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Name |
Description |
Object |
Legend |
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hsa04012
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ErbB signaling pathway |
... adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or ... |
C00076 (Calcium cation) C00165 (Diacylglycerol) C01245 (D-myo-Inositol 1,4,5-trisphosphate) C05981 (... |
Non-small cell lung cancer Grb2 Elk ErbB-4 ErbB-4 ErbB-3 ErbB-3 STAT5 ErbB-2 ErbB-2 ErbB-2 ErbB-2... |
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hsa04370
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VEGF signaling pathway |
...r, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein... |
C00533 (Nitric oxide) C00076 (Calcium cation) C01245 (D-myo-Inositol 1,4,5-trisphosphate) C00165 (Di... |
Cdc42 DAG Calcium signaling pathway Focal adhesion MAPK signaling pathway VEGFR2 PLCγ SPK PIP PGI CO... |
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hsa04024
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cAMP signaling pathway |
cAMP is one of the most common and universal second messengers, and its formation is promoted by ade... |
...AC1), 5880 (RAC2), 5881 (RAC3) 5058 (PAK1) 1081 (CGA), 2488 (FSHB) 5020 (OXT) 5443 (POMC) 2695 (GIP)... |
cAMP SIGNALING PATHWAY Sarcoplasmic Reticulum (SR) VDCC RyR2 SERCA2a TnI Calcium signaling pathway... |
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hsa04080
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Neuroactive ligand-receptor interaction |
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...3) 4142 (MAS1) 2847 (MCHR1), 84539 (MCHR2) 1081 (CGA), 7252 (TSHB) 1081 (CGA), 3972 (LHB) 1081 (CGA)... |
PARRS Gastric inhibitory peptide Glucagon Glucagon-like peptide Parathyroid hormone Growth hormone-r... |
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hsa04913
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Ovarian steroidogenesis |
The ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine ... |
...3294 (HSD17B2), 8644 (AKR1C3) 3973 (LHCGR) 1081 (CGA), 3972 (LHB) 6770 (STAR) 1583 (CYP11A1) 1586 (C... |
OVARIAN STEROIDOGENESIS Steroid hormone biosynthesis Ovary (theca interstitial cell) Ovary (granulo... |
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hsa04929
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GnRH secretion |
Hypothalamic gonadotropin-releasing hormone (GnRH) neurons are key regulators of reproduction. They ... |
...2) 348980 (HCN1), 57657 (HCN3), 610 (HCN2) 1081 (CGA), 6696 (SPP1) 1081 (CGA), 3972 (LHB) 2852 (GPER... |
GnRH SECRETION GnRH neuron /11 PLC DAG PKC Calcium signaling pathway PI3K PKB/Akt Endoplasmic retic... |
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hsa04623
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Cytosolic DNA-sensing pathway |
Specific families of pattern recognition receptors are responsible for detecting foreign DNA from in... |
... 9560 (CCL4L2) 6352 (CCL5) 11277 (TREX1) 115004 (CGAS) 1777 (DNASE2), 58511 (DNASE2B) 25939 (SAMHD1)... |
...Y Endoplasmic reticulum NF-κ B signaling pathway cGAS cGAMP Cytosolic dsDNA pool DNASE2 SAMHD1 via c... |
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hsa05131
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Shigellosis |
Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enter... |
... 4671 (NAIP) 114548 (NLRP3) 11146 (GLMN) 115004 (CGAS) 340061 (STING1) 340061 (STING1) 29110 (TBK1) ... |
...P3 GLMN IpaH7.8 Pyroptosis IpaB Macrophage dsDNA cGAS cGAMP STING STING (ER) (vesicle) TBK1 IRF3 DNA... |
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hsa05163
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Human cytomegalovirus infection |
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-her... |
..., 3452 (IFNA21) 29110 (TBK1) 3661 (IRF3) 115004 (CGAS) 340061 (STING1) |
...γ Gβγ PKA Gβγ Gαs IFN-β IFN-α TBK1 IRF3 +p DNA cGAS UL82 STING Viral dsDNA cGAMP Cytosolic DNA-sig... |
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hsa05168
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Herpes simplex virus 1 infection |
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal ... |
...4) 3654 (IRAK1) 3665 (IRF7) 7187 (TRAF3) 115004 (CGAS) 340061 (STING1) 29110 (TBK1) 3105 (HLA-A), 31... |
...KB1 REL CCL2 NFκB IκB IKK IRAK4 IRAK1 IRF7 TRAF3 cGAS STING TBK1 cGAMP ICP0 US3 ICP0 ICP0 US3 US3 ds... |
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hsa05170
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Human immunodeficiency virus 1 infection |
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency... |
..., 3452 (IFNA21) 29110 (TBK1) 3661 (IRF3) 115004 (CGAS) 340061 (STING1) 920 (CD4) 1234 (CCR5) 4615 (M... |
...way ERp57 CRT β2M IFN-β IFN-α TBK1 IRF3 +p DNA cGAS STING Reverse transcription DNA product cGAMP ... |
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hsa05171
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Coronavirus disease - COVID-19 |
Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused b... |
...5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 115004 (CGAS) 340061 (STING1) 29110 (TBK1) 3569 (IL6) 3572 ... |
...angiotensin system Fc γ R- mediated phagocytosis cGAS STING TBK1 cGAMP dsDNA Reverse transcription C... |
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hsa04912
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GnRH signaling pathway |
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the ... |
..., 114 (ADCY8), 115 (ADCY9), 196883 (ADCY4) 1081 (CGA) 3972 (LHB) 23236 (PLCB1), 5330 (PLCB2), 5331 (... |
PKC αGSU LHβ PA, PE DAG PLCβ CDC42 cAMP CREB CaMK MKK3/6 p38MAPK MEKK BMK PLA2 IP3R CaM q/11 MT1 GnR... |
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hsa04917
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Prolactin signaling pathway |
Prolactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological function... |
...CGR) 2099 (ESR1), 2100 (ESR2) 3973 (LHCGR) 1081 (CGA), 3972 (LHB) 1586 (CYP17A1) 2099 (ESR1), 2100 (... |
Jak_STAT signaling pathway MAPK signaling pathway PIP Akt/PKB PI3K PROLACTIN SIGNALING PATHWAY ERK... |
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hsa04918
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Thyroid hormone synthesis |
Thyroid hormones triiodothyronine (T3) and thyroxine (T4) are essential for normal development, grow... |
...566 (PRKACA), 5567 (PRKACB), 5568 (PRKACG) 1081 (CGA), 7252 (TSHB) 7253 (TSHR) 2776 (GNAQ) 23236 (PL... |
THYROID HORMONE SYNTHESIS Blood Follicular lumen Tight junction Apical membrane Basal membrane Thy... |
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hsa04923
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Regulation of lipolysis in adipocytes |
Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and gl... |
...HR) 2167 (FABP4) 2167 (FABP4) 2167 (FABP4) 1081 (CGA), 7252 (TSHB) 4886 (NPY1R) 4852 (NPY) 3991 (LIP... |
REGULATION OF LIPOLYSIS IN ADIPOCYTES PKA cAMP β-AR Epinephrine HSL Lypolysis Norepinephrine NPR... |
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hsa05320
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Autoimmune thyroid disease |
The classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chro... |
...A-F), 3135 (HLA-G) 3002 (GZMB) 5551 (PRF1) 1081 (CGA), 7252 (TSHB) 102723407 (IGH) 102723407 (IGH) 1... |
T cell receptor signaling pathway MHCII TCR CD40L CD40 TCR MHCII APC B cell Antigen processing and ... |