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Name |
Description |
Object |
Legend |
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hsa04060
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Cytokine-cytokine receptor interaction |
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulat... |
...F12A) 8792 (TNFRSF11A) 8742 (TNFSF12) 8794 (TNFRSF10C) 4982 (TNFRSF11B) 8795 (TNFRSF10B), 8797 (TNFR... |
...31RA OSMR IL1RN IL1F5 IL1F6 IL1F7 IL1F8 IL1F9 IL1F10 IL33 IL1RAP IL1RL2 ST2 Non-classified IL16 IL32... |
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hsa04061
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Viral protein interaction with cytokine and cytokine receptor |
Viruses have evolved diverse mechanisms to evade detection and destruction by the immune system, inc... |
...SF1A) 7133 (TNFRSF1B) 8764 (TNFRSF14) 8793 (TNFRSF10D), 8794 (TNFRSF10C) 8795 (TNFRSF10B), 8797 (TNF... |
Chemokines CCL CCR1 vCCI CCL3 vav US28 U12 CCL3 hcmv hhv6 vCCI CCL7 vav CCL7 US28 hcmv MC148 CCR1 vC... |
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hsa04210
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Apoptosis |
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by a... |
... (IL3RA) 4914 (NTRK1) 7132 (TNFRSF1A) 8795 (TNFRSF10B), 8797 (TNFRSF10A) 355 (FAS) 3562 (IL3) 4803 (... |
Mitochondrion p53 signaling pathway TNF signaling pathway Bcl-XL ICAD ATM p53 ENDO-G AIF Bcl-2 IAP/X... |
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hsa04217
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Necroptosis |
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumo... |
...3717 (JAK2), 3718 (JAK3), 7297 (TYK2) 8795 (TNFRSF10B), 8797 (TNFRSF10A) 8743 (TNFSF10) 355 (FAS) 35... |
NECROPTOSIS TNF TNFR1 TRADD TRAF2/5 MLKL TLR4 IFNR LPS IFN JAKs TRAILR TRAIL Fas FasL IAPs Casp8 cFL... |
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hsa04650
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Natural killer cell mediated cytotoxicity |
Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in early def... |
...534 (PPP3R1), 5535 (PPP3R2) 2534 (FYN) 8743 (TNFSF10) 3459 (IFNGR1), 3460 (IFNGR2) 5335 (PLCG1), 533... |
IgG NFAT CaN PI(3,4,5)P Fyn TRAIL IFNγR PLCγ LAT Perforin HLA-E IFN-γ GM-CSF TNF-α PKC 3BP2 PLCγ LAT... |
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hsa05168
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Herpes simplex virus 1 infection |
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal ... |
...3), 163131 (ZNF780B), 163223 (ZNF676), 163227 (ZNF100), 163255 (ZNF540), 168374 (ZNF92), 168417 (ZNF... |
HERPES SIMPLEX VIRUS 1 INFECTION Herpes simplex virus-1 LTα LIGHT HVEM Nectin PILRα Heparan sulf... |
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hsa05130
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Pathogenic Escherichia coli infection |
Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic ... |
... 8772 (FADD) 8717 (TRADD) 8772 (FADD) 8795 (TNFRSF10B), 8797 (TNFRSF10A) 355 (FAS) 8743 (TNFSF10) 35... |
Golgi Regulation of actin cytoskeleton Flagellar assembly Tight junction Toll-like receptor signalin... |
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hsa05132
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Salmonella infection |
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid ... |
...), 330 (BIRC3) 841 (CASP8) 840 (CASP7) 8743 (TNFSF10) 578 (BAK1), 581 (BAX) 836 (CASP3) 8772 (FADD) ... |
SopB AvrA MyD88 MyD88 MyD88 ERK IKKβ TAK1 p38 IRAK1/4 IKKα IL-8 TIRAP MyD88 JNK IL-1β TRAF6 IL-6 TAB... |
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hsa05164
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Influenza A |
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus... |
...4939 (OAS2), 4940 (OAS3) 6041 (RNASEL) 8743 (TNFSF10) 8795 (TNFRSF10B), 8797 (TNFRSF10A) 291 (SLC25A... |
INFLUENZA A Alveolar and bronchial epithelial cells Alveolar macrophages Type II pneumocytes Endoso... |
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hsa05417
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Lipid and atherosclerosis |
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-r... |
...FATC2), 4775 (NFATC3) 7132 (TNFRSF1A) 8795 (TNFRSF10B), 8797 (TNFRSF10A) 355 (FAS) 7124 (TNF) 8743 (... |
PIP AKT PDK1 PI3K p53 signaling pathway LIPID AND ATHEROSCLEROSIS GSK3β p53 Apoptosis Apoptosis Fa... |
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hsa04115
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p53 signaling pathway |
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and ... |
...51512 (GTSE1) 581 (BAX) 55367 (PIDD1) 8795 (TNFRSF10B), 8797 (TNFRSF10A) 841 (CASP8) 983 (CDK1) 317 ... |
Siah-1 IGF-BP3 Gadd45 MDM-X CHK1 ATR CHK2 ATM Reprimo 14-3-3-σ CDK2 Cyclin E Cell cycle Apoptosis TS... |
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hsa05225
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Hepatocellular carcinoma |
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neo... |
...(BAD) 2549 (GAB1) 60 (ACTB), 71 (ACTG1) 55274 (PHF10), 8110 (DPF3), 8193 (DPF1) 51412 (ACTL6B), 86 (... |
HEPATOCELLULAR CARCINOMA EGFR Ras Raf MEK ERK1/2 Shc Grb2 SOS mTOR S6K IGF-II IGF1R PI3K-Akt signal... |
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hsa04610
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Complement and coagulation cascades |
The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a ... |
... 2160 (F11) 2158 (F9) 7450 (VWF) 2157 (F8) 2159 (F10) 2147 (F2) 2153 (F5) 2243 (FGA), 2244 (FGB), 22... |
... Tissue damage F7a F12a F12 F11 F11a F9a VWF F8a F10a F10 F2a (Thrombin) F5a Fibrin monomer Fibrino... |
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hsa03022
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Basal transcription factors |
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...129685 (TAF8) 51616 (TAF9B), 6880 (TAF9) 6881 (TAF10) 6882 (TAF11) 2959 (GTF2B) 11036 (GTF2A1L), 295... |
...P TAF1 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TAF10 TAF11 TFIIB TFIIA1 TFIIA2 TFII-I TFIIF1 TFIIF2 ... |
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hsa03082
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ATP-dependent chromatin remodeling |
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...6528 (ARID2) 55193 (PBRM1) 29117 (BRD7) 55274 (PHF10) 65980 (BRD9) 29998 (BICRA) 23506 (BICRAL) 1107... |
...38 CECR2 A2/4 ACTB ACTL6 BCL7 ARID2 PBRM1 BRD7 PHF10 BRD9 BICRA BICRAL CHD3 CHD4 HDAC MBD2 MBD3 MTA ... |
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hsa04148
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Efferocytosis |
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...4035 (LRP1) 811 (CALR) 84465 (MEGF11), 84466 (MEGF10) 26762 (HAVCR1), 84868 (HAVCR2), 91937 (TIMD4) ... |
...optotic cell p130CAS CD36 GAS6 CD47 LRP1 CALR MEGF10 TIM PROS TYRO Don’t eat me signal CD24 CD31 RAG... |
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hsa03040
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Spliceosome |
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. ... |
...NPM), 5093 (PCBP1), 642659 (HNRNPA1L3) 10772 (SRSF10), 10929 (SRSF8), 29896 (TRA2A), 6426 (SRSF1), 6... |
complex pre-mRNA Exon 5' splice site 3' splice site Branch point complex complex complex B* Post-spl... |
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hsa04010
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MAPK signaling pathway |
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in... |
..., 2252 (FGF7), 2253 (FGF8), 2254 (FGF9), 2255 (FGF10), 2277 (VEGFD), 2323 (FLT3LG), 26281 (FGF20), 2... |
LPS RasGRF MKP PTP PP2CB FASL DAG cAMP HGK cPLA2 STMN1 Tau NFκB IKK NIK ERK MP1 MEK2 MEK1 Raf1 RafB ... |
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hsa04014
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Ras signaling pathway |
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating c... |
..., 2252 (FGF7), 2253 (FGF8), 2254 (FGF9), 2255 (FGF10), 2277 (VEGFD), 2323 (FLT3LG), 26281 (FGF20), 2... |
MAPK signaling pathway RAS SIGNALING PATHWAY ERK MEK Raf-1 Ras PI3K-Akt signaling pathway Grb2 SOS... |
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hsa04015
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Rap1 signaling pathway |
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction fo... |
..., 2252 (FGF7), 2253 (FGF8), 2254 (FGF9), 2255 (FGF10), 2277 (VEGFD), 26281 (FGF20), 26291 (FGF21), 2... |
MAPK signaling pathway RAP1 SIGNALING PATHWAY ERK MEK Raf-1 Rap1 RIAM RTK RalGDS Rac RapL MEK3,6 p... |