KEGG    Network variation - Glycosaminoglycan degradation
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ENTRYnt06012
NameGlycosaminoglycan degradation
CategoryPathway view; Glycan/glycoprotein metabolism
Pathwayhsa00531 Glycosaminoglycan degradation
Modulehsa_M00076 Dermatan sulfate degradation
hsa_M00078 Heparan sulfate degradation
hsa_M00079 Keratan sulfate degradation
DiseaseH00421 Mucopolysaccharidosis (MPS)
Display drug-target relation   disease type
N00610    DS−IDS⇉IDUA⇉ARSB⇉HYAL→G00872
   D3,D4,D5
 |
    MPS II   IDS*
     D6
 |
    MPS I     IDUA*
       D7
 |
    MPS VI       ARSB*
    MPS IX         HYAL1*
N00615    HS−IDS⇉IDUA⇉SGSH⇉HGSNAT⇉NAGLU⇉GUSB⇉GNS→G02632
   D3,D4,D5
 |
    MPS II   IDS*
     D6
 |
    MPS I     IDUA*
    MPS IIIA       SGSH*
    MPS IIIC         HGSNAT*
    MPS IIIB           NAGLU*
             D2
 |
    MPS VII             GUSB*
    MPS IIID               GNS*
N00623    KS−GALNS⇉GLB1⇉GNS⇉HEXA/B→G01391
   D1
 |
    MPS IVA   GALNS*
    MPS IVB     GLB1*
    MPS IIID       GNS*

Disease nameDisease category
MPS IIH00129Mucopolysaccharidosis type IIInherited metabolic disorder, Lysosomal disease
MPS IH00128Mucopolysaccharidosis type IInherited metabolic disorder, Lysosomal disease
MPS VIH00131Mucopolysaccharidosis type VIInherited metabolic disorder, Lysosomal disease
MPS IXH00133Mucopolysaccharidosis type IXInherited metabolic disorder, Lysosomal disease
MPS IIIAH00130Mucopolysaccharidosis type IIIInherited metabolic disorder, Lysosomal disease
MPS IIICH00130Mucopolysaccharidosis type IIIInherited metabolic disorder, Lysosomal disease
MPS IIIBH00130Mucopolysaccharidosis type IIIInherited metabolic disorder, Lysosomal disease
MPS VIIH00132Mucopolysaccharidosis type VIIInherited metabolic disorder, Lysosomal disease
MPS IIIDH00130Mucopolysaccharidosis type IIIInherited metabolic disorder, Lysosomal disease
MPS IVAH00123Mucopolysaccharidosis type IVInherited metabolic disorder, Lysosomal disease
MPS IVBH00123Mucopolysaccharidosis type IVInherited metabolic disorder, Lysosomal disease


Drug name
D1D10333Elosulfase alfa (USAN)
D2D11004Vestronidase alfa (USAN/INN)
D3D04499Idursulfase (USAN/INN)
D4D11025Idursulfase beta (INN)
D5D11812Pabinafusp alfa (genetical recombination) (JAN)
D6D04670Laronidase (USAN)
D7D06565Galsulfase (USAN/INN)