KEGG ENZYME: 1.14.17.1

ENZYME: 1.14.17.1

Entry

EC 1.14.17.1 Enzyme

Name

dopamine beta-monooxygenase;
dopamine beta-hydroxylase;
MDBH (membrane-associated dopamine beta-monooxygenase);
SDBH (soluble dopamine beta-monooxygenase);
dopamine-B-hydroxylase;
3,4-dihydroxyphenethylamine beta-oxidase;
4-(2-aminoethyl)pyrocatechol beta-oxidase;
dopa beta-hydroxylase;
dopamine beta-oxidase;
dopamine hydroxylase;
phenylamine beta-hydroxylase;
(3,4-dihydroxyphenethylamine)beta-mono-oxygenase;
DbetaM (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

Reaction(IUBMB)

dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O [RN:R02535]

Reaction(KEGG)

R02535

Substrate

dopamine [CPD:C03758];
ascorbate [CPD:C00072];
O2 [CPD:C00007]

Product

noradrenaline [CPD:C00547];
monodehydroascorbate [CPD:C01041];
H2O [CPD:C00001]

Comment

A copper protein. The enzyme, found in animals, binds two copper ions with distinct roles during catalysis. Stimulated by fumarate.

History

EC 1.14.17.1 created 1965 as EC 1.14.2.1, transferred 1972 to EC 1.14.17.1, modified 2020

Pathway

ec00350

Tyrosine metabolism

ec01100

Metabolic pathways

Orthology

K00503

dopamine beta-monooxygenase

Genes

HSA:

1621(DBH)

PTR:	464827(DBH)

PPS:	100985587(DBH)

GGO:	101154486(DBH)

PON:	100461514(DBH)

NLE:	100597609(DBH)

MCC:	574105(DBH)

MCF:	102139527(DBH)

CSAB:

103239676(DBH)

RRO:	104669786(DBH)

RBB:	108513277(DBH)

CJC:	100406041(DBH)

SBQ:	101046079(DBH)

MMU:	13166(Dbh)

MCAL:

110290214(Dbh)

MPAH:

110319201(Dbh)

RNO:	25699(Dbh)

MUN:	110557516(Dbh)

CGE:	100761411(Dbh)

NGI:	103742818(Dbh)

HGL:	101724312(Dbh)

CCAN:

109677868(Dbh)

OCU:	103347199(DBH)

TUP:	102468703(DBH)

CFA:	448806(DBH)

VVP:	112906947(DBH)

AML:	100480347(DBH)

UMR:	103679922(DBH)

UAH:	113266575(DBH)

ORO:	101362871(DBH)

ELK:

111146214

FCA:	101082957(DBH)

PTG:	102961078(DBH)

PPAD:

109258287(DBH)

AJU:	106988258(DBH)

BTA:	280758(DBH)

BOM:	102286194(DBH)

BIU:	109566610(DBH)

BBUB:

102409301(DBH)

CHX:	102176244(DBH)

OAS:	114113851(DBH)

SSC:	733609(DBH)

CFR:	102523816(DBH)

CDK:	105106327(DBH)

BACU:

103001548(DBH)

LVE:	103082302(DBH)

OOR:	101269198(DBH)

DLE:	111177039(DBH)

PCAD:

102990638(DBH)

ECB:	791247(DBH)

EPZ:	103564043(DBH)

EAI:	106845350(DBH)

MYB:	102264141(DBH)

MYD:	102763656(DBH)

MNA:	107524669(DBH)

HAI:	109381156(DBH)

DRO:	112306436(DBH)

PALE:

102882740(DBH)

RAY:	107506265(DBH)

MJV:	108398386(DBH)

LAV:	100675803(DBH)

TMU:

101344432

MDO:	100018814(DBH)

SHR:	100925655(DBH)

PCW:	110205374(DBH)

OAA:	100073905(DBH)

GGA:	395549(DBH)

MGP:	100544779(DBH)

CJO:	107321868(DBH)

NMEL:

110406867(DBH)

APLA:

101793381(DBH)

ACYG:

106044068(DBH)

TGU:	100224356(DBH)

LSR:	110477727(DBH)

SCAN:

103818963(DBH)

GFR:	102038113(DBH)

FAB:	101810825(DBH)

PHI:	102100810(DBH)

PMAJ:

107211985(DBH)

CCAE:

111937045(DBH)

CCW:	104688340(DBH)

ETL:	114059130(DBH)

FPG:	101923335(DBH)

FCH:	102048380(DBH)

CLV:	102097674(DBH)

EGZ:	104129357(DBH)

NNI:	104023198(DBH)

ACUN:

113486646(DBH)

PADL:

103915345(DBH)

AAM:	106484479(DBH)

ASN:	102377750(DBH)

AMJ:	102562465(DBH)

PSS:	102455557(DBH)

CMY:	102935981(DBH)

CPIC:

101944381(DBH)

ACS:	100566843(dbh)

PVT:	110089291(DBH)

PBI:	103050577(DBH)

PMUR:

107291028(DBH)

TSR:	106552853(DBH)

PMUA:

114588914(DBH)

GJA:	107106563(DBH)

XLA:	108698178(dbh.L) 108699900(dbh.S)

XTR:	100492247(dbh)

NPR:	108792841(DBH)

DRE:	30505(dbh)

SRX:	107713263 107744238

SANH:

107658656 107685164

SGH:	107595570(dbh) 107597665

CCAR:

109052532 109080215

IPU:	108276829(dbh)

PHYP:

113544042(dbh)

AMEX:

103038160(dbh)

EEE:	113576331(dbh)

TRU:	101066621(dbh)

TNG:	GSTEN00024729G001

LCO:	104923914(dbh)

NCC:	104968179(dbh)

MZE:	101464817(dbh)

ONL:	100708156(dbh)

OLA:	101157870(dbh)

XMA:	102218690(dbh)

XCO:	114149436(dbh)

PRET:

103473626(dbh)

CVG:	107088692(dbh)

NFU:	107372400(dbh)

KMR:	108232649(dbh)

ALIM:

106514559(dbh)

AOCE:

111567020(dbh)

CSEM:

103389065(dbh)

POV:	109626136(dbh)

LCF:	108879254(dbh)

SDU:	111238762(dbh)

SLAL:

111666075(dbh)

HCQ:	109517071(dbh)

BPEC:

110174164(dbh)

MALB:

109963454(dbh)

SASA:

106568424(dbh)

OTW:

112257386

SALP:

111980057

ELS:	105014776(dbh)

SFM:	108934136(dbh)

PKI:	111854168(dbh)

LCM:	102359119(DBH)

CMK:	103182970(dbh)

BFO:

118421819

CIN:

100176680

SPU:	586320 752850

APLC:

110976390

SKO:

102804261

DME:	Dmel_CG1543(Tbh)

DER:

6551562

DSE:

6620197

DSI:	Dsimw501_GD16874(Dsim_Tbh)

DYA:	Dyak_GE15754

DAN:

6503980

DSR:

110178084

DPO:	Dpse_GA22782

DPE:

6600415

DMN:

108165110

DWI:

6641182

DGR:	Dgri_GH24481

DMO:	Dmoj_GI11219

DAZ:

DNV:

DHE:

DVI:

MDE:

LCQ:

AGA:	AgaP_AGAP010485

AAG:

5574019

AALB:

109427529 115256503

CQU:	CpipJ_CPIJ019622

AME:	751102(Tbh)

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

TCA:	663011(TcTBH)

DPA:	109535855 109541252 109541259

ATD:

109600593

NVL:

108563606

BMOR:

100862766(Tbh)

BMAN:

114239450

DPL:	KGM_207724

PMAC:

PRAP:

HAW:

TNL:

PXY:	105395691 105397436

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

PHU:	Phum_PHUM211140

ZNE:

110838985

FCD:

110851639

DPX:	DAPPUDRAFT_1839

ISC:	IscW_ISCW000229

TUT:

DPTE:

CSCU:

PTEP:

CEL:	CELE_H13N06.6(tbh-1)

CBR:	CBG07714(Cbr-tbh-1)

HRO:	HELRODRAFT_64253

LGI:	LOTGIDRAFT_120180 LOTGIDRAFT_162200 LOTGIDRAFT_191156 LOTGIDRAFT_233457 LOTGIDRAFT_233458 LOTGIDRAFT_234237

PCAN:

112557427 112561909 112563147 112570227 112570228 112570230 112570414 112570415 112575465 112576338

CRG:	105321753 105324389 105329831 105342404 105343978 105344230 105348387

MYI:	110442054 110447535 110447536 110450515 110452901 110454243 110454251 110455641 110456098 110456174 110467057 110467403

OBI:

106875923

LAK:	106150741 106165088 106173926 106180620 106181793

SMM:	Smp_163900

OVI:	T265_00912

AQU:	100635830 105315872

» show all

Reference

1 [PMID:14416204]

Authors

LEVIN EY, LEVENBERG B, KAUFMAN S.

Title

The enzymatic conversion of 3,4-dihydroxyphenylethylamine to norepinephrine.

Journal

J Biol Chem 235:2080-6 (1960)

Reference

2 [PMID:5846992]

Authors

Friedman S, Kaufman S.

Title

3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity.

Journal

J Biol Chem 240:4763-73 (1965)

Reference

3 [PMID:7388045]

Authors

Skotland T, Ljones T

Title

Direct spectrophotometric detection of ascorbate free radical formed by dopamine beta-monooxygenase and by ascorbate oxidase.

Journal

Biochim Biophys Acta 630:30-5 (1980)
DOI:10.1016/0304-4165(80)90134-8

Reference

4 [PMID:12966104]

Authors

Evans JP, Ahn K, Klinman JP

Title

Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase. Implications for the reactive oxygen species.

Journal

J Biol Chem 278:49691-8 (2003)
DOI:10.1074/jbc.M300797200

Other DBs

ExplorEnz - The Enzyme Database:

1.14.17.1

IUBMB Enzyme Nomenclature:

1.14.17.1

ExPASy - ENZYME nomenclature database:

1.14.17.1

BRENDA, the Enzyme Database:

1.14.17.1

CAS:

9013-38-1

LinkDB

DBGET integrated database retrieval system