA4) 399 (RHOH) 4478 (MSN), 7430 (EZR... |
...CXCR4 Thy1 VCAM1 ICAM1 PLCγ Actin MLC ROCK RhoA Cdc42 PI(4,5)P ITGA4 RhoH ERM Vinculin VASP PI3K α-a... |
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hsa04722
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Neurotrophin signaling pathway |
Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cel... |
...B3), 25970 (SH2B1) 25 (ABL1) 5609 (MAP2K7) 998 (CDC42) 5879 (RAC1) 7161 (TP73) 7189 (TRAF6) 10782 (Z... |
... Retrograde transport Retrograde transport MKK7 Cdc42 Rac1 p73 TRAF6 NRIF NRAGE SC-1 NADE RIP2 IRAK ... |
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hsa04810
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Regulation of actin cytoskeleton |
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...7144 (PAK5) 8874 (ARHGEF7), 9459 (ARHGEF6) 998 (CDC42) 5879 (RAC1), 5880 (RAC2), 5881 (RAC3) 387 (RH... |
...LCP MLC MLCK GIT1 Mena IRSp53 Drf3 ROCK PAK PIX Cdc42 Rac Rho RhoGEF IQGAP GRLF1 Vav/Tiam1 ERK MEK R... |
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hsa04912
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GnRH signaling pathway |
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the ... |
..., 5330 (PLCB2), 5331 (PLCB3), 5332 (PLCB4) 998 (CDC42) 468 (ATF4) 815 (CAMK2A), 816 (CAMK2B), 817 (C... |
PKC αGSU LHβ PA, PE DAG PLCβ CDC42 cAMP CREB CaMK MKK3/6 p38MAPK MEKK BMK PLA2 IP3R CaM q/11 MT1 GnR... |
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hsa04932
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Non-alcoholic fatty liver disease |
Non-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to mor... |
...(IL1B) 3569 (IL6) 7124 (TNF) 4217 (MAP3K5) 998 (CDC42) 5879 (RAC1) 4296 (MAP3K11) 7124 (TNF) 5599 (M... |
...-6 TNFα ASK1 Apoptosis Mitochondria dysfunction Cdc42 Rac1 MLK3 TNFα JNK1/2 ITCH +ps Inflammation Fa... |