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Name |
Description |
Object |
Legend |
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hsa05223
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Non-small cell lung cancer |
...r genes, such as p53, p16INK4a, RAR-beta, and RASSF1. Point mutations within the K-RAS gene inactiva... |
... 6256 (RXRA), 6257 (RXRB), 6258 (RXRG) 11186 (RASSF1) 83593 (RASSF5) 595 (CCND1) 1029 (CDKN2A) 10000... |
...CyclinD1 ERBB2 EGF RARβ PDK1 Sos Grb2 PIP RXR RASSF1 NORE1A CyclinD1 p16 PKB/Akt PI3K FHIT NON-SMALL... |
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hsa04060
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Cytokine-cytokine receptor interaction |
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulat... |
...(RELL2), 768211 (RELL1), 84957 (RELT) 55504 (TNFRSF19) 60401 (EDA2R) 10913 (EDAR) 115650 (TNFRSF13C)... |
...IL1RAP IL1RL2 ST2 Non-classified IL16 IL32 IL34 CSF1 CD4 CSF1R DR3 NGF ACVR1C ACVR1C INHA ACVR2A ACV... |
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hsa04061
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Viral protein interaction with cytokine and cytokine receptor |
Viruses have evolved diverse mechanisms to evade detection and destruction by the immune system, inc... |
...33 (IL20RB) 58985 (IL22RA1) 146433 (IL34) 1435 (CSF1) 1436 (CSF1R) 1435 (CSF1) 8764 (TNFRSF14) 4055 ... |
...dv IL20RB IL22RA1 IL20RB IL22RA1 134R yldv IL34 CSF1 CSF1R CSF1 BARF1 ebv HVEM LTBR LIGHT LTA TNFR1 ... |
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hsa04672
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Intestinal immune network for IgA production |
The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunit... |
...cid) 7040 (TGFB1) 3567 (IL5) 3569 (IL6) 8741 (TNFSF13) 10673 (TNFSF13B) 959 (CD40LG) 958 (CD40) 1156... |
TGFβ Gut lumen M cell Antigen processing and presentation T cell receptor signaling pathway B c... |
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hsa04064
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NF-kappa B signaling pathway |
Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that fu... |
...8737 (RIPK1) 8717 (TRADD) 3554 (IL1R1) 7132 (TNFRSF1A) 3553 (IL1B) 7124 (TNF) 8740 (TNFSF14) 4055 (L... |
Cytokine-cytokine receptor interaction Bcl-XL Bcl-2 c-IAP1/2 IκBα IRAK1/4 MyD88 TRAF2/5 RIP1 TRADD I... |
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hsa05323
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Rheumatoid arthritis |
Rheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affect... |
...) C00584 (Prostaglandin E2) C00080 (H+) 8600 (TNFSF11) 8792 (TNFRSF11A) 8600 (TNFSF11) 3605 (IL17A) ... |
Th17 cell RHEUMATOID ARTHRITIS RANKL RANK Osteoclast differentiation RANKL IL17 IL1 TNFα IL6 IL23... |
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hsa04210
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Apoptosis |
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by a... |
...39 (CSF2RB), 3563 (IL3RA) 4914 (NTRK1) 7132 (TNFRSF1A) 8795 (TNFRSF10B), 8797 (TNFRSF10A) 355 (FAS) ... |
Mitochondrion p53 signaling pathway TNF signaling pathway Bcl-XL ICAD ATM p53 ENDO-G AIF Bcl-2 IAP/X... |
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hsa04380
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Osteoclast differentiation |
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage... |
...alcium cation) C00027 (Hydrogen peroxide) 1436 (CSF1R) 7186 (TRAF2), 7189 (TRAF6) 8792 (TNFRSF11A) 8... |
OSTEOCLAST DIFFERENTIATION c-Fms TRAF2/6 RANK RANKL M-CSF OPG CYLD Gab2 NIK IKKα IKKγ IKKα IKKβ IκB... |
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hsa05130
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Pathogenic Escherichia coli infection |
Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic ... |
...3553 (IL1B) 114548 (NLRP3) 4671 (NAIP) 7132 (TNFRSF1A) 7124 (TNF) 7430 (EZR) 5970 (RELA) 4792 (NFKBI... |
Golgi Regulation of actin cytoskeleton Flagellar assembly Tight junction Toll-like receptor signalin... |
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hsa05206
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MicroRNAs in cancer |
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, ... |
...IR602) 574031 (MIR363) 693210 (MIR625) 11186 (RASSF1) 693187 (MIR602) 406935 (MIR143) 406902 (MIR10A... |
...R-20a miR-324 miR-221 miR-602 miR-363 miR-625 RASSF1A miR-602 miR-143 miR-10a miR-23 miR-122a miR-12... |
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hsa05200
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Pathways in cancer |
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...(MAP2K1), 5605 (MAP2K2) 83593 (RASSF5) 11186 (RASSF1) 4792 (NFKBIA) 4790 (NFKB1), 4791 (NFKB2), 5970... |
...cl-XL STAT3 STAT1 Grb2 Sos Ras Raf MEK NORE1A RASSF1 IκBα NFκB MST1 CyclinD1 RET/PTC RASSF1A PLCγ Ra... |
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hsa04217
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Necroptosis |
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumo... |
...te) C00076 (Calcium cation) 7124 (TNF) 7132 (TNFRSF1A) 8717 (TRADD) 7186 (TRAF2), 7188 (TRAF5) 19725... |
NECROPTOSIS TNF TNFR1 TRADD TRAF2/5 MLKL TLR4 IFNR LPS IFN JAKs TRAILR TRAIL Fas FasL IAPs Casp8 cFL... |
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hsa04650
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Natural killer cell mediated cytotoxicity |
Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in early def... |
...5534 (PPP3R1), 5535 (PPP3R2) 2534 (FYN) 8743 (TNFSF10) 3459 (IFNGR1), 3460 (IFNGR2) 5335 (PLCG1), 53... |
IgG NFAT CaN PI(3,4,5)P Fyn TRAIL IFNγR PLCγ LAT Perforin HLA-E IFN-γ GM-CSF TNF-α PKC 3BP2 PLCγ LAT... |
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hsa05132
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Salmonella infection |
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid ... |
...2), 330 (BIRC3) 841 (CASP8) 840 (CASP7) 8743 (TNFSF10) 578 (BAK1), 581 (BAX) 836 (CASP3) 8772 (FADD)... |
SopB AvrA MyD88 MyD88 MyD88 ERK IKKβ TAK1 p38 IRAK1/4 IKKα IL-8 TIRAP MyD88 JNK IL-1β TRAF6 IL-6 TAB... |
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hsa05164
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Influenza A |
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus... |
... 4939 (OAS2), 4940 (OAS3) 6041 (RNASEL) 8743 (TNFSF10) 8795 (TNFRSF10B), 8797 (TNFRSF10A) 291 (SLC25... |
INFLUENZA A Alveolar and bronchial epithelial cells Alveolar macrophages Type II pneumocytes Endoso... |
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hsa05168
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Herpes simplex virus 1 infection |
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal ... |
...trisphosphate) C20935 (2-5A) 4049 (LTA) 8740 (TNFSF14) 8764 (TNFRSF14) 5818 (NECTIN1), 5819 (NECTIN2... |
HERPES SIMPLEX VIRUS 1 INFECTION Herpes simplex virus-1 LTα LIGHT HVEM Nectin PILRα Heparan sulf... |
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hsa05417
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Lipid and atherosclerosis |
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-r... |
...(NFATC1), 4773 (NFATC2), 4775 (NFATC3) 7132 (TNFRSF1A) 8795 (TNFRSF10B), 8797 (TNFRSF10A) 355 (FAS) ... |
PIP AKT PDK1 PI3K p53 signaling pathway LIPID AND ATHEROSCLEROSIS GSK3β p53 Apoptosis Apoptosis Fa... |
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hsa04014
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Ras signaling pathway |
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating c... |
... 399694 (SHC4), 53358 (SHC3), 6464 (SHC1) 1435 (CSF1), 1942 (EFNA1), 1943 (EFNA2), 1944 (EFNA3), 194... |
...Gene expression AF6 Cell-cell junctions Nore1 RASSF1 Mst1 Mst1 Repac Rap1 Nore1 TIAM1 PI3K AF6 Raf-1... |
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hsa04668
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TNF signaling pathway |
Tumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal... |
7124 (TNF) 7132 (TNFRSF1A) 8717 (TRADD) 7186 (TRAF2), 7188 (TRAF5) 8737 (RIPK1) 329 (BIRC2), 330 (BI... |
...cl5 Ccl20 Cxcl1 Cxcl2 Cxcl3 Cxcl5 Cxcl10 Cx3cl1 Csf1 Csf2 Fas IL18R1 Jag1 IL1b IL6 IL15 Lif Tnf Bcl3... |
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hsa04010
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MAPK signaling pathway |
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in... |
...) 2768 (GNA12), 55970 (GNG12) 2885 (GRB2) 1436 (CSF1R), 1956 (EGFR), 1969 (EPHA2), 2064 (ERBB2), 206... |
LPS RasGRF MKP PTP PP2CB FASL DAG cAMP HGK cPLA2 STMN1 Tau NFκB IKK NIK ERK MP1 MEK2 MEK1 Raf1 RafB ... |