Homo sapiens (human): 3425
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Entry
3425 CDS
T01001
Symbol
IDUA, IDA, MPS1, MPSI
Name
(RefSeq) alpha-L-iduronidase
KO
K01217
L-iduronidase [EC:
3.2.1.76
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00531
Glycosaminoglycan degradation
hsa01100
Metabolic pathways
hsa04142
Lysosome
Module
hsa_M00076
Dermatan sulfate degradation
hsa_M00078
Heparan sulfate degradation
Network
nt06012
Glycosaminoglycan degradation
Element
N00610
Dermatan sulfate degradation
N00615
Heparan sulfate degradation
Disease
H00128
Mucopolysaccharidosis type I
H00421
Mucopolysaccharidosis
Drug target
Laronidase:
D04670
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09107 Glycan biosynthesis and metabolism
00531 Glycosaminoglycan degradation
3425 (IDUA)
09140 Cellular Processes
09141 Transport and catabolism
04142 Lysosome
3425 (IDUA)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.2 Glycosylases
3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
3.2.1.76 L-iduronidase
3425 (IDUA)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Glyco_hydro_39
Glyco_hydro_39_C
Motif
Other DBs
NCBI-GeneID:
3425
NCBI-ProteinID:
NP_000194
OMIM:
252800
HGNC:
5391
Ensembl:
ENSG00000127415
UniProt:
P35475
Structure
PDB
LinkDB
All DBs
Position
4:986997..1008351
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AA seq
653 aa
AA seq
DB search
MRPLRPRAALLALLASLLAAPPVAPAEAPHLVHVDAARALWPLRRFWRSTGFCPPLPHSQ
ADQYVLSWDQQLNLAYVGAVPHRGIKQVRTHWLLELVTTRGSTGRGLSYNFTHLDGYLDL
LRENQLLPGFELMGSASGHFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETW
NEPDHHDFDNVSMTMQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSWGLLRH
CHDGTNFFTGEAGVRLDYISLHRKGARSSISILEQEKVVAQQIRQLFPKFADTPIYNDEA
DPLVGWSLPQPWRADVTYAAMVVKVIAQHQNLLLANTTSAFPYALLSNDNAFLSYHPHPF
AQRTLTARFQVNNTRPPHVQLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGV
LASAHRPQGPADAWRAAVLIYASDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGL
CSPDGEWRRLGRPVFPTAEQFRRMRAAEDPVAAAPRPLPAGGRLTLRPALRLPSLLLVHV
CARPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQFSQDGKAYTPVSRKPS
TFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYLEVPVPRGPPSPGNP
NT seq
1962 nt
NT seq
+upstream
nt +downstream
nt
atgcgtcccctgcgcccccgcgccgcgctgctggcgctcctggcctcgctcctggccgcg
cccccggtggccccggccgaggccccgcacctggtgcatgtggacgcggcccgcgcgctg
tggcccctgcggcgcttctggaggagcacaggcttctgccccccgctgccacacagccag
gctgaccagtacgtcctcagctgggaccagcagctcaacctcgcctatgtgggcgccgtc
cctcaccgcggcatcaagcaggtccggacccactggctgctggagcttgtcaccaccagg
gggtccactggacggggcctgagctacaacttcacccacctggacgggtacctggacctt
ctcagggagaaccagctcctcccagggtttgagctgatgggcagcgcctcgggccacttc
actgactttgaggacaagcagcaggtgtttgagtggaaggacttggtctccagcctggcc
aggagatacatcggtaggtacggactggcgcatgtttccaagtggaacttcgagacgtgg
aatgagccagaccaccacgactttgacaacgtctccatgaccatgcaaggcttcctgaac
tactacgatgcctgctcggagggtctgcgcgccgccagccccgccctgcggctgggaggc
cccggcgactccttccacaccccaccgcgatccccgctgagctggggcctcctgcgccac
tgccacgacggtaccaacttcttcactggggaggcgggcgtgcggctggactacatctcc
ctccacaggaagggtgcgcgcagctccatctccatcctggagcaggagaaggtcgtcgcg
cagcagatccggcagctcttccccaagttcgcggacacccccatttacaacgacgaggcg
gacccgctggtgggctggtccctgccacagccgtggagggcggacgtgacctacgcggcc
atggtggtgaaggtcatcgcgcagcatcagaacctgctactggccaacaccacctccgcc
ttcccctacgcgctcctgagcaacgacaatgccttcctgagctaccacccgcaccccttc
gcgcagcgcacgctcaccgcgcgcttccaggtcaacaacacccgcccgccgcacgtgcag
ctgttgcgcaagccggtgctcacggccatggggctgctggcgctgctggatgaggagcag
ctctgggccgaagtgtcgcaggccgggaccgtcctggacagcaaccacacggtgggcgtc
ctggccagcgcccaccgcccccagggcccggccgacgcctggcgcgccgcggtgctgatc
tacgcgagcgacgacacccgcgcccaccccaaccgcagcgtcgcggtgaccctgcggctg
cgcggggtgccccccggcccgggcctggtctacgtcacgcgctacctggacaacgggctc
tgcagccccgacggcgagtggcggcgcctgggccggcccgtcttccccacggcagagcag
ttccggcgcatgcgcgcggctgaggacccggtggccgcggcgccccgccccttacccgcc
ggcggccgcctgaccctgcgccccgcgctgcggctgccgtcgcttttgctggtgcacgtg
tgtgcgcgccccgagaagccgcccgggcaggtcacgcggctccgcgccctgcccctgacc
caagggcagctggttctggtctggtcggatgaacacgtgggctccaagtgcctgtggaca
tacgagatccagttctctcaggacggtaaggcgtacaccccggtcagcaggaagccatcg
accttcaacctctttgtgttcagcccagacacaggtgctgtctctggctcctaccgagtt
cgagccctggactactgggcccgaccaggccccttctcggaccctgtgccgtacctggag
gtccctgtgccaagagggcccccatccccgggcaatccatga
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