| Entry |
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| Name |
5-carboxymethyl-2-hydroxymuconate Delta-isomerase;
CHM isomerase;
5-carboxymethyl-2-hydroxymuconic acid isomerase
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| Class |
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
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| Sysname |
5-carboxymethyl-2-hydroxymuconate Delta2,Delta4-2-oxo,Delta3-isomerase
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| Reaction(IUBMB) |
5-carboxymethyl-2-hydroxymuconate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate [RN: R04379]
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| Reaction(KEGG) |
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| Substrate |
5-carboxymethyl-2-hydroxymuconate [CPD: C04186]
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| Product |
(3E,5R)-5-carboxy-2-oxohept-3-enedioate
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| Comment |
Part of the homoprotocatechuate degradation pathway in Escherichia coli C.
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| History |
EC 5.3.3.10 created 1984
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K01826 | 5-carboxymethyl-2-hydroxymuconate isomerase |
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| Genes |
» show all
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| Reference |
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| Authors |
Garrido-Peritierra A, Cooper RA |
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| Title |
Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli. |
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| Journal |
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| Reference |
2 |
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| Authors |
Johnson, W.H., Jr., Hajipour, G. and Whitman, C.P. |
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| Title |
Stereochemical studies of 5-(carboxymethyl)-2-hydroxymuconate isomerase and 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dioate decarboxylase from Escherichia coli C: mechanistic and evolutionary implications. |
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| Journal |
J Am Chem Soc 117:8719-8726 (1995) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.3.3.10 |
| ExPASy - ENZYME nomenclature database: | 5.3.3.10 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 5.3.3.10 |
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| LinkDB |
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