KEGG   DRUG: Tramadol hydrochloride and acetaminophen
Entry
D09999            Mixture   Drug                                   
Name
Tramadol hydrochloride and acetaminophen;
Tramcet (TN)
Product
  Generic
TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Amneal Pharmaceuticals of New York LLC), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Asclemed USA), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Asclemed USA), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Aurobindo Pharma Limited), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (AvPAK), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Direct_Rx), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Medsource Pharmaceuticals), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Micro Labs Limited), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (NuCare Pharmaceuticals), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Preferred Pharmaceuticals), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Proficient Rx LP), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Proficient Rx LP), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (Proficient Rx LP), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (REMEDYREPACK), TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (St. Mary's Medical Park Pharmacy)
Component
Tramadol hydrochloride [DR:D01355], Acetaminophen [DR:D00217]
Class
Analgesic
 DG01984  Opioid analgesics
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1149
ATC code: N02AJ13
Product: D09999<JP/US>
Efficacy
Pain relief
Comment
Tramadol is a substrate of CYP2D6 and CYP3A4.
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AJ Opioids in combination with non-opioid analgesics
     N02AJ13 Tramadol and paracetamol
      D09999  Tramadol hydrochloride and acetaminophen <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Analgesics Combinations
   Acetaminophen/ Tramadol Hydrochloride
    D09999  Tramadol hydrochloride and acetaminophen
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D09999  Tramadol hydrochloride and acetaminophen
Drug groups [BR:br08330]
 Analgesic
  DG01984  Opioid analgesics
   D09999  Tramadol hydrochloride and acetaminophen
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D09999  Tramadol hydrochloride and acetaminophen
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D09999  Tramadol hydrochloride and acetaminophen
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09999
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D09999
Other DBs
PubChem: 135626720
LinkDB

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