Network variation - ERK signaling (cancer)
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ENTRY
nt06210
Name
ERK signaling (cancer)
Category
Disease view; Cancer signaling
Display
drug-target relation
disease type
N00001
EGF
→
EGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
→
CCND1
N00276
EGF*
→
EGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00229
TGFA
→
EGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00230
TGFA*
→
EGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00277
EREG
→
EGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00278
EREG*
→
EGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00279
AREG
→
EGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00280
AREG*
→
EGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N01354
BPA
→
EGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00014
EGFR*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
→
CCND1
N00513
EGFR*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
→
CCND1
N00006
EGFR*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00041
EGFR*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00021
EGF
→
(ERBB2+EGFR)
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00022
EGF
→
(
ERBB2*
+
EGFR
)
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00252
EGF
→
(
ERBB2*
+
EGFR
)
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00015
PDGF
→
PDGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00016
PDGF*
→
PDGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00018
PDGFR*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00215
KITLG
→
KIT
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00003
KIT*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00019
FGF
→
FGFR
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00020
FGFR*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00011
FGFR3*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
→
MSK1
→
MYC
N00217
FLT3LG
→
FLT3
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00004
FLT3*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00233
IGF
→
IGF1R
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00235
IGF2*
→
IGF1R
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00237
IGF2
→
IGF1R*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00216
HGF
→
MET
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00246
HGF*
→
MET
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00005
MET*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
→
CCND1
N00259
MET*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00248
MET*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N01062
MET*
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00002
BCR-ABL
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
N00274
NS5A
⊣
GRB2
N01408
Metals
→
ROS
→
RAS
→
RAF
→
MEK
→
ERK
→
AP1
N00009
TRK*
→
RAS
→
RAF
→
MEK
→
ERK
N01064
RET*
→
RAS
→
RAF
→
MEK
→
ERK
N00008
RET*
→
RAS
→
RAF
→
MEK
→
ERK
N00007
EML4-ALK
→
RAS
→
RAF
→
MEK
→
ERK
→
CCND1
N00160
K1
→
RAS
N00077
HRAS*
→
RAF
→
MEK
→
ERK
→
MSK1
→
MYC
N00078
HRAS*
→
RAF
→
MEK
→
ERK
→
MSK1
→
MYC
N00012
(
KRAS*
,
NRAS*
)
→
RAF
→
MEK
→
ERK
→
CCND1
N00013
BRAF*
→
MEK
→
ERK
N01360
P4
→
(PGR+SRC)
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
→
CCND1
N01361
(
P4
,
MPA
)
→
(
PGR
+
SRC
)
→
GRB2
→
SOS
→
RAS
→
RAF
→
MEK
→
ERK
→
CCND1
N01351
E2
→
ESR1/2
→
SRC
→
RAS
→
RAF
→
MEK
→
ERK
→
CREB
N01353
E2
→
ESR1/2
→
SRC
→
RAS
→
RAF
→
MEK
→
ERK
→
(
ESR1/2
,
AP1
)
⇒
CHRNA9
N01352
BPA
→
ESR1/2
→
SRC
→
RAS
→
RAF
→
MEK
→
ERK
N01343
ACh
→
CHRNA7
→
Ca2+
→
RAS
→
RAF
→
MEK
→
ERK
→
CREB
N01344
(
NNK
,
NNN
)
→
CHRN
→
Ca2+
→
RAS
→
RAF
→
MEK
→
ERK
→
(
FOS
,
JUN
,
MYC
,
BCL2
)