Entry |
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Name |
5-carboxymethyl-2-hydroxymuconate Delta-isomerase;
CHM isomerase;
5-carboxymethyl-2-hydroxymuconic acid isomerase
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Class |
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
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Sysname |
5-carboxymethyl-2-hydroxymuconate Delta2,Delta4-2-oxo,Delta3-isomerase
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Reaction(IUBMB) |
5-carboxymethyl-2-hydroxymuconate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate [RN: R04379]
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Reaction(KEGG) |
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Substrate |
5-carboxymethyl-2-hydroxymuconate [CPD: C04186]
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Product |
(3E,5R)-5-carboxy-2-oxohept-3-enedioate
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Comment |
Part of the homoprotocatechuate degradation pathway in Escherichia coli C.
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History |
EC 5.3.3.10 created 1984
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Pathway |
ec01120 | Microbial metabolism in diverse environments |
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Orthology |
K01826 | 5-carboxymethyl-2-hydroxymuconate isomerase |
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Genes |
» show all
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Reference |
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Authors |
Garrido-Peritierra A, Cooper RA |
Title |
Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli. |
Journal |
|
Reference |
2 |
Authors |
Johnson, W.H., Jr., Hajipour, G. and Whitman, C.P. |
Title |
Stereochemical studies of 5-(carboxymethyl)-2-hydroxymuconate isomerase and 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dioate decarboxylase from Escherichia coli C: mechanistic and evolutionary implications. |
Journal |
J Am Chem Soc 117:8719-8726 (1995) |
Other DBs |
ExplorEnz - The Enzyme Database: | 5.3.3.10 |
ExPASy - ENZYME nomenclature database: | 5.3.3.10 |
UM-BBD (Biocatalysis/Biodegradation Database): | 5.3.3.10 |
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LinkDB |
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