Entry |
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Name |
dopamine beta-monooxygenase;
dopamine beta-hydroxylase;
MDBH (membrane-associated dopamine beta-monooxygenase);
SDBH (soluble dopamine beta-monooxygenase);
dopamine-B-hydroxylase;
3,4-dihydroxyphenethylamine beta-oxidase;
4-(2-aminoethyl)pyrocatechol beta-oxidase;
dopa beta-hydroxylase;
dopamine beta-oxidase;
dopamine hydroxylase;
phenylamine beta-hydroxylase;
(3,4-dihydroxyphenethylamine)beta-mono-oxygenase;
DbetaM (gene name)
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Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
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Sysname |
dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
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Reaction(IUBMB) |
dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O [RN: R02535]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
A copper protein. The enzyme, found in animals, binds two copper ions with distinct roles during catalysis. Stimulated by fumarate.
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History |
EC 1.14.17.1 created 1965 as EC 1.14.2.1, transferred 1972 to EC 1.14.17.1, modified 2020
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Pathway |
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Orthology |
K00503 | dopamine beta-monooxygenase |
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Genes |
» show all
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Reference |
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Authors |
LEVIN EY, LEVENBERG B, KAUFMAN S. |
Title |
The enzymatic conversion of 3,4-dihydroxyphenylethylamine to norepinephrine. |
Journal |
J Biol Chem 235:2080-6 (1960) |
Reference |
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Authors |
Friedman S, Kaufman S. |
Title |
3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity. |
Journal |
J Biol Chem 240:4763-73 (1965) |
Reference |
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Authors |
Skotland T, Ljones T |
Title |
Direct spectrophotometric detection of ascorbate free radical formed by dopamine beta-monooxygenase and by ascorbate oxidase. |
Journal |
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Reference |
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Authors |
Evans JP, Ahn K, Klinman JP |
Title |
Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase. Implications for the reactive oxygen species. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.14.17.1 |
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LinkDB |
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